This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identifie... See more...
Aliases for SUPT4H1 Gene
Aliases for SUPT4H1 Gene
External Ids for SUPT4H1 Gene
- HGNC: 11467
- Entrez Gene: 6827
- Ensembl: ENSG00000213246
- OMIM: 603555
- UniProtKB: P63272
Previous HGNC Symbols for SUPT4H1 Gene
- SUPT4H
Previous GeneCards Identifiers for SUPT4H1 Gene
- GC17M056166
- GC17M058904
- GC17M056764
- GC17M056897
- GC17M053777
- GC17M056422
- GC17M051783
Summaries for SUPT4H1 Gene
-
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for SUPT4H1 Gene
SUPT4H1 (SPT4 Homolog, DSIF Elongation Factor Subunit) is a Protein Coding gene. Diseases associated with SUPT4H1 include Spinocerebellar Ataxia 36. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity.
UniProtKB/Swiss-Prot Summary for SUPT4H1 Gene
-
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Additional gene information for SUPT4H1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUPT4H1 Gene
Genomics for SUPT4H1 Gene
GeneHancer (GH) Regulatory Elements for SUPT4H1 Gene
Promoters and enhancers for SUPT4H1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SUPT4H1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SUPT4H1 gene promoter:
-
- c-Ets-1
- C/EBPbeta
- FOXI1
- FOXO1
- FOXO1a
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- p53
- Pax-5
Genomic Locations for SUPT4H1 Gene
Genomic Locations for SUPT4H1 Gene
- chr17:58,345,175-58,353,093
- (GRCh38/hg38)
- Size:
- 7,919 bases
- Orientation:
- Minus strand
- chr17:56,422,539-56,430,454
- (GRCh37/hg19)
- Size:
- 7,916 bases
- Orientation:
- Minus strand
Genomic View for SUPT4H1 Gene
Genes around SUPT4H1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
SUPT4H1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SUPT4H1 Gene
Proteins for SUPT4H1 Gene
-
Protein details for SUPT4H1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P63272-SPT4H_HUMAN
- Recommended name:
- Transcription elongation factor SPT4
- Protein Accession:
- P63272
- B2R4X8
- D3DTZ4
- Q16550
- Q62387
- Q6ZP89
Protein attributes for SUPT4H1 Gene
- Size:
- 117 amino acids
- Molecular mass:
- 13193 Da
- Quaternary structure:
-
- Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of NELFA, NELFB, NELFD and NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1.
Protein Expression for SUPT4H1 Gene
Post-translational modifications for SUPT4H1 Gene
Other Protein References for SUPT4H1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SPT4H Polyclonal Antibody and Immunotag™ SPT4H Antibody
- Creative Diagnostics Anti-SUPT4H1 monoclonal antibody, clone FQS7211(3) and Anti-SUPT4H1 (aa 18-117) polyclonal antibody
-
Creative Biolabs
- Novus Biologicals Antibodies for SUPT4H1
-
Abcam antibodies for SUPT4H1
- Invitrogen Antibodies for SUPT4H1 (AFLGC-SUPT4H1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SUPT4H1
Protein Products
- Creative Biomart Recombinant Human SUPT4H1 and Recombinant Human SUPT4H1 293 Cell Lysate
-
OriGene Purified Proteins for SUPT4H1
- Search Origene for MassSpec and Protein Over-expression Lysates for SUPT4H1
- Origene Custom Protein Services for SUPT4H1
-
Abcam proteins for SUPT4H1
No data available for DME Specific Peptides for SUPT4H1 Gene
Domains & Families for SUPT4H1 Gene
Gene Families for SUPT4H1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SUPT4H1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SUPT4H1 Gene
- GenScript: Design optimal peptide antigens:
-
- Suppressor of Ty 4 homolog 1 (S. cerevisiae), isoform CRA_b (D3DTZ5_HUMAN)
- DRB sensitivity-inducing factor small subunit (SPT4H_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P63272- Family:
-
- Belongs to the SPT4 family.
