This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherite... See more...

Aliases for SULT2A1 Gene

Aliases for SULT2A1 Gene

  • Sulfotransferase Family 2A Member 1 2 3 5
  • DHEA-ST 2 3 4
  • Sulfotransferase Family, Cytosolic, 2A, Dehydroepiandrosterone (DHEA)-Preferring, Member 1 2 3
  • Sulfotransferase 2A1 3 4
  • DHEA-ST8 3 4
  • SULT2A3 3 4
  • ST2A1 3 4
  • HST 3 4
  • ST2 3 4
  • STD 3 4
  • Alcohol/Hydroxysteroid Sulfotransferase 3
  • Dehydroepiandrosterone Sulfotransferase 4
  • Bile-Salt Sulfotranasferase 2A1 3
  • Hydroxysteroid Sulfotransferase 4
  • Bile Salt Sulfotransferase 4
  • EC 2.8.2.14 4
  • EC 2.8.2.2 4
  • SULT2A1 5
  • DHEAS 3
  • ST2A3 3
  • HSTa 3

External Ids for SULT2A1 Gene

Previous HGNC Symbols for SULT2A1 Gene

  • STD

Previous GeneCards Identifiers for SULT2A1 Gene

  • GC19M049020
  • GC19M048765
  • GC19M053049
  • GC19M053065
  • GC19M048373
  • GC19M044800

Summaries for SULT2A1 Gene

Entrez Gene Summary for SULT2A1 Gene

  • This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

GeneCards Summary for SULT2A1 Gene

SULT2A1 (Sulfotransferase Family 2A Member 1) is a Protein Coding gene. Diseases associated with SULT2A1 include Mixed Epithelial Stromal Tumour and Adrenal Cortical Adenoma. Among its related pathways are Drug metabolism - cytochrome P450 and Farnesoid X Receptor Pathway. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and bile-salt sulfotransferase activity. An important paralog of this gene is SULT2B1.

UniProtKB/Swiss-Prot Summary for SULT2A1 Gene

  • Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:7678732, PubMed:2268288, PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:21187059, PubMed:29671343, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:21187059, PubMed:19589875, PubMed:14573603). Plays a key role in bile acid metabolism (PubMed:2268288). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).

Gene Wiki entry for SULT2A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT2A1 Gene

Genomics for SULT2A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SULT2A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047884 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 250.7 +0.7 741 3.1 SSRP1 CEBPA NFIC YY1 MXD4 FEZF1 HOMEZ KMT2B THAP11 FOXA2 SULT2A1 LINC01595 HSALNG0126814 RF00017-2745 CRX
GH19J047657 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 10.3 +223.1 223052 10.6 ZNF600 IKZF1 JUND CEBPA ATF3 BRCA1 YY1 CEBPB HES1 TBP ENSG00000278999 lnc-ZNF541-4 BICRA NOP53 ZC3H4 CCDC9 ZNF541 SNORD23 SULT2A1 GRWD1
GH19J047509 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.5 +373.4 373372 7.1 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 ZNF580 ATF2 POLR2A NAPA lnc-BICRA-4 ZC3H4 BICRA CYTH2 GRWD1 LIG1 NOP53-AS1 INAFM1 KDELR1
GH19J047963 Enhancer 0.8 ENCODE 10.5 -77.0 -77034 0.2 ZNF654 ZNF580 ZIC2 REST TRIM22 ZEB1 CTCF RAD21 CUX1 SMC3 BSPH1 PLA2G4C ELSPBP1 CABP5 SULT2A1 LMTK3 SYNGR4 TMEM143 SNAR-C1 piR-34822-164
GH19J048091 Enhancer 0.8 Ensembl ENCODE 9.8 -205.3 -205286 1.2 TCF7L2 PRDM10 ZNF384 JUND BHLHE40 POLR2A FOS EP300 PKNOX1 ZFHX2 lnc-LIG1-3 CABP5 BSPH1 ELSPBP1 SULT2A1 LMTK3 PLA2G4C HSALNG0126829 piR-37472-003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT2A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT2A1

Top Transcription factor binding sites by QIAGEN in the SULT2A1 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for SULT2A1 Gene

Latest Assembly
chr19:47,870,467-47,886,315
(GRCh38/hg38)
Size:
15,849 bases
Orientation:
Minus strand

Previous Assembly
chr19:48,373,724-48,389,572
(GRCh37/hg19 by Entrez Gene)
Size:
15,849 bases
Orientation:
Minus strand

chr19:48,373,723-48,389,654
(GRCh37/hg19 by Ensembl)
Size:
15,932 bases
Orientation:
Minus strand

Genomic View for SULT2A1 Gene

Genes around SULT2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT2A1 Gene

Proteins for SULT2A1 Gene

  • Protein details for SULT2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06520-ST2A1_HUMAN
    Recommended name:
    Sulfotransferase 2A1
    Protein Accession:
    Q06520

