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This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nu... See more...
Aliases for SUMO2 Gene
Aliases for SUMO2 Gene
- Small Ubiquitin Like Modifier 2 2 3 5
- SMT3B 2 3 4
- Small Ubiquitin-Related Modifier 2 3 4
- Ubiquitin-Like Protein SMT3B 3 4
- SMT3 Homolog 2 3 4
- SMT3H2 3 4
- HSMT3 3 4
- SMT3 Suppressor Of Mif Two 3 Homolog 2 (S. Cerevisiae) 2
- SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 2 2
- SMT3 Suppressor Of Mif Two 3 Homolog 2 (Yeast) 2
External Ids for SUMO2 Gene
- HGNC: 11125
- Entrez Gene: 6613
- Ensembl: ENSG00000188612
- OMIM: 603042
- UniProtKB: P61956
Previous HGNC Symbols for SUMO2 Gene
- SMT3H2
Previous GeneCards Identifiers for SUMO2 Gene
- GC17M073761
- GC17M070675
- GC17M073163
- GC17M068573
Summaries for SUMO2 Gene
-
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for SUMO2 Gene
SUMO2 (Small Ubiquitin Like Modifier 2) is a Protein Coding gene. Diseases associated with SUMO2 include Gordon Holmes Syndrome. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO3.
UniProtKB/Swiss-Prot Summary for SUMO2 Gene
-
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Additional gene information for SUMO2 Gene
- HGNC(11125)
- Entrez Gene(6613)
- Ensembl(ENSG00000188612)
- OMIM(603042)
- UniProtKB(P61956)
- Open Targets Platform(ENSG00000188612)
- Search for SUMO2 at DataMed
- Search for SUMO2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUMO2 Gene
Genomics for SUMO2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SUMO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SUMO2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUMO2
- Top Transcription factor binding sites by QIAGEN in the SUMO2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
Genomic Locations for SUMO2 Gene
Genomic Locations for SUMO2 Gene
- chr17:75,165,586-75,182,959
- (GRCh38/hg38)
- Size:
- 17,374 bases
- Orientation:
- Minus strand
- chr17:73,163,408-73,179,098
- (GRCh37/hg19)
- Size:
- 15,691 bases
- Orientation:
- Minus strand
Genomic View for SUMO2 Gene
Genes around SUMO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
SUMO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SUMO2 Gene
Proteins for SUMO2 Gene
-
Protein details for SUMO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61956-SUMO2_HUMAN
- Recommended name:
- Small ubiquitin-related modifier 2
- Protein Accession:
- P61956
- B2R4I2
- P55855
- Q32Q42
- Q6IPZ6
- Q96HK1
Protein attributes for SUMO2 Gene
- Size:
- 95 amino acids
- Molecular mass:
- 10871 Da
- Quaternary structure:
-
- Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with MTA1. Interacts with Epstein-barr virus BGLF4.
Three dimensional structures from OCA and Proteopedia for SUMO2 Gene
Protein Expression for SUMO2 Gene
Post-translational modifications for SUMO2 Gene
- Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
- Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
- Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
-
Ubiquitination at Lys5, Lys7, and Lys21
- NX_P61956 (NX_P61956-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SUMO2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SUMO2 Antibody
- RayBiotech Rabbit anti-Human SUMO-2
- NSJ Bioreagents SUMO2 Antibody (Mouse Monoclonal)
- Novus Biologicals Antibodies for SUMO2
-
Abcam antibodies for SUMO2
- Invitrogen Antibodies for SUMO2 (AFLGC-SUMO2)
- antibodies-online: Show 107 available SUMO2 Antibodies ranked by validation data
- Compare Top SUMO2 Antibodies
-
Recommended
- 153 WB Antibodies (anti-human)
- 54 IHC (p) Antibodies (anti-human)
- 21 IHC (f) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 49 IHC (p) Antibodies (anti-rat)
- 36 WB Antibodies (anti-rat)
- 21 IHC (f) Antibodies (anti-rat)
- 6 IHC Antibodies (anti-rat)
- 4 FACS Antibodies (anti-rat)
- 48 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
-
Custom Antibody ServicesProSci Antibodies for SUMO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SUMO2
- Sino Biological Antibodies for SUMO2
Protein Products
- Recombinant Human SUMO2 Protein, CF (UL-752)
- Recombinant Human HA-SUMO2 Vinyl Sulfone Protein, CF (UL-759)
- Recombinant Human Poly-SUMO2 Wild-type Chains (3-8), CF (ULC-220)
- Recombinant Human Poly-SUMO2 Wild-type Chains (2-8), CF (ULC-210)
- Recombinant Human Di-SUMO2 Wild-type Chains Protein, CF (ULC-200)
- Search Origene for MassSpec and Protein Over-expression Lysates for SUMO2
- Origene Custom Protein Services for SUMO2
- ProSpec Recombinant Proteins for SUMO2
-
Signalway Proteins for SUMO2
-
ProSci Proteins for SUMO2
-
Abcam proteins for SUMO2
No data available for DME Specific Peptides for SUMO2 Gene
Domains & Families for SUMO2 Gene
Gene Families for SUMO2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SUMO2 Gene
- InterPro:
- Blocks:
-
- Ubiquitin domain
- ProtoNet:
Suggested Antigen Peptide Sequences for SUMO2 Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin-like protein SMT3A (SUMO2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P61956- Family:
-
- Belongs to the ubiquitin family. SUMO subfamily.
