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This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
SUPT4H1 (SPT4 Homolog, DSIF Elongation Factor Subunit) is a Protein Coding gene. Diseases associated with SUPT4H1 include Spinocerebellar Ataxia 36 and Dermatopathia Pigmentosa Reticularis. Among its related pathways are HIV Transcription Elongation and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000993 | RNA polymerase II complex binding | IBA | 21873635 |
GO:0003700 | DNA-binding transcription factor activity | TAS | 8649394 |
GO:0003727 | single-stranded RNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 10075709 |
GO:0008270 | zinc ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IDA | 8649394 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0032044 | DSIF complex | IDA | 9450929 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Transcription Elongation | ||
2 | HIV Life Cycle |
.91
.65
|
.45
|
3 | Gene Expression |
.48
|
|
4 | Chromatin Regulation / Acetylation | ||
5 | Regulation of TP53 Activity |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9450929 |
GO:0006325 | chromatin organization | IBA | 21873635 |
GO:0006338 | chromatin remodeling | TAS | 8649394 |
GO:0006355 | regulation of transcription, DNA-templated | TAS | 8786137 |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 8649394 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SUPT4H1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | SUPT4H1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Supt4a 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SUPT4H1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Supt4h1 30 |
|
||
Chicken (Gallus gallus) |
Aves | SUPT4H1 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | supt4h1 30 |
|
||
Str.5867 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23755 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | supt4h1 30 31 |
|
OneToOne | |
Dr.29315 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1288 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005428 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | spt4 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | spt-4 30 31 32 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPT4 31 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5304 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03838 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.956 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia 36 |
|
|
dermatopathia pigmentosa reticularis |
|
|