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Aliases for SUV39H2 Gene
Aliases for SUV39H2 Gene
External Ids for SUV39H2 Gene
- HGNC: 17287
- Entrez Gene: 79723
- Ensembl: ENSG00000152455
- OMIM: 606503
- UniProtKB: Q9H5I1
Previous GeneCards Identifiers for SUV39H2 Gene
- GC10P014903
- GC10P015071
- GC10P014924
- GC10P014960
- GC10P014921
- GC10P014831
- GC10P014922
Summaries for SUV39H2 Gene
GeneCards Summary for SUV39H2 Gene
SUV39H2 (Suppressor Of Variegation 3-9 Homolog 2) is a Protein Coding gene. Diseases associated with SUV39H2 include Hyperoxaluria, Primary, Type I and Primary Hyperoxaluria. Among its related pathways are Lysine degradation and PKMTs methylate histone lysines. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is SUV39H1.
UniProtKB/Swiss-Prot Summary for SUV39H2 Gene
-
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
Additional gene information for SUV39H2 Gene
- HGNC(17287)
- Entrez Gene(79723)
- Ensembl(ENSG00000152455)
- OMIM(606503)
- UniProtKB(Q9H5I1)
- Open Targets Platform(ENSG00000152455)
- Monarch Initiative
- Search for SUV39H2 at DataMed
- Search for SUV39H2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUV39H2 Gene
Genomics for SUV39H2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SUV39H2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SUV39H2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUV39H2
- Top Transcription factor binding sites by QIAGEN in the SUV39H2 gene promoter:
-
- ATF6
- Evi-1
- FOXL1
- MRF-2
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- POU6F1 (c2)
- Sox5
Genomic Locations for SUV39H2 Gene
Genomic Locations for SUV39H2 Gene
- chr10:14,878,783-14,904,315
- (GRCh38/hg38)
- Size:
- 25,533 bases
- Orientation:
- Plus strand
- chr10:14,920,782-14,946,314
- (GRCh37/hg19)
- Size:
- 25,533 bases
- Orientation:
- Plus strand
Genomic View for SUV39H2 Gene
Genes around SUV39H2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p13 by HGNC
- 10p13 by Entrez Gene
- 10p13 by Ensembl
SUV39H2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SUV39H2 Gene
Proteins for SUV39H2 Gene
-
Protein details for SUV39H2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H5I1-SUV92_HUMAN
- Recommended name:
- Histone-lysine N-methyltransferase SUV39H2
- Protein Accession:
- Q9H5I1
- D3DRT4
- Q5JSS4
- Q5JSS5
- Q6I9Y3
- Q8ND06
Protein attributes for SUV39H2 Gene
- Size:
- 410 amino acids
- Molecular mass:
- 46682 Da
- Quaternary structure:
-
- Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex.
Protein Expression for SUV39H2 Gene
Selected DME Specific Peptides for SUV39H2 Gene
- Q9H5I1:
-
- AGEELTFDY
- EYYLVKW
- SFVMEYVGE
- VKWKGWP
- EATFGCSCTDCFF
- ITSEEAERRGQ
- VDLEGPP
- QIKIPPG
- KNHKGMI
- NHSCDPN
- TLQELCRKE
- SSDSIDHSPAKKR
- VFIDNLD
- KCCPAEAGV
- TVCKCGA
- DFYYINEYKPAPGI
- CPNRIVQKGTQYSLCIF
- CKSIGIT
- PIYECNSRC
- TVDAARYGN
Post-translational modifications for SUV39H2 Gene
Other Protein References for SUV39H2 Gene
Antibody Products
- LifeSpan BioSciences SUV39H2 Antibody
- G Biosciences Immunotag™ SUV39H2 Antibody
- NSJ Bioreagents SUV39H2 Antibody (KMT1B)
-
Custom Antibody ServicesOriGene Antibodies for SUV39H2
- Novus Biologicals Antibodies for SUV39H2
-
Abcam antibodies for SUV39H2
- Invitrogen Antibodies for SUV39H2 (AFLGC-SUV39H2)
-
Biorbyt antibodies for SUV39H2
-
Boster Bio Antibodies for SUV39H2
- Sino Biological Antibodies for SUV39H2
Protein Products
-
OriGene Purified Proteins for SUV39H2
- Search Origene for MassSpec and Protein Over-expression Lysates for SUV39H2
- Origene Custom Protein Services for SUV39H2
- antibodies-online: Show 8 available SUV39H2 Proteins ranked by validation data
- Compare Top SUV39H2 Proteins
-
Quality Products:
-
Abcam proteins for SUV39H2
Domains & Families for SUV39H2 Gene
Gene Families for SUV39H2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for SUV39H2 Gene
- InterPro:
- Blocks:
-
- Chromo domain
- Nuclear protein SET
- Nuclear protein Zn2+-binding
- SET-related region
- ProtoNet:
Suggested Antigen Peptide Sequences for SUV39H2 Gene
- GenScript: Design optimal peptide antigens:
-
- Suppressor of variegation 3-9 homolog 2 (Drosophila) (Q5JSS3_HUMAN)
- Suppressor of variegation 3-9 homolog 2 (SUV92_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H5I1UniProtKB/Swiss-Prot:
SUV92_HUMAN :- Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
- Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
- Domain:
-
- Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
- In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
- Family:
-
- Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
Function for SUV39H2 Gene
Molecular function for SUV39H2 Gene
- UniProtKB/Swiss-Prot Function:
- Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60276, Rhea:RHEA-COMP:15538, Rhea:RHEA-COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.355; Evidence={ECO:0000255|PROSITE-ProRule:PRU00912};.
