Aliases for SVOP Gene

Aliases for SVOP Gene

  • SV2 Related Protein 2 3 5
  • Synaptic Vesicle 2-Related Protein 3 4
  • SV2 Related Protein Homolog (Rat) 2
  • SV2 Related Protein Homolog 3
  • SV2-Related Protein 4
  • DKFZp761H039 2
  • SVOP 5

External Ids for SVOP Gene

Previous GeneCards Identifiers for SVOP Gene

  • GC12M107808
  • GC12M109304
  • GC12M106369

Summaries for SVOP Gene

GeneCards Summary for SVOP Gene

SVOP (SV2 Related Protein) is a Protein Coding gene. Diseases associated with SVOP include Familial Atrial Fibrillation. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SVOPL.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SVOP Gene

Genomics for SVOP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SVOP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J109020 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.7 +0.5 467 1.6 GATAD2A ZNF629 REST TFE3 IKZF1 NFKBIZ ZNF692 RCOR2 ZNF7 TARDBP ENSG00000279630 SVOP lnc-ALKBH2-4 lnc-ALKBH2-5 lnc-SVOP-3 DAO
GH12J108911 Enhancer 0.6 ENCODE 13.8 +109.1 109127 1.4 CTBP1 KLF4 ZNF217 GATAD2B CUX1 ELK1 MBD2 DPF2 ELF1 ZNF687 lnc-SVOP-1 SVOP piR-48759-067 DAO
GH12J108950 Enhancer 1 Ensembl ENCODE 5.8 +71.8 71767 4.6 GATAD2A CTCF JUND FOXA1 LARP7 ZNF143 RXRB REST RAD21 IRF2 RNU6-361P SSH1 ALKBH2 UNG SELPLG TMEM119 FICD LINC01498 SVOP lnc-SSH1-3
GH12J108913 Enhancer 0.3 Ensembl ENCODE 14.5 +107.1 107067 2 SVOP SSH1 lnc-SVOP-1 piR-48759-067 DAO
GH12J108906 Enhancer 0.9 FANTOM5 ENCODE 3.1 +113.2 113196 2.6 TEAD4 ZNF311 ZNF148 ZNF248 ZNF444 ZIK1 PKNOX1 ZFHX2 ZNF621 SPI1 ALKBH2 SART3 USP30 DAO SVOP lnc-SVOP-1 RF00017-1252
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SVOP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SVOP

Genomic Locations for SVOP Gene

Genomic Locations for SVOP Gene
chr12:108,907,741-109,021,068
(GRCh38/hg38)
Size:
113,328 bases
Orientation:
Minus strand
chr12:109,304,658-109,459,045
(GRCh37/hg19)
Size:
154,388 bases
Orientation:
Minus strand

Genomic View for SVOP Gene

Genes around SVOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOP Gene

Proteins for SVOP Gene

  • Protein details for SVOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4V2-SVOP_HUMAN
    Recommended name:
    Synaptic vesicle 2-related protein
    Protein Accession:
    Q8N4V2
    Secondary Accessions:
    • Q9NPW5

    Protein attributes for SVOP Gene

    Size:
    548 amino acids
    Molecular mass:
    60769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SVOP Gene

Post-translational modifications for SVOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SVOP Gene

Domains & Families for SVOP Gene

Gene Families for SVOP Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SVOP Gene

Suggested Antigen Peptide Sequences for SVOP Gene

GenScript: Design optimal peptide antigens:
  • Synaptic vesicle 2-related protein (SVOP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N4V2

UniProtKB/Swiss-Prot:

SVOP_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SVOP: view

Function for SVOP Gene

Phenotypes From GWAS Catalog for SVOP Gene

Gene Ontology (GO) - Molecular Function for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SVOP: view
genes like me logo Genes that share phenotypes with SVOP: view

Animal Models for SVOP Gene

MGI Knock Outs for SVOP:
  • Svop Svop<tm1.1Baj>

Animal Model Products

  • Taconic Biosciences Mouse Models for SVOP

CRISPR Products

miRNA for SVOP Gene

miRTarBase miRNAs that target SVOP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SVOP

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SVOP Gene

Localization for SVOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOP Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SVOP gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SVOP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SVOP Gene

Pathways & Interactions for SVOP Gene

PathCards logo

SuperPathways for SVOP Gene

No Data Available

Interacting Proteins for SVOP Gene

Gene Ontology (GO) - Biological Process for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SVOP: view

No data available for Pathways by source and SIGNOR curated interactions for SVOP Gene

Drugs & Compounds for SVOP Gene

No Compound Related Data Available

Transcripts for SVOP Gene

mRNA/cDNA for SVOP Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SVOP

Alternative Splicing Database (ASD) splice patterns (SP) for SVOP Gene

No ASD Table

Relevant External Links for SVOP Gene

GeneLoc Exon Structure for
SVOP

Expression for SVOP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SVOP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOP Gene

This gene is overexpressed in Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x6.6), and Brain - Anterior cingulate cortex (BA24) (x6.5).

