This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi inte... See more...

Aliases for SURF4 Gene

Aliases for SURF4 Gene

  • Surfeit 4 2 3 5
  • Surfeit Locus Protein 4 2 3 4
  • Surface 4 Integral Membrane Protein 2 3
  • ERV29 2 3
  • MGC102753 2
  • FLJ22993 2
  • SURF-4 4
  • SURF4 5

External Ids for SURF4 Gene

Previous GeneCards Identifiers for SURF4 Gene

  • GC09M127318
  • GC09M127785
  • GC09M129582
  • GC09M131504
  • GC09M133257
  • GC09M135206
  • GC09M135218
  • GC09M136228
  • GC09M105728

Summaries for SURF4 Gene

Entrez Gene Summary for SURF4 Gene

  • This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SURF4 Gene

SURF4 (Surfeit 4) is a Protein Coding gene. Diseases associated with SURF4 include Colorectal Cancer, Hereditary Nonpolyposis, Type 2 and Macular Degeneration, Age-Related, 6. Among its related pathways are Innate Immune System and Golgi-to-ER retrograde transport. An important paralog of this gene is SURF1.

UniProtKB/Swiss-Prot Summary for SURF4 Gene

  • May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.

Gene Wiki entry for SURF4 Gene

Additional gene information for SURF4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SURF4 Gene

Genomics for SURF4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SURF4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SURF4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SURF4

Top Transcription factor binding sites by QIAGEN in the SURF4 gene promoter:
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • HEN1
  • Lmo2
  • Nkx2-5
  • Pax-4a
  • STAT5A
  • ZID

Genomic Locations for SURF4 Gene

Genomic Locations for SURF4 Gene
chr9:133,361,449-133,377,949
(GRCh38/hg38)
Size:
16,501 bases
Orientation:
Minus strand
chr9:136,228,325-136,242,970
(GRCh37/hg19)
Size:
14,646 bases
Orientation:
Minus strand

Genomic View for SURF4 Gene

Genes around SURF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SURF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SURF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SURF4 Gene

Proteins for SURF4 Gene

  • Protein details for SURF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15260-SURF4_HUMAN
    Recommended name:
    Surfeit locus protein 4
    Protein Accession:
    O15260
    Secondary Accessions:
    • B7Z6A4
    • O60923
    • Q5T8U6
    • Q9UNZ0
    • Q9UNZ1

    Protein attributes for SURF4 Gene

    Size:
    269 amino acids
    Molecular mass:
    30394 Da
    Quaternary structure:
    • Found in a complex composed at least of SURF4, TMED2 and TMED10 (PubMed:18287528). May interact with LMAN1 (PubMed:18287528). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts with STING1 (PubMed:29251827).

    Alternative splice isoforms for SURF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SURF4 Gene

Post-translational modifications for SURF4 Gene

  • Ubiquitination at Lys139
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SURF4 Gene

Domains & Families for SURF4 Gene

Gene Families for SURF4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SURF4 Gene

InterPro:
Blocks:
  • Surf4 protein
  • Surfeit locus 4-related
ProtoNet:

Suggested Antigen Peptide Sequences for SURF4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79379, highly similar to Surfeit locus protein 4 (B7Z1G8_HUMAN)
  • cDNA FLJ50656, highly similar to Surfeit locus protein 4 (B7Z6A4_HUMAN)
  • cDNA FLJ50722, highly similar to Surfeit locus protein 4 (B7Z7A8_HUMAN)
  • Surfeit locus protein 4 (SURF4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15260

UniProtKB/Swiss-Prot:

SURF4_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Belongs to the SURF4 family.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Family:
  • Belongs to the SURF4 family.
genes like me logo Genes that share domains with SURF4: view

Function for SURF4 Gene

Molecular function for SURF4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.
GENATLAS Biochemistry:
surfeit 4 (see SURF@),putative integral membrane protein of the endoplasmic reticulum,30kDa

Phenotypes From GWAS Catalog for SURF4 Gene

Gene Ontology (GO) - Molecular Function for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18287528
genes like me logo Genes that share ontologies with SURF4: view
genes like me logo Genes that share phenotypes with SURF4: view

Animal Model Products

CRISPR Products

miRNA for SURF4 Gene

miRTarBase miRNAs that target SURF4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SURF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SURF4 Gene

