SUMO2 Gene (Protein Coding)

Small Ubiquitin Like Modifier 2

GC17M075165
GIFtS:
41
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nu... See more...

Aliases for SUMO2 Gene

Aliases for SUMO2 Gene

  • Small Ubiquitin Like Modifier 2 2 3 5
  • SMT3B 2 3 4
  • Small Ubiquitin-Related Modifier 2 3 4
  • Ubiquitin-Like Protein SMT3B 3 4
  • SMT3 Homolog 2 3 4
  • SMT3H2 3 4
  • HSMT3 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 (S. Cerevisiae) 2
  • SMT3 (Suppressor Of Mif Two 3, Yeast) Homolog 2 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 (Yeast) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 3
  • Ubiquitin-Like Protein SMT3A 3
  • Sentrin 2 3
  • Sentrin-2 4
  • SUMO-2 4
  • SUMO-3 4
  • SUMO3 3
  • Smt3A 3
  • SUMO2 5
  • Smt3B 4

External Ids for SUMO2 Gene

Previous HGNC Symbols for SUMO2 Gene

  • SMT3H2

Previous GeneCards Identifiers for SUMO2 Gene

  • GC17M073761
  • GC17M070675
  • GC17M073163
  • GC17M068573

Summaries for SUMO2 Gene

Entrez Gene Summary for SUMO2 Gene

  • This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMO2 Gene

SUMO2 (Small Ubiquitin Like Modifier 2) is a Protein Coding gene. Diseases associated with SUMO2 include Gordon Holmes Syndrome. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO4.

UniProtKB/Swiss-Prot Summary for SUMO2 Gene

  • Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Gene Wiki entry for SUMO2 Gene

Additional gene information for SUMO2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUMO2 Gene

Genomics for SUMO2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SUMO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUMO2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUMO2

Top Transcription factor binding sites by QIAGEN in the SUMO2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for SUMO2 Gene

Latest Assembly
chr17:75,165,586-75,182,959
(GRCh38/hg38)
Size:
17,374 bases
Orientation:
Minus strand

Previous Assembly
chr17:73,161,681-73,179,054
(GRCh37/hg19 by Entrez Gene)
Size:
17,374 bases
Orientation:
Minus strand

chr17:73,163,408-73,179,078
(GRCh37/hg19 by Ensembl)
Size:
15,671 bases
Orientation:
Minus strand

Genomic View for SUMO2 Gene

Genes around SUMO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUMO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUMO2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SUMO2 Gene

Proteins for SUMO2 Gene

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  • Protein details for SUMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61956-SUMO2_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 2
    Protein Accession:
    P61956
    Secondary Accessions:
    • B2R4I2
    • P55855
    • Q32Q42
    • Q6IPZ6
    • Q96HK1

    Protein attributes for SUMO2 Gene

    Size:
    95 amino acids
    Molecular mass:
    10871 Da
    Quaternary structure:
    • Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with MTA1. Interacts with Epstein-barr virus BGLF4.

    Three dimensional structures from OCA and Proteopedia for SUMO2 Gene

    Alternative splice isoforms for SUMO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUMO2 Gene

Protein Expression for SUMO2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SUMO2 Gene

  • Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
  • Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
  • Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
  • Ubiquitination at Lys5, Lys7, and Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for SUMO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for SUMO2 Gene

Domains & Families for SUMO2 Gene

Gene Families for SUMO2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SUMO2 Gene

InterPro:
Blocks:
  • Ubiquitin domain
ProtoNet:

Suggested Antigen Peptide Sequences for SUMO2 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-like protein SMT3A (SUMO2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61956

UniProtKB/Swiss-Prot:

SUMO2_HUMAN :
  • Belongs to the ubiquitin family. SUMO subfamily.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO2: view

Function for SUMO2 Gene

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  6. Cell Lines for research

Molecular function for SUMO2 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Phenotypes From GWAS Catalog for SUMO2 Gene

Gene Ontology (GO) - Molecular Function for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IEA,IPI 15383276
GO:0031386 protein tag IBA 21873635
GO:0031625 ubiquitin protein ligase binding IPI 18408734
GO:0044389 ubiquitin-like protein ligase binding IBA 21873635
genes like me logo Genes that share ontologies with SUMO2: view
genes like me logo Genes that share phenotypes with SUMO2: view

Animal Models for SUMO2 Gene

MGI Knock Outs for SUMO2:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUMO2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUMO2 Gene

Localization for SUMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMO2 Gene

Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUMO2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 21965678
GO:0005654 nucleoplasm TAS --
GO:0016605 PML body IEA,IDA 22406621
genes like me logo Genes that share ontologies with SUMO2: view

Pathways & Interactions for SUMO2 Gene

genes like me logo Genes that share pathways with SUMO2: view

Pathways by source for SUMO2 Gene

1 BioSystems pathway for SUMO2 Gene
2 KEGG pathways for SUMO2 Gene
2 Qiagen pathways for SUMO2 Gene
  • JAK-STAT Pathway
  • SUMO Pathway
1 GeneTex pathway for SUMO2 Gene

