SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009] See more...

Aliases for SUPT7L Gene

Aliases for SUPT7L Gene

  • SPT7 Like, STAGA Complex Subunit Gamma 2 3 5
  • STAF65gamma 2 3 4
  • SPTF-Associated Factor 65 Gamma 3 4
  • STAGA Complex 65 Subunit Gamma 3 4
  • Adenocarcinoma Antigen ART1 3 4
  • Suppressor Of Ty 7-Like 3 4
  • KIAA0764 2 4
  • STAF65 2 3
  • SPT7L 2 3
  • Suppressor Of Ty 7 (S. Cerevisiae)-Like 2
  • SPT7 Like, STAGA Complex Gamma Subunit 3
  • STAGA Complex 65 Gamma Subunit 3
  • STAF65(Gamma) 3
  • STAF65G 3
  • SUPT7H 3
  • SUPT7L 5

External Ids for SUPT7L Gene

Previous GeneCards Identifiers for SUPT7L Gene

  • GC02M027786
  • GC02M027727
  • GC02M027873
  • GC02M027614
  • GC02M027650
  • GC02M027647

Summaries for SUPT7L Gene

Entrez Gene Summary for SUPT7L Gene

  • SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SUPT7L Gene

SUPT7L (SPT7 Like, STAGA Complex Subunit Gamma) is a Protein Coding gene. Among its related pathways are Chromatin organization and Validated targets of C-MYC transcriptional activation. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity.

Gene Wiki entry for SUPT7L Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUPT7L Gene

Genomics for SUPT7L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SUPT7L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUPT7L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUPT7L

Top Transcription factor binding sites by QIAGEN in the SUPT7L gene promoter:
  • Elk-1
  • IRF-2
  • p300
  • TBP
  • TFIID

Genomic Locations for SUPT7L Gene

Latest Assembly
chr2:27,642,568-27,663,840
(GRCh38/hg38)
Size:
21,273 bases
Orientation:
Minus strand

Previous Assembly
chr2:27,873,676-27,886,481
(GRCh37/hg19 by Entrez Gene)
Size:
12,806 bases
Orientation:
Minus strand

chr2:27,873,679-27,886,676
(GRCh37/hg19 by Ensembl)
Size:
12,998 bases
Orientation:
Minus strand

Genomic View for SUPT7L Gene

Genes around SUPT7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPT7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPT7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT7L Gene

Proteins for SUPT7L Gene

  • Protein details for SUPT7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94864-ST65G_HUMAN
    Recommended name:
    STAGA complex 65 subunit gamma
    Protein Accession:
    O94864
    Secondary Accessions:
    • B4E3W3
    • Q6IB21
    • Q9H2T6

    Protein attributes for SUPT7L Gene

    Size:
    414 amino acids
    Molecular mass:
    46193 Da
    Quaternary structure:
    • Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9.
    SequenceCaution:
    • Sequence=BAA34484.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SUPT7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUPT7L Gene

Post-translational modifications for SUPT7L Gene

No data available for DME Specific Peptides for SUPT7L Gene

Domains & Families for SUPT7L Gene

Gene Families for SUPT7L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SUPT7L Gene

InterPro:

Suggested Antigen Peptide Sequences for SUPT7L Gene

GenScript: Design optimal peptide antigens:
  • Suppressor of Ty 7-like (ST65G_HUMAN)
genes like me logo Genes that share domains with SUPT7L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SUPT7L Gene

Function for SUPT7L Gene

Phenotypes From GWAS Catalog for SUPT7L Gene

Gene Ontology (GO) - Molecular Function for SUPT7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IBA,IDA 11564863
GO:0004402 histone acetyltransferase activity IEA --
GO:0005515 protein binding IPI 15870280
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with SUPT7L: view
genes like me logo Genes that share phenotypes with SUPT7L: view

Animal Models for SUPT7L Gene

MGI Knock Outs for SUPT7L:
  • Supt7l Supt7l<tm1a(EUCOMM)Wtsi>

miRNA for SUPT7L Gene

miRTarBase miRNAs that target SUPT7L

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUPT7L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT7L Gene

