SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direc... See more...

Aliases for SUN2 Gene

Aliases for SUN2 Gene

  • Sad1 And UNC84 Domain Containing 2 2 3 5
  • SUN Domain-Containing Protein 2 3 4
  • Sad1/Unc-84 Protein-Like 2 3 4
  • Protein Unc-84 Homolog B 3 4
  • Rab5-Interacting Protein 3 4
  • UNC84B 3 4
  • Rab5IP 3 4
  • Unc-84 Homolog B (C. Elegans) 2
  • Sad1 Unc-84 Domain Protein 2 3
  • Nuclear Envelope Protein 3
  • Unc-84 Homolog B 3
  • KIAA0668 4
  • RAB5IP 4
  • FRIGG 4
  • SUN2 5

External Ids for SUN2 Gene

Previous HGNC Symbols for SUN2 Gene

  • UNC84B

Previous GeneCards Identifiers for SUN2 Gene

  • GC22M039132
  • GC22M022096
  • GC22M039213
  • GC22M039418
  • GC22M040102
  • GC22M038755
  • GC22M038866
  • GC22M042767
  • GC22M042882
  • GC22M042938
  • GC22M044549
  • GC22M038864
  • GC22M039937
  • GC22M040625
  • GC22M041072
  • GC22M041468
  • GC22M041879
  • GC22M042308
  • GC22M042659

Summaries for SUN2 Gene

Entrez Gene Summary for SUN2 Gene

  • SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]

GeneCards Summary for SUN2 Gene

SUN2 (Sad1 And UNC84 Domain Containing 2) is a Protein Coding gene. Diseases associated with SUN2 include Emery-Dreifuss Muscular Dystrophy and Emery-Dreifuss Muscular Dystrophy 7, Autosomal Dominant. Among its related pathways are Meiosis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include identical protein binding and lamin binding. An important paralog of this gene is SUN1.

UniProtKB/Swiss-Prot Summary for SUN2 Gene

  • As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

Gene Wiki entry for SUN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUN2 Gene

Genomics for SUN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SUN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUN2

Genomic Locations for SUN2 Gene

Genomic Locations for SUN2 Gene
chr22:38,734,725-38,794,143
(GRCh38/hg38)
Size:
59,419 bases
Orientation:
Minus strand
chr22:39,130,719-39,190,148
(GRCh37/hg19)
Size:
59,430 bases
Orientation:
Minus strand

Genomic View for SUN2 Gene

Genes around SUN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUN2 Gene

Proteins for SUN2 Gene

  • Protein details for SUN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UH99-SUN2_HUMAN
    Recommended name:
    SUN domain-containing protein 2
    Protein Accession:
    Q9UH99
    Secondary Accessions:
    • B0QY62
    • O75156
    • Q2NKN8
    • Q2T9F7
    • Q504T5
    • Q6B4H1
    • Q7Z3E3

    Protein attributes for SUN2 Gene

    Size:
    717 amino acids
    Molecular mass:
    80311 Da
    Quaternary structure:
    • Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts with SYNE2; the SUN2:SYNE2/KASH2 LINC complex is a heterohexamer; the homotrimeric cloverleave-like conformation of the SUN domain is a prerequisite for LINC complex formation in which three separate SYNE2/KASH2 peptides bind at the interface of adjacent SUN domains. Component of a probable SUN2:KASH5 LINC complex. Interacts with SYNE1 and SYNE3; probably forming respective LINC complexes. Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable (By similarity). Interacts with EMD and RAB5A. Interacts with TMEM43 and TMEM201.
    SequenceCaution:
    • Sequence=BAA31643.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUN2 Gene

    Alternative splice isoforms for SUN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUN2 Gene

Post-translational modifications for SUN2 Gene

  • The disulfid bond with SYNE2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. The disulfid bond is proposed to be conserved in LINC complexes involved in force transmission.
  • Glycosylation at Asn636
  • Ubiquitination at Lys300, Lys392, Lys409, Lys491, Lys533, and Lys570
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

No data available for DME Specific Peptides for SUN2 Gene

Domains & Families for SUN2 Gene

Gene Families for SUN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SUN2 Gene

InterPro:
Blocks:
  • Sad1/UNC-like, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for SUN2 Gene

