Aliases for SUPT5H Gene
External Ids for SUPT5H Gene
Previous GeneCards Identifiers for SUPT5H Gene
GeneCards Summary for SUPT5H Gene
SUPT5H (SPT5 Homolog, DSIF Elongation Factor Subunit) is a Protein Coding gene. Diseases associated with SUPT5H include Immunodeficiency With Hyper-Igm, Type 2 and Schuurs-Hoeijmakers Syndrome. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot Summary for SUPT5H Gene
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.