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This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly as... See more...
Aliases for SVIL Gene
Aliases for SVIL Gene
External Ids for SVIL Gene
- HGNC: 11480
- Entrez Gene: 6840
- Ensembl: ENSG00000197321
- OMIM: 604126
- UniProtKB: O95425
Previous GeneCards Identifiers for SVIL Gene
- GC10M029481
- GC10M029896
- GC10M029750
- GC10M029786
- GC10M029841
- GC10M030028
- GC10M030082
- GC10M030086
- GC10M030282
- GC10M029485
- GC10M029650
- GC10M029649
- GC10M029676
- GC10M029762
- GC10M029844
- GC10M029928
- GC10M029978
Summaries for SVIL Gene
-
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]
GeneCards Summary for SVIL Gene
SVIL (Supervillin) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is AVIL.
UniProtKB/Swiss-Prot Summary for SVIL Gene
-
[Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420).
-
[Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).
Additional gene information for SVIL Gene
- HGNC(11480)
- Entrez Gene(6840)
- Ensembl(ENSG00000197321)
- OMIM(604126)
- UniProtKB(O95425)
- Open Targets Platform(ENSG00000197321)
- Monarch Initiative
- Search for SVIL at DataMed
- Search for SVIL at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SVIL Gene
Genomics for SVIL Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SVIL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SVIL on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SVIL
- Top Transcription factor binding sites by QIAGEN in the SVIL gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- FOXD3
- Msx-1
- Nkx3-1 v3
- Olf-1
Genomic Locations for SVIL Gene
Genomic Locations for SVIL Gene
- chr10:29,457,338-29,736,959
- (GRCh38/hg38)
- Size:
- 279,622 bases
- Orientation:
- Minus strand
- chr10:29,746,267-30,025,710
- (GRCh37/hg19)
- Size:
- 279,444 bases
- Orientation:
- Minus strand
Genomic View for SVIL Gene
Genes around SVIL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p11.23 by HGNC
- 10p11.23 by Entrez Gene
- 10p11.23 by Ensembl
SVIL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SVIL Gene
Proteins for SVIL Gene
-
Protein details for SVIL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95425-SVIL_HUMAN
- Recommended name:
- Supervillin
- Protein Accession:
- O95425
- D3DRW9
- M1J557
- O60611
- O60612
- Q5VZK5
- Q5VZK6
- Q9H1R7
Protein attributes for SVIL Gene
- Size:
- 2214 amino acids
- Molecular mass:
- 247746 Da
- Quaternary structure:
-
- Associates with F-actin (By similarity). Interacts with NEB (By similarity). Interacts with MYH9 (By similarity). Interacts with MYLK (By similarity).
- [Isoform 2]: Interacts with TRIP6 (By similarity). Interacts with DYNLT1 (By similarity). Interacts with KIF14; at midbody during cytokinesis (By similarity).
Protein Expression for SVIL Gene
Post-translational modifications for SVIL Gene
Other Protein References for SVIL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005252627.1
- XP_005252628.1
- XP_005252630.1
- XP_011517936.1
- XP_011517937.1
- XP_024303906.1
- XP_024303907.1
- XP_024303908.1
- XP_024303909.1
- XP_024303910.1
- XP_024303911.1
- XP_024303912.1
- XP_024303913.1
- XP_024303914.1
- XP_024303915.1
- XP_024303916.1
- XP_024303917.1
- NP_001310528.1
- NP_001310529.1
- NP_003165.2
- NP_068506.2
Antibody Products
- Creative Diagnostics Anti-SVIL (aa 1679-1786) polyclonal antibody
- Creative Biolabs Recombinant Mouse anti-Human SVIL Monoclonal antibody (EML1652)
- Novus Biologicals Antibodies for SVIL
- Invitrogen Antibodies for SVIL (AFLGC-SVIL)
-
Boster Bio Antibodies for SVIL
-
Santa Cruz Biotechnology (SCBT) Antibodies for SVIL
Protein Products
-
OriGene Purified Proteins for SVIL
- Search Origene for MassSpec and Protein Over-expression Lysates for SVIL
- Origene Custom Protein Services for SVIL
- antibodies-online: Show 5 available SVIL Proteins ranked by validation data
- Compare Top SVIL Proteins
-
Quality Products:
-
Abcam proteins for SVIL
Assay Products
- antibodies-online: Show 6 available SVIL Elisa Kits ranked by validation data
- Compare Top SVIL Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SVIL Gene
Domains & Families for SVIL Gene
Gene Families for SVIL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SVIL Gene
- InterPro:
- Blocks:
-
- Villin headpiece
- Gelsolin family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for SVIL Gene
- GenScript: Design optimal peptide antigens:
-
- SVIL protein (Q569J5_HUMAN)
- p205/p250 (SVIL_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95425UniProtKB/Swiss-Prot:
SVIL_HUMAN :- As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop).
- Belongs to the villin/gelsolin family.
- Domain:
-
- As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop).
- Family:
-
- Belongs to the villin/gelsolin family.
