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Aliases for SYBU Gene

Aliases for SYBU Gene

  • Syntabulin 2 3 3 5
  • Golgi-Localized Syntaphilin-Related Protein 3 4
  • Syntabulin (Syntaxin-Interacting) 2 3
  • Syntaxin-1-Binding Protein 3 4
  • GOLSYN 3 4
  • Implicated In Syntaxin Trafficking In Neurons 3
  • Microtubule-Associated Protein 3
  • Golgi-Localized Protein 3
  • Syntaphilin-Like 2
  • GOLSYN A Protein 3
  • GOLSYN B Protein 3
  • GOLSYN C Protein 3
  • KIAA1472 4
  • OCSYN 3
  • SNPHL 3

External Ids for SYBU Gene

Previous GeneCards Identifiers for SYBU Gene

  • GC08M110586
  • GC08M105908

Summaries for SYBU Gene

Entrez Gene Summary for SYBU Gene

  • Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SYBU Gene

SYBU (Syntabulin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding and syntaxin-1 binding. An important paralog of this gene is SNPH.

UniProtKB/Swiss-Prot for SYBU Gene

  • Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.

Gene Wiki entry for SYBU Gene

Additional gene information for SYBU Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYBU Gene

Genomics for SYBU Gene

GeneHancer (GH) Regulatory Elements for SYBU Gene

Promoters and enhancers for SYBU Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I109642 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.2 +47.4 47427 3.5 FOXA2 MLX ARID4B SIN3A YBX1 DMAP1 ZBTB7B YY1 ZNF207 ZNF143 LOC100132813 SYBU PKHD1L1
GH08I109691 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 555.6 +0.1 141 1.2 CTCF USF1 NFIB SIN3A CEBPG ZNF48 RFX5 ZNF335 E2F1 ZFHX2 SYBU PKHD1L1 MAPK6PS5 LOC100132813
GH08I109648 Promoter 0.7 EPDnew 560.8 +43.0 42969 0.1 POLR2A CREB1 SYBU LOC100132813
GH08I109680 Promoter 0.5 EPDnew 550.4 +10.9 10856 0.1 SYBU LOC100132813
GH08I109604 Enhancer 1.3 Ensembl ENCODE dbSUPER 17 +85.1 85117 4.7 PKNOX1 FOXA2 FEZF1 YY1 FOS NFYC MAFF RFX3 HNF4A WT1 SYBU LOC100132813 PKHD1L1 EBAG9 GC08P109564
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYBU on UCSC Golden Path with GeneCards custom track

Genomic Locations for SYBU Gene

Genomic Locations for SYBU Gene
chr8:109,573,978-109,691,791
(GRCh38/hg38)
Size:
117,814 bases
Orientation:
Minus strand
chr8:110,586,207-110,704,020
(GRCh37/hg19)

Genomic View for SYBU Gene

Genes around SYBU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYBU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYBU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYBU Gene

Proteins for SYBU Gene

  • Protein details for SYBU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX95-SYBU_HUMAN
    Recommended name:
    Syntabulin
    Protein Accession:
    Q9NX95
    Secondary Accessions:
    • A8K354
    • B3KQX3
    • B3KU61
    • Q5R1T1
    • Q5R1T2
    • Q5R1T3
    • Q5Y2M6
    • Q8ND49
    • Q8TCR6
    • Q96D80
    • Q9P256

    Protein attributes for SYBU Gene

    Size:
    663 amino acids
    Molecular mass:
    72388 Da
    Quaternary structure:
    • Interacts with STX1A and KIF5B.

    Alternative splice isoforms for SYBU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYBU Gene

Post-translational modifications for SYBU Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYBU Gene

Domains & Families for SYBU Gene

Gene Families for SYBU Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SYBU Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYBU: view

No data available for UniProtKB/Swiss-Prot for SYBU Gene

Function for SYBU Gene

Molecular function for SYBU Gene

UniProtKB/Swiss-Prot Function:
Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.

