This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008] See more...

Aliases for SULT4A1 Gene

Aliases for SULT4A1 Gene

  • Sulfotransferase Family 4A Member 1 2 3 5
  • Brain Sulfotransferase-Like Protein 3 4
  • Nervous System Sulfotransferase 3 4
  • Sulfotransferase 4A1 3 4
  • HBR-STL-1 3 4
  • HBR-STL 3 4
  • SULTX3 3 4
  • ST4A1 3 4
  • NST 3 4
  • Nervous System Cytosolic Sulfotransferase 3
  • Sulfotransferase Family 4A, Member 1 2
  • Sulfotransferase-Related Protein 3
  • EC 2.8.2.- 4
  • DJ388M5.3 3
  • BR-STL-1 3
  • BRSTL1 3

External Ids for SULT4A1 Gene

Previous GeneCards Identifiers for SULT4A1 Gene

  • GC22M040837
  • GC22M042478
  • GC22M042545
  • GC22M042551
  • GC22M044220
  • GC22M027174

Summaries for SULT4A1 Gene

Entrez Gene Summary for SULT4A1 Gene

  • This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT4A1 Gene

SULT4A1 (Sulfotransferase Family 4A Member 1) is a Protein Coding gene. Diseases associated with SULT4A1 include Anteroseptal Myocardial Infarction and Myeloproliferative Syndrome, Transient. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C4.

UniProtKB/Swiss-Prot Summary for SULT4A1 Gene

  • Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.

Gene Wiki entry for SULT4A1 Gene

Additional gene information for SULT4A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT4A1 Gene

Genomics for SULT4A1 Gene

GeneHancer (GH) Regulatory Elements for SULT4A1 Gene

Promoters and enhancers for SULT4A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J043863 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 506.7 +0.3 313 2 EP300 JUND ZNF639 ZBTB26 ATF2 HDAC2 MXI1 RBM25 EZH2 CREB1 SULT4A1 EFCAB6 RF00017-3866
GH22J043820 Enhancer 1 Ensembl ENCODE dbSUPER 11.1 +39.9 39912 4 TEAD4 ZIC2 FOXA2 POLR2A USF1 SAP130 FOSL2 JUND FOXP1 SMAD4 SULT4A1 EFCAB6 LOC105373058 lnc-SULT4A1-1 piR-42780
GH22J043811 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 5.6 +49.9 49913 2.4 ZBTB40 EP300 TCF12 SIN3A SP1 PHF8 FOS ZFX ZNF354C POLR2A EFCAB6 ENSG00000261251 lnc-SULT4A1-2 PNPLA5 SULT4A1 LOC105373058
GH22J043825 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.1 +34.5 34481 6.5 CTCF ZIC2 RAD21 ZBTB17 MAFF SMC3 MAFK POLR2A ZFHX2 RCOR1 NONHSAG034093.2 lnc-SULT4A1-1 EFCAB6 SULT4A1 piR-42780 LOC105373057
GH22J043789 Enhancer 0.8 Ensembl ENCODE 10.5 +72.9 72912 1.2 JUND FOS MXI1 NR2F2 BATF STAT3 IKZF1 ZNF146 RCOR1 RAD21 SULT4A1 HMGN2P9 EFCAB6 lnc-SULT4A1-2 LOC100419506
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT4A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT4A1

Top Transcription factor binding sites by QIAGEN in the SULT4A1 gene promoter:
  • AREB6
  • ATF6
  • E4BP4
  • HEN1
  • NRSF form 1
  • NRSF form 2
  • Olf-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SULT4A1 Gene

Genomic Locations for SULT4A1 Gene
chr22:43,824,507-43,862,513
(GRCh38/hg38)
Size:
38,007 bases
Orientation:
Minus strand
chr22:44,220,387-44,258,398
(GRCh37/hg19)
Size:
38,012 bases
Orientation:
Minus strand

Genomic View for SULT4A1 Gene

Genes around SULT4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT4A1 Gene

Proteins for SULT4A1 Gene

  • Protein details for SULT4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR01-ST4A1_HUMAN
    Recommended name:
    Sulfotransferase 4A1
    Protein Accession:
    Q9BR01
    Secondary Accessions:
    • B2R7N3
    • O43728

    Protein attributes for SULT4A1 Gene

    Size:
    284 amino acids
    Molecular mass:
    33085 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT4A1 Gene

    Alternative splice isoforms for SULT4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT4A1 Gene

Post-translational modifications for SULT4A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT4A1 Gene

No data available for DME Specific Peptides for SULT4A1 Gene

Domains & Families for SULT4A1 Gene

Gene Families for SULT4A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SULT4A1 Gene

Blocks:
  • Sulfotransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SULT4A1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54996, moderately similar to Sulfotransferase 4A1 (EC 2.8.2.-) (B7Z2E1_HUMAN)
  • Nervous system sulfotransferase (ST4A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BR01

UniProtKB/Swiss-Prot:

ST4A1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT4A1: view

Function for SULT4A1 Gene

Molecular function for SULT4A1 Gene

UniProtKB/Swiss-Prot Function:
Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.

