Aliases for SYCE1L Gene

Aliases for SYCE1L Gene

  • Synaptonemal Complex Central Element Protein 1 Like 2 3 5
  • Synaptonemal Complex Central Element Protein 1-Like 2 3 4
  • Meiosis-Related Protein 2 3 4
  • MRP2 3

External Ids for SYCE1L Gene

Previous GeneCards Identifiers for SYCE1L Gene

  • GC16P075791
  • GC16P077233
  • GC16P062989

Summaries for SYCE1L Gene

GeneCards Summary for SYCE1L Gene

SYCE1L (Synaptonemal Complex Central Element Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is SYCE1.

UniProtKB/Swiss-Prot Summary for SYCE1L Gene

Additional gene information for SYCE1L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYCE1L Gene

Genomics for SYCE1L Gene

GeneHancer (GH) Regulatory Elements for SYCE1L Gene

Promoters and enhancers for SYCE1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J077199 Promoter 0.5 EPDnew 505.3 +0.1 141 0.1 AGO2 POLR2A SYCE1L NONHSAG020037.2 MON1B piR-44063
GH16J077211 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 56.8 +13.7 13715 3 HNRNPK TCF12 SP1 PHF8 JUND FOS ZNF639 ZIC2 POLR2A ZBTB10 lnc-ADAMTS18-12 SYCE1L MON1B VN2R10P ENSG00000261707 piR-55985-066 NONHSAG020037.2 ENSG00000261063
GH16J077190 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 43.3 -8.2 -8207 3.2 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 MON1B piR-43500 SYCE1L
GH16J077224 Enhancer 0.8 Ensembl 48.5 +25.3 25292 1.4 ZNF639 ZNF10 ZNF623 ZNF510 CTBP1 ATF2 OSR2 ZNF266 BCL11A KLF9 SYCE1L MON1B VN2R10P WWOX lnc-SYCE1L-3 ENSG00000260922 ENSG00000261063
GH16J077899 Enhancer 1 Ensembl ENCODE 33.7 +697.6 697575 2.4 ZNF300 TRIM28 ATF2 ZNF341 OSR2 ZNF491 WT1 CEBPB ZNF195 NFIC SYCE1L ENSG00000261707 VAT1L WWOX PPIAP50 lnc-CLEC3A-9 FJ601684-163 L13712-008
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYCE1L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYCE1L

Genomic Locations for SYCE1L Gene

Genomic Locations for SYCE1L Gene
chr16:77,199,408-77,213,215
(GRCh38/hg38)
Size:
13,808 bases
Orientation:
Plus strand
chr16:77,233,294-77,247,112
(GRCh37/hg19)
Size:
13,819 bases
Orientation:
Plus strand

Genomic View for SYCE1L Gene

Genes around SYCE1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCE1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCE1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE1L Gene

Proteins for SYCE1L Gene

  • Protein details for SYCE1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT33-SYC1L_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 1-like
    Protein Accession:
    A8MT33
    Secondary Accessions:
    • A6NF23

    Protein attributes for SYCE1L Gene

    Size:
    242 amino acids
    Molecular mass:
    27397 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SYCE1L Gene

Post-translational modifications for SYCE1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCE1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCE1L Gene

Domains & Families for SYCE1L Gene

Gene Families for SYCE1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYCE1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCE1L Gene

GenScript: Design optimal peptide antigens:
  • Meiosis-related protein (SYC1L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MT33

UniProtKB/Swiss-Prot:

SYC1L_HUMAN :
  • Belongs to the SYCE family.
Family:
  • Belongs to the SYCE family.
genes like me logo Genes that share domains with SYCE1L: view

Function for SYCE1L Gene

Molecular function for SYCE1L Gene

UniProtKB/Swiss-Prot Function:
May be involved in meiosis.

Phenotypes From GWAS Catalog for SYCE1L Gene

Phenotypes for SYCE1L Gene

MGI mutant phenotypes for SYCE1L:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SYCE1L: view

Animal Models for SYCE1L Gene

MGI Knock Outs for SYCE1L:
  • Syce1l Syce1l<tm1.1(KOMP)Vlcg>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYCE1L Gene

Localization for SYCE1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYCE1L gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYCE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex IBA 21873635
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with SYCE1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SYCE1L Gene

Pathways & Interactions for SYCE1L Gene

PathCards logo

SuperPathways for SYCE1L Gene

No Data Available

Interacting Proteins for SYCE1L Gene

;

Gene Ontology (GO) - Biological Process for SYCE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007128 meiotic prophase I IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0051321 meiotic cell cycle IEA --
GO:0070193 synaptonemal complex organization IEA --
genes like me logo Genes that share ontologies with SYCE1L: view

No data available for Pathways by source and SIGNOR curated interactions for SYCE1L Gene

Drugs & Compounds for SYCE1L Gene

No Compound Related Data Available

Transcripts for SYCE1L Gene

mRNA/cDNA for SYCE1L Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE1L Gene

No ASD Table

Relevant External Links for SYCE1L Gene

GeneLoc Exon Structure for
SYCE1L

Expression for SYCE1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYCE1L Gene

mRNA differential expression in normal tissues according to GTEx for SYCE1L Gene

This gene is overexpressed in Testis (x9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SYCE1L Gene



Protein tissue co-expression partners for SYCE1L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYCE1L

SOURCE GeneReport for Unigene cluster for SYCE1L Gene:

Hs.734779
genes like me logo Genes that share expression patterns with SYCE1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYCE1L Gene

Orthologs for SYCE1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCE1L 31 30
  • 99.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856750 30
  • 84.19 (n)
SYCE1L 31
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCE1L 31 30
  • 79.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Syce1l 17 31 30
  • 71.79 (n)
rat
(Rattus norvegicus)
Mammalia Syce1l 30
  • 69.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 22 (a)
OneToMany
Species where no ortholog for SYCE1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SYCE1L Gene

ENSEMBL:
Gene Tree for SYCE1L (if available)
TreeFam:
Gene Tree for SYCE1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SYCE1L: view image

Paralogs for SYCE1L Gene

Paralogs for SYCE1L Gene

(1) SIMAP similar genes for SYCE1L Gene using alignment to 2 proteins:

  • SYC1L_HUMAN
  • H3BME6_HUMAN
genes like me logo Genes that share paralogs with SYCE1L: view

Variants for SYCE1L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SYCE1L Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
684734 Benign: Non-obstructive azoospermia; not provided 77,199,473(+) C/G MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
773306 Benign: not provided 77,212,570(+) G/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for SYCE1L Gene

Structural Variations from Database of Genomic Variants (DGV) for SYCE1L Gene

Variant ID Type Subtype PubMed ID
dgv3027n100 CNV gain 25217958
esv3582331 CNV loss 25503493
esv3639164 CNV loss 21293372
nsv1055234 CNV gain 25217958
nsv1056676 CNV loss 25217958
nsv1065048 CNV gain 25217958

Variation tolerance for SYCE1L Gene

Gene Damage Index Score: 9.83; 89.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYCE1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYCE1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCE1L Gene

Disorders for SYCE1L Gene

Additional Disease Information for SYCE1L

No disorders were found for SYCE1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYCE1L Gene

Publications for SYCE1L Gene

  1. Identification of a new transcript specifically expressed in mouse spermatocytes: mmrp2. (PMID: 16328886) Gu S … Guo M (Molecular biology reports 2005) 2 3 54
  2. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 54

Products for SYCE1L Gene

Sources for SYCE1L Gene