GenScript: Design optimal peptide antigens:
  • Unc-84 homolog B (C. elegans) (B0QY60_HUMAN)
  • Unc-84 homolog B (C. elegans) (B0QY61_HUMAN)
  • UNC84B protein (Q2T9F7_HUMAN)
  • UNC84B protein (Q504T5_HUMAN)
  • UNC84B protein (Q6NT72_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UH99

UniProtKB/Swiss-Prot:

SUN2_HUMAN :
  • The coiled coil domains differentially mediate trimerization required for binding to nesprins and are proposed to dynamically regulate the oligomeric state by locking the SUN domain in an inactive confirmation (By similarity). The coiled coil domains are proposed to be involved in load-bearing and force transmission from the cytoskeleton.
Domain:
  • The coiled coil domains differentially mediate trimerization required for binding to nesprins and are proposed to dynamically regulate the oligomeric state by locking the SUN domain in an inactive confirmation (By similarity). The coiled coil domains are proposed to be involved in load-bearing and force transmission from the cytoskeleton.
  • The SUN domain may play a role in the nuclear anchoring and/or migration.
genes like me logo Genes that share domains with SUN2: view

Function for SUN2 Gene

Molecular function for SUN2 Gene

UniProtKB/Swiss-Prot Function:
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

Phenotypes From GWAS Catalog for SUN2 Gene

Gene Ontology (GO) - Molecular Function for SUN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18396275
GO:0005521 lamin binding IDA 19933576
GO:0008017 microtubule binding TAS 10375507
GO:0042802 identical protein binding IPI 22632968
GO:0043495 protein membrane anchor IBA 21873635
genes like me logo Genes that share ontologies with SUN2: view
genes like me logo Genes that share phenotypes with SUN2: view

Animal Models for SUN2 Gene

MGI Knock Outs for SUN2:
  • Sun2 Sun2<tm1.1Cyh>
  • Sun2 Sun2<tm1Mhan>
  • Sun2 Sun2<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUN2 Gene

Localization for SUN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUN2 Gene

Nucleus inner membrane. Single-pass type II membrane protein. Nucleus envelope. Endosome membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUN2 gene
Compartment Confidence
nucleus 5
endosome 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
cytosol 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IEA --
GO:0000794 condensed nuclear chromosome IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS 10375507
genes like me logo Genes that share ontologies with SUN2: view

Pathways & Interactions for SUN2 Gene

PathCards logo

SuperPathways for SUN2 Gene

SuperPathway Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with SUN2: view

Pathways by source for SUN2 Gene

3 Reactome pathways for SUN2 Gene

SIGNOR curated interactions for SUN2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for SUN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IBA,IGI 16380439
GO:0007052 mitotic spindle organization TAS 10375507
GO:0007097 nuclear migration TAS 10508607
GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IEA --
GO:0030335 positive regulation of cell migration ISS --
genes like me logo Genes that share ontologies with SUN2: view

Drugs & Compounds for SUN2 Gene

No Compound Related Data Available

Transcripts for SUN2 Gene

mRNA/cDNA for SUN2 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUN2

Alternative Splicing Database (ASD) splice patterns (SP) for SUN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b ^ 11 ^
SP1: - - - - - - -
SP2: - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6:
SP7:
SP8: - - - - - - - - -
SP9: - - - -
SP10:
SP11:
SP12: - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - - - - - -
SP15: - -
SP16: -
SP17: - -
SP18:
SP19:

ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - -

Relevant External Links for SUN2 Gene

GeneLoc Exon Structure for
SUN2

Expression for SUN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUN2 Gene

Protein differential expression in normal tissues from HIPED for SUN2 Gene

This gene is overexpressed in CD8 Tcells (11.7), Peripheral blood mononuclear cells (9.3), Nasal epithelium (7.3), and CD4 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SUN2 Gene



Protein tissue co-expression partners for SUN2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUN2

SOURCE GeneReport for Unigene cluster for SUN2 Gene:

Hs.517622

mRNA Expression by UniProt/SwissProt for SUN2 Gene:

Q9UH99-SUN2_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.