Enzyme Numbers (IUBMB) for SULT4A1 Gene

Phenotypes From GWAS Catalog for SULT4A1 Gene

Gene Ontology (GO) - Molecular Function for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19439498
GO:0008146 sulfotransferase activity NAS 10698717
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 19439498
genes like me logo Genes that share ontologies with SULT4A1: view
genes like me logo Genes that share phenotypes with SULT4A1: view

Animal Model Products

CRISPR Products

miRNA for SULT4A1 Gene

miRTarBase miRNAs that target SULT4A1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT4A1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT4A1 Gene

Localization for SULT4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT4A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT4A1 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT4A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT4A1 Gene

Pathways & Interactions for SULT4A1 Gene

genes like me logo Genes that share pathways with SULT4A1: view

Pathways by source for SULT4A1 Gene

SIGNOR curated interactions for SULT4A1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for SULT4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006790 sulfur compound metabolic process IEA --
GO:0008150 biological_process ND --
GO:0008202 steroid metabolic process IEA --
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with SULT4A1: view

Drugs & Compounds for SULT4A1 Gene

(1) Drugs for SULT4A1 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antipsychotic Agents Pharma 2881
genes like me logo Genes that share compounds with SULT4A1: view

Transcripts for SULT4A1 Gene

mRNA/cDNA for SULT4A1 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT4A1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT4A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d
SP1:
SP2: -
SP3: -
SP4: -
SP5: - - - -
SP6: - - - - -

Relevant External Links for SULT4A1 Gene

GeneLoc Exon Structure for
SULT4A1

Expression for SULT4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT4A1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.1), Brain - Cortex (x8.0), Brain - Anterior cingulate cortex (BA24) (x6.9), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for SULT4A1 Gene

This gene is overexpressed in Frontal cortex (27.7), Brain (23.8), and Spinal cord (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT4A1 Gene



Protein tissue co-expression partners for SULT4A1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT4A1

SOURCE GeneReport for Unigene cluster for SULT4A1 Gene:

Hs.189810

mRNA Expression by UniProt/SwissProt for SULT4A1 Gene:

Q9BR01-ST4A1_HUMAN
Tissue specificity: Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas (PubMed:10698717). Highly expressed in fetal brain and occipital lobe, slightly less in the whole brain, frontal lobe, hippocampus, and lung, very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney and appendix (PubMed:12039030).

Evidence on tissue expression from TISSUES for SULT4A1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with SULT4A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT4A1 Gene

Orthologs for SULT4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT4A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT4A1 31 30
  • 99.77 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SULT4A1 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULT4A1 31 30
  • 94.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SULT4A1 31 30
  • 92.72 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SULT4A1 31
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sult4a1 17 31 30
  • 91.55 (n)
rat
(Rattus norvegicus)
Mammalia Sult4a1 30
  • 91.08 (n)
chicken
(Gallus gallus)
Aves SULT4A1 31 30
  • 79.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SULT4A1 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sult4a1 30
  • 79.23 (n)
zebrafish
(Danio rerio)
Actinopterygii sult4a1 31 30
  • 78.29 (n)
OneToOne
Dr.19215 30
fruit fly
(Drosophila melanogaster)
Insecta CG16733 32
  • 33 (a)
CG5428 32
  • 32 (a)
CG6704 32
  • 32 (a)
St2 31
  • 30 (a)
OneToMany
Species where no ortholog for SULT4A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT4A1 Gene

ENSEMBL:
Gene Tree for SULT4A1 (if available)
TreeFam:
Gene Tree for SULT4A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT4A1: view image

Paralogs for SULT4A1 Gene

(13) SIMAP similar genes for SULT4A1 Gene using alignment to 3 proteins:

  • ST4A1_HUMAN
  • B7Z2E1_HUMAN
  • F8WE22_HUMAN
genes like me logo Genes that share paralogs with SULT4A1: view

Variants for SULT4A1 Gene

Additional dbSNP identifiers (rs#s) for SULT4A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SULT4A1 Gene

Variant ID Type Subtype PubMed ID
esv1037241 CNV deletion 17803354
esv1523199 CNV deletion 17803354
esv1538910 CNV deletion 17803354
esv2510122 CNV deletion 19546169
esv2724327 CNV deletion 23290073
esv2724329 CNV deletion 23290073
esv28783 CNV loss 19812545
esv3568432 CNV loss 25503493
nsv1073166 CNV deletion 25765185
nsv1150513 CNV duplication 26484159
nsv191452 CNV deletion 16902084
nsv3647 CNV deletion 18451855
nsv512659 CNV loss 21212237
nsv589099 CNV loss 21841781
nsv829263 CNV gain 20364138
nsv829265 CNV loss 20364138
nsv834217 CNV gain 17160897
nsv834218 CNV loss 17160897
nsv834219 CNV gain 17160897
nsv955172 CNV deletion 24416366

Variation tolerance for SULT4A1 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT4A1 Gene

Human Gene Mutation Database (HGMD)
SULT4A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT4A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT4A1 Gene

Disorders for SULT4A1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SULT4A1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SULT4A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SULT4A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT4A1 Gene

Publications for SULT4A1 Gene

  1. Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain. (PMID: 10698717) Falany CN … Falany JL (The Biochemical journal 2000) 2 3 4 23 54
  2. Lack of exonic sulfotransferase 4A1 mutations in controls and schizophrenia cases. (PMID: 19125109) Lewis AG … Minchin RF (Psychiatric genetics 2009) 3 23 41 54
  3. Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder. (PMID: 18823757) Meltzer HY … Jayathilake K (Schizophrenia research 2008) 3 23 41 54
  4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 41 54
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 41 54

Products for SULT4A1 Gene

Sources for SULT4A1 Gene