Aliases for SUMO3 Gene
Aliases for SUMO3 Gene
External Ids for SUMO3 Gene
- HGNC: 11124
- Entrez Gene: 6612
- Ensembl: ENSG00000184900
- OMIM: 602231
- UniProtKB: P55854
Previous HGNC Symbols for SUMO3 Gene
- SMT3H1
Previous GeneCards Identifiers for SUMO3 Gene
- GC21M045083
- GC21M045049
- GC21M046191
- GC21M031598
- GC21M046548
- GC21M046735
Summaries for SUMO3 Gene
-
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]
GeneCards Summary for SUMO3 Gene
SUMO3 (Small Ubiquitin-Like Modifier 3) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO2.
UniProtKB/Swiss-Prot for SUMO3 Gene
-
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO3 Gene
Genomics for SUMO3 Gene
GeneHancer (GH) Regulatory Elements for SUMO3 Gene
Promoters and enhancers for SUMO3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SUMO3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SUMO3 Gene
Genomic Locations for SUMO3 Gene
- chr21:44,805,617-44,818,779
- (GRCh38/hg38)
- Size:
- 13,163 bases
- Orientation:
- Minus strand
- chr21:46,225,532-46,238,694
- (GRCh37/hg19)
Genomic View for SUMO3 Gene
Genes around SUMO3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by Ensembl
- 21q22.3 by Entrez Gene
- 21q22.3 by HGNC
SUMO3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SUMO3 Gene
Proteins for SUMO3 Gene
-
Protein details for SUMO3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55854-SUMO3_HUMAN
- Recommended name:
- Small ubiquitin-related modifier 3
- Protein Accession:
- P55854
- B2R5X4
- B4DUW4
- Q53HI9
- Q6FGD4
- Q9BWR4
Protein attributes for SUMO3 Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11637 Da
- Quaternary structure:
-
- Covalently attached to a number of proteins. Interacts with ARNTL/BMAL1 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I.
Protein Expression for SUMO3 Gene
Post-translational modifications for SUMO3 Gene
- Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.
- Polymeric chains can be formed through Lys-11 cross-linking.
- Ubiquitination at isoforms=25, posLast=77, and isoforms=2, 1, 220
- Modification sites at PhosphoSitePlus
Other Protein References for SUMO3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SUMO3 (SUMO3)
-
Custom Antibody ServicesOriGene Antibodies for SUMO3
- Novus Biologicals Antibodies for SUMO3
-
Abcam antibodies for SUMO3
- Invitrogen Antibodies for SUMO3
- GeneTex SUMO3 antibody for SUMO3
-
Custom Antibody ServicesProSci Antibodies for SUMO3
-
Santa Cruz Biotechnology (SCBT) Antibodies for SUMO3
- Sino Biological Antibodies for SUMO3
Protein Products
- R&D Systems Proteins and Enzymes for SUMO3 (Di-SUMO3)
- R&D Systems Proteins and Enzymes for SUMO3 (Poly-SUMO3)
- R&D Systems Proteins and Enzymes for SUMO3
- Search Origene for MassSpec and Protein Over-expression Lysates for SUMO3
- Origene Custom Protein Services for SUMO3
- ProSpec Recombinant Proteins for SUMO3
- Search GeneTex for Proteins for SUMO3
-
Abcam proteins for SUMO3
Assay Products
- R&D Systems Activity Assays and other biochemical assays for SUMO3 (SUMO3)
No data available for DME Specific Peptides for SUMO3 Gene
Domains & Families for SUMO3 Gene
Gene Families for SUMO3 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SUMO3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SUMO3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P55854- Family:
-
- Belongs to the ubiquitin family. SUMO subfamily.