Localization for SURF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SURF4 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi. {ECO:0000269 PubMed:18287528}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SURF4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
lysosome 4
golgi apparatus 4
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with SURF4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SURF4 Gene

Pathways & Interactions for SURF4 Gene

genes like me logo Genes that share pathways with SURF4: view

Gene Ontology (GO) - Biological Process for SURF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007030 Golgi organization IMP 18287528
GO:0010638 positive regulation of organelle organization IMP 18287528
GO:0032527 NOT protein exit from endoplasmic reticulum IMP 18287528
GO:0034498 NOT early endosome to Golgi transport IMP 18287528
genes like me logo Genes that share ontologies with SURF4: view

No data available for SIGNOR curated interactions for SURF4 Gene

Drugs & Compounds for SURF4 Gene

No Compound Related Data Available

Transcripts for SURF4 Gene

mRNA/cDNA for SURF4 Gene

7 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SURF4

Alternative Splicing Database (ASD) splice patterns (SP) for SURF4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: -
SP8: - - - - - -
SP9:
SP10: - - - - - -

Relevant External Links for SURF4 Gene

GeneLoc Exon Structure for
SURF4

Expression for SURF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SURF4 Gene

Protein differential expression in normal tissues from HIPED for SURF4 Gene

This gene is overexpressed in Nasal epithelium (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SURF4 Gene



Protein tissue co-expression partners for SURF4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SURF4

SOURCE GeneReport for Unigene cluster for SURF4 Gene:

Hs.512465

Evidence on tissue expression from TISSUES for SURF4 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Skin(4.4)
  • Pancreas(4.3)
  • Kidney(4.2)
  • Intestine(3.7)
  • Liver(3.3)
  • Eye(2.9)
  • Heart(2.1)
  • Muscle(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SURF4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SURF4 Gene

Orthologs for SURF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SURF4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SURF4 30 31
  • 99.88 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SURF4 31
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 92 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SURF4 30
  • 91.33 (n)
Dog
(Canis familiaris)
Mammalia SURF4 30 31
  • 90.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Surf4 30 17 31
  • 90.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Surf4 30
  • 89.71 (n)
Chicken
(Gallus gallus)
Aves SURF4 30 31
  • 81.04 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SURF4 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia surf4.2 30
  • 80.42 (n)
MGC76061 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.33420 30
Zebrafish
(Danio rerio)
Actinopterygii surf4l 31
  • 87 (a)
OneToOne
surf4 30
  • 79.68 (n)
zgc65806 30
Fruit Fly
(Drosophila melanogaster)
Insecta Surf4 30 31 32
  • 64.41 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001069 30
  • 58.52 (n)
Worm
(Caenorhabditis elegans)
Secernentea sft-4 30 31 32
  • 60.07 (n)
OneToOne
T02E1.7 32
  • 33 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGL340C 30
  • 48.54 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03102g 30
  • 46.48 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV29 30 31 33
  • 45.56 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5467 31
  • 58 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU03319 30
  • 50.97 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC970.06 30
  • 45.8 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3084 30
Species where no ortholog for SURF4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SURF4 Gene

ENSEMBL:
Gene Tree for SURF4 (if available)
TreeFam:
Gene Tree for SURF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SURF4: view image

Paralogs for SURF4 Gene

Paralogs for SURF4 Gene

genes like me logo Genes that share paralogs with SURF4: view

Variants for SURF4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SURF4 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
666282 Uncertain Significance: not provided 133,376,557(-) C/A NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for SURF4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SURF4 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1125319 OTHER inversion 24896259

Variation tolerance for SURF4 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SURF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SURF4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SURF4 Gene

Disorders for SURF4 Gene

Additional Disease Information for SURF4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SURF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SURF4 Gene

Publications for SURF4 Gene

  1. The surf-4 gene encodes a novel 30 kDa integral membrane protein. (PMID: 7540914) Reeves JE … Fried M (Molecular membrane biology 1995) 2 3 4
  2. Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity. (PMID: 29251827) Shang J … Guo L (Proteomics 2018) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. (PMID: 18287528) Mitrovic S … Hauri HP (Molecular biology of the cell 2008) 3 4

Products for SURF4 Gene

Sources for SURF4 Gene