Aliases for SULT6B1 Gene

Aliases for SULT6B1 Gene

  • Sulfotransferase Family 6B Member 1 2 3 5
  • Sulfotransferase Family, Cytosolic, 6B, Member 1 2 3
  • Thyroxine Sulfotransferase 3 4
  • Sulfotransferase 6B1 3 4
  • ST6B1 3 4
  • Sulfotransferase SULT6B1 3
  • EC 2.8.2.n2 4
  • SULT6B1 5

External Ids for SULT6B1 Gene

Previous GeneCards Identifiers for SULT6B1 Gene

  • GC02M037307
  • GC02M037248
  • GC02M037134
  • GC02M037394

Summaries for SULT6B1 Gene

GeneCards Summary for SULT6B1 Gene

SULT6B1 (Sulfotransferase Family 6B Member 1) is a Protein Coding gene. Diseases associated with SULT6B1 include Partial Motor Epilepsy. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT2A1.

UniProtKB/Swiss-Prot Summary for SULT6B1 Gene

  • Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT6B1 Gene

Genomics for SULT6B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SULT6B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT6B1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT6B1

Top Transcription factor binding sites by QIAGEN in the SULT6B1 gene promoter:
  • AREB6
  • HNF-1
  • HNF-1A
  • Nkx5-1
  • POU2F1
  • POU2F1a
  • Sox9
  • Tal-1
  • USF-1
  • USF1

Genomic Locations for SULT6B1 Gene

Latest Assembly
chr2:37,167,820-37,196,598
(GRCh38/hg38)
Size:
28,779 bases
Orientation:
Minus strand

Previous Assembly
chr2:37,394,963-37,423,230
(GRCh37/hg19 by Entrez Gene)
Size:
28,268 bases
Orientation:
Minus strand

chr2:37,394,963-37,423,741
(GRCh37/hg19 by Ensembl)
Size:
28,779 bases
Orientation:
Minus strand

Genomic View for SULT6B1 Gene

Genes around SULT6B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT6B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT6B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT6B1 Gene

Proteins for SULT6B1 Gene

  • Protein details for SULT6B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMI4-ST6B1_HUMAN
    Recommended name:
    Sulfotransferase 6B1
    Protein Accession:
    Q6IMI4
    Secondary Accessions:
    • B2RTS7

    Protein attributes for SULT6B1 Gene

    Size:
    303 amino acids
    Molecular mass:
    34919 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI40798.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA01772.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SULT6B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT6B1 Gene

Post-translational modifications for SULT6B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT6B1 Gene

No data available for DME Specific Peptides for SULT6B1 Gene

Domains & Families for SULT6B1 Gene

Gene Families for SULT6B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT6B1 Gene

InterPro:
Blocks:
  • Sulfotransferase

Suggested Antigen Peptide Sequences for SULT6B1 Gene

GenScript: Design optimal peptide antigens:
  • Thyroxine sulfotransferase (ST6B1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IMI4

UniProtKB/Swiss-Prot:

ST6B1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT6B1: view

Function for SULT6B1 Gene

Molecular function for SULT6B1 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2;.

Enzyme Numbers (IUBMB) for SULT6B1 Gene

Phenotypes From GWAS Catalog for SULT6B1 Gene

Gene Ontology (GO) - Molecular Function for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA,IBA 21873635
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT6B1: view

Phenotypes for SULT6B1 Gene

genes like me logo Genes that share phenotypes with SULT6B1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT6B1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SULT6B1 Gene

Localization for SULT6B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT6B1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT6B1 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT6B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT6B1 Gene

Pathways & Interactions for SULT6B1 Gene

genes like me logo Genes that share pathways with SULT6B1: view

Pathways by source for SULT6B1 Gene

Interacting Proteins for SULT6B1 Gene

Gene Ontology (GO) - Biological Process for SULT6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS --
GO:0051923 sulfation IBA 21873635
genes like me logo Genes that share ontologies with SULT6B1: view

