Aliases for SV2B Gene
External Ids for SV2B Gene
Previous GeneCards Identifiers for SV2B Gene
This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]
GeneCards Summary for SV2B Gene
SV2B (Synaptic Vesicle Glycoprotein 2B) is a Protein Coding gene. Diseases associated with SV2B include Temporal Lobe Epilepsy and Foodborne Botulism. Among its related pathways are Toxicity of botulinum toxin type F (BoNT/F) and Uptake and actions of bacterial toxins. Gene Ontology (GO) annotations related to this gene include transporter activity and transmembrane transporter activity. An important paralog of this gene is SV2A.
UniProtKB/Swiss-Prot Summary for SV2B Gene
Probably plays a role in the control of regulated secretion in neural and endocrine cells.
(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.