Gene Ontology (GO) - Molecular Function for SYBU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15459722
GO:0008017 microtubule binding IEA --
GO:0017075 syntaxin-1 binding IEA --
GO:0019894 kinesin binding IEA --
genes like me logo Genes that share ontologies with SYBU: view
genes like me logo Genes that share phenotypes with SYBU: view

Animal Model Products

miRNA for SYBU Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYBU Gene

Localization for SYBU Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYBU Gene

Isoform 1: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in neuronal processes.
Isoform 3: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 4: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 5: Golgi apparatus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYBU gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SYBU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 colocalizes_with microtubule IDA 15459722
genes like me logo Genes that share ontologies with SYBU: view

Pathways & Interactions for SYBU Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYBU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019896 axonal transport of mitochondrion IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0060025 regulation of synaptic activity IEA --
GO:0060074 synapse maturation IEA --
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
genes like me logo Genes that share ontologies with SYBU: view

No data available for Pathways by source and SIGNOR curated interactions for SYBU Gene

Drugs & Compounds for SYBU Gene

No Compound Related Data Available

Transcripts for SYBU Gene

Unigene Clusters for SYBU Gene

Syntabulin (syntaxin-interacting):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYBU Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - - - - - - -
SP9: - - -

Relevant External Links for SYBU Gene

GeneLoc Exon Structure for
SYBU
ECgene alternative splicing isoforms for
SYBU

Expression for SYBU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYBU Gene

mRNA differential expression in normal tissues according to GTEx for SYBU Gene

This gene is overexpressed in Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for SYBU Gene

This gene is overexpressed in Pancreas (31.6), Peripheral blood mononuclear cells (13.2), Retina (11.7), and Liver (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYBU Gene



NURSA nuclear receptor signaling pathways regulating expression of SYBU Gene:

SYBU

SOURCE GeneReport for Unigene cluster for SYBU Gene:

Hs.390738

mRNA Expression by UniProt/SwissProt for SYBU Gene:

Q9NX95-SYBU_HUMAN
Tissue specificity: Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine.

Evidence on tissue expression from TISSUES for SYBU Gene

  • Nervous system(5)
  • Liver(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with SYBU: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYBU Gene

Orthologs for SYBU Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYBU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYBU 33 34
  • 99.65 (n)
mouse
(Mus musculus)
Mammalia Sybu 33 16 34
  • 83.96 (n)
dog
(Canis familiaris)
Mammalia SYBU 33 34
  • 83.66 (n)
rat
(Rattus norvegicus)
Mammalia Sybu 33
  • 83.36 (n)
oppossum
(Monodelphis domestica)
Mammalia SYBU 34
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYBU 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves SYBU 33 34
  • 68.28 (n)
lizard
(Anolis carolinensis)
Reptilia SYBU 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sybu 33
  • 64.09 (n)
Str.16935 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8441 33
zebrafish
(Danio rerio)
Actinopterygii sybu 33 34
  • 56.16 (n)
Species where no ortholog for SYBU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYBU Gene

ENSEMBL:
Gene Tree for SYBU (if available)
TreeFam:
Gene Tree for SYBU (if available)

Paralogs for SYBU Gene

Paralogs for SYBU Gene

genes like me logo Genes that share paralogs with SYBU: view

Variants for SYBU Gene

Sequence variations from dbSNP and Humsavar for SYBU Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000035104 -- 109,608,493(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000133751 -- 109,623,028(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000139632 -- 109,604,676(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000155661 -- 109,666,586(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000164524 -- 109,626,998(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYBU Gene

Variant ID Type Subtype PubMed ID
esv1058770 CNV insertion 17803354
esv275395 CNV gain+loss 21479260
esv993723 CNV insertion 20482838
nsv1125952 CNV tandem duplication 24896259
nsv396337 CNV insertion 16902084
nsv398033 CNV insertion 16902084
nsv519645 CNV loss 19592680

Variation tolerance for SYBU Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYBU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYBU

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYBU Gene

Disorders for SYBU Gene

Additional Disease Information for SYBU

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SYBU Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYBU Gene

Publications for SYBU Gene

  1. Molecular cloning and characterization of gene for Golgi-localized syntaphilin-related protein on human chromosome 8q23. (PMID: 15656992) Funakoshi E … Ito F (Gene 2005) 2 3 4 58
  2. Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons. (PMID: 15459722) Su Q … Sheng ZH (Nature cell biology 2004) 2 3 4 58
  3. Syntabulin-kinesin-1 family member 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly. (PMID: 17611281) Cai Q … Sheng ZH (The Journal of neuroscience : the official journal of the Society for Neuroscience 2007) 2 3 58
  4. Expression of m-Golsyn/Syntabulin gene during mouse brain development. (PMID: 16750881) Funakoshi E … Ito F (Neuroscience letters 2006) 2 3 58
  5. Syntabulin-mediated anterograde transport of mitochondria along neuronal processes. (PMID: 16157705) Cai Q … Sheng ZH (The Journal of cell biology 2005) 2 3 58

Products for SYBU Gene

Sources for SYBU Gene

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