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This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
SUMO2 (Small Ubiquitin Like Modifier 2) is a Protein Coding gene. Diseases associated with SUMO2 include Gordon Holmes Syndrome. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include SUMO transferase activity. An important paralog of this gene is SUMO3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0005515 | protein binding | IEA,IPI | 15383276 |
GO:0031386 | protein tag | IBA | 21873635 |
GO:0031625 | ubiquitin protein ligase binding | IPI | 18408734 |
GO:0044389 | ubiquitin-like protein ligase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 21965678 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0016605 | PML body | IEA,IDA | 22406621 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | SUMOylation |
.95
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2 | DNA Double-Strand Break Repair |
.53
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3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
4 | Metabolism of proteins | ||
5 | Transport of the SLBP independent Mature mRNA |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016925 | protein sumoylation | IDA | 17081986 |
GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA | 18408734 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SUMO2 30 |
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||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Dog (Canis familiaris) |
Mammalia | SUMO2 30 |
|
||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | SUMO2 30 |
|
||
-- 31 |
|
ManyToMany | |||
Mouse (Mus musculus) |
Mammalia | Sumo2 30 17 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Sumo2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | SUMO2 30 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sumo2 30 |
|
||
Str.5818 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | smt3h2-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sumo3b 31 |
|
ManyToMany | |
sumo2b 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | smt3 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001701 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SMT3 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11356 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17850328 | - | p.Asp16Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
gordon holmes syndrome |
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