The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016] See more...

Aliases for SVOPL Gene

Aliases for SVOPL Gene

  • SVOP Like 2 3 5
  • Putative Transporter SVOPL 3 4
  • SV2 Related Protein Homolog (Rat)-Like 2
  • SV2 Related Protein Homolog-Like 3
  • SV2-Related Protein-Like 4
  • SVOP-Like Protein 4
  • SVOP-Like 2

External Ids for SVOPL Gene

Previous GeneCards Identifiers for SVOPL Gene

  • GC07M137930
  • GC07M138279
  • GC07M132588

Summaries for SVOPL Gene

Entrez Gene Summary for SVOPL Gene

  • The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]

GeneCards Summary for SVOPL Gene

SVOPL (SVOP Like) is a Protein Coding gene. Diseases associated with SVOPL include Retinitis Pigmentosa 45 and Combat Disorder. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SVOP.

Additional gene information for SVOPL Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SVOPL Gene

Genomics for SVOPL Gene

GeneHancer (GH) Regulatory Elements for SVOPL Gene

Promoters and enhancers for SVOPL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J138661 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.3 +37.0 36979 5.5 ZNF217 EP300 NCOR1 TEAD4 ZBTB10 ZBTB26 TRIM28 KLF7 KLF9 FOXA2 SVOPL piR-48348-078 RF00017-6667
GH07J138701 Enhancer 0.4 Ensembl 500.7 +0.0 40 1 EP300 YY1 CEBPB POLR2A TCF7L2 SVOPL UQCRFS1P2 piR-50443-347 ENSG00000252188 RF00017-6668
GH07J138751 Enhancer 1 Ensembl ENCODE 11.4 -50.7 -50747 4.6 USF1 NCOR1 TEAD4 ZIC2 TCF7 EP300 SKI TBX3 RAD51 ESRRA SVOPL UQCRFS1P2 lnc-SVOPL-1 RF00017-6669 ATP6V0A4
GH07J138400 Enhancer 1 Ensembl ENCODE 10.6 +300.6 300553 1.6 ZBTB11 CTBP1 TAF9B NCOR1 RELA TRIM25 ZNF316 NFIC ARNT GABPA SVOPL ENSG00000201465 lnc-SVOPL-2 lnc-TRIM24-1
GH07J138738 Enhancer 1 Ensembl ENCODE 10.9 -37.5 -37490 1.3 CTCF REST MYC RAD21 TRIM22 HINFP SMC3 RBM25 LEF1 DEK SVOPL UQCRFS1P2 ENSG00000201465 piR-50443-348 lnc-SVOPL-1 ATP6V0A4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SVOPL on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SVOPL

Top Transcription factor binding sites by QIAGEN in the SVOPL gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • ITF-2
  • Tal-1beta

Genomic Locations for SVOPL Gene

Genomic Locations for SVOPL Gene
chr7:138,594,285-138,701,354
(GRCh38/hg38)
Size:
107,070 bases
Orientation:
Minus strand
chr7:138,279,030-138,386,097
(GRCh37/hg19)
Size:
107,068 bases
Orientation:
Minus strand

Genomic View for SVOPL Gene

Genes around SVOPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVOPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVOPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOPL Gene

Proteins for SVOPL Gene

  • Protein details for SVOPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N434-SVOPL_HUMAN
    Recommended name:
    Putative transporter SVOPL
    Protein Accession:
    Q8N434

    Protein attributes for SVOPL Gene

    Size:
    492 amino acids
    Molecular mass:
    53991 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SVOPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SVOPL Gene

Post-translational modifications for SVOPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SVOPL Gene

Domains & Families for SVOPL Gene

Gene Families for SVOPL Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SVOPL Gene

Suggested Antigen Peptide Sequences for SVOPL Gene

GenScript: Design optimal peptide antigens:
  • SVOP-like protein (SVOPL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N434

UniProtKB/Swiss-Prot:

SVOPL_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SVOPL: view

Function for SVOPL Gene

Phenotypes From GWAS Catalog for SVOPL Gene

Gene Ontology (GO) - Molecular Function for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SVOPL: view
genes like me logo Genes that share phenotypes with SVOPL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SVOPL

CRISPR Products

Clone Products

  • Addgene plasmids for SVOPL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SVOPL Gene

Localization for SVOPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOPL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SVOPL gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SVOPL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SVOPL Gene

Pathways & Interactions for SVOPL Gene

PathCards logo

SuperPathways for SVOPL Gene

No Data Available

Interacting Proteins for SVOPL Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000405482 Q8N434-SVOPL_HUMAN for SVOPL Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SVOPL: view

No data available for Pathways by source and SIGNOR curated interactions for SVOPL Gene

Drugs & Compounds for SVOPL Gene

No Compound Related Data Available

Transcripts for SVOPL Gene

mRNA/cDNA for SVOPL Gene

3 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for SVOPL

Alternative Splicing Database (ASD) splice patterns (SP) for SVOPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -
SP2:

Relevant External Links for SVOPL Gene

GeneLoc Exon Structure for
SVOPL

Expression for SVOPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SVOPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOPL Gene

This gene is overexpressed in Testis (x8.2) and Kidney - Cortex (x7.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SVOPL

SOURCE GeneReport for Unigene cluster for SVOPL Gene:

Hs.99414
genes like me logo Genes that share expression patterns with SVOPL: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SVOPL Gene

Orthologs for SVOPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVOPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SVOPL 31 30
  • 99.32 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SVOPL 31
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SVOPL 31 30
  • 88.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SVOPL 31 30
  • 88.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Svopl 17 31 30
  • 87.53 (n)
rat
(Rattus norvegicus)
Mammalia RGD1566053 30
  • 84.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SVOPL 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SVOPL 31 30
  • 76.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SVOPL 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia svopl 30
  • 69.74 (n)
zebrafish
(Danio rerio)
Actinopterygii svopl 31 30
  • 60 (n)
OneToOne
Species where no ortholog for SVOPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVOPL Gene

ENSEMBL:
Gene Tree for SVOPL (if available)
TreeFam:
Gene Tree for SVOPL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SVOPL: view image

Paralogs for SVOPL Gene

(2) SIMAP similar genes for SVOPL Gene using alignment to 3 proteins:

  • SVOPL_HUMAN
  • C9JVJ9_HUMAN
  • F8WES3_HUMAN
genes like me logo Genes that share paralogs with SVOPL: view

Variants for SVOPL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SVOPL Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
713102 Benign: not provided 138,644,827(-) G/A MISSENSE_VARIANT
726066 Benign: not provided 138,649,024(-) G/A SYNONYMOUS_VARIANT
740628 Benign: not provided 138,649,074(-) C/T MISSENSE_VARIANT
777830 Likely Benign: not provided 138,644,837(-) A/G SYNONYMOUS_VARIANT
779254 Likely Benign: not provided 138,656,474(-) G/A NONSENSE

Additional dbSNP identifiers (rs#s) for SVOPL Gene

Structural Variations from Database of Genomic Variants (DGV) for SVOPL Gene

Variant ID Type Subtype PubMed ID
esv1010083 CNV deletion 20482838
esv1471021 CNV deletion 17803354
esv2543778 CNV deletion 19546169
esv2657210 CNV deletion 23128226
esv2659373 CNV deletion 23128226
esv2678647 CNV deletion 23128226
esv2735212 CNV deletion 23290073
esv2735218 CNV deletion 23290073
esv2735219 CNV deletion 23290073
esv2735220 CNV deletion 23290073
esv2735221 CNV deletion 23290073
esv2735222 CNV deletion 23290073
esv3359 CNV loss 18987735
esv3438653 CNV duplication 20981092
esv3542504 CNV deletion 23714750
esv3542505 CNV deletion 23714750
esv3542506 CNV deletion 23714750
esv3542507 CNV deletion 23714750
esv3615196 CNV loss 21293372
esv3615197 CNV loss 21293372
esv6486 CNV loss 19470904
esv7121 CNV loss 19470904
esv993410 CNV deletion 20482838
nsv1030956 CNV gain 25217958
nsv1076002 CNV deletion 25765185
nsv1076954 CNV deletion 25765185
nsv1109920 CNV deletion 24896259
nsv1112160 CNV deletion 24896259
nsv1119138 CNV deletion 24896259
nsv1120922 CNV deletion 24896259
nsv1140852 CNV deletion 24896259
nsv365934 CNV deletion 16902084
nsv512927 CNV insertion 21212237
nsv512928 CNV insertion 21212237
nsv5968 CNV insertion 18451855
nsv956979 CNV deletion 24416366
nsv970584 CNV duplication 23825009

Variation tolerance for SVOPL Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.47; 96.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SVOPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SVOPL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVOPL Gene

Disorders for SVOPL Gene

MalaCards: The human disease database

(3) MalaCards diseases for SVOPL Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 45
  • rp45
combat disorder
  • combat neurosis
transient neonatal diabetes mellitus
  • tndm1
- elite association - COSMIC cancer census association via MalaCards
Search SVOPL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SVOPL

genes like me logo Genes that share disorders with SVOPL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SVOPL Gene

Publications for SVOPL Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson JA … Fredriksson R (Genomics 2007) 3 4 54
  2. UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. (PMID: 27593939) Hu L … Weng C (Oncogene 2017) 3 54
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L … Jackson PK (Cell 2011) 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 54

Products for SVOPL Gene

Sources for SVOPL Gene