    Protein attributes for SULT2A1 Gene

    Size:
    285 amino acids
    Molecular mass:
    33780 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT2A1 Gene

neXtProt entry for SULT2A1 Gene

Post-translational modifications for SULT2A1 Gene

Other Protein References for SULT2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SULT2A1 Gene

Domains & Families for SULT2A1 Gene

Gene Families for SULT2A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT2A1 Gene

InterPro:
Blocks:
  • Sulfotransferase

Suggested Antigen Peptide Sequences for SULT2A1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93953, highly similar to Homo sapiens sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1 (SULT2A1), mRNA (A8K015_HUMAN)
  • Sulfotransferase 2A1 (ST2A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q06520

UniProtKB/Swiss-Prot:

ST2A1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT2A1: view

Function for SULT2A1 Gene

Molecular function for SULT2A1 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:7678732, PubMed:2268288, PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:21187059, PubMed:29671343, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:21187059, PubMed:19589875, PubMed:14573603). Plays a key role in bile acid metabolism (PubMed:2268288). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+); Xref=Rhea:RHEA:22552, ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:83414; EC=2.8.2.2; Evidence={ECO:0000269|PubMed:18042734, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21187059, ECO:0000269|PubMed:2268288, ECO:0000269|PubMed:7678732, ECO:0000269|PubMed:7854148};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:52344, ChEBI:CHEBI:15378, ChEBI:CHEBI:34310, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136566; Evidence={ECO:0000269|PubMed:19589875};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:52348, ChEBI:CHEBI:15378, ChEBI:CHEBI:34310, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136567; Evidence={ECO:0000269|PubMed:19589875};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:52352, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136566, ChEBI:CHEBI:136568; Evidence={ECO:0000269|PubMed:19589875};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:51216, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57905, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; Evidence={ECO:0000269|PubMed:14573603, ECO:0000269|PubMed:18042734, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21187059, ECO:0000269|PubMed:2268288, ECO:0000269|PubMed:7678732};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate; Xref=Rhea:RHEA:52356, ChEBI:CHEBI:15378, ChEBI:CHEBI:16581, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133000; Evidence={ECO:0000269|PubMed:29671343};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one = 3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:60644, ChEBI:CHEBI:15378, ChEBI:CHEBI:16032, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133003; Evidence={ECO:0000269|PubMed:14573603, ECO:0000269|PubMed:18042734};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate sulfate; Xref=Rhea:RHEA:14013, ChEBI:CHEBI:15378, ChEBI:CHEBI:17179, ChEBI:CHEBI:58301, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; EC=2.8.2.14; Evidence={ECO:0000269|PubMed:2268288};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate; Xref=Rhea:RHEA:51064, ChEBI:CHEBI:15378, ChEBI:CHEBI:29744, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133940; Evidence={ECO:0000269|PubMed:2268288};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 uM for DHEA {ECO:0000269|PubMed:21187059}; KM=3.1 uM for DHEA {ECO:0000269|PubMed:14573603}; KM=1.6 uM for DHEA {ECO:0000269|PubMed:2268288}; KM=0.1 uM for (24S)-hydroxycholesterol 24-sulfate {ECO:0000269|PubMed:19589875}; KM=3.7 uM for (24S)-hydroxycholesterol {ECO:0000269|PubMed:19589875}; KM=1.5 uM for lithocholic acid {ECO:0000269|PubMed:2268288}; KM=4.2 uM for taurolithocholate {ECO:0000269|PubMed:2268288}; KM=2.1 uM for 3alpha-hydroxy-5alpha-androstan-17-one, {ECO:0000269|PubMed:14573603}; KM=1.4 uM for androsterone {ECO:0000269|PubMed:18042734}; KM=24.88 uM for PAPS {ECO:0000269|PubMed:29671343}; Vmax=227 nmol/min/mg enzyme with DHEA {ECO:0000269|PubMed:18042734}; Vmax=22.55 nmol/min/mg enzyme with DHEA {ECO:0000269|PubMed:29671343}; Vmax=54.3 umol/min/mg enzyme with lithocholic acid {ECO:0000269|PubMed:2268288}; Vmax=203 nmol/min/mg enzyme with androsterone as substrate {ECO:0000269|PubMed:18042734}; Vmax=245 nmol/min/mg enzyme with DHEA {ECO:0000269|PubMed:21187059};
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to substrate inhibition. Alternate orientations for binding of steroid substrates to SULT2A1 may play a role in substrate inhibition.
GENATLAS Biochemistry:
hydroxysteroid dehydroepiandrosterone (DHEA) sulfotransferase,cytosolic,involved in the fine control of target cell sensitivity to hormone action,catalyzing the formation of DHEA-S,a major adrenal steroid,precursor for androgen and estrogen biosynthesis in peripheral tissues

