Aliases for SUPT5H Gene
Aliases for SUPT5H Gene
External Ids for SUPT5H Gene
- HGNC: 11469
- Entrez Gene: 6829
- Ensembl: ENSG00000196235
- OMIM: 602102
- UniProtKB: O00267
Previous GeneCards Identifiers for SUPT5H Gene
- GC19P040577
- GC19P040327
- GC19P044612
- GC19P044628
- GC19P039936
- GC19P036382
Summaries for SUPT5H Gene
GeneCards Summary for SUPT5H Gene
SUPT5H (SPT5 Homolog, DSIF Elongation Factor Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat. Gene Ontology (GO) annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot for SUPT5H Gene
-
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Additional gene information for SUPT5H Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUPT5H Gene
Genomics for SUPT5H Gene
GeneHancer (GH) Regulatory Elements for SUPT5H Gene
Promoters and enhancers for SUPT5H Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SUPT5H on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SUPT5H gene promoter:
-
- Pax-4a
- GATA-1
- YY1
- ZIC2
- HSF2
Regulatory Element Products
Genomic Locations for SUPT5H Gene
Genomic Locations for SUPT5H Gene
- chr19:39,436,156-39,476,670
- (GRCh38/hg38)
- Size:
- 40,515 bases
- Orientation:
- Plus strand
- chr19:39,926,796-39,967,310
- (GRCh37/hg19)
- Size:
- 40,515 bases
- Orientation:
- Plus strand
Genomic View for SUPT5H Gene
Genes around SUPT5H on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
- 19q13.2 by Ensembl
SUPT5H Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SUPT5H Gene
Proteins for SUPT5H Gene
-
Protein details for SUPT5H Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00267-SPT5H_HUMAN
- Recommended name:
- Transcription elongation factor SPT5
- Protein Accession:
- O00267
- O43279
- Q59G52
- Q99639
Protein attributes for SUPT5H Gene
- Size:
- 1087 amino acids
- Molecular mass:
- 121000 Da
- Quaternary structure:
-
- Interacts with SUPT4H1 to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and RDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin.
- SequenceCaution:
-
- Sequence=BAD92494.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for SUPT5H Gene
Protein Expression for SUPT5H Gene
Post-translational modifications for SUPT5H Gene
- Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II.
- Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing and can stimulate transcriptional elongation from the HIV-1 LTR. P-TEFb dependent phosphorylation is stimulated by the HIV-1 Tat protein. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis.
- Ubiquitination at isoforms=2718, isoforms=2650, isoforms=2323, isoforms=2306, posLast=213213, posLast=199199, and posLast=147147
- Modification sites at PhosphoSitePlus
Other Protein References for SUPT5H Gene
Antibody Products
- Novus Biologicals Antibodies for SUPT5H
-
Abcam antibodies for SUPT5H
- Invitrogen Antibodies for SUPT5H
- GeneTex SUPT5H Antibody for SUPT5H
-
Boster Bio Antibodies for SUPT5H
-
Santa Cruz Biotechnology (SCBT) Antibodies for SUPT5H
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SUPT5H
- Origene Custom Protein Services for SUPT5H
- Novus Biologicals proteins for SUPT5H
- antibodies-online: Search results for 7 available SUPT5H Proteins ranked by validation data
- Compare Top SUPT5H Proteins
-
Quality Products:
- Search GeneTex for Proteins for SUPT5H
Assay Products
- antibodies-online: Search results for 3 available SUPT5H Elisa Kits ranked by validation data
- Compare Top SUPT5H Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SUPT5H Gene
Domains & Families for SUPT5H Gene
Gene Families for SUPT5H Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SUPT5H Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SUPT5H Gene
Graphical View of Domain Structure for InterPro Entry
O00267- Family:
-
- Belongs to the SPT5 family.
