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This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]
SUMO3 (Small Ubiquitin Like Modifier 3) is a Protein Coding gene. Diseases associated with SUMO3 include Brachydactyly, Type A1. Among its related pathways are HIF Repressors and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17000644 |
GO:0031386 | protein tag | IBA | 21873635 |
GO:0044389 | ubiquitin-like protein ligase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000776 | kinetochore | TAS | 9119407 |
GO:0005634 | nucleus | IEA,IDA | 21965678 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0016605 | PML body | IEA,IDA | 19050011 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | SUMOylation |
.95
|
|
2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
3 | HIF Repressors |
.38
|
.38
|
4 | Metabolism of proteins | ||
5 | Fluid shear stress and atherosclerosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016925 | protein sumoylation | IDA | 11889051 |
GO:0043392 | negative regulation of DNA binding | IDA | 16626738 |
GO:1900180 | regulation of protein localization to nucleus | IDA | 19050011 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 10f | · | 10g |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: | |||
SP10: | |||
SP11: | |||
SP12: | |||
SP13: | |||
SP14: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SUMO3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Cow (Bos Taurus) |
Mammalia | SUMO3 30 |
|
||
-- 31 |
|
ManyToMany | |||
Mouse (Mus musculus) |
Mammalia | Sumo3 30 17 |
|
||
4933411G06Rik 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Sumo3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | SUMO3 30 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sumo3 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC64297 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sumo3b 30 |
|
||
sumo2a 31 |
|
ManyToMany | |||
wufa94a11 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | smt3 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000852 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SMT3 31 |
|
OneToMany | |
Rice (Oryza sativa) |
Liliopsida | Os.24729 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11356 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3647135 | CNV | loss | 21293372 |
esv3647136 | CNV | loss | 21293372 |
nsv1058550 | CNV | loss | 25217958 |
nsv1071763 | CNV | deletion | 25765185 |
nsv3540 | CNV | insertion | 18451855 |
nsv459298 | CNV | loss | 19166990 |
nsv587813 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
brachydactyly, type a1 |
|
|