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Aliases for SVIP Gene

Aliases for SVIP Gene

  • Small VCP Interacting Protein 2 3 5
  • Small VCP/P97-Interacting Protein 2

External Ids for SVIP Gene

Previous GeneCards Identifiers for SVIP Gene

  • GC11M022527

Summaries for SVIP Gene

Entrez Gene Summary for SVIP Gene

  • Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete this process. The protein encoded by this gene is an inhibitor of ERAD, functioning to disrupt the interaction of these protein components. This downregulation of ERAD may be needed to protect the cell from overactive protein degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for SVIP Gene

SVIP (Small VCP Interacting Protein) is a Protein Coding gene. Among its related pathways are Innate Immune System and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include protein self-association.

Additional gene information for SVIP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVIP Gene

Genomics for SVIP Gene

GeneHancer (GH) Regulatory Elements for SVIP Gene

Promoters and enhancers for SVIP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I022828 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 575.9 +1.0 951 2.4 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 ZNF548 SP3 SVIP ENSG00000246225 GC11P022744
GH11I022792 Enhancer 1.2 FANTOM5 Ensembl ENCODE 14.3 +37.7 37698 1.1 FOXA2 RARA CHAMP1 FOS THAP11 ZNF592 NFIL3 KLF16 RCOR2 CEBPA SVIP ENSG00000254768 SLC17A6 ENSG00000246225 GC11P022744 GAS2
GH11I022875 Enhancer 0.7 ENCODE 12 -45.8 -45771 0.2 CTCF FOXA2 TEAD4 RAD21 RFX5 TEAD3 GATA3 SMC3 ZNF143 RCOR1 SVIP CCDC179 ENSG00000246225 GC11P023099
GH11I022808 Enhancer 0.6 Ensembl 11.9 +21.7 21698 0.4 CBFB JUN ZBED1 JUNB DPF2 BATF ATF2 IRF4 IKZF1 ETV6 ENSG00000246225 SVIP GC11P022744 GAS2
GH11I022860 Promoter 0.6 EPDnew 11.8 -30.2 -30190 0.1 CTCF CCDC179 SVIP ENSG00000246225 GC11P023099
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SVIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SVIP gene promoter:

Genomic Locations for SVIP Gene

Genomic Locations for SVIP Gene
16,501 bases
Minus strand

Genomic View for SVIP Gene

Genes around SVIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVIP Gene

Proteins for SVIP Gene

  • Protein details for SVIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small VCP/p97-interacting protein
    Protein Accession:

    Protein attributes for SVIP Gene

    77 amino acids
    Molecular mass:
    8443 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP.

neXtProt entry for SVIP Gene

Post-translational modifications for SVIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVIP Gene

No data available for DME Specific Peptides for SVIP Gene

Domains & Families for SVIP Gene

Gene Families for SVIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SVIP Gene


Suggested Antigen Peptide Sequences for SVIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SVIP family.
  • Belongs to the SVIP family.
genes like me logo Genes that share domains with SVIP: view

Function for SVIP Gene

Phenotypes From GWAS Catalog for SVIP Gene

Gene Ontology (GO) - Molecular Function for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17872946
GO:0043621 protein self-association IMP 24055875
GO:0051117 ATPase binding IPI 17872946
genes like me logo Genes that share ontologies with SVIP: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SVIP Gene

Localization for SVIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVIP Gene

Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SVIP gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 4
nucleus 3
golgi apparatus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA 17872946
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SVIP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SVIP Gene

Pathways & Interactions for SVIP Gene

genes like me logo Genes that share pathways with SVIP: view

Pathways by source for SVIP Gene

3 Reactome pathways for SVIP Gene
1 KEGG pathway for SVIP Gene

Gene Ontology (GO) - Biological Process for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IMP 21909394
GO:0031333 negative regulation of protein complex assembly IMP 17872946
GO:0043312 neutrophil degranulation TAS --
GO:1903061 positive regulation of protein lipidation IMP 21909394
GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process IMP 17872946
genes like me logo Genes that share ontologies with SVIP: view

No data available for SIGNOR curated interactions for SVIP Gene

Drugs & Compounds for SVIP Gene

No Compound Related Data Available

Transcripts for SVIP Gene

mRNA/cDNA for SVIP Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SVIP Gene

Small VCP/p97-interacting protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SVIP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - - -
SP2: -
SP4: -

Relevant External Links for SVIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SVIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SVIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SVIP Gene

This gene is overexpressed in Spinal cord (19.7), Frontal cortex (13.1), Peripheral blood mononuclear cells (10.8), and Bone (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SVIP Gene

NURSA nuclear receptor signaling pathways regulating expression of SVIP Gene:


SOURCE GeneReport for Unigene cluster for SVIP Gene:


Evidence on tissue expression from TISSUES for SVIP Gene

  • Nervous system(3.7)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with SVIP: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SVIP Gene

Orthologs for SVIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SVIP 33 34
  • 99.13 (n)
(Canis familiaris)
Mammalia SVIP 33 34
  • 90.91 (n)
(Bos Taurus)
Mammalia SVIP 33
  • 90.48 (n)
(Rattus norvegicus)
Mammalia Svip 33
  • 81.58 (n)
(Mus musculus)
Mammalia Svip 33 16 34
  • 77.92 (n)
(Ornithorhynchus anatinus)
Mammalia SVIP 34
  • 58 (a)
(Monodelphis domestica)
Mammalia SVIP 34
  • 29 (a)
(Gallus gallus)
Aves SVIP 34
  • 52 (a)
(Danio rerio)
Actinopterygii SVIP 34
  • 48 (a)
Species where no ortholog for SVIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVIP Gene

Gene Tree for SVIP (if available)
Gene Tree for SVIP (if available)

Paralogs for SVIP Gene

No data available for Paralogs for SVIP Gene

Variants for SVIP Gene

Sequence variations from dbSNP and Humsavar for SVIP Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000399963 -- 22,820,691(-) T/A 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000523794 -- 22,823,789(-) G/A intron_variant
rs1000573423 -- 22,825,808(-) T/C intron_variant
rs1000694128 -- 22,829,184(-) A/G intron_variant
rs1000707330 -- 22,829,351(-) C/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SVIP Gene

Variant ID Type Subtype PubMed ID
esv3625623 CNV gain 21293372
nsv1046773 CNV loss 25217958
nsv1049802 CNV gain 25217958
nsv523451 CNV loss 19592680
nsv524283 CNV loss 19592680

Variation tolerance for SVIP Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SVIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVIP Gene

Disorders for SVIP Gene

Additional Disease Information for SVIP

No disorders were found for SVIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVIP Gene

Publications for SVIP Gene

  1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M … Freedman BI (American journal of nephrology 2011) 3 44 58
  2. Regulation of ER-associated degradation via p97/VCP-interacting motif. (PMID: 18793143) Ballar P … Fang S (Biochemical Society transactions 2008) 2 3 58
  3. Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation. (PMID: 17872946) Ballar P … Fang S (The Journal of biological chemistry 2007) 2 3 58
  4. SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation. (PMID: 12529442) Nagahama M … Tagaya M (Molecular biology of the cell 2003) 2 3 58
  5. SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78. (PMID: 28301499) Khodayari N … Brantly M (PloS one 2017) 3 58

Products for SVIP Gene

Sources for SVIP Gene

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