Aliases for SUMO1P1 Gene

Aliases for SUMO1P1 Gene

  • SUMO1 Pseudogene 1 2 3 4 5
  • Ubiquitin-Like 2 2 3 4
  • Ubiquitin-Like 6 2 3 4
  • UBL2 3 4
  • UBL6 3 4
  • Small Ubiquitin-Related Modifier 5 4
  • SUMO-5 4
  • PIC1L 3
  • SUMO5 4

External Ids for SUMO1P1 Gene

Previous HGNC Symbols for SUMO1P1 Gene

  • UBL2
  • UBL6

Previous GeneCards Identifiers for SUMO1P1 Gene

  • GC20M051924
  • GC20M052492
  • GC20M049237

Summaries for SUMO1P1 Gene

GeneCards Summary for SUMO1P1 Gene

SUMO1P1 (SUMO1 Pseudogene 1) is a Pseudogene.

UniProtKB/Swiss-Prot Summary for SUMO1P1 Gene

  • Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs.

Additional gene information for SUMO1P1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUMO1P1 Gene

Genomics for SUMO1P1 Gene

GeneHancer (GH) Regulatory Elements for SUMO1P1 Gene

Promoters and enhancers for SUMO1P1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J053875 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 505.2 +0.2 208 0.6 ZNF316 GABPA CTCF TRIM24 CEBPG NFXL1 ATF3 SPI1 CHAMP1 EP400 SUMO1P1 RNU7-14P lnc-PFDN4-10
GH20J053890 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.7 -17.1 -17137 6.1 RXRA HNRNPK TCF12 SP1 BCLAF1 JUND FOS ZBTB5 EP300 RELA RNU7-14P ENSG00000236352 SUMO1P1 lnc-PFDN4-4
GH20J053862 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +7.3 7349 11.2 EP300 CTCF ZSCAN5C TCF12 USF1 BCLAF1 FOS KDM6A TCF7 AFF1 lnc-PFDN4-10 RNU7-14P PFDN4 ZNF217 lnc-BCAS1-5 SUMO1P1
GH20J053879 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.7 -4.3 -4322 3.4 BCLAF1 ZIC2 SKI NR2F2 FOXA2 USF1 ZKSCAN1 SAP130 NFXL1 MBD1 ENSG00000236352 RNU7-14P SUMO1P1 lnc-PFDN4-4
GH20J053897 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.3 -25.5 -25476 7.5 ZBTB40 ZSCAN5C TCF12 SP1 BCLAF1 JUND FOS ZNF639 ZNF10 ZNF354C lnc-PFDN4-4 ZNF217 ENSG00000236352 SUMO1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUMO1P1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SUMO1P1 gene promoter:
  • aMEF-2
  • Evi-1
  • FOXD3
  • Gfi-1
  • ITF-2
  • MEF-2
  • MEF-2A
  • Pbx1a
  • RORalpha1
  • Tal-1beta

Genomic Locations for SUMO1P1 Gene

Genomic Locations for SUMO1P1 Gene
chr20:53,874,498-53,875,709
(GRCh38/hg38)
Size:
1,212 bases
Orientation:
Minus strand
chr20:52,491,037-52,492,248
(GRCh37/hg19)
Size:
1,212 bases
Orientation:
Minus strand

Genomic View for SUMO1P1 Gene

Genes around SUMO1P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUMO1P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUMO1P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO1P1 Gene

Proteins for SUMO1P1 Gene

  • Protein details for SUMO1P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    G2XKQ0-SUMO5_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 5
    Protein Accession:
    G2XKQ0

    Protein attributes for SUMO1P1 Gene

    Size:
    101 amino acids
    Molecular mass:
    11526 Da
    Quaternary structure:
    • Interacts with CBX4 (PubMed:27211601). Interacts with PIAS1 (PubMed:27211601). Found in a complex with SAE2 (PubMed:27211601). Interacts with UBE2I (PubMed:27211601). Interacts with SP100 (PubMed:27211601). Interacts with HIPK2 (PubMed:27211601). Interacts with DAXX (PubMed:27211601). Interacts with PML-RARA oncoprotein; PML-RARalpha outcompetes PML for SUMO1P1/SUMO5 conjugation (PubMed:27211601).
    Miscellaneous:
    • Highly conserved among primate species, however is not detected in mice.

