SUV39H2 Gene (Protein Coding)

Suppressor Of Variegation 3-9 Homolog 2

GC10P014878
GIFtS:
42

Aliases for SUV39H2 Gene

Aliases for SUV39H2 Gene

  • Suppressor Of Variegation 3-9 Homolog 2 2 3 4 5
  • Histone-Lysine N-Methyltransferase SUV39H2 3 4
  • Histone H3-K9 Methyltransferase 2 3 4
  • Lysine N-Methyltransferase 1B 3 4
  • Su(Var)3-9 Homolog 2 3 4
  • H3-K9-HMTase 2 3 4
  • EC 2.1.1.43 4 54
  • KMT1B 3 4
  • Suppressor Of Variegation 3-9 Homolog 2 (Drosophila) 2

External Ids for SUV39H2 Gene

Previous GeneCards Identifiers for SUV39H2 Gene

  • GC10P014903
  • GC10P015071
  • GC10P014924
  • GC10P014960
  • GC10P014921
  • GC10P014831
  • GC10P014922

Summaries for SUV39H2 Gene

GeneCards Summary for SUV39H2 Gene

SUV39H2 (Suppressor Of Variegation 3-9 Homolog 2) is a Protein Coding gene. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is SUV39H1.

UniProtKB/Swiss-Prot Summary for SUV39H2 Gene

  • Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Gene Wiki entry for SUV39H2 Gene

Additional gene information for SUV39H2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUV39H2 Gene

Genomics for SUV39H2 Gene

GeneHancer (GH) Regulatory Elements for SUV39H2 Gene

Promoters and enhancers for SUV39H2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUV39H2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SUV39H2 gene promoter:
  • ATF6
  • Evi-1
  • FOXL1
  • MRF-2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • POU6F1 (c2)
  • Sox5

Genomic Locations for SUV39H2 Gene

Genomic Locations for SUV39H2 Gene
chr10:14,878,783-14,904,315
(GRCh38/hg38)
Size:
25,533 bases
Orientation:
Plus strand
chr10:14,920,782-14,946,314
(GRCh37/hg19)
Size:
25,533 bases
Orientation:
Plus strand

Genomic View for SUV39H2 Gene

Genes around SUV39H2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUV39H2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUV39H2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SUV39H2 Gene

Proteins for SUV39H2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SUV39H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5I1-SUV92_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase SUV39H2
    Protein Accession:
    Q9H5I1
    Secondary Accessions:
    • D3DRT4
    • Q5JSS4
    • Q5JSS5
    • Q6I9Y3
    • Q8ND06

    Protein attributes for SUV39H2 Gene

    Size:
    410 amino acids
    Molecular mass:
    46682 Da
    Quaternary structure:
    • Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex.

    Three dimensional structures from OCA and Proteopedia for SUV39H2 Gene

    Alternative splice isoforms for SUV39H2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUV39H2 Gene

Protein Expression for SUV39H2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for SUV39H2 Gene

Q9H5I1:
  • AGEELTFDY
  • EYYLVKW
  • SFVMEYVGE
  • VKWKGWP
  • EATFGCSCTDCFF
  • ITSEEAERRGQ
  • VDLEGPP
  • QIKIPPG
  • KNHKGMI
  • NHSCDPN
  • TLQELCRKE
  • SSDSIDHSPAKKR
  • VFIDNLD
  • KCCPAEAGV
  • TVCKCGA
  • DFYYINEYKPAPGI
  • CPNRIVQKGTQYSLCIF
  • CKSIGIT
  • PIYECNSRC
  • TVDAARYGN

Post-translational modifications for SUV39H2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUV39H2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SUV39H2 Gene

Gene Families for SUV39H2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SUV39H2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SUV39H2 Gene

GenScript: Design optimal peptide antigens:
  • Suppressor of variegation 3-9 homolog 2 (Drosophila) (Q5JSS3_HUMAN)
  • Suppressor of variegation 3-9 homolog 2 (SUV92_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H5I1

UniProtKB/Swiss-Prot:

SUV92_HUMAN :
  • Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
Domain:
  • Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
  • In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
genes like me logo Genes that share domains with SUV39H2: view

Function for SUV39H2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SUV39H2 Gene

UniProtKB/Swiss-Prot Function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43; Evidence=. ;.

Enzyme Numbers (IUBMB) for SUV39H2 Gene

Phenotypes From GWAS Catalog for SUV39H2 Gene

Gene Ontology (GO) - Molecular Function for SUV39H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0005515 protein binding IPI,IEA 17474147
GO:0008168 methyltransferase activity IEA --
GO:0008270 zinc ion binding IEA,IDA 20084102
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SUV39H2: view
genes like me logo Genes that share phenotypes with SUV39H2: view

Animal Models for SUV39H2 Gene

MGI Knock Outs for SUV39H2:

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUV39H2 Gene

Localization for SUV39H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUV39H2 Gene

Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUV39H2 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUV39H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000785 chromatin IDA 10949293
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with SUV39H2: view