Function for SVIL Gene
Molecular function for SVIL Gene
- UniProtKB/Swiss-Prot Function:
- [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420).
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).
- GENATLAS Biochemistry:
- superviller,205 kDa,F-actin binding protein,highly expressed in skeletal,cardiac and smooth muscle
Phenotypes From GWAS Catalog for SVIL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 18639526 |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IBA | 21873635 |
| GO:0051015 | actin filament binding | IDA | 12711699 |
Phenotypes for SVIL Gene
- MGI mutant phenotypes for SVIL:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SVIL:
-
- no effect
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased cell migration
- Decreased POU5F1-GFP protein expression
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased viability
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased nuclear migration speed
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SVIL - Select products 50% OFF >
- * SVIL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SVIL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SVIL
-
Santa Cruz Biotechnology (SCBT) CRISPR for SVIL
miRNA for SVIL Gene
- miRTarBase miRNAs that target SVIL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SVIL
- Browse OriGene Inhibitory RNA Products For SVIL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SVIL
Clone Products
- Applied Biological Materials (abm): Clones for SVIL - Select products 50% OFF >
- * SVIL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SVIL
- Addgene plasmids for SVIL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SVIL
Cell Line Products
-
Horizon Cell Lines for SVIL
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SVIL Gene
Localization for SVIL Gene
Subcellular locations from UniProtKB/Swiss-Prot for SVIL Gene
- Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody. Cleavage furrow. Note=Tightly associated with both actin filaments and plasma membranes.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Actin filaments (3)
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002102 | podosome | IEA | -- |
| GO:0005634 | nucleus | IDA | 12711699 |
| GO:0005737 | cytoplasm | IEA,IDA | 12711699 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for SVIL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Coregulation of Androgen receptor activity | ||
Pathways by source for SVIL Gene
1 BioSystems pathway for SVIL Gene
Interacting Proteins for SVIL Gene
Selected Interacting proteins:
O95425-SVIL_HUMAN
ENSP00000348128
for SVIL Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SVIL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0007519 | skeletal muscle tissue development | IMP | 12711699 |
| GO:0008154 | actin polymerization or depolymerization | IBA | 21873635 |
| GO:0032467 | positive regulation of cytokinesis | ISS | -- |
| GO:0051014 | actin filament severing | IBA | 21873635 |
No data available for SIGNOR curated interactions for SVIL Gene
Transcripts for SVIL Gene
mRNA/cDNA for SVIL Gene
- 4 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000355867 7586 nts (view in UCSC)
- ENST00000375398 8201 nts (view in UCSC)
- ENST00000375400 6729 nts (view in UCSC)
- ENST00000460007 779 nts (view in UCSC)
- ENST00000464726 2240 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SVIL - Select products 50% OFF >
- * SVIL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SVIL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SVIL
-
Santa Cruz Biotechnology (SCBT) CRISPR for SVIL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SVIL
- Browse OriGene Inhibitory RNA Products For SVIL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SVIL
Clone Products
- Applied Biological Materials (abm): Clones for SVIL - Select products 50% OFF >
- * SVIL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SVIL
- Addgene plasmids for SVIL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SVIL
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||
| SP17: |
Relevant External Links for SVIL Gene
- GeneLoc Exon Structure for
- SVIL
Expression for SVIL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Skeletal Muscle (Muscoskeletal System)
-
Larynx (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for SVIL Gene
This gene is overexpressed in Muscle - Skeletal (x12.7) and Colon - Sigmoid (x5.5).
This gene is overexpressed in Urinary Bladder (17.6) and Colon (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SVIL Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SVIL
SOURCE GeneReport for Unigene cluster for SVIL Gene:
Hs.499209mRNA Expression by UniProt/SwissProt for SVIL Gene:
O95425-SVIL_HUMAN
Tissue specificity:
Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific.
