Aliases for SWI5 Gene

Aliases for SWI5 Gene

  • SWI5 Homologous Recombination Repair Protein 2 3 5
  • SAE3 2 3 4
  • HBV DNAPTP1-Transactivated Protein A 3 4
  • DNA Repair Protein SWI5 Homolog 3 4
  • Protein SAE3 Homolog 3 4
  • C9orf119 3 4
  • SWI5 Recombination Repair Homolog (Yeast) 2
  • Chromosome 9 Open Reading Frame 119 2
  • SWI5 Recombination Repair Homolog 3
  • BA395P17.9 2
  • SWI5 5

External Ids for SWI5 Gene

Previous HGNC Symbols for SWI5 Gene

  • C9orf119

Previous GeneCards Identifiers for SWI5 Gene

  • GC09P131038
  • GC09P131039
  • GC09P131041
  • GC09P131044
  • GC09P131059

Summaries for SWI5 Gene

GeneCards Summary for SWI5 Gene

SWI5 (SWI5 Homologous Recombination Repair Protein) is a Protein Coding gene. Diseases associated with SWI5 include Ceroid Lipofuscinosis, Neuronal, 2 and Ceroid Lipofuscinosis, Neuronal, 1.

UniProtKB/Swiss-Prot Summary for SWI5 Gene

  • Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SWI5 Gene

Genomics for SWI5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SWI5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SWI5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SWI5

Genomic Locations for SWI5 Gene

Latest Assembly
chr9:128,275,356-128,316,123
(GRCh38/hg38)
Size:
40,768 bases
Orientation:
Plus strand

Previous Assembly
chr9:131,037,635-131,051,268
(GRCh37/hg19 by Entrez Gene)
Size:
13,634 bases
Orientation:
Plus strand

chr9:131,037,658-131,051,269
(GRCh37/hg19 by Ensembl)
Size:
13,612 bases
Orientation:
Plus strand

Genomic View for SWI5 Gene

Genes around SWI5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SWI5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SWI5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SWI5 Gene

Proteins for SWI5 Gene

  • Protein details for SWI5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1ZZU3-SWI5_HUMAN
    Recommended name:
    DNA repair protein SWI5 homolog
    Protein Accession:
    Q1ZZU3
    Secondary Accessions:
    • Q5SYX7
    • Q5SYX8
    • Q8N2W6

    Protein attributes for SWI5 Gene

    Size:
    235 amino acids
    Molecular mass:
    26739 Da
    Quaternary structure:
    • Component of the SWI5-SFR1 complex. Interacts with RAD51.

neXtProt entry for SWI5 Gene

Post-translational modifications for SWI5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SWI5 Gene

Domains & Families for SWI5 Gene

Gene Families for SWI5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SWI5 Gene

InterPro:

Suggested Antigen Peptide Sequences for SWI5 Gene

GenScript: Design optimal peptide antigens:
  • Protein SAE3 homolog (SWI5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q1ZZU3

UniProtKB/Swiss-Prot:

SWI5_HUMAN :
  • Belongs to the SWI5/SAE3 family.
Family:
  • Belongs to the SWI5/SAE3 family.
genes like me logo Genes that share domains with SWI5: view

Function for SWI5 Gene

Molecular function for SWI5 Gene

UniProtKB/Swiss-Prot Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

Phenotypes From GWAS Catalog for SWI5 Gene

Gene Ontology (GO) - Molecular Function for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21252223
genes like me logo Genes that share ontologies with SWI5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SWI5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SWI5 Gene

Localization for SWI5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SWI5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SWI5 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0032798 Swi5-Sfr1 complex IDA, IBA 21252223
GO:0034974 Swi5-Swi2 complex IBA 21873635
genes like me logo Genes that share ontologies with SWI5: view

Pathways & Interactions for SWI5 Gene

PathCards logo

SuperPathways for SWI5 Gene

No Data Available

Interacting Proteins for SWI5 Gene

Selected Interacting proteins: Q1ZZU3-SWI5_HUMAN for SWI5 Gene via IID

Gene Ontology (GO) - Biological Process for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP, IBA 21252223
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0071479 cellular response to ionizing radiation IDA 23754376
genes like me logo Genes that share ontologies with SWI5: view

No data available for Pathways by source and SIGNOR curated interactions for SWI5 Gene

Drugs & Compounds for SWI5 Gene

No Compound Related Data Available

Transcripts for SWI5 Gene

mRNA/cDNA for SWI5 Gene

4 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SWI5

Alternative Splicing Database (ASD) splice patterns (SP) for SWI5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for SWI5 Gene

GeneLoc Exon Structure for
SWI5

Expression for SWI5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SWI5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SWI5 Gene

This gene is overexpressed in Testis (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SWI5

SOURCE GeneReport for Unigene cluster for SWI5 Gene:

Hs.259594

Evidence on tissue expression from TISSUES for SWI5 Gene

  • Nervous system(4.3)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with SWI5: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SWI5 Gene

Orthologs for SWI5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SWI5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SWI5 29 30
  • 99.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SWI5 29 30
  • 81.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Swi5 29
  • 79.46 (n)
Oppossum
(Monodelphis domestica)
Mammalia SWI5 30
  • 78 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Swi5 29 16 30
  • 77.52 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SWI5 30
  • 71 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SWI5 30
  • 61 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SWI5 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia swi5 29
  • 61.49 (n)
Str.1722 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.33205 29
Zebrafish
(Danio rerio)
Actinopterygii swi5 30
  • 36 (a)
OneToOne
Species where no ortholog for SWI5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SWI5 Gene

ENSEMBL:
Gene Tree for SWI5 (if available)
TreeFam:
Gene Tree for SWI5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SWI5: view image
Alliance of Genome Resources:
Additional Orthologs for SWI5

Paralogs for SWI5 Gene

Pseudogenes.org Pseudogenes for SWI5 Gene

genes like me logo Genes that share paralogs with SWI5: view

No data available for Paralogs for SWI5 Gene

Variants for SWI5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SWI5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SWI5 Gene

Variant ID Type Subtype PubMed ID
nsv831728 CNV loss 17160897
nsv972808 CNV duplication 23825009

Variation tolerance for SWI5 Gene

Gene Damage Index Score: 4.54; 64.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SWI5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SWI5
Leiden Open Variation Database (LOVD)
SWI5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SWI5 Gene

Disorders for SWI5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SWI5 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search SWI5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SWI5

genes like me logo Genes that share disorders with SWI5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SWI5 Gene

Publications for SWI5 Gene

  1. The role of the human SWI5-MEI5 complex in homologous recombination repair. (PMID: 21252223) Yuan J … Chen J (The Journal of biological chemistry 2011) 2 3 4
  2. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PMID: 23754376) Yuan J … Chen J (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4
  3. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. (PMID: 20976249) Akamatsu Y … Jasin M (PLoS genetics 2010) 2 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. Downregulation of SWI5 and CTC1 genes: hepatitis B virus DNA polymerase transactivated protein 1-mediated inhibition of DNA repair. (PMID: 27265469) Yao XK … Sui W (Acta virologica 2016) 3

Products for SWI5 Gene

Sources for SWI5 Gene