Pathways & Interactions for SUV39H2 Gene

genes like me logo Genes that share pathways with SUV39H2: view

Pathways by source for SUV39H2 Gene

2 BioSystems pathways for SUV39H2 Gene
1 KEGG pathway for SUV39H2 Gene
1 GeneTex pathway for SUV39H2 Gene

Gene Ontology (GO) - Biological Process for SUV39H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 21402781
GO:0006325 chromatin organization IEA --
GO:0006333 chromatin assembly or disassembly IMP 10949293
GO:0006338 chromatin remodeling IDA 10949293
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with SUV39H2: view

No data available for SIGNOR curated interactions for SUV39H2 Gene

Drugs & Compounds for SUV39H2 Gene

Products:

  1. Drug

(1) Drugs for SUV39H2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for SUV39H2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
 485-80-3
genes like me logo Genes that share compounds with SUV39H2: view

Transcripts for SUV39H2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SUV39H2 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(87) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUV39H2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3:
SP4: - - -

Relevant External Links for SUV39H2 Gene

GeneLoc Exon Structure for
SUV39H2
ECgene alternative splicing isoforms for
SUV39H2

Expression for SUV39H2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUV39H2 Gene

mRNA expression in normal human tissues for SUV39H2 Gene
mRNA expression by GTEx for SUV39H2 GenemRNA expression by BioGPS for SUV39H2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUV39H2 Gene

This gene is overexpressed in Testis (x5.7).

Protein differential expression in normal tissues from HIPED for SUV39H2 Gene

This gene is overexpressed in Testis (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUV39H2 Gene



Protein tissue co-expression partners for SUV39H2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUV39H2 Gene:

SUV39H2

SOURCE GeneReport for Unigene cluster for SUV39H2 Gene:

Hs.554883

Evidence on tissue expression from TISSUES for SUV39H2 Gene

  • Bone marrow(4.1)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with SUV39H2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUV39H2 Gene

Orthologs for SUV39H2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUV39H2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SUV39H2 33 32
  • 99.51 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia -- 33
  • 98 (a)
 OneToMany
SUV39H2 32
  • 95.15 (n)
-- 33
  • 90 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia SUV39H2 33 32
  • 94.24 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Suv39h2 32
  • 88.67 (n)
oppossum
(Monodelphis domestica)
 Mammalia SUV39H2 33
  • 88 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Suv39h2 17 33 32
  • 87.82 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia SUV39H2 33
  • 87 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SUV39H2 33 32
  • 79.44 (n)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia suv39h2 32
  • 72.35 (n)
Str.423 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.19244 32
zebrafish
(Danio rerio)
 Actinopterygii wufe02c04 32
fruit fly
(Drosophila melanogaster)
 Insecta Su(var)3-9 33 34
  • 24 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea mes-4 33
  • 6 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SET2 33
  • 6 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 64 (a)
 ManyToMany
CSA.9082 33
  • 47 (a)
 ManyToMany
Cin.12074 32
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.12074 32
Species where no ortholog for SUV39H2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUV39H2 Gene

ENSEMBL:
Gene Tree for SUV39H2 (if available)
TreeFam:
Gene Tree for SUV39H2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SUV39H2: view image

Paralogs for SUV39H2 Gene

Paralogs for SUV39H2 Gene

(10) SIMAP similar genes for SUV39H2 Gene using alignment to 6 proteins:

  • SUV92_HUMAN
  • C9IYH9_HUMAN
  • C9JMB4_HUMAN
  • G5E9A8_HUMAN
  • H0Y306_HUMAN
  • Q5JSS2_HUMAN

Pseudogenes.org Pseudogenes for SUV39H2 Gene

genes like me logo Genes that share paralogs with SUV39H2: view

Variants for SUV39H2 Gene

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Sequence variations from dbSNP and Humsavar for SUV39H2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
VAR_036344 A breast cancer sample p.Asp383His
rs1000053246 -- 14,902,331(+) A/G intron_variant
rs1000216570 -- 14,883,379(+) A/G intron_variant
rs1000407858 -- 14,878,713(+) G/A upstream_transcript_variant
rs1000513871 -- 14,901,580(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SUV39H2 Gene

Variant ID Type Subtype PubMed ID
esv2184273 CNV deletion 18987734
esv2733484 CNV deletion 23290073
esv3545939 CNV deletion 23714750
esv3880 CNV loss 18987735
esv6295 CNV loss 19470904
esv997994 CNV deletion 20482838
nsv1150299 CNV deletion 26484159
nsv469720 CNV gain 16826518
nsv831793 CNV loss 17160897
nsv958510 CNV deletion 24416366

Variation tolerance for SUV39H2 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUV39H2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUV39H2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUV39H2 Gene

Disorders for SUV39H2 Gene

Additional Disease Information for SUV39H2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SUV39H2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUV39H2 Gene

Publications for SUV39H2 Gene

  1. Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer. (PMID: 16774942) Yoon KA … Lee JS (Carcinogenesis 2006) 3 23 43 56
  2. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. (PMID: 11094092) O'Carroll D … Jenuwein T (Molecular and cellular biology 2000) 2 3 23 56
  3. Structural biology of human H3K9 methyltransferases. (PMID: 20084102) Wu H … Schapira M (PloS one 2010) 3 4 56
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

ExternalLinks

View latest publications for SUV39H2 gene in Mastermind

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