Enzyme Numbers (IUBMB) for SULT2A1 Gene

Phenotypes From GWAS Catalog for SULT2A1 Gene

Gene Ontology (GO) - Molecular Function for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004027 alcohol sulfotransferase activity IEA,IDA 7854148
GO:0005515 protein binding IPI 21988832
GO:0008146 sulfotransferase activity IDA 19548878
GO:0016740 transferase activity IEA --
GO:0047704 bile-salt sulfotransferase activity IEA,IDA 1588921
genes like me logo Genes that share ontologies with SULT2A1: view
genes like me logo Genes that share phenotypes with SULT2A1: view

miRNA for SULT2A1 Gene

miRTarBase miRNAs that target SULT2A1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT2A1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT2A1 Gene

Localization for SULT2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT2A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT2A1 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
peroxisome 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT2A1: view

Pathways & Interactions for SULT2A1 Gene

genes like me logo Genes that share pathways with SULT2A1: view

Gene Ontology (GO) - Biological Process for SULT2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process IDA 7854148
GO:0008202 steroid metabolic process IDA,IMP 29671343
GO:0008203 cholesterol metabolic process IDA 19589875
genes like me logo Genes that share ontologies with SULT2A1: view

No data available for SIGNOR curated interactions for SULT2A1 Gene

Drugs & Compounds for SULT2A1 Gene

(34) Drugs for SULT2A1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Enzyme, substrate TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 469
Abiraterone Approved Pharma Enzyme, substrate Potent CYP17 inhibitor 0
Methyldopa Approved Pharma Enzyme, substrate 19
Palbociclib Approved, Investigational Pharma Enzyme, substrate 264
Pindolol Approved, Investigational Pharma Enzyme, substrate beta3 partial agonist 16

(24) Additional Compounds for SULT2A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7-Hydroxymethyl-12-methylbenz[a]anthracene
  • 12-Methylbenz[a]anthracene-7-methanol
  • 7-HM-12-MBA
  • 7-Hydroxymethyl-12-methylbenz(a)anthracene
7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
  • 7-Hydroxymethyl-12-methylbenz[a]anthracene sulfuric acid
  • 7-Hydroxymethyl-12-methylbenz[a]anthracene sulphate
  • 7-Hydroxymethyl-12-methylbenz[a]anthracene sulphuric acid
Androsterone
  • (3alpha,5alpha)-3-Hydroxyandrostan-17-one
  • 3-Epihydroxyetioallocholan-17-one
  • 3alpha-Hydroxy-5alpha-androstan-17-one
  • 3alpha-Hydroxyetioallocholan-17-one
  • 5alpha-Androstane-3alpha-ol-17-one
53-41-8
Lithocholic acid glycine conjugate
  • Glycolithocholate
  • Lithocholylglycine
  • N-((3-alpha,5-beta)-3-Hydroxy-24-oxocholan-24-yl)glycine
  • Glycolithocholic acid
  • N-((3-a,5-b)-3-Hydroxy-24-oxocholan-24-yl)glycine
474-74-8
Lithocholyltaurine
  • 2-[(3alpha-Hydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid
  • 2-[[(3a,5b)-3-Hydroxy-24-oxocholan-24-yl]amino]-ethanesulfonate
  • 2-[[(3a,5b)-3-Hydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid
  • 3a-Hydroxy-5b-cholanoyltaurine
  • 3a-Hydroxy-N-(2-sulfoethyl)-5b-cholan-24-amide
516-90-5
genes like me logo Genes that share compounds with SULT2A1: view

Transcripts for SULT2A1 Gene

mRNA/cDNA for SULT2A1 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT2A1

Alternative Splicing Database (ASD) splice patterns (SP) for SULT2A1 Gene

No ASD Table

Relevant External Links for SULT2A1 Gene

GeneLoc Exon Structure for
SULT2A1

Expression for SULT2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT2A1 Gene

This gene is overexpressed in Liver (x38.0) and Adrenal Gland (x13.4).

Protein differential expression in normal tissues from HIPED for SULT2A1 Gene

This gene is overexpressed in Liver, secretome (19.8), Gallbladder (18.8), Liver (15.2), and Adrenal (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SULT2A1 Gene



Protein tissue co-expression partners for SULT2A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT2A1

SOURCE GeneReport for Unigene cluster for SULT2A1 Gene:

Hs.515835

mRNA Expression by UniProt/SwissProt for SULT2A1 Gene:

Q06520-ST2A1_HUMAN
Tissue specificity: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.

Evidence on tissue expression from TISSUES for SULT2A1 Gene

  • Liver(4.8)
  • Adrenal gland(4.7)
  • Intestine(2.8)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with SULT2A1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT2A1 Gene

Orthologs for SULT2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT2A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SULT2A1 29 30
  • 98.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SULT2A1 29 30
  • 78.01 (n)
OneToMany
-- 30
  • 68 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Sult2a1 29
  • 72.34 (n)
Mouse
(Mus musculus)
Mammalia Sult2a1 29 16 30
  • 72.28 (n)
OneToMany
Sult2a6 16 30
  • 64 (a)
OneToMany
Sult2a3 16 30
  • 63 (a)
OneToMany
Sult2a4 16 30
  • 63 (a)
OneToMany
Sult2a5 16 30
  • 63 (a)
OneToMany
2810007J24Rik 30
  • 60 (a)
OneToMany
Sult2a7 30
  • 59 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia SULT2A1 30
  • 47 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 37 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 29 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 31 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 47 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sult2a1 29
  • 58.1 (n)
Str.6711 29
Zebrafish
(Danio rerio)
Actinopterygii sult2st1 30 30
  • 40 (a)
ManyToMany
sult2st2 30
  • 39 (a)
ManyToMany
sult2st3 30
  • 38 (a)
ManyToMany
si:dkey-236e20.3 30
  • 36 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea Y113G7A.11 31
  • 32 (a)
Species where no ortholog for SULT2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SULT2A1 Gene

ENSEMBL:
Gene Tree for SULT2A1 (if available)
TreeFam:
Gene Tree for SULT2A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT2A1: view image
Alliance of Genome Resources:
Additional Orthologs for SULT2A1

Paralogs for SULT2A1 Gene

(13) SIMAP similar genes for SULT2A1 Gene using alignment to 2 proteins:

  • ST2A1_HUMAN
  • A8K015_HUMAN

Pseudogenes.org Pseudogenes for SULT2A1 Gene

genes like me logo Genes that share paralogs with SULT2A1: view

Variants for SULT2A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT2A1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11569680 Likely Benign: not provided 47,874,723(-) T/C
NM_003167.4(SULT2A1):c.679A>G (p.Lys227Glu)
MISSENSE
rs11569681 Benign: not provided 47,883,735(-) C/Gp.Ala63Pro
NM_003167.4(SULT2A1):c.187G>C (p.Ala63Pro)
MISSENSE
rs11569682 Benign: not provided 47,883,664(-) T/G
NM_003167.4(SULT2A1):c.258A>C (p.Ala86=)
SYNONYMOUS
rs11569679 -- p.Ala261Thr
VAR_083881 -- p.Lys44Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SULT2A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SULT2A1 Gene

Variant ID Type Subtype PubMed ID
esv1006582 CNV insertion 20482838
esv2676204 CNV deletion 23128226
esv2718669 CNV deletion 23290073
esv3556495 CNV deletion 23714750
esv3644559 CNV gain 21293372
esv3644566 CNV loss 21293372
esv3644567 CNV loss 21293372
esv3644568 CNV gain 21293372
esv3893227 CNV loss 25118596
nsv1056164 CNV gain 25217958
nsv1058622 CNV gain 25217958
nsv1066097 CNV gain 25217958
nsv1066782 CNV loss 25217958
nsv1114020 CNV deletion 24896259
nsv2513 CNV deletion 18451855
nsv428367 CNV gain+loss 18775914
nsv458715 CNV gain 19166990
nsv509748 CNV insertion 20534489
nsv523319 CNV loss 19592680
nsv579897 CNV gain 21841781
nsv579898 CNV loss 21841781
nsv579899 CNV loss 21841781
nsv828571 CNV loss 20364138

Variation tolerance for SULT2A1 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT2A1 Gene

Human Gene Mutation Database (HGMD)
SULT2A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT2A1
Leiden Open Variation Database (LOVD)
SULT2A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT2A1 Gene

Disorders for SULT2A1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SULT2A1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
mixed epithelial stromal tumour
adrenal cortical adenoma
  • adrenocortical adenoma
polycystic ovary syndrome
  • multicystic ovaries
adrenal adenoma
  • adenoma of the adrenal gland
conn's syndrome
  • conn syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SULT2A1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SULT2A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT2A1 Gene

Publications for SULT2A1 Gene

  1. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. (PMID: 14573603) Chang HJ … Lin SX (The Journal of biological chemistry 2004) 3 4 22 25
  2. Identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (SULT2A1). (PMID: 18042734) Lu LY … Yang YS (Molecular pharmacology 2008) 3 4 22
  3. Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome. (PMID: 17426092) Goodarzi MO … Azziz R (The Journal of clinical endocrinology and metabolism 2007) 3 22 40
  4. Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate. (PMID: 11988089) Rehse PH … Lin SX (The Biochemical journal 2002) 3 4 22
  5. Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. (PMID: 10854859) Pedersen LC … Negishi M (FEBS letters 2000) 3 4 22

Products for SULT2A1 Gene

Sources for SULT2A1 Gene