    Three dimensional structures from OCA and Proteopedia for SUMO1P1 Gene

neXtProt entry for SUMO1P1 Gene

Post-translational modifications for SUMO1P1 Gene

No data available for DME Specific Peptides for SUMO1P1 Gene

Domains & Families for SUMO1P1 Gene

Protein Domains for SUMO1P1 Gene

Graphical View of Domain Structure for InterPro Entry

G2XKQ0

UniProtKB/Swiss-Prot:

SUMO5_HUMAN :
  • Belongs to the ubiquitin family. SUMO subfamily.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO1P1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SUMO1P1 Gene

Function for SUMO1P1 Gene

Molecular function for SUMO1P1 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs.

Phenotypes From GWAS Catalog for SUMO1P1 Gene

Gene Ontology (GO) - Molecular Function for SUMO1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24722188
GO:0008134 transcription factor binding ISS --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with SUMO1P1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SUMO1P1 Gene

Localization for SUMO1P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUMO1P1 Gene

Nucleus. Note=Forms prominent non-membrane-bound structures in the nucleus. {ECO:0000269 PubMed:27211601}.

Gene Ontology (GO) - Cellular Components for SUMO1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 27211601
genes like me logo Genes that share ontologies with SUMO1P1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SUMO1P1 Gene

Pathways & Interactions for SUMO1P1 Gene

PathCards logo

SuperPathways for SUMO1P1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUMO1P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation ISS --
GO:0030578 PML body organization IMP 27211601
genes like me logo Genes that share ontologies with SUMO1P1: view

No data available for Pathways by source and SIGNOR curated interactions for SUMO1P1 Gene

Drugs & Compounds for SUMO1P1 Gene

No Compound Related Data Available

Transcripts for SUMO1P1 Gene

mRNA/cDNA for SUMO1P1 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO1P1 Gene

No ASD Table

Relevant External Links for SUMO1P1 Gene

GeneLoc Exon Structure for
SUMO1P1

Expression for SUMO1P1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUMO1P1 Gene

mRNA differential expression in normal tissues according to GTEx for SUMO1P1 Gene

This gene is overexpressed in Testis (x28.7) and Whole Blood (x15.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUMO1P1

SOURCE GeneReport for Unigene cluster for SUMO1P1 Gene:

Hs.449977

mRNA Expression by UniProt/SwissProt for SUMO1P1 Gene:

G2XKQ0-SUMO5_HUMAN
Tissue specificity: High expression levels in testes and peripheral blood leukocyte (PubMed:27211601). Expressed also in lung, placenta, liver, spleen and thymus (PubMed:27211601).
genes like me logo Genes that share expression patterns with SUMO1P1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUMO1P1 Gene

Orthologs for SUMO1P1 Gene

Evolution for SUMO1P1 Gene

ENSEMBL:
Gene Tree for SUMO1P1 (if available)
TreeFam:
Gene Tree for SUMO1P1 (if available)

No data available for Orthologs for SUMO1P1 Gene

Paralogs for SUMO1P1 Gene

No data available for Paralogs for SUMO1P1 Gene

Variants for SUMO1P1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SUMO1P1 Gene

Variant ID Type Subtype PubMed ID
dgv66n68 CNV loss 17160897
esv34060 CNV loss 18971310
nsv1060372 CNV loss 25217958
nsv586222 CNV loss 21841781
nsv586224 CNV gain 21841781

Additional Variant Information for SUMO1P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUMO1P1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for SUMO1P1 Gene

Disorders for SUMO1P1 Gene

Additional Disease Information for SUMO1P1

No disorders were found for SUMO1P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUMO1P1 Gene

Publications for SUMO1P1 Gene

  1. SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies. (PMID: 27211601) Liang YC … Yang WM (Scientific reports 2016) 3 4 54
  2. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. (PMID: 12383504) Su HL … Li SS (Gene 2002) 2 3 54
  3. The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes. (PMID: 9465300) Howe K … Solomon E (Genomics 1998) 2 3 54
  4. Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches. (PMID: 30675988) Albert L … Vázquez O (Chembiochem : a European journal of chemical biology 2019) 4 54
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 54

Products for SUMO1P1 Gene

Sources for SUMO1P1 Gene