Function for SUPT5H Gene
Molecular function for SUPT5H Gene
- UniProtKB/Swiss-Prot Function:
- Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3 terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
- GENATLAS Biochemistry:
- putative chromatin structure regulator yeast Spt5 homolog,(histones group)
Phenotypes From GWAS Catalog for SUPT5H Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003729 | mRNA binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 10075709 |
Phenotypes for SUPT5H Gene
- MGI mutant phenotypes for SUPT5H:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SUPT5H:
-
- Decreased shRNA abundance (Z-score < -2)
- G0/1 arrest
- Increased G1 DNA content
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Downregulation of NFkappaB pathway
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Decreased IL-8 secretion
- Increased viability
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for SUPT5H Gene
- MGI Knock Outs for SUPT5H:
-
- Supt5 Supt5<tm2a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SUPT5H
-
CRISPR Products
-
OriGene CRISPR knockouts for SUPT5H
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUPT5H
- genomics-online: gRNA clones - Search results for available SUPT5H gene related products
- Applied Biological Materials CRISPR for SUPT5H
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT5H
- GenScript: Design CRISPR guide RNA sequences for SUPT5H
miRNA for SUPT5H Gene
- miRTarBase miRNAs that target SUPT5H
-
- hsa-mir-155-5p (MIRT020754)
- hsa-mir-34a-5p (MIRT025307)
- hsa-mir-26b-5p (MIRT029450)
- hsa-mir-1229-3p (MIRT036363)
- hsa-mir-935 (MIRT036670)
- hsa-mir-93-3p (MIRT038889)
- hsa-mir-92b-3p (MIRT040704)
- hsa-mir-484 (MIRT042043)
- hsa-mir-324-3p (MIRT042864)
- hsa-mir-149-5p (MIRT045555)
- hsa-mir-92a-3p (MIRT049464)
- hsa-mir-16-5p (MIRT051148)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SUPT5H
- Browse OriGene Inhibitory RNA Products For SUPT5H
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUPT5H
- genomics-online: shRNA clones - Search results for available SUPT5H gene related products
Clone Products
- Sino Biological Human cDNA Clone for SUPT5H
- VectorBuilder custom plasmid, inducible vectors for SUPT5H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT5H
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUPT5H
- genomics-online: cdna clones - Search results for available SUPT5H gene related products
- orf clones - Search results for available SUPT5H gene related products
- Applied Biological Materials Clones for SUPT5H
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT5H Gene
Localization for SUPT5H Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUPT5H Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 10075709 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0032044 | DSIF complex | IDA | 9450929 |
Pathways & Interactions for SUPT5H Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
.93
|
|
| 2 | HIV Life Cycle |
.91
.64
|
.45
|
| 3 | Gene Expression |
.48
|
|
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | Regulation of TP53 Activity | ||
Pathways by source for SUPT5H Gene
2 BioSystems pathways for SUPT5H Gene
1 Cell Signaling Technology pathway for SUPT5H Gene
Interacting Proteins for SUPT5H Gene
Selected Interacting proteins:
O00267-SPT5H_HUMAN
ENSP00000404029
for SUPT5H Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SUPT5H
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 10075709 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA,IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | -- |
Transcripts for SUPT5H Gene
mRNA/cDNA for SUPT5H Gene
- (7) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (471) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000594990 558 bps (uc060yli.1)
- ENST00000396843 467 bps (uc060ylj.1)
- ENST00000599117 3902 bps (uc002olo.5)
- ENST00000601515 396 bps (uc060yll.1)
- ENST00000595368 659 bps (uc060ylm.1)
Unigene Clusters for SUPT5H Gene
- Suppressor of Ty 5 homolog (S. cerevisiae):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SUPT5H
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUPT5H
- genomics-online: gRNA clones - Search results for available SUPT5H gene related products
- Applied Biological Materials CRISPR for SUPT5H
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT5H
- GenScript: Design CRISPR guide RNA sequences for SUPT5H
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SUPT5H
- Browse OriGene Inhibitory RNA Products For SUPT5H
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUPT5H
- genomics-online: shRNA clones - Search results for available SUPT5H gene related products
Clone Products
- Sino Biological Human cDNA Clone for SUPT5H
- VectorBuilder custom plasmid, inducible vectors for SUPT5H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUPT5H
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUPT5H