Function for SUPT4H1 Gene
Molecular function for SUPT4H1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
- GENATLAS Biochemistry:
- putative chromatin structure regulator,yeast spt4 (suppressor of Ty) homolog,ubiquitously expressed
Phenotypes From GWAS Catalog for SUPT4H1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000993 | RNA polymerase II complex binding | IBA | 21873635 |
| GO:0003700 | DNA-binding transcription factor activity | TAS | 8649394 |
| GO:0003727 | single-stranded RNA binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 10075709 |
| GO:0008270 | zinc ion binding | IEA | -- |
Phenotypes for SUPT4H1 Gene
- MGI mutant phenotypes for SUPT4H1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SUPT4H1:
-
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for SUPT4H1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SUPT4H1 - Select products 50% OFF >
- * SUPT4H1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for SUPT4H1
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- genomics-online: gRNA clones - Search results for available SUPT4A gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT4H1
miRNA for SUPT4H1 Gene
- miRTarBase miRNAs that target SUPT4H1
-
- hsa-mir-7-5p (MIRT025924)
- hsa-mir-96-5p (MIRT027878)
- hsa-let-7e-5p (MIRT051537)
- hsa-mir-1827 (MIRT738153)
- hsa-mir-185-5p (MIRT738269)
- hsa-mir-2467-3p (MIRT739308)
- hsa-mir-3689d (MIRT742499)
- hsa-mir-4306 (MIRT743926)
- hsa-mir-4459 (MIRT744850)
- hsa-mir-4644 (MIRT746398)
- hsa-mir-4722-5p (MIRT747628)
- hsa-mir-5192 (MIRT749956)
- hsa-mir-6134 (MIRT752470)
- hsa-mir-6792-5p (MIRT756055)
- hsa-mir-6851-5p (MIRT757623)
- hsa-mir-6880-5p (MIRT758337)
miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available SUPT4A gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SUPT4H1 - Select products 50% OFF >
- * SUPT4H1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SUPT4H1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for SUPT4H1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUPT4H1
- genomics-online: cdna clones - Search results for available SUPT4A gene related products
- orf clones - Search results for available SUPT4A gene related products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUPT4H1 Gene
Localization for SUPT4H1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUPT4H1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,TAS | 8649394 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0032044 | DSIF complex | IDA | 9450929 |
Pathways & Interactions for SUPT4H1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Tat-mediated elongation of the HIV-1 transcript | ||
| 2 | HIV Life Cycle |
.91
.64
|
.45
|
| 3 | Gene Expression |
.48
|
|
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | Regulation of TP53 Activity | ||
Pathways by source for SUPT4H1 Gene
1 BioSystems pathway for SUPT4H1 Gene
1 Cell Signaling Technology pathway for SUPT4H1 Gene
Interacting Proteins for SUPT4H1 Gene
Selected Interacting proteins:
P63272-SPT4H_HUMAN
ENSP00000225504
for SUPT4H1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SUPT4H1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9450929 |
| GO:0006325 | chromatin organization | IBA | 21873635 |
| GO:0006338 | chromatin remodeling | TAS | 8649394 |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 8786137 |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 8649394 |
No data available for SIGNOR curated interactions for SUPT4H1 Gene
Drugs & Compounds for SUPT4H1 Gene
No Compound Related Data Available
Drug Products
- Creative Biomart Recombinant Human SUPT4H1 and Recombinant Human SUPT4H1 293 Cell Lysate
Transcripts for SUPT4H1 Gene
mRNA/cDNA for SUPT4H1 Gene
- (1) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (568) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000225504 1488 bps (ENST00000225504.7)
- ENST00000577396 1643 bps (ENST00000577396.5)
- ENST00000579289 318 bps (ENST00000579289.1)
- ENST00000580947 574 bps (ENST00000580947.1)
- ENST00000581166 1401 bps (ENST00000581166.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SUPT4H1 - Select products 50% OFF >
- * SUPT4H1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SUPT4H1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for SUPT4H1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUPT4H1
- genomics-online: gRNA clones - Search results for available SUPT4A gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUPT4H1
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for SUPT4H1 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for SUPT4H1
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- genomics-online: cdna clones - Search results for available SUPT4A gene related products
- orf clones - Search results for available SUPT4A gene related products
Expression for SUPT4H1 Gene
mRNA differential expression in normal tissues according to GTEx for SUPT4H1 Gene
This gene is overexpressed in Whole Blood (x4.9).