Function for SUMO2 Gene
Molecular function for SUMO2 Gene
- UniProtKB/Swiss-Prot Function:
- Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Phenotypes From GWAS Catalog for SUMO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0005515 | protein binding | IEA,IPI | 15383276 |
| GO:0031386 | protein tag | IBA | 21873635 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 18408734 |
| GO:0044389 | ubiquitin-like protein ligase binding | IBA | 21873635 |
Phenotypes for SUMO2 Gene
- MGI mutant phenotypes for SUMO2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SUMO2:
Animal Models for SUMO2 Gene
- MGI Knock Outs for SUMO2:
-
- Sumo2 Sumo2<tm1Weiy>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SUMO2 - Select products 50% OFF >
- * SUMO2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SUMO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUMO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUMO2
miRNA for SUMO2 Gene
- miRTarBase miRNAs that target SUMO2
-
- hsa-miR-186-5p (MIRT045212)
- hsa-let-7b-5p (MIRT051926)
- hsa-miR-129-5p (MIRT289012)
- hsa-miR-1303 (MIRT492127)
- hsa-miR-4320 (MIRT492128)
- hsa-miR-3162-3p (MIRT492129)
- hsa-miR-32-3p (MIRT492130)
- hsa-miR-188-5p (MIRT492131)
- hsa-miR-6866-3p (MIRT492132)
- hsa-miR-6516-5p (MIRT492133)
- hsa-miR-576-5p (MIRT492134)
- hsa-miR-4263 (MIRT492135)
- hsa-miR-455-3p (MIRT492136)
- hsa-let-7e-3p (MIRT492137)
- hsa-miR-3165 (MIRT492138)
- hsa-miR-6880-5p (MIRT492139)
- hsa-miR-8071 (MIRT492140)
- hsa-miR-4764-5p (MIRT492141)
- hsa-miR-4328 (MIRT492142)
- hsa-miR-4735-5p (MIRT492143)
- hsa-miR-1244 (MIRT492144)
- hsa-miR-1265 (MIRT492145)
- hsa-miR-6848-3p (MIRT553905)
- hsa-miR-6843-3p (MIRT553906)
- hsa-miR-580-3p (MIRT553907)
- hsa-miR-302d-5p (MIRT553908)
- hsa-miR-302b-5p (MIRT553909)
- hsa-miR-4461 (MIRT553910)
- hsa-miR-380-3p (MIRT553911)
- hsa-miR-665 (MIRT652979)
- hsa-miR-4664-3p (MIRT652980)
- hsa-miR-1180-3p (MIRT652981)
- hsa-miR-2054 (MIRT652982)
- hsa-miR-7977 (MIRT652983)
- hsa-miR-1203 (MIRT652984)
- hsa-miR-208b-5p (MIRT652985)
- hsa-miR-208a-5p (MIRT652987)
- hsa-miR-6807-5p (MIRT698712)
- hsa-miR-7847-3p (MIRT698713)
- hsa-miR-6499-3p (MIRT698714)
- hsa-miR-6086 (MIRT698715)
- hsa-miR-377-5p (MIRT698716)
- hsa-miR-631 (MIRT698717)
- hsa-miR-3661 (MIRT698718)
- hsa-miR-4254 (MIRT698719)
- hsa-miR-1228-3p (MIRT698720)
- hsa-miR-619-3p (MIRT698721)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUMO2
- Browse OriGene Inhibitory RNA Products For SUMO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUMO2
Clone Products
- Applied Biological Materials (abm): Clones for SUMO2 - Select products 50% OFF >
- * SUMO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200259
- MG225920
- MR225920
- MR225920L3
- MR225920L4
- RC222664
- RC222664L1
- RC222664L2
- RC222664L3
- RC222664L4
- RC224336
- RC224336L1
- RC224336L2
- RC224336L3
- RC224336L4
- RG222664
- RG224336
- RR201432
- RR201432L3
- RR201432L4
- MR225920L3V
- MR225920L4V
- RC222664L1V
- RC222664L2V
- RC222664L3V
- RC222664L4V
- RC224336L1V
- RC224336L2V
- RC224336L3V
- RC224336L4V
- RR201432L3V
- RR201432L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SUMO2
- Addgene plasmids for SUMO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUMO2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUMO2 Gene
Localization for SUMO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUMO2 Gene
- Nucleus. Nucleus, PML body.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 21965678 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016605 | PML body | IEA,IDA | 22406621 |
Pathways & Interactions for SUMO2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | SUMOylation |
.95
|
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 4 | Metabolism of proteins | ||
| 5 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for SUMO2 Gene
1 Sino Biological pathway for SUMO2 Gene
1 BioSystems pathway for SUMO2 Gene
2 KEGG pathways for SUMO2 Gene
2 Qiagen pathways for SUMO2 Gene
- JAK-STAT Pathway
- SUMO Pathway
1 GeneTex pathway for SUMO2 Gene
Interacting Proteins for SUMO2 Gene
Selected Interacting proteins:
P61956-SUMO2_HUMAN
ENSP00000405965
for SUMO2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SUMO2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016925 | protein sumoylation | IDA | 17081986 |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA | 18408734 |
No data available for SIGNOR curated interactions for SUMO2 Gene
Transcripts for SUMO2 Gene
mRNA/cDNA for SUMO2 Gene
- 2 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000314523 809 nts (view in UCSC)
- ENST00000420826 3166 nts (view in UCSC)
- ENST00000578238 490 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SUMO2 - Select products 50% OFF >
- * SUMO2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SUMO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SUMO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUMO2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUMO2
- Browse OriGene Inhibitory RNA Products For SUMO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUMO2
Clone Products
- Applied Biological Materials (abm): Clones for SUMO2 - Select products 50% OFF >
- * SUMO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200259
- MG225920
- MR225920
- MR225920L3
- MR225920L4
- RC222664
- RC222664L1
- RC222664L2
- RC222664L3
- RC222664L4
- RC224336
- RC224336L1
- RC224336L2
- RC224336L3
- RC224336L4
- RG222664
- RG224336
- RR201432
- RR201432L3
- RR201432L4
- MR225920L3V
- MR225920L4V
- RC222664L1V
- RC222664L2V
- RC222664L3V
- RC222664L4V
- RC224336L1V
- RC224336L2V
- RC224336L3V
- RC224336L4V
- RR201432L3V
- RR201432L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SUMO2
- Addgene plasmids for SUMO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SUMO2
Relevant External Links for SUMO2 Gene
- GeneLoc Exon Structure for
- SUMO2
Expression for SUMO2 Gene
This gene is overexpressed in Tlymphocyte (7.0), Oral epithelium (6.9), and Nasal epithelium (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SUMO2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUMO2
SOURCE GeneReport for Unigene cluster for SUMO2 Gene:
Hs.380973mRNA Expression by UniProt/SwissProt for SUMO2 Gene:
P61956-SUMO2_HUMAN
Tissue specificity:
Broadly expressed.
Evidence on tissue expression from TISSUES for SUMO2 Gene
- Nervous system(5)
- Lung(4.9)
- Skin(4.8)
- Bone(4.6)
- Bone marrow(4.5)
- Intestine(4.2)
- Liver(4)
- Pancreas(3.9)
- Kidney(3.8)
- Eye(3.5)
- Muscle(3.5)
- Blood(3.5)
- Heart(3.3)
- Lymph node(2.7)
- Thyroid gland(2.7)
- Spleen(2.7)
- Adrenal gland(2.4)
- Stomach(2.3)
Primer Products
-
OriGene qPCR primer pairs for SUMO2
-
OriGene qPCR primer pairs and template standards for SUMO2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUMO2 Gene
Orthologs for SUMO2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SUMO2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Dog (Canis familiaris) |
Mammalia | SUMO2 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | SUMO2 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Sumo2 30 17 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Sumo2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | SUMO2 30 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sumo2 30 |
|
||
| Str.5818 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | smt3h2-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sumo3b 31 |
|
ManyToMany | |
| sumo2b 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | smt3 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001701 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SMT3 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11356 31 |
|
OneToMany |
- Species where no ortholog for SUMO2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SUMO2 Gene
- ENSEMBL:
- Gene Tree for SUMO2 (if available)
- TreeFam:
- Gene Tree for SUMO2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SUMO2: view image
Paralogs for SUMO2 Gene
(4) SIMAP similar genes for SUMO2 Gene using alignment to 2 proteins:
- SUMO2_HUMAN
- J3KRH1_HUMAN
Pseudogenes.org Pseudogenes for SUMO2 Gene
- PGOHUM00000292950
- PGOHUM00000293219
- PGOHUM00000294147
- PGOHUM00000294474
- PGOHUM00000296260
- PGOHUM00000296305
- PGOHUM00000299394
- PGOHUM00000300265
- PGOHUM00000300610
- PGOHUM00000301014
- PGOHUM00000301028
- PGOHUM00000301185
- PGOHUM00000301308
- PGOHUM00000301500
- PGOHUM00000301660
- PGOHUM00000301668
- PGOHUM00000302073
- PGOHUM00000302493
- PGOHUM00000302636
- PGOHUM00000303149
- PGOHUM00000303244
- PGOHUM00000303316
- PGOHUM00000303336
- PGOHUM00000304133
- PGOHUM00000289009
- PGOHUM00000306836
- PGOHUM00000289162
- PGOHUM00000289260
- PGOHUM00000289354
- PGOHUM00000289441
- PGOHUM00000306940
Variants for SUMO2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SUMO2 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17850328 | - | p.Asp16Asn |
Residual Variation Intolerance Score:
62.8% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SUMO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SUMO2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO2 Gene
Disorders for SUMO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gordon holmes syndrome |
|
|
Search SUMO2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SUMO2
No data available for UniProtKB/Swiss-Prot and Genatlas for SUMO2 Gene
Publications for SUMO2 Gene
- A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PMID: 15296745) Reverter D … Lima CD (Structure (London, England : 1993) 2004) 3 4 23
- Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins. (PMID: 15479240) Huang WC … Wang AH (European journal of biochemistry 2004) 3 4 23
- Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su HL … Li SS (Gene 2002) 3 4 23
- Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PMID: 11451954) Tatham MH … Hay RT (The Journal of biological chemistry 2001) 3 4 23
- Characterization of a second member of the sentrin family of ubiquitin-like proteins. (PMID: 9556629) Kamitani T … Yeh ET (The Journal of biological chemistry 1998) 3 4 23
ExternalLinks
Products for SUMO2 Gene
- View all R&D Systems SUMO2 (Di-SUMO2) Products
- View all 2 R&D Systems SUMO2 (Poly-SUMO2) Products
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- View all 2 R&D Systems SUMO2 (Poly-SUMO2) Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for SUMO2
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- MG200259
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder Custom and pre-made DNA vectors for SUMO2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SUMO2 (ie. lentivirus, AAV, adenovirus)
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- Addgene plasmids for SUMO2
- antibodies-online: Show 107 available SUMO2 Antibodies ranked by validation data
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- 153 WB Antibodies (anti-human)
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- 1 EIA Antibody (anti-human)
- 49 IHC (p) Antibodies (anti-rat)
- 36 WB Antibodies (anti-rat)
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- 6 IHC Antibodies (anti-rat)
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- 48 WB Antibodies (anti-mouse)
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- antibodies-online: Show 22 available SUMO2 Elisa Kits ranked by validation data
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- antibodies-online: Show 29 available SUMO2 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for SUMO2
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Sources for SUMO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89)