- genomics-online: cdna clones - Search results for available SUPT5H gene related products
- orf clones - Search results for available SUPT5H gene related products
- Applied Biological Materials Clones for SUPT5H
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30a | · | 30b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||
| SP8: |
Expression for SUPT5H Gene
This gene is overexpressed in Peripheral blood mononuclear cells (13.3), CD8 Tcells (9.4), and Lymph node (9.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUPT5H Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SUPT5H Gene:
SUPT5HSOURCE GeneReport for Unigene cluster for SUPT5H Gene:
Hs.631604mRNA Expression by UniProt/SwissProt for SUPT5H Gene:
O00267-SPT5H_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for SUPT5H Gene
- Nervous system(5)
- Liver(4.3)
- Muscle(4.3)
- Pancreas(3.5)
- Lung(2.8)
- Blood(2.6)
Primer Products
-
OriGene qPCR primer pairs and template standards for SUPT5H
-
OriGene qPCR primer pairs for SUPT5H
- genomics-online: primer clones - Search results for available SUPT5H gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUPT5H Gene
Orthologs for SUPT5H Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SUPT5H 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SUPT5H 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SUPT5H 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SUPT5H 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SUPT5H 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Supt5h 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Supt5 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | SUPT5H 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SUPT5H 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | supt5h 33 |
|
||
| Str.2822 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5044 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | supt5h 34 33 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005021 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Spt5 34 35 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | spt-5 34 33 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR187W 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B00891g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPT5 36 34 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | GTA2 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0772000 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06929 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spt5 33 |
|
- Species where no ortholog for SUPT5H was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for SUPT5H Gene
- ENSEMBL:
- Gene Tree for SUPT5H (if available)
- TreeFam:
- Gene Tree for SUPT5H (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SUPT5H: view image
Paralogs for SUPT5H Gene
No data available for Paralogs for SUPT5H Gene
Variants for SUPT5H Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000035407 | -- | 39,444,068(+) | CTC/C | upstream_transcript_variant | |
| rs1000094731 | -- | 39,471,970(+) | C/T | intron_variant | |
| rs1000139640 | -- | 39,443,744(+) | C/A | upstream_transcript_variant | |
| rs1000207127 | -- | 39,449,222(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000275443 | -- | 39,447,020(+) | C/G | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
0.867% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.90;
35.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SUPT5H Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPT5H Gene
Disorders for SUPT5H Gene
Additional Disease Information for SUPT5H
No disorders were found for SUPT5H Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUPT5H Gene
Publications for SUPT5H Gene
- Structure and function of the human transcription elongation factor DSIF. (PMID: 10075709) Yamaguchi Y … Handa H (The Journal of biological chemistry 1999) 2 3 4 22 58
- Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5. (PMID: 8975720) Chiang PW … Kurnit DM (Genomics 1996) 2 3 4 22 58
- Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface. (PMID: 19860741) Wenzel S … Wöhrl BM (The Biochemical journal 2009) 3 4 22 58
- Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. (PMID: 16327805) Larochelle S … Fisher RP (Nature structural & molecular biology 2006) 3 4 22 58
- Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. (PMID: 15060154) Endoh M … Handa H (Molecular and cellular biology 2004) 3 4 22 58
Products for SUPT5H Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SUPT5H
- Origene Custom Protein Services for SUPT5H
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SUPT5H
- Browse OriGene Inhibitory RNA Products For SUPT5H
- OriGene qPCR primer pairs and template standards for SUPT5H
- OriGene qPCR primer pairs for SUPT5H
- OriGene CRISPR knockouts for SUPT5H
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SUPT5H