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Aliases for SVBP Gene

Aliases for SVBP Gene

  • Small Vasohibin Binding Protein 2 3 5
  • Coiled-Coil Domain Containing 23 2 3
  • CCDC23 3 4
  • Coiled-Coil Domain-Containing Protein 23 3
  • Coiled Coil Domain-Containing Protein 23 4
  • Small Vasohibin-Binding Protein 3

External Ids for SVBP Gene

Previous HGNC Symbols for SVBP Gene

  • CCDC23

Summaries for SVBP Gene

GeneCards Summary for SVBP Gene

SVBP (Small Vasohibin Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SVBP Gene

  • Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2.

Additional gene information for SVBP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVBP Gene

Genomics for SVBP Gene

GeneHancer (GH) Regulatory Elements for SVBP Gene

Promoters and enhancers for SVBP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I042815 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 588.8 +0.3 329 2.5 HDGF FOXA2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B SVBP ERMAP PPIH ENSG00000228192 ZNF691 P3H1 SLC2A1-AS1 GC01M042733 TMEM269
GH01I042818 Enhancer 0.9 dbSUPER 557.8 -1.7 -1710 1 HDGF HDAC1 ATF1 RB1 ARNT ZBTB40 YY1 POLR2B ATF7 CREM SVBP ERMAP ENSG00000228192 ZNF691 P3H1
GH01I042829 Promoter 0.6 EPDnew 550.4 -12.1 -12061 0.1 KDM1A SVBP ERMAP ENSG00000228192
GH01I042764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 35.6 +50.9 50937 4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B P3H1 C1orf50 ENSG00000283580 SVBP PPIH SZT2 KDM4A-AS1 MED8 ZNF691 GC01M042747
GH01I042680 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.7 +134.9 134858 4.1 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 YBX1 SZT2 PPIH P3H1 SVBP MED8 ZNF691 FOXJ3 KDM4A HYI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SVBP on UCSC Golden Path with GeneCards custom track

Genomic Locations for SVBP Gene

Genomic Locations for SVBP Gene
10,337 bases
Minus strand

Genomic View for SVBP Gene

Genes around SVBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVBP Gene

Proteins for SVBP Gene

  • Protein details for SVBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small vasohibin-binding protein
    Protein Accession:
    Secondary Accessions:
    • A8K5P1
    • D3DPW7

    Protein attributes for SVBP Gene

    66 amino acids
    Molecular mass:
    7808 Da
    Quaternary structure:
    • Interacts with VASH1 and VASH2.

neXtProt entry for SVBP Gene

Post-translational modifications for SVBP Gene

No Post-translational modifications

Other Protein References for SVBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SVBP Gene

Domains & Families for SVBP Gene

Gene Families for SVBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SVBP Gene


Suggested Antigen Peptide Sequences for SVBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SVBP family.
  • Belongs to the SVBP family.
genes like me logo Genes that share domains with SVBP: view

Function for SVBP Gene

Molecular function for SVBP Gene

UniProtKB/Swiss-Prot Function:
Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2.

Phenotypes From GWAS Catalog for SVBP Gene

genes like me logo Genes that share phenotypes with SVBP: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SVBP Gene

Localization for SVBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVBP Gene

Secreted. Note=Detected both intracellularly and extracellularly. Within cells, localizes mainly to the apical part of the cell. {ECO:0000250 UniProtKB:Q99LQ4}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SVBP gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SVBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0045177 apical part of cell IDA 20736312
genes like me logo Genes that share ontologies with SVBP: view

Pathways & Interactions for SVBP Gene

No Data Available

Interacting Proteins for SVBP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8N300-SVBP_HUMAN ENSP00000361599 for SVBP Gene via IID STRING

Gene Ontology (GO) - Biological Process for SVBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IDA 20736312
GO:0010596 negative regulation of endothelial cell migration IGI 20736312
GO:0031397 negative regulation of protein ubiquitination IDA 20736312
genes like me logo Genes that share ontologies with SVBP: view

No data available for Pathways by source and SIGNOR curated interactions for SVBP Gene

Drugs & Compounds for SVBP Gene

No Compound Related Data Available

Transcripts for SVBP Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SVBP Gene

No ASD Table

Relevant External Links for SVBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SVBP Gene

NURSA nuclear receptor signaling pathways regulating expression of SVBP Gene:


Evidence on tissue expression from TISSUES for SVBP Gene

  • Nervous system(4.4)
  • Lung(4.3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SVBP Gene

Orthologs for SVBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC23 34 33
  • 100 (n)
(Canis familiaris)
Mammalia CCDC23 34 33
  • 94.44 (n)
(Bos Taurus)
Mammalia CCDC23 34 33
  • 94.44 (n)
(Rattus norvegicus)
Mammalia Ccdc23 33
  • 90.4 (n)
(Mus musculus)
Mammalia Ccdc23 34 33
  • 89.39 (n)
Svbp 16
(Monodelphis domestica)
Mammalia CCDC23 34
  • 61 (a)
(Anolis carolinensis)
Reptilia CCDC23 34
  • 70 (a)
(Danio rerio)
Actinopterygii CCDC23 34
  • 68 (a)
Species where no ortholog for SVBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVBP Gene

Gene Tree for SVBP (if available)
Gene Tree for SVBP (if available)

Paralogs for SVBP Gene

No data available for Paralogs for SVBP Gene

Variants for SVBP Gene

Sequence variations from dbSNP and Humsavar for SVBP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000119763 -- 42,817,601(-) C/T upstream_transcript_variant
rs1000193435 -- 42,818,031(-) A/G upstream_transcript_variant
rs1000884905 -- 42,808,280(-) T/C intron_variant
rs1000977241 -- 42,816,218(-) C/T intron_variant
rs1001110559 -- 42,807,022(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SVBP Gene

Variant ID Type Subtype PubMed ID
esv3585854 CNV loss 21293372
esv3577249 CNV gain 25503493
esv2668067 CNV deletion 23128226

Variation tolerance for SVBP Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SVBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVBP Gene

Disorders for SVBP Gene

Additional Disease Information for SVBP

No disorders were found for SVBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVBP Gene

Publications for SVBP Gene

  1. Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion. (PMID: 20736312) Suzuki Y … Sato Y (Journal of cell science 2010) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release. (PMID: 27879017) Kadonosono T … Kizaka-Kondoh S (Protein science : a publication of the Protein Society 2017) 3 58
  5. Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma. (PMID: 22614011) Xue X … Kondo Y (Oncogene 2013) 3 58

Products for SVBP Gene

Sources for SVBP Gene

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