Evidence on tissue expression from TISSUES for SUN2 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Pancreas(4.3)
  • Skin(2.8)
  • Muscle(2.8)
  • Heart(2.5)
  • Blood(2.4)
  • Bone marrow(2.4)
  • Kidney(2.4)
  • Lymph node(2.4)
  • Spleen(2.3)
  • Intestine(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with SUN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUN2 Gene

Orthologs for SUN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUN2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SUN2 30 31
  • 99.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SUN2 30 31
  • 85.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SUN2 30
  • 84.64 (n)
UNC84B 31
  • 84 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sun2 30
  • 82.94 (n)
Mouse
(Mus musculus)
Mammalia Sun2 30 17 31
  • 82.33 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SUN2 31
  • 64 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SUN2 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SUN2 30 31
  • 61.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SUN2 31
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sun2 30
  • 52.37 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-92f12.2 30
  • 49.48 (n)
SUN2 31
  • 38 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta koi 31
  • 27 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea unc-84 31
  • 13 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToMany
Species where no ortholog for SUN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SUN2 Gene

ENSEMBL:
Gene Tree for SUN2 (if available)
TreeFam:
Gene Tree for SUN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SUN2: view image

Paralogs for SUN2 Gene

Paralogs for SUN2 Gene

(6) SIMAP similar genes for SUN2 Gene using alignment to 11 proteins:

  • SUN2_HUMAN
  • B0QY60_HUMAN
  • B0QY63_HUMAN
  • B0QY64_HUMAN
  • B0QY65_HUMAN
  • B0QY66_HUMAN
  • B0QY67_HUMAN
  • B0QY68_HUMAN
  • B0QY69_HUMAN
  • H0Y686_HUMAN
  • J3KQE0_HUMAN
genes like me logo Genes that share paralogs with SUN2: view

Variants for SUN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SUN2 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
639248 Uncertain Significance: Emery-Dreifuss muscular dystrophy 38,742,515(-) C/T MISSENSE_VARIANT
639766 Uncertain Significance: Emery-Dreifuss muscular dystrophy 38,751,207(-) C/G INTRON_VARIANT
641394 Uncertain Significance: Emery-Dreifuss muscular dystrophy 38,739,356(-) G/GCGTA FRAMESHIFT_VARIANT
644029 Uncertain Significance: Emery-Dreifuss muscular dystrophy 38,738,968(-) G/A NONSENSE
647243 Uncertain Significance: Emery-Dreifuss muscular dystrophy 38,750,314(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SUN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SUN2 Gene

Variant ID Type Subtype PubMed ID
dgv4566n100 CNV gain 25217958
dgv769n67 CNV gain 20364138
esv991516 CNV deletion 20482838
nsv1055817 CNV loss 25217958
nsv471916 CNV novel sequence insertion 20440878

Variation tolerance for SUN2 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUN2 Gene

Human Gene Mutation Database (HGMD)
SUN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUN2 Gene

Disorders for SUN2 Gene

MalaCards: The human disease database

(23) MalaCards diseases for SUN2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
emery-dreifuss muscular dystrophy
  • muscular dystrophy, tardive, dreifuss-emery type, with contractures
emery-dreifuss muscular dystrophy 7, autosomal dominant
  • edmd7
muscular dystrophy
  • muscular dystrophies
emerinopathy
laminopathy
- elite association - COSMIC cancer census association via MalaCards
Search SUN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SUN2

genes like me logo Genes that share disorders with SUN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUN2 Gene

Publications for SUN2 Gene

  1. Isolation of differentially expressed genes in human heart tissues. (PMID: 12393179) Sun G … Ping Leung M (Biochimica et biophysica acta 2002) 3 4 23
  2. UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. (PMID: 10375507) Malone CJ … Han M (Development (Cambridge, England) 1999) 2 3 4
  3. LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins. (PMID: 22632968) Sosa BA … Schwartz TU (Cell 2012) 3 4
  4. Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. (PMID: 22170055) Zhou Z … Wang Q (The Journal of biological chemistry 2012) 3 4
  5. TMEM43 mutations in Emery-Dreifuss muscular dystrophy-related myopathy. (PMID: 21391237) Liang WC … Hayashi YK (Annals of neurology 2011) 3 4

Products for SUN2 Gene

Sources for SUN2 Gene