Aliases for SUPT20HL2 Gene

Aliases for SUPT20HL2 Gene

  • SUPT20H Like 2 2 3 5
  • Putative Transcription Factor SPT20 Homolog-Like 2 3 4
  • Family With Sequence Similarity 48, Member B2 2 3
  • FAM48B2 3 4
  • Suppressor Of Ty 20 Homolog (S. Cerevisiae)-Like 2 2
  • Family With Sequence Similarity 48, Member B1 3
  • SPT20 Homolog, SAGA Complex Component Like 2 2
  • SPT20 Homolog, SAGA Complex Component-Like 2 3
  • Suppressor Of Ty 20 Homolog-Like 2 3
  • Putative Protein FAM48B2 3
  • SUPT20HL2 5
  • FAM48B1 3

External Ids for SUPT20HL2 Gene

Previous HGNC Symbols for SUPT20HL2 Gene

  • FAM48B2

Summaries for SUPT20HL2 Gene

GeneCards Summary for SUPT20HL2 Gene

SUPT20HL2 (SUPT20H Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription coregulator activity. An important paralog of this gene is SUPT20HL1.

Additional gene information for SUPT20HL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUPT20HL2 Gene

Genomics for SUPT20HL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SUPT20HL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ024309 Enhancer 0.2 Ensembl 4.9 +3.3 3278 3.2 HSALNG0137050 SUPT20HL2 HSALNG0137051 ZFX
GH0XJ024144 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 +164.8 164836 9.9 ZNF207 ZNF654 IKZF1 ZNF600 MYC JUND ZNF580 ATF2 CEBPA ZNF223 ZFX ZFX-AS1 RPL9P7 POLA1 HSALNG0137040 RF00017-7634 RF00017-7632 SUPT20HL2
GH0XJ024306 Enhancer 0.4 Ensembl 0.4 +7.4 7378 0.2 PKNOX1 RAD21 CTCF NR2F2 HSALNG0137051 RF00017-7632 RF00017-7639 SUPT20HL2 ZFX
GH0XJ024229 Enhancer 1 Ensembl ENCODE 0.2 +83.4 83359 2.4 NCOR1 IKZF1 JUND ZNF592 BHLHE40 ZNF639 ZEB1 TAF9B MAFF NBN ZFX RF00017-7634 HSALNG0137047 RF00017-7632 SUPT20HL2
GH0XJ024282 Enhancer 0.6 Ensembl ENCODE 0.3 +30.9 30851 2.3 ZNF189 RUNX3 NR2F2 HSALNG0137049 HSALNG0137048 RF00017-7632 SUPT20HL2 ZFX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUPT20HL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUPT20HL2

Genomic Locations for SUPT20HL2 Gene

Latest Assembly
chrX:24,308,210-24,314,079
(GRCh38/hg38)
Size:
5,870 bases
Orientation:
Minus strand

Previous Assembly
chrX:24,326,332-24,331,510
(GRCh37/hg19 by Entrez Gene)
Size:
5,179 bases
Orientation:
Minus strand

chrX:24,328,979-24,331,432
(GRCh37/hg19 by Ensembl)
Size:
2,454 bases
Orientation:
Minus strand

Genomic View for SUPT20HL2 Gene

Genes around SUPT20HL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUPT20HL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUPT20HL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUPT20HL2 Gene

Proteins for SUPT20HL2 Gene

  • Protein details for SUPT20HL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7V6-SP202_HUMAN
    Recommended name:
    Putative transcription factor SPT20 homolog-like 2
    Protein Accession:
    P0C7V6

    Protein attributes for SUPT20HL2 Gene

    Size:
    817 amino acids
    Molecular mass:
    87541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SUPT20HL2 Gene

Post-translational modifications for SUPT20HL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUPT20HL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SUPT20HL2 Gene

Domains & Families for SUPT20HL2 Gene

Protein Domains for SUPT20HL2 Gene

InterPro:

Suggested Antigen Peptide Sequences for SUPT20HL2 Gene

GenScript: Design optimal peptide antigens:
  • Putative protein FAM48B2 (F48B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C7V6

UniProtKB/Swiss-Prot:

SP202_HUMAN :
  • Belongs to the SPT20 family.
Family:
  • Belongs to the SPT20 family.
genes like me logo Genes that share domains with SUPT20HL2: view

No data available for Gene Families for SUPT20HL2 Gene

Function for SUPT20HL2 Gene

Phenotypes From GWAS Catalog for SUPT20HL2 Gene

Gene Ontology (GO) - Molecular Function for SUPT20HL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IBA 21873635
genes like me logo Genes that share ontologies with SUPT20HL2: view
genes like me logo Genes that share phenotypes with SUPT20HL2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUPT20HL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SUPT20HL2 Gene

Localization for SUPT20HL2 Gene

Gene Ontology (GO) - Cellular Components for SUPT20HL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA 21873635
GO:0005615 extracellular space HDA 23580065
genes like me logo Genes that share ontologies with SUPT20HL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SUPT20HL2 Gene

Pathways & Interactions for SUPT20HL2 Gene

PathCards logo

SuperPathways for SUPT20HL2 Gene

No Data Available

Interacting Proteins for SUPT20HL2 Gene

Gene Ontology (GO) - Biological Process for SUPT20HL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with SUPT20HL2: view

No data available for Pathways by source and SIGNOR curated interactions for SUPT20HL2 Gene

Drugs & Compounds for SUPT20HL2 Gene

No Compound Related Data Available

Transcripts for SUPT20HL2 Gene

mRNA/cDNA for SUPT20HL2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUPT20HL2

Alternative Splicing Database (ASD) splice patterns (SP) for SUPT20HL2 Gene

No ASD Table

Relevant External Links for SUPT20HL2 Gene

GeneLoc Exon Structure for
SUPT20HL2

Expression for SUPT20HL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUPT20HL2 Gene

mRNA differential expression in normal tissues according to GTEx for SUPT20HL2 Gene

This gene is overexpressed in Testis (x14.0), Fallopian Tube (x9.2), and Uterus (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SUPT20HL2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUPT20HL2

SOURCE GeneReport for Unigene cluster for SUPT20HL2 Gene:

Hs.716893
genes like me logo Genes that share expression patterns with SUPT20HL2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUPT20HL2 Gene

Orthologs for SUPT20HL2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SUPT20HL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM48B2 29
  • 98.82 (n)
Species where no ortholog for SUPT20HL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SUPT20HL2 Gene

ENSEMBL:
Gene Tree for SUPT20HL2 (if available)
TreeFam:
Gene Tree for SUPT20HL2 (if available)
Alliance of Genome Resources:
Additional Orthologs for SUPT20HL2

Paralogs for SUPT20HL2 Gene

Paralogs for SUPT20HL2 Gene

(3) SIMAP similar genes for SUPT20HL2 Gene using alignment to 1 proteins:

  • SP202_HUMAN
genes like me logo Genes that share paralogs with SUPT20HL2: view

Variants for SUPT20HL2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SUPT20HL2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SUPT20HL2 Gene

Variant ID Type Subtype PubMed ID
nsv483074 CNV loss 15286789

Additional Variant Information for SUPT20HL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUPT20HL2
Leiden Open Variation Database (LOVD)
SUPT20HL2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SUPT20HL2 Gene

Disorders for SUPT20HL2 Gene

Additional Disease Information for SUPT20HL2

No disorders were found for SUPT20HL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUPT20HL2 Gene

Publications for SUPT20HL2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  2. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. (PMID: 23580065) Pieragostino D … Del Boccio P (Molecular bioSystems 2013) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for SUPT20HL2 Gene

Sources for SUPT20HL2 Gene