Aliases for SULT2B1 Gene
External Ids for SULT2B1 Gene
Previous GeneCards Identifiers for SULT2B1 Gene
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for SULT2B1 Gene
SULT2B1 (Sulfotransferase Family 2B Member 1) is a Protein Coding gene. Diseases associated with SULT2B1 include Ichthyosis, Congenital, Autosomal Recessive 14 and Ichthyosis, Congenital, Autosomal Recessive 2. Among its related pathways are Vitamin A and Carotenoid Metabolism and Steroid hormone biosynthesis. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT2A1.
UniProtKB/Swiss-Prot Summary for SULT2B1 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).
Isoform 2: Sulfonates pregnenolone but not cholesterol.