Protein differential expression in normal tissues from HIPED for SVOP Gene

This gene is overexpressed in Retina (26.6), Fetal Brain (25.3), and Frontal cortex (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SVOP Gene



Protein tissue co-expression partners for SVOP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SVOP

SOURCE GeneReport for Unigene cluster for SVOP Gene:

Hs.4221

Evidence on tissue expression from TISSUES for SVOP Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with SVOP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SVOP Gene

Orthologs for SVOP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SVOP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SVOP 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SVOP 31
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SVOP 30 31
  • 92.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SVOP 30 31
  • 92.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Svop 30 17 31
  • 88.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Svop 30
  • 87.71 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SVOP 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SVOP 30 31
  • 80.05 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SVOP 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia svop 30
  • 76.82 (n)
Zebrafish
(Danio rerio)
Actinopterygii svopa 30 31
  • 71.47 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.259 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007660 30
  • 55.56 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG4324 30 31
  • 55.03 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea svop-1 30 31
  • 54.88 (n)
OneToOne
Rice
(Oryza sativa)
Liliopsida Os03g0638200 30
  • 48.15 (n)
Species where no ortholog for SVOP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SVOP Gene

ENSEMBL:
Gene Tree for SVOP (if available)
TreeFam:
Gene Tree for SVOP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SVOP: view image

Paralogs for SVOP Gene

(7) SIMAP similar genes for SVOP Gene using alignment to 4 proteins:

  • SVOP_HUMAN
  • F8VNW2_HUMAN
  • H0YHK4_HUMAN
  • H0YHQ5_HUMAN
genes like me logo Genes that share paralogs with SVOP: view

Variants for SVOP Gene

Additional dbSNP identifiers (rs#s) for SVOP Gene

Structural Variations from Database of Genomic Variants (DGV) for SVOP Gene

Variant ID Type Subtype PubMed ID
esv1008019 CNV loss 20482838
esv2422361 CNV duplication 17116639
esv3449316 CNV insertion 20981092
esv3630711 CNV gain 21293372
esv6912 CNV loss 19470904
nsv1115437 CNV duplication 24896259
nsv1119983 CNV deletion 24896259
nsv1138167 CNV deletion 24896259
nsv455711 CNV loss 19166990
nsv473460 CNV novel sequence insertion 20440878
nsv473750 CNV novel sequence insertion 20440878
nsv473787 CNV novel sequence insertion 20440878
nsv474121 CNV novel sequence insertion 20440878
nsv475148 CNV novel sequence insertion 20440878
nsv475455 CNV novel sequence insertion 20440878
nsv475880 CNV novel sequence insertion 20440878
nsv476008 CNV novel sequence insertion 20440878
nsv477133 CNV novel sequence insertion 20440878
nsv477368 CNV novel sequence insertion 20440878
nsv478991 CNV novel sequence insertion 20440878
nsv479049 CNV novel sequence insertion 20440878
nsv479675 CNV novel sequence insertion 20440878
nsv479755 CNV novel sequence insertion 20440878
nsv479856 CNV novel sequence insertion 20440878
nsv479892 CNV novel sequence insertion 20440878
nsv480221 CNV novel sequence insertion 20440878
nsv480371 CNV novel sequence insertion 20440878
nsv480648 CNV novel sequence insertion 20440878
nsv480875 CNV novel sequence insertion 20440878
nsv480920 CNV novel sequence insertion 20440878
nsv481116 CNV novel sequence insertion 20440878
nsv481157 CNV novel sequence insertion 20440878
nsv481390 CNV novel sequence insertion 20440878
nsv525664 CNV loss 19592680
nsv560115 CNV loss 21841781

Additional Variant Information for SVOP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SVOP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SVOP Gene

Disorders for SVOP Gene

MalaCards: The human disease database

(1) MalaCards diseases for SVOP Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search SVOP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SVOP

genes like me logo Genes that share disorders with SVOP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SVOP Gene

Publications for SVOP Gene

  1. SVOP is a nucleotide binding protein. (PMID: 19390693) Yao J … Bajjalieh SM (PloS one 2009) 2 3 23
  2. Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals. (PMID: 21953179) Jeanguenin L … Hanson AD (Functional & integrative genomics 2012) 2 3
  3. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson JA … Fredriksson R (Genomics 2007) 3 4
  4. SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles. (PMID: 9801366) Janz R … Südhof TC (The Journal of neuroscience : the official journal of the Society for Neuroscience 1998) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SVOP Gene

Sources for SVOP Gene