Aliases for SULT2A1 Gene
External Ids for SULT2A1 Gene
Previous HGNC Symbols for SULT2A1 Gene
Previous GeneCards Identifiers for SULT2A1 Gene
This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]
GeneCards Summary for SULT2A1 Gene
SULT2A1 (Sulfotransferase Family 2A Member 1) is a Protein Coding gene. Diseases associated with SULT2A1 include Mixed Epithelial Stromal Tumour and Adrenal Cortical Adenoma. Among its related pathways are Drug metabolism - cytochrome P450 and Farnesoid X Receptor Pathway. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and bile-salt sulfotransferase activity. An important paralog of this gene is SULT2B1.
UniProtKB/Swiss-Prot Summary for SULT2A1 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:7678732, PubMed:2268288, PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:21187059, PubMed:29671343, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:21187059, PubMed:19589875, PubMed:14573603). Plays a key role in bile acid metabolism (PubMed:2268288). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).