No data available for SIGNOR curated interactions for SULT6B1 Gene

Drugs & Compounds for SULT6B1 Gene

(6) Drugs for SULT6B1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methyldopa Approved Pharma Enzyme, substrate 19
Pindolol Approved, Investigational Pharma Enzyme, substrate beta3 partial agonist 16
Terbutaline Approved Pharma Enzyme, substrate 52
Levothyroxine Approved Pharma 0
3'-phospho-5'-adenylyl sulfate Experimental Pharma 0
genes like me logo Genes that share compounds with SULT6B1: view

Transcripts for SULT6B1 Gene

mRNA/cDNA for SULT6B1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT6B1

Alternative Splicing Database (ASD) splice patterns (SP) for SULT6B1 Gene

No ASD Table

Relevant External Links for SULT6B1 Gene

GeneLoc Exon Structure for
SULT6B1

Expression for SULT6B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT6B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT6B1 Gene

This gene is overexpressed in Testis (x48.0).

Protein differential expression in normal tissues from HIPED for SULT6B1 Gene

This gene is overexpressed in Testis (59.4) and Platelet (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT6B1 Gene



Protein tissue co-expression partners for SULT6B1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT6B1

SOURCE GeneReport for Unigene cluster for SULT6B1 Gene:

Hs.631892

mRNA Expression by UniProt/SwissProt for SULT6B1 Gene:

Q6IMI4-ST6B1_HUMAN
Tissue specificity: Specifically expressed in kidney and testis.
genes like me logo Genes that share expression patterns with SULT6B1: view

Primer products for research

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT6B1 Gene

Orthologs for SULT6B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SULT6B1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SULT6B1 29 30
  • 98.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SULT6B1 29 30
  • 89.77 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SULT6B1 29 30
  • 89.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sult6b1 29
  • 85.17 (n)
Mouse
(Mus musculus)
Mammalia Sult6b1 29 16 30
  • 84.66 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SULT6B1 30
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 25 (a)
OneToMany
Chicken
(Gallus gallus)
Aves SULT6B1 29 30
  • 72.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 47 (a)
OneToMany
-- 30
  • 45 (a)
OneToMany
-- 30
  • 45 (a)
OneToMany
-- 30
  • 44 (a)
OneToMany
-- 30
  • 41 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100135365 29
  • 62.26 (n)
Zebrafish
(Danio rerio)
Actinopterygii sult6b1 29 30
  • 57.58 (n)
OneToOne
Species where no ortholog for SULT6B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SULT6B1 Gene

ENSEMBL:
Gene Tree for SULT6B1 (if available)
TreeFam:
Gene Tree for SULT6B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT6B1: view image
Alliance of Genome Resources:
Additional Orthologs for SULT6B1

Paralogs for SULT6B1 Gene

(13) SIMAP similar genes for SULT6B1 Gene using alignment to 2 proteins:

  • ST6B1_HUMAN
  • C9JFH2_HUMAN
genes like me logo Genes that share paralogs with SULT6B1: view

Variants for SULT6B1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT6B1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs10205833 -- p.Leu150Phe
rs45439591 -- p.Arg181Ser
rs45493492 -- p.Lys88Glu
rs45495394 -- p.Lys296Arg
rs45552433 -- p.Ala61Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SULT6B1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SULT6B1 Gene

Variant ID Type Subtype PubMed ID
nsv2683 CNV insertion 18451855

Variation tolerance for SULT6B1 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.33; 90.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT6B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT6B1
Leiden Open Variation Database (LOVD)
SULT6B1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT6B1 Gene

Disorders for SULT6B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SULT6B1 Gene - From: COP

Disorder Aliases PubMed IDs
partial motor epilepsy
  • epilepsy, focal motor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SULT6B1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SULT6B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT6B1 Gene

Publications for SULT6B1 Gene

  1. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PMID: 14676822) Freimuth RR … Weinshilboum RM (The pharmacogenomics journal 2004) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan. (PMID: 26660633) Fang JL … Beland FA (Toxicological sciences : an official journal of the Society of Toxicology 2016) 3
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for SULT6B1 Gene

Sources for SULT6B1 Gene