Evidence on tissue expression from TISSUES for SVIL Gene
- Kidney(4.5)
- Blood(4.4)
- Liver(4.3)
- Muscle(3.6)
- Heart(3.1)
- Skin(2.7)
- Thyroid gland(2.7)
- Gall bladder(2.7)
- Intestine(2.6)
- Nervous system(2.6)
- Lymph node(2.4)
- Lung(2.3)
- Bone marrow(2.3)
Primer Products
-
OriGene qPCR primer pairs for SVIL
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SVIL Gene
Orthologs for SVIL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SVIL 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SVIL 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SVIL 30 31 31 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Svil 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Svil 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SVIL 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SVIL 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SVIL 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SVIL 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | svil 30 |
|
||
| Str.16538 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | svila 30 31 |
|
OneToMany | |
| svilb 31 |
|
OneToMany | |||
| SVIL (2 of 3) 31 |
|
OneToMany | |||
| Dr.11428 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG33232 30 31 |
|
OneToOne | |
| CG1141 32 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007181 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | viln-1 31 |
|
OneToOne | |
| C10H11.1 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for SVIL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SVIL Gene
- ENSEMBL:
- Gene Tree for SVIL (if available)
- TreeFam:
- Gene Tree for SVIL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SVIL: view image
Paralogs for SVIL Gene
(6) SIMAP similar genes for SVIL Gene using alignment to 5 proteins:
- SVIL_HUMAN
- F5GXV0_HUMAN
- F5H2Q5_HUMAN
- L0R8G3_HUMAN
- Q569J5_HUMAN
Pseudogenes.org Pseudogenes for SVIL Gene
Variants for SVIL Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SVIL Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708325 | Likely Benign: not provided | 29,462,267(-) | G/A | INTRON_VARIANT | |
| 709567 | Benign: not provided | 29,512,750(-) | C/T | SYNONYMOUS_VARIANT | |
| 710443 | Likely Benign: not provided | 29,480,776(-) | G/A | MISSENSE_VARIANT | |
| 712490 | Benign: not provided | 29,486,203(-) | A/C | MISSENSE_VARIANT | |
| 712586 | Likely Benign: not provided | 29,458,449(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1019439 | CNV | insertion | 17803354 |
| esv1599217 | CNV | deletion | 17803354 |
| esv1993198 | CNV | deletion | 18987734 |
| esv2678748 | CNV | deletion | 23128226 |
| esv2734961 | CNV | deletion | 23290073 |
| esv2734972 | CNV | deletion | 23290073 |
| esv2858680 | CNV | duplication | 24192839 |
| esv3546096 | CNV | deletion | 23714750 |
| esv3622775 | CNV | loss | 21293372 |
| esv3622777 | CNV | loss | 21293372 |
| nsv1038080 | CNV | gain | 25217958 |
| nsv1129323 | OTHER | inversion | 24896259 |
| nsv1137891 | CNV | deletion | 24896259 |
| nsv1152229 | CNV | duplication | 26484159 |
| nsv24186 | CNV | deletion | 16902084 |
| nsv519699 | CNV | loss | 19592680 |
| nsv519798 | CNV | loss | 19592680 |
| nsv528427 | CNV | loss | 19592680 |
| nsv550323 | CNV | loss | 21841781 |
| nsv550324 | CNV | loss | 21841781 |
| nsv6210 | CNV | deletion | 18451855 |
| nsv6221 | CNV | insertion | 18451855 |
| nsv831819 | CNV | loss | 17160897 |
| nsv947800 | CNV | duplication | 23825009 |
| nsv947801 | CNV | duplication | 23825009 |
| nsv947805 | CNV | duplication | 23825009 |
| nsv947806 | CNV | duplication | 23825009 |
| nsv947807 | CNV | duplication | 23825009 |
| nsv958358 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.31;
94.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SVIL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVIL Gene
Disorders for SVIL Gene
Additional Disease Information for SVIL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for SVIL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVIL Gene
Publications for SVIL Gene
- How to arm a supervillin: designing F-actin binding activity into supervillin headpiece. (PMID: 19683541) Brown JW … McKnight CJ (Journal of molecular biology 2009) 3 4 23
- Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. (PMID: 19109420) Crowley JL … Luna EJ (Molecular biology of the cell 2009) 3 4 23
- Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. (PMID: 12711699) Oh SW … Luna EJ (Journal of cell science 2003) 3 4 23
- Cloning, characterization, and chromosomal localization of human superillin (SVIL). (PMID: 9867483) Pope RK … Luna EJ (Genomics 1998) 3 4 23
- Supervillin-mediated suppression of p53 protein enhances cell survival. (PMID: 23382381) Fang Z … Luna EJ (The Journal of biological chemistry 2013) 3 4
ExternalLinks
Products for SVIL Gene
- Browse OriGene Antibodies
- Custom Antibody Services
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- OriGene Purified Proteins for SVIL
- Search Origene for MassSpec and Protein Over-expression Lysates for SVIL
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for SVIL
- Browse OriGene Inhibitory RNA Products For SVIL
- OriGene qPCR primer pairs for SVIL
- OriGene CRISPR knockouts for SVIL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SVIL
- Sino Biological Human cDNA Clone for SVIL
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for SVIL
- Novus Biologicals proteins and lysates for SVIL
- Browse Antibodies
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- Abcam proteins for SVIL
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- Invitrogen Antibodies for SVIL (AFLGC-SVIL)
- VectorBuilder Custom and pre-made DNA vectors for SVIL (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SVIL (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SVIL (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SVIL CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SVIL
- Addgene plasmids for SVIL
- antibodies-online: Show 9 available SVIL Antibodies ranked by validation data
- Compare Top SVIL Antibodies
- antibodies-online: Show 6 available SVIL Elisa Kits ranked by validation data
- Compare Top SVIL Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available SVIL Proteins ranked by validation data
- Compare Top SVIL Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SVIL
- Search Santa Cruz Biotechnology (SCBT) for SVIL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SVIL
- Horizon Cell Lines for SVIL
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SVIL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SVIL
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SVIL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SVIL
- Boster Bio Antibodies for SVIL
- Browse Boster Bio ELISA Kits
Sources for SVIL Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB