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Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical... See more...
Aliases for SULT2B1 Gene
Aliases for SULT2B1 Gene
External Ids for SULT2B1 Gene
- HGNC: 11459
- Entrez Gene: 6820
- Ensembl: ENSG00000088002
- OMIM: 604125
- UniProtKB: O00204
Previous GeneCards Identifiers for SULT2B1 Gene
- GC19P049699
- GC19P049423
- GC19P053731
- GC19P053747
- GC19P049055
- GC19P045434
Summaries for SULT2B1 Gene
-
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for SULT2B1 Gene
SULT2B1 (Sulfotransferase Family 2B Member 1) is a Protein Coding gene. Diseases associated with SULT2B1 include Ichthyosis, Congenital, Autosomal Recessive 14 and Ichthyosis, Congenital, Autosomal Recessive 1. Among its related pathways are Cytochrome P450 - arranged by substrate type and Sulfation Biotransformation Reaction. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT2A1.
UniProtKB/Swiss-Prot Summary for SULT2B1 Gene
-
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).
-
[Isoform 2]: Sulfonates pregnenolone but not cholesterol.
Additional gene information for SULT2B1 Gene
- HGNC(11459)
- Entrez Gene(6820)
- Ensembl(ENSG00000088002)
- OMIM(604125)
- UniProtKB(O00204)
- Open Targets Platform(ENSG00000088002)
- Monarch Initiative
- Search for SULT2B1 at DataMed
- Search for SULT2B1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT2B1 Gene
Genomics for SULT2B1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SULT2B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SULT2B1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT2B1
- Top Transcription factor binding sites by QIAGEN in the SULT2B1 gene promoter:
-
- AP-4
- C/EBPalpha
- C/EBPbeta
- Egr-3
- FOXO1
- FOXO1a
- FOXO4
- Lmo2
- Nkx6-1
- RORalpha2
Genomic Locations for SULT2B1 Gene
Genomic Locations for SULT2B1 Gene
- chr19:48,552,172-48,599,427
- (GRCh38/hg38)
- Size:
- 47,256 bases
- Orientation:
- Plus strand
- chr19:49,055,332-49,102,684
- (GRCh37/hg19)
- Size:
- 47,353 bases
- Orientation:
- Plus strand
Genomic View for SULT2B1 Gene
Genes around SULT2B1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
SULT2B1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SULT2B1 Gene
Proteins for SULT2B1 Gene
-
Protein details for SULT2B1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00204-ST2B1_HUMAN
- Recommended name:
- Sulfotransferase 2B1
- Protein Accession:
- O00204
- O00205
- O75814
Protein attributes for SULT2B1 Gene
- Size:
- 365 amino acids
- Molecular mass:
- 41308 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for SULT2B1 Gene
Protein Expression for SULT2B1 Gene
Selected DME Specific Peptides for SULT2B1 Gene
- O00204:
-
- PKSGTTW
- GDWKNHFTVAQ
Post-translational modifications for SULT2B1 Gene
- Phosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SULT2B1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents SULT2B1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SULT2B1
- Novus Biologicals Antibodies for SULT2B1
-
Abcam antibodies for SULT2B1
- Invitrogen Antibodies for SULT2B1 (AFLGC-SULT2B1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SULT2B1
- Sino Biological Antibodies for SULT2B1
Protein Products
- G Biosciences Human SULT2B1/Cytosolic Sulfotransferase 2B1, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for SULT2B1
- Origene Custom Protein Services for SULT2B1
- Sino Biological Recombinant Proteins for SULT2B1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for SULT2B1
-
ProSci Proteins for SULT2B1
-
Abcam proteins for SULT2B1
Assay Products
- RayBiotech Custom Human SULT2B1 ELISA
- antibodies-online: Show 3 available SULT2B1 Elisa Kits ranked by validation data
- Compare Top SULT2B1 Elisa Kits
-
Quality Products:
- Sino Biological Assays for SULT2B1
Domains & Families for SULT2B1 Gene
Gene Families for SULT2B1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for SULT2B1 Gene
- InterPro:
- Blocks:
-
- Sulfotransferase
- ProtoNet:
Suggested Antigen Peptide Sequences for SULT2B1 Gene
- GenScript: Design optimal peptide antigens:
-
- Hydroxysteroid sulfotransferase 2 (ST2B1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00204UniProtKB/Swiss-Prot:
ST2B1_HUMAN :- The C-terminus, which contains a proline/serine-rich region is involved in nuclear translocation and enzymatic thermostability.
- Belongs to the sulfotransferase 1 family.
- Domain:
-
- The C-terminus, which contains a proline/serine-rich region is involved in nuclear translocation and enzymatic thermostability.
- Family:
-
- Belongs to the sulfotransferase 1 family.
Function for SULT2B1 Gene
Molecular function for SULT2B1 Gene
- UniProtKB/Swiss-Prot Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: Sulfonates pregnenolone but not cholesterol.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+); Xref=Rhea:RHEA:22552, ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:83414; EC=2.8.2.2; Evidence={ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:9799594};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:51216, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57905, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; Evidence={ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:9799594};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:52348, ChEBI:CHEBI:15378, ChEBI:CHEBI:34310, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136567; Evidence={ECO:0000269|PubMed:19589875};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+); Xref=Rhea:RHEA:52368, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136579; Evidence={ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:12923182};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate; Xref=Rhea:RHEA:52356, ChEBI:CHEBI:15378, ChEBI:CHEBI:16581, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133000; Evidence={ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:12923182, ECO:0000269|PubMed:21855633};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=23.5 uM for (24S)-hydroxycholesterol {ECO:0000269|PubMed:19589875}; KM=10.9 uM for DHEA (at 37 degrees Celsius, in the presence of 1 mM MgCl2) {ECO:0000269|PubMed:21855633}; KM=3.8 uM for DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2) {ECO:0000269|PubMed:16855051}; KM=11.8 uM for pregnenolone (at 37 degrees Celsius, in the presence of 1 mM MgCl2) {ECO:0000269|PubMed:21855633}; KM=0.6 uM for PAPS (at 37 degrees Celsius, in the presence of 1 mM MgCl2) {ECO:0000269|PubMed:21855633}; Vmax=1752 pmol/min/mg enzyme toward DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2) {ECO:0000269|PubMed:16855051}; Temperature dependence: Optimum temperature is 37 degrees Celsius. Retains 70% and 20% of activity when incubated at 42 degrees Celsius for 45 and 120 minutes, respectively. Activity is lost after 200 minutes incubation at 42 degrees Celsius. {ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:21855633};
- GENATLAS Biochemistry:
- hydroxysteroid sulfotransferase,highly expressed in placenta,prostate,trachea,with two isoforms SULT2B1A and SULT2B1B
Enzyme Numbers (IUBMB) for SULT2B1 Gene
Phenotypes From GWAS Catalog for SULT2B1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IMP | 12923182 |
| GO:0004027 | alcohol sulfotransferase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008146 | sulfotransferase activity | IEA | -- |
| GO:0015485 | cholesterol binding | IDA | 12923182 |
Phenotypes for SULT2B1 Gene
- MGI mutant phenotypes for SULT2B1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SULT2B1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- shRNA abundance <= 25%
- Decreased shRNA abundance
- Increased transferrin (TF) endocytosis
- FOXO1 nuclear localization
- Inconclusive
- Downregulation of RLR pathway after Sendai virus (SeV) infection
Animal Models for SULT2B1 Gene
- MGI Knock Outs for SULT2B1:
-
- Sult2b1 Sult2b1<tm1Rus>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SULT2B1 - Select products 50% OFF >
- * SULT2B1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SULT2B1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SULT2B1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SULT2B1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SULT2B1
- Browse OriGene Inhibitory RNA Products For SULT2B1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT2B1
Clone Products
- Applied Biological Materials (abm): Clones for SULT2B1 - Select products 50% OFF >
- * SULT2B1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SULT2B1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SULT2B1
Cell Line Products
-
Horizon Cell Lines for SULT2B1
No data available for miRNA , Transcription Factor Targets and HOMER Transcription for SULT2B1 Gene
Localization for SULT2B1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SULT2B1 Gene
- Cytoplasm, cytosol. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus. {ECO:0000269 PubMed:21855633}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 4 |
| endoplasmic reticulum | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | TAS | 9799594 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IEA,IDA | -- |
Pathways & Interactions for SULT2B1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type | ||
| 2 | Steroid hormone biosynthesis | ||
| 3 | Metabolism |
.40
|
|
| 4 | Androstenedione and testosterone biosynthesis and metabolism p.1 |
Estrone metabolism
.57
|
|
| 5 | Sulfation Biotransformation Reaction | ||
Pathways by source for SULT2B1 Gene
3 BioSystems pathways for SULT2B1 Gene
4 Reactome pathways for SULT2B1 Gene
1 KEGG pathway for SULT2B1 Gene
1 GeneGo (Thomson Reuters) pathway for SULT2B1 Gene
- Estrone metabolism
Interacting Proteins for SULT2B1 Gene
Selected Interacting proteins:
O00204-ST2B1_HUMAN
ENSP00000201586
for SULT2B1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SULT2B1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000103 | sulfate assimilation | IEA | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0008202 | steroid metabolic process | IEA,IDA | 9799594 |
| GO:0008203 | cholesterol metabolic process | IMP | 28575648 |
| GO:0008285 | negative regulation of cell proliferation | IMP | 28575648 |
No data available for SIGNOR curated interactions for SULT2B1 Gene
Drugs & Compounds for SULT2B1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pregnenolone | Approved, Experimental | Pharma | Target | 0 | ||
| Dehydroepiandrosterone | Approved, Investigational | Nutra | Enzyme, substrate | 113 | ||
| cholesterol | Approved, Investigational | Pharma | Agonist | 0 | ||
| Cytarabine | Approved, Experimental, Investigational | Pharma | 1335 | |||
| Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1533,1533 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (+)-Catechin 6-C-glucoside |
|
105371-27-5 |
|
|||
| (+)-Catechin 8-C-glucoside |
|
105371-26-4 |
|
|||
| (±)-2-Hydroxy-3-(2-hydroxyphenyl)propanoic acid |
|
|
||||
| (1E)-1-(4-methoxyphenyl)pent-1-en-3-ol |
|
|
|
|||
| (1E)-4-hydroxy-1-(4-methoxyphenyl)pent-1-en-3-one |
|
|
|
Drug Products
- G Biosciences Human SULT2B1/Cytosolic Sulfotransferase 2B1, Liquid
Transcripts for SULT2B1 Gene
mRNA/cDNA for SULT2B1 Gene
- 2 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000201586 1196 nts (view in UCSC)
- ENST00000323090 1447 nts (view in UCSC)
- ENST00000594274 716 nts (view in UCSC)
- ENST00000597923 1423 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SULT2B1 - Select products 50% OFF >
- * SULT2B1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SULT2B1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SULT2B1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SULT2B1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SULT2B1
- Browse OriGene Inhibitory RNA Products For SULT2B1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT2B1
Clone Products
- Applied Biological Materials (abm): Clones for SULT2B1 - Select products 50% OFF >
- * SULT2B1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SULT2B1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SULT2B1
Relevant External Links for SULT2B1 Gene
- GeneLoc Exon Structure for
- SULT2B1
Expression for SULT2B1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SULT2B1 Gene
This gene is overexpressed in Esophagus - Mucosa (x16.1), Skin - Sun Exposed (Lower leg) (x9.2), Skin - Not Sun Exposed (Suprapubic) (x8.8), Vagina (x6.5), and Cervix - Ectocervix (x4.4).
This gene is overexpressed in Cervix (54.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SULT2B1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT2B1
SOURCE GeneReport for Unigene cluster for SULT2B1 Gene:
Hs.369331mRNA Expression by UniProt/SwissProt for SULT2B1 Gene:
O00204-ST2B1_HUMAN
Tissue specificity:
Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level) (PubMed:28575648). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung (PubMed:9799594).
Evidence on tissue expression from TISSUES for SULT2B1 Gene
- Skin(4.6)
- Nervous system(2.3)
- Intestine(2.2)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for SULT2B1
-
OriGene qPCR primer pairs and template standards for SULT2B1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT2B1 Gene
Orthologs for SULT2B1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SULT2B1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SULT2B1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SULT2B1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sult2b1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Sult2b1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SULT2B1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SULT2B1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LOC769841 30 |
|
||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100144919 30 |
|
||
| Str.5857 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23902 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sult2st3 30 |
|
||
| si:dkey-236e20.1 31 |
|
ManyToMany | |||
| Dr.25239 30 |
|
- Species where no ortholog for SULT2B1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SULT2B1 Gene
- ENSEMBL:
- Gene Tree for SULT2B1 (if available)
- TreeFam:
- Gene Tree for SULT2B1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SULT2B1: view image
Paralogs for SULT2B1 Gene
Paralogs for SULT2B1 Gene
(12) SIMAP similar genes for SULT2B1 Gene using alignment to 1 proteins:
- ST2B1_HUMAN
Variants for SULT2B1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT2B1 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710148 | Benign: not provided | 48,592,741(+) | C/T | SYNONYMOUS_VARIANT | |
| 711605 | Benign: not provided | 48,552,267(+) | C/T | SYNONYMOUS_VARIANT | |
| 719579 | Benign: not provided | 48,596,922(+) | G/A | INTRON_VARIANT | |
| 720878 | Benign: not provided | 48,591,686(+) | G/A | SYNONYMOUS_VARIANT | |
| 726656 | Benign: not provided | 48,576,021(+) | T/C | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3617n100 | CNV | gain | 25217958 |
| esv3556507 | CNV | deletion | 23714750 |
| esv3644590 | CNV | loss | 21293372 |
| esv3644591 | CNV | gain | 21293372 |
| nsv1057580 | CNV | gain | 25217958 |
| nsv1058136 | CNV | loss | 25217958 |
| nsv1058767 | CNV | gain | 25217958 |
| nsv138413 | CNV | deletion | 16902084 |
| nsv507899 | OTHER | sequence alteration | 20534489 |
| nsv510882 | OTHER | complex | 20534489 |
| nsv817853 | CNV | loss | 17921354 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.04;
50.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SULT2B1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT2B1 Gene
Disorders for SULT2B1 Gene
(19) MalaCards diseases for SULT2B1 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ichthyosis, congenital, autosomal recessive 14 |
|
|
| ichthyosis, congenital, autosomal recessive 1 |
|
|
| ichthyosis, congenital, autosomal recessive 2 |
|
|
| autosomal recessive congenital ichthyosis |
|
|
| ichthyosis |
|
|
Search SULT2B1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ST2B1_HUMAN- Ichthyosis, congenital, autosomal recessive 14 (ARCI14) [MIM:617571]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. {ECO:0000269 PubMed:28575648}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SULT2B1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for SULT2B1 Gene
Publications for SULT2B1 Gene
- Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. (PMID: 9799594) Her C … Weinshilboum RM (Genomics 1998) 2 3 4 23
- Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. (PMID: 12923182) Lee KA … Pedersen LC (The Journal of biological chemistry 2003) 3 4 23
- Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase. (PMID: 12145317) Fuda H … Strott CA (The Journal of biological chemistry 2002) 3 4 23
- Mutations in SULT2B1 Cause Autosomal-Recessive Congenital Ichthyosis in Humans. (PMID: 28575648) Heinz L … Fischer J (American journal of human genetics 2017) 3 4
- Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PMID: 20214802) Li J … Hall P (Breast cancer research : BCR 2010) 3 41
ExternalLinks
Products for SULT2B1 Gene
- View all 3 R&D Systems SULT2B1 (Cytosolic Sulfotransferase 2B1/SULT2B1) Products
- View all R&D Systems SULT2B1 (Cytosolic Sulfotransferase 2B1/SULT2B1) Proteins and Enzymes
- View all 2 R&D Systems SULT2B1 (Cytosolic Sulfotransferase 2B1/SULT2B1) Primary Antibodies
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- antibodies-online: Show 20 available SULT2B1 Antibodies ranked by validation data
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Sources for SULT2B1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
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- (64) Proteopedia
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
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- (75) Invitrogen
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