Gene Ontology (GO) - Biological Process for SUMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation IBA,IDA 17081986
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 18408734
genes like me logo Genes that share ontologies with SUMO2: view

No data available for SIGNOR curated interactions for SUMO2 Gene

Drugs & Compounds for SUMO2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for SUMO2 Gene

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mRNA/cDNA for SUMO2 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUMO2

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO2 Gene

No ASD Table

Relevant External Links for SUMO2 Gene

GeneLoc Exon Structure for
SUMO2

Expression for SUMO2 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUMO2 Gene

mRNA expression in normal human tissues for SUMO2 Gene
mRNA expression by GTEx for SUMO2 GenemRNA expression by BioGPS for SUMO2 Gene

Protein differential expression in normal tissues from HIPED for SUMO2 Gene

This gene is overexpressed in Tlymphocyte (7.0), Oral epithelium (6.9), and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SUMO2 Gene



Protein tissue co-expression partners for SUMO2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUMO2

SOURCE GeneReport for Unigene cluster for SUMO2 Gene:

Hs.380973

mRNA Expression by UniProt/SwissProt for SUMO2 Gene:

P61956-SUMO2_HUMAN
Tissue specificity: Broadly expressed.

Evidence on tissue expression from TISSUES for SUMO2 Gene

  • Nervous system(5)
  • Lung(4.9)
  • Skin(4.8)
  • Bone(4.6)
  • Bone marrow(4.5)
  • Intestine(4.2)
  • Liver(4)
  • Pancreas(3.8)
  • Kidney(3.7)
  • Eye(3.5)
  • Muscle(3.4)
  • Blood(3.4)
  • Heart(3.2)
  • Lymph node(2.6)
  • Thyroid gland(2.6)
  • Spleen(2.6)
  • Adrenal gland(2.3)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with SUMO2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUMO2 Gene

Orthologs for SUMO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUMO2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SUMO2 30
  • 99.65 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 99 (a)
 ManyToMany
Dog
(Canis familiaris)
 Mammalia SUMO2 30
  • 97.89 (n)
-- 31
  • 70 (a)
 ManyToMany
Cow
(Bos Taurus)
 Mammalia SUMO2 30
  • 97.19 (n)
-- 31
  • 46 (a)
 ManyToMany
Mouse
(Mus musculus)
 Mammalia Sumo2 30 17
  • 95.79 (n)
Rat
(Rattus norvegicus)
 Mammalia Sumo2 30
  • 95.79 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 85 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves SUMO2 30 31
  • 91.58 (n)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia sumo2 30
  • 84.91 (n)
Str.5818 30
African clawed frog
(Xenopus laevis)
 Amphibia smt3h2-prov 30
Zebrafish
(Danio rerio)
 Actinopterygii sumo3b 31
  • 95 (a)
 ManyToMany
sumo2b 30
  • 81.72 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta smt3 31
  • 73 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001701 30
  • 67.03 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SMT3 31
  • 43 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.11356 31
  • 73 (a)
 OneToMany
Species where no ortholog for SUMO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SUMO2 Gene

ENSEMBL:
Gene Tree for SUMO2 (if available)
TreeFam:
Gene Tree for SUMO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SUMO2: view image

Paralogs for SUMO2 Gene

Paralogs for SUMO2 Gene

(4) SIMAP similar genes for SUMO2 Gene using alignment to 2 proteins:

  • SUMO2_HUMAN
  • J3KRH1_HUMAN

Pseudogenes.org Pseudogenes for SUMO2 Gene

genes like me logo Genes that share paralogs with SUMO2: view

Variants for SUMO2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SUMO2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs17850328 - p.Asp16Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SUMO2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SUMO2 Gene

Variant ID Type Subtype PubMed ID
nsv1113889 CNV deletion 24896259
nsv2141 CNV deletion 18451855
nsv470602 CNV loss 18288195
nsv960527 CNV duplication 23825009

Variation tolerance for SUMO2 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUMO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUMO2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO2 Gene

Disorders for SUMO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SUMO2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
gordon holmes syndrome
  • gdhs
- elite association - COSMIC cancer census association via MalaCards
Search SUMO2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SUMO2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SUMO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUMO2 Gene

Publications for SUMO2 Gene

  1. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PMID: 15296745) Reverter D ā€¦ Lima CD (Structure (London, England : 1993) 2004) 3 4 23
  2. Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins. (PMID: 15479240) Huang WC ā€¦ Wang AH (European journal of biochemistry 2004) 3 4 23
  3. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su HL ā€¦ Li SS (Gene 2002) 3 4 23
  4. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PMID: 11451954) Tatham MH ā€¦ Hay RT (The Journal of biological chemistry 2001) 3 4 23
  5. Characterization of a second member of the sentrin family of ubiquitin-like proteins. (PMID: 9556629) Kamitani T ā€¦ Yeh ET (The Journal of biological chemistry 1998) 3 4 23

ExternalLinks

View latest publications for SUMO2 gene in Mastermind

Products for SUMO2 Gene

  • Addgene plasmids for SUMO2

Sources for SUMO2 Gene