Function for SUMO3 Gene
Molecular function for SUMO3 Gene
- UniProtKB/Swiss-Prot Function:
- Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Phenotypes From GWAS Catalog for SUMO3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17000644 |
| GO:0019899 | enzyme binding | IPI | 11889051 |
| GO:0031386 | protein tag | IBA | -- |
Phenotypes for SUMO3 Gene
- MGI mutant phenotypes for SUMO3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SUMO3:
Animal Models for SUMO3 Gene
- MGI Knock Outs for SUMO3:
-
- Sumo3 tm1Weiy
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SUMO3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SUMO3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUMO3 gene
- Search ViGene Biosciences for SUMO3
CRISPR Products
-
OriGene CRISPR knockouts for SUMO3
- genomics-online: gRNA clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials CRISPR for SUMO3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUMO3
- GenScript: Design CRISPR guide RNA sequences for SUMO3
miRNA for SUMO3 Gene
- miRTarBase miRNAs that target SUMO3
miRNA Products
- Search ViGene Biosciences for SUMO3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SUMO3
- Browse OriGene Inhibitory RNA Products For SUMO3
- genomics-online: shRNA clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for SUMO3 gene
Clone Products
- Sino Biological Human cDNA Clone for SUMO3
- VectorBuilder custom plasmid, inducible vectors for SUMO3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUMO3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SUMO3
- genomics-online: cdna clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- orf clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials Clones for SUMO3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SUMO3
-
ViGene Biosciences adenoviral particle packaged cDNA for SUMO3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SUMO3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUMO3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUMO3 Gene
Localization for SUMO3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUMO3 Gene
- Cytoplasm. Nucleus. Nucleus, PML body.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 1 |
| cytosol | 1 |
- Nuclear bodies (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | TAS | 9119407 |
| GO:0005634 | nucleus | IDA,IEA | 21965678 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016605 | PML body | IEA | -- |
Pathways & Interactions for SUMO3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | SUMOylation |
.95
|
|
| 2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 3 | HIF Repressor Pathways | ||
| 4 | Metabolism of proteins | ||
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for SUMO3 Gene
1 Sino Biological pathway for SUMO3 Gene
1 GeneTex pathway for SUMO3 Gene
1 BioSystems pathway for SUMO3 Gene
15 Reactome pathways for SUMO3 Gene
2 KEGG pathways for SUMO3 Gene
2 R&D Systems pathways for SUMO3 Gene
2 Qiagen pathways for SUMO3 Gene
Interacting Proteins for SUMO3 Gene
Selected Interacting proteins:
ENSP00000330343
P55854-SUMO3_HUMAN
for SUMO3 Gene via
STRING
IID
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016925 | protein sumoylation | TAS | -- |
| GO:0043392 | negative regulation of DNA binding | IDA | 16626738 |
| GO:0070911 | global genome nucleotide-excision repair | TAS | -- |
No data available for SIGNOR curated interactions for SUMO3 Gene
Transcripts for SUMO3 Gene
mRNA/cDNA for SUMO3 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (677) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SUMO3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SUMO3
- genomics-online: gRNA clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials CRISPR for SUMO3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUMO3
- GenScript: Design CRISPR guide RNA sequences for SUMO3
miRNA Products
- Search ViGene Biosciences for SUMO3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SUMO3
- Browse OriGene Inhibitory RNA Products For SUMO3
- genomics-online: shRNA clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for SUMO3 gene
Clone Products
- Sino Biological Human cDNA Clone for SUMO3
- VectorBuilder custom plasmid, inducible vectors for SUMO3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUMO3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SUMO3
- genomics-online: cdna clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- orf clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials Clones for SUMO3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 10f | · | 10g |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: | |||
| SP14: |
Expression for SUMO3 Gene
This gene is overexpressed in Oral epithelium (8.1), Frontal cortex (7.9), and Fetal ovary (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUMO3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SUMO3 Gene:
SUMO3SOURCE GeneReport for Unigene cluster for SUMO3 Gene:
Hs.474005mRNA Expression by UniProt/SwissProt for SUMO3 Gene:
P55854-SUMO3_HUMAN
Tissue specificity:
Expressed predominantly in liver.
