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SUV39H2 (Suppressor Of Variegation 3-9 Homolog 2) is a Protein Coding gene. Diseases associated with SUV39H2 include Hyperoxaluria, Primary, Type I and Primary Hyperoxaluria. Among its related pathways are Lysine degradation and PKMTs methylate histone lysines. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is SUV39H1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
GO:0005515 | protein binding | IEA,IPI | 17474147 |
GO:0008168 | methyltransferase activity | IEA | -- |
GO:0008270 | zinc ion binding | IEA,IDA | 20084102 |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000785 | chromatin | IDA | 10949293 |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chromatin organization | ||
2 | PKMTs methylate histone lysines | ||
3 | Lysine degradation | ||
4 | Metabolism | ||
5 | Circadian rythm related genes |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 21402781 |
GO:0006325 | chromatin organization | IEA | -- |
GO:0006333 | chromatin assembly or disassembly | IMP | 10949293 |
GO:0006338 | chromatin remodeling | IDA | 10949293 |
GO:0007049 | cell cycle | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
s-adenosylhomocysteine | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
s-adenosylmethionine |
|
485-80-3 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: | |||||||||||||||||||
SP4: | - | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SUV39H2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
SUV39H2 30 |
|
||||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | SUV39H2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Suv39h2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SUV39H2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Suv39h2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SUV39H2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SUV39H2 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | suv39h2 30 |
|
||
Str.423 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.19244 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | wufe02c04 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Su(var)3-9 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | mes-4 31 |
|
ManyToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SET2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
CSA.9082 31 |
|
ManyToMany | |||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12074 30 |
|
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711031 | Benign: not provided | 14,899,533(+) | G/C | INTRON_VARIANT | |
VAR_036344 | A breast cancer sample | p.Asp383His |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2184273 | CNV | deletion | 18987734 |
esv2733484 | CNV | deletion | 23290073 |
esv3545939 | CNV | deletion | 23714750 |
esv3880 | CNV | loss | 18987735 |
esv6295 | CNV | loss | 19470904 |
esv997994 | CNV | deletion | 20482838 |
nsv1150299 | CNV | deletion | 26484159 |
nsv469720 | CNV | gain | 16826518 |
nsv831793 | CNV | loss | 17160897 |
nsv958510 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hyperoxaluria, primary, type i |
|
|
primary hyperoxaluria |
|
|
carbohydrate metabolic disorder |
|
|