Enzyme Numbers (IUBMB) for SUV39H2 Gene
Phenotypes From GWAS Catalog for SUV39H2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0005515 | protein binding | IEA,IPI | 17474147 |
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0008270 | zinc ion binding | IEA,IDA | 20084102 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for SUV39H2 Gene
- MGI mutant phenotypes for SUV39H2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SUV39H2:
Animal Models for SUV39H2 Gene
- MGI Knock Outs for SUV39H2:
-
- Suv39h2 Suv39h2<tm1Jnw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SUV39H2 - Select products 50% OFF >
- * SUV39H2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SUV39H2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUV39H2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUV39H2
miRNA for SUV39H2 Gene
- miRTarBase miRNAs that target SUV39H2
-
- hsa-miR-186-3p (MIRT560836)
- hsa-miR-885-5p (MIRT560837)
- hsa-miR-95-5p (MIRT560838)
- hsa-miR-4262 (MIRT560839)
- hsa-miR-4733-5p (MIRT560840)
- hsa-miR-181d-5p (MIRT560841)
- hsa-miR-181c-5p (MIRT560842)
- hsa-miR-181b-5p (MIRT560843)
- hsa-miR-181a-5p (MIRT560844)
- hsa-miR-3156-5p (MIRT560845)
- hsa-miR-6768-3p (MIRT560846)
- mmu-miR-10b-5p (MIRT577599)
- mmu-miR-10a-5p (MIRT577600)
- mmu-miR-466l-3p (MIRT577601)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUV39H2
- Browse OriGene Inhibitory RNA Products For SUV39H2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUV39H2
Clone Products
- Applied Biological Materials (abm): Clones for SUV39H2 - Select products 50% OFF >
- * SUV39H2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203330
- MG227389
- MR203330
- MR203330L3
- MR203330L4
- MR227389
- MR227389L3
- MR227389L4
- RC203032
- RC203032L1
- RC203032L2
- RC203032L3
- RC203032L4
- RC231011
- RC231011L3
- RC231011L4
- RC231078
- RC231078L3
- RC231078L4
- RC231216
- RC231216L1
- RC231216L2
- RC231216L3
- RC231216L4
- RC232549
- RG203032
- RG231011
- RG231078
- RG231216
- RG232549
- RR207552
- RR207552L3
- RR207552L4
- MR203330L3V
- MR203330L4V
- MR227389L3V
- MR227389L4V
- RC203032L1V
- RC203032L2V
- RC203032L3V
- RC203032L4V
- RC231011L3V
- RC231011L4V
- RC231078L3V
- RC231078L4V
- RC231216L1V
- RC231216L2V
- RC231216L3V
- RC231216L4V
- RR207552L3V
- RR207552L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SUV39H2
- Addgene plasmids for SUV39H2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUV39H2
Cell Line Products
-
Horizon Cell Lines for SUV39H2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUV39H2 Gene
Localization for SUV39H2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUV39H2 Gene
- Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| cytosol | 1 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000785 | chromatin | IDA | 10949293 |
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for SUV39H2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
| 2 | PKMTs methylate histone lysines | ||
| 3 | Lysine degradation | ||
| 4 | Metabolism | ||
| 5 | Circadian rythm related genes | ||
Pathways by source for SUV39H2 Gene
2 BioSystems pathways for SUV39H2 Gene
3 Reactome pathways for SUV39H2 Gene
2 KEGG pathways for SUV39H2 Gene
1 GeneTex pathway for SUV39H2 Gene
Interacting Proteins for SUV39H2 Gene
Selected Interacting proteins:
Q9H5I1-SUV92_HUMAN
ENSP00000346997
for SUV39H2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SUV39H2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 21402781 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006333 | chromatin assembly or disassembly | IMP | 10949293 |
| GO:0006338 | chromatin remodeling | IDA | 10949293 |
| GO:0007049 | cell cycle | IEA | -- |
No data available for SIGNOR curated interactions for SUV39H2 Gene
Drugs & Compounds for SUV39H2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| s-adenosylhomocysteine | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
485-80-3 |
|
Transcripts for SUV39H2 Gene
mRNA/cDNA for SUV39H2 Gene
- 5 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000313519 3087 nts (view in UCSC)
- ENST00000354919 3059 nts (view in UCSC)
- ENST00000358298 1611 nts (view in UCSC)
- ENST00000378325 1292 nts (view in UCSC)
- ENST00000378331 2959 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SUV39H2 - Select products 50% OFF >
- * SUV39H2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SUV39H2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUV39H2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUV39H2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUV39H2
- Browse OriGene Inhibitory RNA Products For SUV39H2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUV39H2
Clone Products
- Applied Biological Materials (abm): Clones for SUV39H2 - Select products 50% OFF >
- * SUV39H2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203330
- MG227389
- MR203330
- MR203330L3
- MR203330L4
- MR227389
- MR227389L3
- MR227389L4
- RC203032
- RC203032L1
- RC203032L2
- RC203032L3
- RC203032L4
- RC231011
- RC231011L3
- RC231011L4
- RC231078
- RC231078L3
- RC231078L4
- RC231216