Evidence on tissue expression from TISSUES for SUMO3 Gene
- Nervous system(5)
- Kidney(4.5)
- Bone marrow(4.3)
- Lung(3.4)
- Eye(3)
- Skin(3)
- Liver(2.5)
- Blood(2.2)
- Heart(2.2)
- Intestine(2.2)
- Muscle(2.1)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for SUMO3
-
OriGene qPCR primer pairs and template standards for SUMO3
- genomics-online: primer clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
-
Recommended
- pLenti-C-mGFP
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-XL5
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUMO3 Gene
Orthologs for SUMO3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SUMO3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| cow (Bos Taurus) |
Mammalia | SUMO3 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Sumo3 33 16 |
|
||
| 4933411G06Rik 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Sumo3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | SUMO3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sumo3 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64297 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sumo3b 33 |
|
||
| sumo2a 34 |
|
ManyToMany | |||
| wufa94a11 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | smt3 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000852 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SMT3 34 |
|
OneToMany | |
| rice (Oryza sativa) |
Liliopsida | Os.24729 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11356 34 |
|
OneToMany |
- Species where no ortholog for SUMO3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SUMO3 Gene
(6) SIMAP similar genes for SUMO3 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for SUMO3 Gene
Variants for SUMO3 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000074792 | -- | 44,808,213(-) | AAAAAAAAA/AAAAAAAAAA/AAAAAAAAAAA | intron_variant | |
| rs1000082421 | -- | 44,819,634(-) | G/C | upstream_transcript_variant | |
| rs1000312058 | -- | 44,815,678(-) | G/A | intron_variant | |
| rs1000315242 | -- | 44,805,788(-) | T/C | 3_prime_UTR_variant | |
| rs1000356114 | -- | 44,818,494(-) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3647135 | CNV | loss | 21293372 |
| esv3647136 | CNV | loss | 21293372 |
| nsv1058550 | CNV | loss | 25217958 |
| nsv1071763 | CNV | deletion | 25765185 |
| nsv3540 | CNV | insertion | 18451855 |
| nsv459298 | CNV | loss | 19166990 |
| nsv587813 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SUMO3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SUMO3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO3 Gene
Disorders for SUMO3 Gene
Additional Disease Information for SUMO3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SUMO3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUMO3 Gene
Publications for SUMO3 Gene
- SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. (PMID: 9119407) Lapenta V … Brahe C (Genomics 1997) 2 3 4 22 58
- A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PMID: 15296745) Reverter D … Lima CD (Structure (London, England : 1993) 2004) 3 4 22 58
- Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su HL … Li SS (Gene 2002) 3 4 22 58
- A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. (PMID: 24105744) Richard P … Manley JL (Genes & development 2013) 3 4 58
- SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. (PMID: 21965678) Cong L … Kumar R (The Journal of biological chemistry 2011) 3 4 58
Products for SUMO3 Gene
- R&D Systems Antibodies for SUMO3 (SUMO3)
- R&D Systems Proteins and Enzymes for SUMO3 (Di-SUMO3)
- R&D Systems Proteins and Enzymes for SUMO3 (Poly-SUMO3)
- R&D Systems Proteins and Enzymes for SUMO3
- R&D Systems Activity Assays and other biochemical assays for SUMO3 (SUMO3)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for SUMO3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SUMO3
- Origene Custom Protein Services for SUMO3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUMO3
- Browse OriGene Inhibitory RNA Products For SUMO3
- OriGene qPCR primer pairs and template standards for SUMO3
- OriGene qPCR primer pairs for SUMO3
- OriGene CRISPR knockouts for SUMO3
- OriGene ORF clones in human for SUMO3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SUMO3
- GenScript: Next-day shipping of latest version cDNA ORF clones for SUMO3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SUMO3
- GenScript Custom Assay Services for SUMO3
- GenScript Custom overexpressing Cell Line Services for SUMO3
- GenScript: Design CRISPR guide RNA sequences for SUMO3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SUMO3
- Sino Biological Human cDNA Clone for SUMO3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Sino Biological Antibodies for SUMO3
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for SUMO3
- Novus Biologicals lysates and proteins for SUMO3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SUMO3
- Abcam proteins for SUMO3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for SUMO3
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for SUMO3
- VectorBuilder custom plasmid, inducible vectors for SUMO3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SUMO3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SUMO3
- antibodies-online: Search results for available SUMO3 related products ranked by validation data
- antibodies-online: Search results for available SUMO3 related products ranked by validation data
- antibodies-online: Search results for available SUMO3 related products ranked by validation data
- GeneTex SUMO3 antibody for SUMO3
- Search GeneTex for Proteins for SUMO3
- ViGene Biosciences adenoviral particle packaged cDNA for SUMO3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SUMO3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SUMO3 gene
- Search ViGene Biosciences for SUMO3
- Santa Cruz Biotechnology (SCBT) Antibodies for SUMO3
- Search Santa Cruz Biotechnology (SCBT) for SUMO3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SUMO3
- Custom Antibody ServicesProSci Antibodies for SUMO3
- Horizon Cell Lines for SUMO3
- genomics-online: cdna clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- orf clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- genomics-online: gRNA clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- genomics-online: primer clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- genomics-online: shRNA clones - Search results for 193 available SUMO3 gene related products
- Overview of 193 available SUMO3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
Sources for SUMO3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems