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Aliases for SUSD6 Gene

Aliases for SUSD6 Gene

  • Sushi Domain Containing 6 2 3 5
  • KIAA0247 2 3 4
  • Drug-Activated Gene Overexpressed Protein 3 4
  • DRAGO 3 4
  • Sushi Domain-Containing Protein 6 3

External Ids for SUSD6 Gene

Previous HGNC Symbols for SUSD6 Gene

  • KIAA0247

Summaries for SUSD6 Gene

GeneCards Summary for SUSD6 Gene

SUSD6 (Sushi Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is SUSD4.

UniProtKB/Swiss-Prot for SUSD6 Gene

  • May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).

Additional gene information for SUSD6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUSD6 Gene

Genomics for SUSD6 Gene

GeneHancer (GH) Regulatory Elements for SUSD6 Gene

Promoters and enhancers for SUSD6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I069609 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 563.9 +4.4 4388 12.2 HDGF FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 IRF4 GLIS2 SUSD6 ENSG00000273797 SRSF5 MED6 SMOC1 DCAF5
GH14I069647 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.4 +40.0 40018 8.8 PKNOX1 CLOCK FOXA2 SMAD1 SIN3A YY1 ZNF207 FOS ATF7 RUNX3 SUSD6 SRSF5 DCAF5 GC14P069648 GC14P069678
GH14I070358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 28.6 +747.8 747807 2 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 COX16 GC14P070361 RNU2-51P SRSF5 MED6 SUSD6 RPL7AP6 ADAM20P1 PTTG4P ERH
GH14I068778 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.1 -823.4 -823372 20.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36L1 DCAF5 ZFYVE26 SRSF5 SUSD6 DDX18P1 RNU6-921P GC14M068736 GC14M068442
GH14I069692 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.8 +86.5 86532 12.2 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B DMAP1 IRF4 SLC30A9 POLR2B SUSD6 SRSF5 TTC9 SLC8A3 PIR54293 GC14P069678
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SUSD6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SUSD6 Gene

Genomic Locations for SUSD6 Gene
chr14:69,611,593-69,715,144
(GRCh38/hg38)
Size:
103,552 bases
Orientation:
Plus strand
chr14:70,078,310-70,181,861
(GRCh37/hg19)

Genomic View for SUSD6 Gene

Genes around SUSD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUSD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUSD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUSD6 Gene

Proteins for SUSD6 Gene

  • Protein details for SUSD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92537-SUSD6_HUMAN
    Recommended name:
    Sushi domain-containing protein 6
    Protein Accession:
    Q92537

    Protein attributes for SUSD6 Gene

    Size:
    303 amino acids
    Molecular mass:
    32090 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13378.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUSD6 Gene

Post-translational modifications for SUSD6 Gene

No Post-translational modifications

Other Protein References for SUSD6 Gene

No data available for DME Specific Peptides for SUSD6 Gene

Domains & Families for SUSD6 Gene

Gene Families for SUSD6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SUSD6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUSD6: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SUSD6 Gene

Function for SUSD6 Gene

Molecular function for SUSD6 Gene

UniProtKB/Swiss-Prot Function:
May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium.

Phenotypes From GWAS Catalog for SUSD6 Gene

Gene Ontology (GO) - Molecular Function for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SUSD6: view
genes like me logo Genes that share phenotypes with SUSD6: view

Animal Models for SUSD6 Gene

MGI Knock Outs for SUSD6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUSD6 Gene

Localization for SUSD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUSD6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUSD6 gene
Compartment Confidence
plasma membrane 3
nucleus 3
extracellular 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUSD6: view

Pathways & Interactions for SUSD6 Gene

SuperPathways for SUSD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 24652652
GO:0008219 cell death IDA 24652652
genes like me logo Genes that share ontologies with SUSD6: view

No data available for Pathways by source and SIGNOR curated interactions for SUSD6 Gene

Drugs & Compounds for SUSD6 Gene

No Compound Related Data Available

Transcripts for SUSD6 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUSD6 Gene

No ASD Table

Relevant External Links for SUSD6 Gene

GeneLoc Exon Structure for
SUSD6
ECgene alternative splicing isoforms for
SUSD6

Expression for SUSD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUSD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUSD6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUSD6 Gene



Protein tissue co-expression partners for SUSD6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUSD6 Gene:

SUSD6

Evidence on tissue expression from TISSUES for SUSD6 Gene

  • Bone marrow(4.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SUSD6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUSD6 Gene

Orthologs for SUSD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUSD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0247 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia KIAA0247 33 34
  • 91.09 (n)
cow
(Bos Taurus)
Mammalia KIAA0247 33 34
  • 90.78 (n)
rat
(Rattus norvegicus)
Mammalia LOC678893 33
  • 88.34 (n)
mouse
(Mus musculus)
Mammalia 4933426M11Rik 33 34
  • 87.97 (n)
Susd6 16
oppossum
(Monodelphis domestica)
Mammalia KIAA0247 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA0247 33 34
  • 73.78 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA0247 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0247 33
  • 65.19 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-11e23.5 33 34
  • 60.34 (n)
Dr.11364 33
Species where no ortholog for SUSD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUSD6 Gene

ENSEMBL:
Gene Tree for SUSD6 (if available)
TreeFam:
Gene Tree for SUSD6 (if available)

Paralogs for SUSD6 Gene

Paralogs for SUSD6 Gene

genes like me logo Genes that share paralogs with SUSD6: view

Variants for SUSD6 Gene

Sequence variations from dbSNP and Humsavar for SUSD6 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000004320 -- 69,627,756(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000063142 -- 69,637,550(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000088828 -- 69,686,840(+) T/G intron_variant
rs1000143394 -- 69,633,973(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000158694 -- 69,697,786(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SUSD6 Gene

Variant ID Type Subtype PubMed ID
esv3634840 CNV loss 21293372
esv3634842 CNV loss 21293372
nsv1070641 CNV deletion 25765185
nsv1143612 CNV deletion 24896259
nsv1336 CNV insertion 18451855
nsv456336 CNV gain 19166990
nsv565007 CNV gain 21841781
nsv826971 CNV loss 20364138
nsv952862 CNV duplication 24416366

Variation tolerance for SUSD6 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUSD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUSD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUSD6 Gene

Disorders for SUSD6 Gene

Additional Disease Information for SUSD6

No disorders were found for SUSD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUSD6 Gene

Publications for SUSD6 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 58
  2. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. (PMID: 24652652) Polato F … Broggini M (Journal of the National Cancer Institute 2014) 3 4 58
  3. Characterization of SVEP1, KIAA, and SRPX2 in an in vitro cell culture model of endotoxemia. (PMID: 20236627) Schwanzer-Pfeiffer D … Falkenhagen D (Cellular immunology 2010) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SUSD6 Gene

Sources for SUSD6 Gene

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