- RC231216L1
- RC231216L2
- RC231216L3
- RC231216L4
- RC232549
- RG203032
- RG231011
- RG231078
- RG231216
- RG232549
- RR207552
- RR207552L3
- RR207552L4
- MR203330L3V
- MR203330L4V
- MR227389L3V
- MR227389L4V
- RC203032L1V
- RC203032L2V
- RC203032L3V
- RC203032L4V
- RC231011L3V
- RC231011L4V
- RC231078L3V
- RC231078L4V
- RC231216L1V
- RC231216L2V
- RC231216L3V
- RC231216L4V
- RR207552L3V
- RR207552L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SUV39H2
- Addgene plasmids for SUV39H2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUV39H2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | - | - | - |
Relevant External Links for SUV39H2 Gene
- GeneLoc Exon Structure for
- SUV39H2
Expression for SUV39H2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Head Mesenchyme (Muscoskeletal System)
- Paraxial Mesoderm Cells Branchial Arch 1
-
Bone (Muscoskeletal System)
- Paraxial Mesoderm Cells Branchial Arch 1
-
Skeletal Muscle (Muscoskeletal System)
- Paraxial Mesoderm Cells Branchial Arch 1
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for SUV39H2 Gene
This gene is overexpressed in Testis (x5.7).
This gene is overexpressed in Testis (66.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUV39H2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUV39H2
SOURCE GeneReport for Unigene cluster for SUV39H2 Gene:
Hs.554883Evidence on tissue expression from TISSUES for SUV39H2 Gene
- Muscle(4.3)
- Bone marrow(4.3)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for SUV39H2
-
OriGene qPCR primer pairs and template standards for SUV39H2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUV39H2 Gene
Orthologs for SUV39H2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SUV39H2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| SUV39H2 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | SUV39H2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Suv39h2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | SUV39H2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Suv39h2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SUV39H2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SUV39H2 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | suv39h2 30 |
|
||
| Str.423 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19244 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | wufe02c04 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Su(var)3-9 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | mes-4 31 |
|
ManyToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SET2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.9082 31 |
|
ManyToMany | |||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12074 30 |
|
- Species where no ortholog for SUV39H2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SUV39H2 Gene
- ENSEMBL:
- Gene Tree for SUV39H2 (if available)
- TreeFam:
- Gene Tree for SUV39H2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SUV39H2: view image
Paralogs for SUV39H2 Gene
Paralogs for SUV39H2 Gene
(10) SIMAP similar genes for SUV39H2 Gene using alignment to 6 proteins:
- SUV92_HUMAN
- C9IYH9_HUMAN
- C9JMB4_HUMAN
- G5E9A8_HUMAN
- H0Y306_HUMAN
- Q5JSS2_HUMAN
Pseudogenes.org Pseudogenes for SUV39H2 Gene
Variants for SUV39H2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SUV39H2 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711031 | Benign: not provided | 14,899,533(+) | G/C | INTRON_VARIANT | |
| VAR_036344 | A breast cancer sample | p.Asp383His |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2184273 | CNV | deletion | 18987734 |
| esv2733484 | CNV | deletion | 23290073 |
| esv3545939 | CNV | deletion | 23714750 |
| esv3880 | CNV | loss | 18987735 |
| esv6295 | CNV | loss | 19470904 |
| esv997994 | CNV | deletion | 20482838 |
| nsv1150299 | CNV | deletion | 26484159 |
| nsv469720 | CNV | gain | 16826518 |
| nsv831793 | CNV | loss | 17160897 |
| nsv958510 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.33;
7.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SUV39H2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SUV39H2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUV39H2 Gene
Disorders for SUV39H2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyperoxaluria, primary, type i |
|
|
| primary hyperoxaluria |
|
|
| carbohydrate metabolic disorder |
|
|
Search SUV39H2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SUV39H2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SUV39H2 Gene
Publications for SUV39H2 Gene
- Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer. (PMID: 16774942) Yoon KA … Lee JS (Carcinogenesis 2006) 3 23 41
- Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. (PMID: 11094092) O'Carroll D … Jenuwein T (Molecular and cellular biology 2000) 2 3 23
- Structural biology of human H3K9 methyltransferases. (PMID: 20084102) Wu H … Schapira M (PloS one 2010) 3 4
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for SUV39H2 Gene
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Sources for SUV39H2 Gene
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