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This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional reg... See more...
Aliases for SUMO3 Gene
Aliases for SUMO3 Gene
External Ids for SUMO3 Gene
- HGNC: 11124
- Entrez Gene: 6612
- Ensembl: ENSG00000184900
- OMIM: 602231
- UniProtKB: P55854
Previous HGNC Symbols for SUMO3 Gene
- SMT3H1
Previous GeneCards Identifiers for SUMO3 Gene
- GC21M045083
- GC21M045049
- GC21M046191
- GC21M031598
- GC21M046548
- GC21M046735
Summaries for SUMO3 Gene
-
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]
GeneCards Summary for SUMO3 Gene
SUMO3 (Small Ubiquitin Like Modifier 3) is a Protein Coding gene. Diseases associated with SUMO3 include Brachydactyly, Type A1. Among its related pathways are HIF Repressors and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO2.
UniProtKB/Swiss-Prot Summary for SUMO3 Gene
-
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Additional gene information for SUMO3 Gene
- HGNC(11124)
- Entrez Gene(6612)
- Ensembl(ENSG00000184900)
- OMIM(602231)
- UniProtKB(P55854)
- Open Targets Platform(ENSG00000184900)
- Search for SUMO3 at DataMed
- Search for SUMO3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUMO3 Gene
Genomics for SUMO3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SUMO3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SUMO3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUMO3
- Top Transcription factor binding sites by QIAGEN in the SUMO3 gene promoter:
-
- aMEF-2
- AML1a
- AP-1
- ATF-2
- ATF6
- c-Jun
- MEF-2A
- p53
Genomic Locations for SUMO3 Gene
Genomic Locations for SUMO3 Gene
- chr21:44,805,617-44,818,779
- (GRCh38/hg38)
- Size:
- 13,163 bases
- Orientation:
- Minus strand
- chr21:46,225,532-46,238,694
- (GRCh37/hg19)
- Size:
- 13,163 bases
- Orientation:
- Minus strand
Genomic View for SUMO3 Gene
Genes around SUMO3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by HGNC
- 21q22.3 by Entrez Gene
- 21q22.3 by Ensembl
SUMO3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SUMO3 Gene
Proteins for SUMO3 Gene
-
Protein details for SUMO3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55854-SUMO3_HUMAN
- Recommended name:
- Small ubiquitin-related modifier 3
- Protein Accession:
- P55854
- B2R5X4
- B4DUW4
- Q53HI9
- Q6FGD4
- Q9BWR4
Protein attributes for SUMO3 Gene
- Size:
- 103 amino acids
- Molecular mass:
- 11637 Da
- Quaternary structure:
-
- Covalently attached to a number of proteins. Interacts with ARNTL/BMAL1 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I.
Three dimensional structures from OCA and Proteopedia for SUMO3 Gene
Protein Expression for SUMO3 Gene
Post-translational modifications for SUMO3 Gene
- Polymeric chains can be formed through Lys-11 cross-linking.
- Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.
-
Ubiquitination at Lys5, Lys7, and Lys20
- NX_P55854 (NX_P55854-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SUMO3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SUMO3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SUMO3
- Novus Biologicals Antibodies for SUMO3
-
Abcam antibodies for SUMO3
- Invitrogen Antibodies for SUMO3 (AFLGC-SUMO3)
-
Custom Antibody ServicesProSci Antibodies for SUMO3
-
Santa Cruz Biotechnology (SCBT) Antibodies for SUMO3
- Sino Biological Antibodies for SUMO3
Protein Products
-
OriGene Purified Proteins for SUMO3
- Search Origene for MassSpec and Protein Over-expression Lysates for SUMO3
- Origene Custom Protein Services for SUMO3
- ProSpec Recombinant Proteins for SUMO3
-
Abcam proteins for SUMO3
No data available for DME Specific Peptides for SUMO3 Gene
Domains & Families for SUMO3 Gene
Gene Families for SUMO3 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SUMO3 Gene
- InterPro:
- Blocks:
-
- Ubiquitin domain
- ProtoNet:
Suggested Antigen Peptide Sequences for SUMO3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57440, moderately similar to Small ubiquitin-related modifier 3 (B4DUW4_HUMAN)
- Ubiquitin-like protein SMT3B (SUMO3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P55854- Family:
-
- Belongs to the ubiquitin family. SUMO subfamily.
Function for SUMO3 Gene
Molecular function for SUMO3 Gene
- UniProtKB/Swiss-Prot Function:
- Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Phenotypes From GWAS Catalog for SUMO3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17000644 |
| GO:0031386 | protein tag | IBA | 21873635 |
| GO:0044389 | ubiquitin-like protein ligase binding | IBA | 21873635 |
Phenotypes for SUMO3 Gene
- MGI mutant phenotypes for SUMO3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SUMO3:
Animal Models for SUMO3 Gene
- MGI Knock Outs for SUMO3:
-
- Sumo3 Sumo3<tm1Weiy>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SUMO3 - Select products 50% OFF >
- * SUMO3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SUMO3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUMO3
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUMO3
miRNA for SUMO3 Gene
- miRTarBase miRNAs that target SUMO3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUMO3
- Browse OriGene Inhibitory RNA Products For SUMO3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUMO3
Clone Products
- Applied Biological Materials (abm): Clones for SUMO3 - Select products 50% OFF >
- * SUMO3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SUMO3
- Addgene plasmids for SUMO3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUMO3
Cell Line Products
-
Horizon Cell Lines for SUMO3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUMO3 Gene
Localization for SUMO3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUMO3 Gene
- Cytoplasm. Nucleus. Nucleus, PML body.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | TAS | 9119407 |
| GO:0005634 | nucleus | IEA,IDA | 21965678 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016605 | PML body | IEA,IDA | 19050011 |
Pathways & Interactions for SUMO3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | SUMOylation |
.95
|
|
| 2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 3 | HIF Repressors |
.38
|
.38
|
| 4 | Metabolism of proteins | ||
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for SUMO3 Gene
1 Sino Biological pathway for SUMO3 Gene
1 BioSystems pathway for SUMO3 Gene
15 Reactome pathways for SUMO3 Gene
2 KEGG pathways for SUMO3 Gene
2 R&D Systems pathways for SUMO3 Gene
2 Qiagen pathways for SUMO3 Gene
- JAK-STAT Pathway
- SUMO Pathway
1 GeneTex pathway for SUMO3 Gene
Interacting Proteins for SUMO3 Gene
Selected Interacting proteins:
P55854-SUMO3_HUMAN
ENSP00000409666
for SUMO3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SUMO3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016925 | protein sumoylation | IDA | 11889051 |
| GO:0043392 | negative regulation of DNA binding | IDA | 16626738 |
| GO:1900180 | regulation of protein localization to nucleus | IDA | 19050011 |
No data available for SIGNOR curated interactions for SUMO3 Gene
Transcripts for SUMO3 Gene
mRNA/cDNA for SUMO3 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332859 1740 nts (view in UCSC)
- ENST00000397893 520 nts (view in UCSC)
- ENST00000397898 1779 nts (view in UCSC)
- ENST00000411651 1921 nts (view in UCSC)
- ENST00000466861 753 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SUMO3 - Select products 50% OFF >
- * SUMO3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SUMO3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUMO3
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUMO3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUMO3
- Browse OriGene Inhibitory RNA Products For SUMO3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUMO3
Clone Products
- Applied Biological Materials (abm): Clones for SUMO3 - Select products 50% OFF >
- * SUMO3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SUMO3
- Addgene plasmids for SUMO3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUMO3
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 10f | · | 10g |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: | |||
| SP14: |
Relevant External Links for SUMO3 Gene
- GeneLoc Exon Structure for
- SUMO3
Expression for SUMO3 Gene
This gene is overexpressed in Oral epithelium (8.1), Frontal cortex (7.9), and Fetal ovary (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUMO3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUMO3
SOURCE GeneReport for Unigene cluster for SUMO3 Gene:
Hs.474005mRNA Expression by UniProt/SwissProt for SUMO3 Gene:
P55854-SUMO3_HUMAN
Tissue specificity:
Expressed predominantly in liver.
Evidence on tissue expression from TISSUES for SUMO3 Gene
- Nervous system(5)
- Kidney(4.6)
- Bone marrow(4.3)
- Lung(3.6)
- Skin(3.6)
- Eye(3.3)
- Liver(2.8)
- Intestine(2.7)
- Spleen(2.6)
- Blood(2.6)
- Heart(2.6)
- Muscle(2.6)
- Lymph node(2.2)
- Pancreas(2.1)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for SUMO3
-
OriGene qPCR primer pairs and template standards for SUMO3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUMO3 Gene
Orthologs for SUMO3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SUMO3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Cow (Bos Taurus) |
Mammalia | SUMO3 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Sumo3 30 17 |
|
||
| 4933411G06Rik 31 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Sumo3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | SUMO3 30 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sumo3 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64297 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sumo3b 30 |
|
||
| sumo2a 31 |
|
ManyToMany | |||
| wufa94a11 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | smt3 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000852 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SMT3 31 |
|
OneToMany | |
| Rice (Oryza sativa) |
Liliopsida | Os.24729 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11356 31 |
|
OneToMany |
- Species where no ortholog for SUMO3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SUMO3 Gene
- ENSEMBL:
- Gene Tree for SUMO3 (if available)
- TreeFam:
- Gene Tree for SUMO3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SUMO3: view image
Paralogs for SUMO3 Gene
(6) SIMAP similar genes for SUMO3 Gene using alignment to 4 proteins:
- SUMO3_HUMAN
- A8MU27_HUMAN
- A8MUA9_HUMAN
- B4DUW4_HUMAN
Pseudogenes.org Pseudogenes for SUMO3 Gene
Variants for SUMO3 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3647135 | CNV | loss | 21293372 |
| esv3647136 | CNV | loss | 21293372 |
| nsv1058550 | CNV | loss | 25217958 |
| nsv1071763 | CNV | deletion | 25765185 |
| nsv3540 | CNV | insertion | 18451855 |
| nsv459298 | CNV | loss | 19166990 |
| nsv587813 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SUMO3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SUMO3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO3 Gene
Disorders for SUMO3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| brachydactyly, type a1 |
|
|
Search SUMO3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SUMO3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SUMO3 Gene
Publications for SUMO3 Gene
- SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. (PMID: 9119407) Lapenta V … Brahe C (Genomics 1997) 2 3 4 23
- A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PMID: 15296745) Reverter D … Lima CD (Structure (London, England : 1993) 2004) 3 4 23
- Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su HL … Li SS (Gene 2002) 3 4 23
- A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. (PMID: 24105744) Richard P … Manley JL (Genes & development 2013) 3 4
- SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. (PMID: 21965678) Cong L … Kumar R (The Journal of biological chemistry 2011) 3 4
ExternalLinks
Products for SUMO3 Gene
- View all R&D Systems SUMO3 (Di-SUMO3) Products
- View all 2 R&D Systems SUMO3 (Poly-SUMO3) Products
- View all 24 R&D Systems SUMO3 (SUMO3) Products
- View all R&D Systems SUMO3 (Di-SUMO3) Proteins and Enzymes
- View all 2 R&D Systems SUMO3 (Poly-SUMO3) Proteins and Enzymes
- View all 14 R&D Systems SUMO3 (SUMO3) Proteins and Enzymes
- View all 8 R&D Systems SUMO3 (SUMO3) Primary Antibodies
- View all 2 R&D Systems SUMO3 (SUMO3) Activity Assays
- Learn more about R&D Systems custom SUMO3 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for SUMO3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SUMO3
- Search Origene for MassSpec and Protein Over-expression Lysates for SUMO3
- Origene Custom Protein Services for SUMO3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUMO3
- Browse OriGene Inhibitory RNA Products For SUMO3
- OriGene qPCR primer pairs for SUMO3
- OriGene qPCR primer pairs and template standards for SUMO3
- OriGene CRISPR knockouts for SUMO3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SUMO3
- Sino Biological Human cDNA Clone for SUMO3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for SUMO3
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SUMO3
- Novus Biologicals proteins and lysates for SUMO3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SUMO3
- Abcam proteins for SUMO3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for SUMO3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SUMO3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SUMO3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SUMO3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SUMO3
- Addgene plasmids for SUMO3
- antibodies-online: Show 103 available SUMO3 Antibodies ranked by validation data
- Compare Top SUMO3 Antibodies
- antibodies-online: Search results for available SUMO3 related products ranked by validation data
- antibodies-online: Show 23 available SUMO3 Proteins ranked by validation data
- Compare Top SUMO3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for SUMO3
- Search Santa Cruz Biotechnology (SCBT) for SUMO3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SUMO3
- Custom Antibody ServicesProSci Antibodies for SUMO3
- Horizon Cell Lines for SUMO3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUMO3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUMO3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SUMO3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUMO3
Sources for SUMO3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB