Aliases for SUMO3 Gene
External Ids for SUMO3 Gene
Previous HGNC Symbols for SUMO3 Gene
Previous GeneCards Identifiers for SUMO3 Gene
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]
GeneCards Summary for SUMO3 Gene
SUMO3 (Small Ubiquitin Like Modifier 3) is a Protein Coding gene. Diseases associated with SUMO3 include Nephronophthisis 7. Among its related pathways are SUMOylation and RNA transport. Gene Ontology (GO) annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO2.
UniProtKB/Swiss-Prot Summary for SUMO3 Gene
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).