Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SULT4A1 Gene

Aliases for SULT4A1 Gene

  • Sulfotransferase Family 4A Member 1 2 3 5
  • Brain Sulfotransferase-Like Protein 3 4
  • Nervous System Sulfotransferase 3 4
  • HBR-STL-1 3 4
  • HBR-STL 3 4
  • SULTX3 3 4
  • ST4A1 3 4
  • NST 3 4
  • Nervous System Cytosolic Sulfotransferase 3
  • Sulfotransferase Family 4A, Member 1 2
  • Sulfotransferase-Related Protein 3
  • Sulfotransferase 4A1 3
  • EC 2.8.2.- 4
  • DJ388M5.3 3
  • BR-STL-1 3
  • BRSTL1 3

External Ids for SULT4A1 Gene

Previous GeneCards Identifiers for SULT4A1 Gene

  • GC22M040837
  • GC22M042478
  • GC22M042545
  • GC22M042551
  • GC22M044220
  • GC22M027174

Summaries for SULT4A1 Gene

Entrez Gene Summary for SULT4A1 Gene

  • This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT4A1 Gene

SULT4A1 (Sulfotransferase Family 4A Member 1) is a Protein Coding gene. Diseases associated with SULT4A1 include Anteroseptal Myocardial Infarction and Schizotypal Personality Disorder. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT6B1.

UniProtKB/Swiss-Prot for SULT4A1 Gene

  • Atypical sulfotransferase family member with very low affinity for 3-phospho-5-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.

Gene Wiki entry for SULT4A1 Gene

Additional gene information for SULT4A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULT4A1 Gene

Genomics for SULT4A1 Gene

GeneHancer (GH) Regulatory Elements for SULT4A1 Gene

Promoters and enhancers for SULT4A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I043862 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 556.7 0.0 -32 0.3 PKNOX1 ATF1 L3MBTL2 ZBTB21 ARNT YY2 BHLHE40 MAX ATF2 ZNF335 SULT4A1 EFCAB6 PNPLA5
GH22I043863 Enhancer 0.4 ENCODE 550.8 +0.2 207 0.2 MXI1 POLR2A ZBTB26 SULT4A1 GC22M043840
GH22I043811 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 5.5 +50.1 50106 2 PKNOX1 SIN3A GLI4 ZNF2 ETS1 GLIS2 ELK1 ZNF207 ZNF143 FOS EFCAB6 ENSG00000261251 PNPLA5 SULT4A1
GH22I043822 Enhancer 0.9 ENCODE dbSUPER 11.1 +39.2 39246 1.7 ELF3 FOXA2 TAF1 SAP130 MLX ZSCAN4 MAX ZIC2 ZNF644 RAD21 SULT4A1 LOC105373058 PIR35779 GC22P043826
GH22I043825 Enhancer 1.1 Ensembl ENCODE dbSUPER 8.1 +34.3 34275 6.1 CTCF KLF1 EBF1 ZIC2 RAD21 ZFHX2 POLR2A SCRT2 SMC3 HNF4A EFCAB6 SULT4A1 PIR35779 GC22P043826 LOC105373057
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SULT4A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SULT4A1 gene promoter:

Genomic Locations for SULT4A1 Gene

Genomic Locations for SULT4A1 Gene
chr22:43,824,507-43,862,503
(GRCh38/hg38)
Size:
37,997 bases
Orientation:
Minus strand
chr22:44,220,387-44,258,398
(GRCh37/hg19)

Genomic View for SULT4A1 Gene

Genes around SULT4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT4A1 Gene

Proteins for SULT4A1 Gene

  • Protein details for SULT4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR01-ST4A1_HUMAN
    Recommended name:
    Sulfotransferase 4A1
    Protein Accession:
    Q9BR01
    Secondary Accessions:
    • B2R7N3
    • O43728

    Protein attributes for SULT4A1 Gene

    Size:
    284 amino acids
    Molecular mass:
    33085 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT4A1 Gene

    Alternative splice isoforms for SULT4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT4A1 Gene

Post-translational modifications for SULT4A1 Gene

No Post-translational modifications

Other Protein References for SULT4A1 Gene

No data available for DME Specific Peptides for SULT4A1 Gene

Domains & Families for SULT4A1 Gene

Gene Families for SULT4A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SULT4A1 Gene

Suggested Antigen Peptide Sequences for SULT4A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BR01

UniProtKB/Swiss-Prot:

ST4A1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT4A1: view

Function for SULT4A1 Gene

Molecular function for SULT4A1 Gene

UniProtKB/Swiss-Prot Function:
Atypical sulfotransferase family member with very low affinity for 3-phospho-5-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.

Enzyme Numbers (IUBMB) for SULT4A1 Gene

Phenotypes From GWAS Catalog for SULT4A1 Gene

Gene Ontology (GO) - Molecular Function for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0005515 protein binding IPI 19439498
GO:0008146 sulfotransferase activity NAS 10698717
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 19439498
genes like me logo Genes that share ontologies with SULT4A1: view
genes like me logo Genes that share phenotypes with SULT4A1: view

Animal Model Products

CRISPR Products

miRNA for SULT4A1 Gene

miRTarBase miRNAs that target SULT4A1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT4A1 Gene

Localization for SULT4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT4A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT4A1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT4A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT4A1 Gene

Pathways & Interactions for SULT4A1 Gene

genes like me logo Genes that share pathways with SULT4A1: view

Pathways by source for SULT4A1 Gene

SIGNOR curated interactions for SULT4A1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006790 sulfur compound metabolic process IEA --
GO:0008150 biological_process ND --
GO:0008202 steroid metabolic process IEA --
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with SULT4A1: view

Drugs & Compounds for SULT4A1 Gene

(1) Drugs for SULT4A1 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antipsychotic Agents Pharma 2483
genes like me logo Genes that share compounds with SULT4A1: view

Transcripts for SULT4A1 Gene

mRNA/cDNA for SULT4A1 Gene

(4) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SULT4A1 Gene

Sulfotransferase family 4A, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT4A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d
SP1:
SP2: -
SP3: -
SP4: -
SP5: - - - -
SP6: - - - - -

Relevant External Links for SULT4A1 Gene

GeneLoc Exon Structure for
SULT4A1
ECgene alternative splicing isoforms for
SULT4A1

Expression for SULT4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SULT4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT4A1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.1), Brain - Cortex (x8.0), Brain - Anterior cingulate cortex (BA24) (x6.9), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for SULT4A1 Gene

This gene is overexpressed in Frontal cortex (27.7), Brain (23.8), and Spinal cord (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SULT4A1 Gene



Protein tissue co-expression partners for SULT4A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SULT4A1 Gene:

SULT4A1

SOURCE GeneReport for Unigene cluster for SULT4A1 Gene:

Hs.189810

mRNA Expression by UniProt/SwissProt for SULT4A1 Gene:

Q9BR01-ST4A1_HUMAN
Tissue specificity: Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas (PubMed:10698717). Highly expressed in fetal brain and occipital lobe, slightly less in the whole brain, frontal lobe, hippocampus, and lung, very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney and appendix (PubMed:12039030).

Evidence on tissue expression from TISSUES for SULT4A1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with SULT4A1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT4A1 Gene

Orthologs for SULT4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT4A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT4A1 33 34
  • 99.77 (n)
oppossum
(Monodelphis domestica)
Mammalia SULT4A1 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT4A1 33 34
  • 94.48 (n)
cow
(Bos Taurus)
Mammalia SULT4A1 33 34
  • 92.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SULT4A1 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult4a1 33 16 34
  • 91.55 (n)
rat
(Rattus norvegicus)
Mammalia Sult4a1 33
  • 91.08 (n)
chicken
(Gallus gallus)
Aves SULT4A1 33 34
  • 79.91 (n)
lizard
(Anolis carolinensis)
Reptilia SULT4A1 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sult4a1 33
  • 79.23 (n)
zebrafish
(Danio rerio)
Actinopterygii sult4a1 33 34
  • 78.29 (n)
Dr.19215 33
fruit fly
(Drosophila melanogaster)
Insecta CG16733 35
  • 33 (a)
CG5428 35
  • 32 (a)
CG6704 35
  • 32 (a)
St2 34
  • 30 (a)
OneToMany
Species where no ortholog for SULT4A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT4A1 Gene

ENSEMBL:
Gene Tree for SULT4A1 (if available)
TreeFam:
Gene Tree for SULT4A1 (if available)

Paralogs for SULT4A1 Gene

Paralogs for SULT4A1 Gene

(13) SIMAP similar genes for SULT4A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SULT4A1: view

Variants for SULT4A1 Gene

Sequence variations from dbSNP and Humsavar for SULT4A1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000061949 -- 43,832,084(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000074666 -- 43,845,187(-) C/G intron_variant
rs1000111178 -- 43,856,999(-) T/C intron_variant
rs1000211923 -- 43,860,446(-) C/T intron_variant
rs1000310438 -- 43,850,073(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SULT4A1 Gene

Variant ID Type Subtype PubMed ID
nsv955172 CNV deletion 24416366
nsv834219 CNV gain 17160897
nsv834218 CNV loss 17160897
nsv834217 CNV gain 17160897
nsv829265 CNV loss 20364138
nsv829263 CNV gain 20364138
nsv589099 CNV loss 21841781
nsv512659 CNV loss 21212237
nsv3647 CNV deletion 18451855
nsv191452 CNV deletion 16902084
nsv1150513 CNV duplication 26484159
nsv1073166 CNV deletion 25765185
esv3568432 CNV loss 25503493
esv28783 CNV loss 19812545
esv2724329 CNV deletion 23290073
esv2724327 CNV deletion 23290073
esv2510122 CNV deletion 19546169
esv1538910 CNV deletion 17803354
esv1523199 CNV deletion 17803354
esv1037241 CNV deletion 17803354

Variation tolerance for SULT4A1 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT4A1 Gene

Human Gene Mutation Database (HGMD)
SULT4A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT4A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT4A1 Gene

Disorders for SULT4A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SULT4A1 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SULT4A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SULT4A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT4A1 Gene

Publications for SULT4A1 Gene

  1. Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. (PMID: 10698717) Falany CN … Falany JL (The Biochemical journal 2000) 2 3 4 22 58
  2. Lack of exonic sulfotransferase 4A1 mutations in controls and schizophrenia cases. (PMID: 19125109) Lewis AG … Minchin RF (Psychiatric genetics 2009) 3 22 44 58
  3. Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder. (PMID: 18823757) Meltzer HY … Jayathilake K (Schizophrenia research 2008) 3 22 44 58
  4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58

Products for SULT4A1 Gene

Sources for SULT4A1 Gene

Content
Loading form....