Localization for SUPT7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUPT7L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUPT7L gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SUPT7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,NAS 10987294
GO:0005654 nucleoplasm IDA --
GO:0030914 STAGA complex IBA,IDA 11564863
genes like me logo Genes that share ontologies with SUPT7L: view

Pathways & Interactions for SUPT7L Gene

genes like me logo Genes that share pathways with SUPT7L: view

Pathways by source for SUPT7L Gene

Gene Ontology (GO) - Biological Process for SUPT7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043966 histone H3 acetylation IBA,IDA 11564863
GO:0045893 positive regulation of transcription, DNA-templated IEA --
GO:0051457 maintenance of protein location in nucleus IDA 15870280
genes like me logo Genes that share ontologies with SUPT7L: view

No data available for SIGNOR curated interactions for SUPT7L Gene

Drugs & Compounds for SUPT7L Gene

No Compound Related Data Available

Transcripts for SUPT7L Gene

mRNA/cDNA for SUPT7L Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUPT7L

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT7L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b ^ 5 ^ 6
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for SUPT7L Gene

GeneLoc Exon Structure for
SUPT7L

Expression for SUPT7L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUPT7L Gene

Protein differential expression in normal tissues from HIPED for SUPT7L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.2) and CD4 Tcells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUPT7L Gene



Protein tissue co-expression partners for SUPT7L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUPT7L

SOURCE GeneReport for Unigene cluster for SUPT7L Gene:

Hs.6232

mRNA Expression by UniProt/SwissProt for SUPT7L Gene:

O94864-ST65G_HUMAN
Tissue specificity: Expressed at high levels in adenocarcinomas and gliomas and low in esophageal cancers and malignant hematological disease. Also expressed at high level in the thymus, low in peripheral blood mononuclear cells, and lowest in the stomach, small intestine, and skeletal muscle.

Evidence on tissue expression from TISSUES for SUPT7L Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Lung(2.9)
  • Intestine(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with SUPT7L: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUPT7L Gene

Orthologs for SUPT7L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUPT7L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SUPT7L 29 30
  • 99.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 98 (a)
OneToMany
-- 30
  • 97 (a)
OneToMany
LOC475708 29
  • 93.28 (n)
-- 30
  • 91 (a)
OneToMany
-- 30
  • 61 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SUPT7L 29 30
  • 91.1 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Supt7l 29 16 30
  • 90.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Supt7l 29
  • 90.53 (n)
Oppossum
(Monodelphis domestica)
Mammalia SUPT7L 30
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SUPT7L 30
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SUPT7L 29 30
  • 78.88 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SUPT7L 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia supt7l 29
  • 73.14 (n)
MGC76026 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.6149 29
Zebrafish
(Danio rerio)
Actinopterygii supt7l 29 30
  • 67.65 (n)
OneToOne
Species where no ortholog for SUPT7L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SUPT7L Gene

ENSEMBL:
Gene Tree for SUPT7L (if available)
TreeFam:
Gene Tree for SUPT7L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SUPT7L: view image
Alliance of Genome Resources:
Additional Orthologs for SUPT7L

Paralogs for SUPT7L Gene

No data available for Paralogs for SUPT7L Gene

Variants for SUPT7L Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SUPT7L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for SUPT7L Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUPT7L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUPT7L
Leiden Open Variation Database (LOVD)
SUPT7L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for SUPT7L Gene

Disorders for SUPT7L Gene

Additional Disease Information for SUPT7L

No disorders were found for SUPT7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUPT7L Gene

Publications for SUPT7L Gene

  1. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. (PMID: 11564863) Martinez E … Roeder RG (Molecular and cellular biology 2001) 2 3 4
  2. The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases. (PMID: 24852358) Hsieh FS … Yang WM (Biochimica et biophysica acta 2014) 2 3
  3. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. (PMID: 17375202) Demény MA … Tora L (PloS one 2007) 3 4
  4. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. (PMID: 15561718) Gocke CB … Kang J (The Journal of biological chemistry 2005) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4

Products for SUPT7L Gene

Sources for SUPT7L Gene