Aliases for SURF4 Gene
External Ids for SURF4 Gene
Previous GeneCards Identifiers for SURF4 Gene
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for SURF4 Gene
SURF4 (Surfeit 4) is a Protein Coding gene. Diseases associated with SURF4 include Colorectal Cancer, Hereditary Nonpolyposis, Type 2 and Macular Degeneration, Age-Related, 6. Among its related pathways are Innate Immune System and Golgi-to-ER retrograde transport. An important paralog of this gene is SURF1.
UniProtKB/Swiss-Prot Summary for SURF4 Gene
May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.