This gene is overexpressed in Breast (14.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUPT4H1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SUPT4H1 Gene:
SUPT4H1SOURCE GeneReport for Unigene cluster for SUPT4H1 Gene:
Hs.439481mRNA Expression by UniProt/SwissProt for SUPT4H1 Gene:
P63272-SPT4H_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for SUPT4H1 Gene
- Nervous system(3.4)
- Lung(2.2)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for SUPT4H1
-
OriGene qPCR primer pairs and template standards for SUPT4H1
- genomics-online: primer clones - Search results for available SUPT4A gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUPT4H1 Gene
Orthologs for SUPT4H1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SUPT4H1 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | SUPT4H1 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Supt4a 17 33 32 |
|
||
| cow (Bos Taurus) |
Mammalia | SUPT4H1 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Supt4h1 32 |
|
||
| chicken (Gallus gallus) |
Aves | SUPT4H1 33 32 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | supt4h1 32 |
|
||
| Str.5867 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23755 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | supt4h1 33 32 |
|
OneToOne | |
| Dr.29315 32 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1288 32 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005428 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | spt4 33 34 32 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | spt-4 33 34 32 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPT4 35 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5304 33 |
|
OneToOne | |
| Cin.956 32 |
|
||||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03838 32 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.956 32 |
|
- Species where no ortholog for SUPT4H1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for SUPT4H1 Gene
- ENSEMBL:
- Gene Tree for SUPT4H1 (if available)
- TreeFam:
- Gene Tree for SUPT4H1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SUPT4H1: view image
Paralogs for SUPT4H1 Gene
Pseudogenes.org Pseudogenes for SUPT4H1 Gene
No data available for Paralogs for SUPT4H1 Gene
Variants for SUPT4H1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000187834 | -- | 58,348,264(-) | A/C/G | intron_variant | |
| rs1000195216 | -- | 58,350,298(-) | G/A | intron_variant | |
| rs1000416541 | -- | 58,350,809(-) | A/G | intron_variant | |
| rs1001197581 | -- | 58,353,982(-) | GGG/GG | upstream_transcript_variant | |
| rs1001355375 | -- | 58,345,132(-) | GG/G | downstream_transcript_variant |
Residual Variation Intolerance Score:
48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SUPT4H1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SUPT4H1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUPT4H1 Gene
Disorders for SUPT4H1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia 36 |
|
|
Search SUPT4H1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SUPT4H1
No data available for UniProtKB/Swiss-Prot and Genatlas for SUPT4H1 Gene
Publications for SUPT4H1 Gene
- Structure and function of the human transcription elongation factor DSIF. (PMID: 10075709) Yamaguchi Y … Handa H (The Journal of biological chemistry 1999) 2 3 4 56
- DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. (PMID: 9450929) Wada T … Handa H (Genes & development 1998) 3 4 23 56
- Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae. (PMID: 8649394) Hartzog GA … Winston F (Molecular and cellular biology 1996) 3 4 23 56
- Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene. (PMID: 8786137) Chiang PW … Kurnit DM (Genomics 1996) 2 3 4 56
- Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface. (PMID: 19860741) Wenzel S … Wöhrl BM (The Biochemical journal 2009) 3 4 56
ExternalLinks
Products for SUPT4H1 Gene
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- antibodies-online: Show 32 available SUPT4A Antibodies ranked by validation data
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- Search Santa Cruz Biotechnology (SCBT) for SUPT4H1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SUPT4H1
- genomics-online: cdna clones - Search results for available SUPT4A gene related products
- orf clones - Search results for available SUPT4A gene related products
- genomics-online: gRNA clones - Search results for available SUPT4A gene related products
- genomics-online: primer clones - Search results for available SUPT4A gene related products
- genomics-online: shRNA clones - Search results for available SUPT4A gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUPT4H1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUPT4H1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SUPT4H1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUPT4H1
Sources for SUPT4H1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource