Aliases for SULT1E1 Gene
External Ids for SULT1E1 Gene
Previous HGNC Symbols for SULT1E1 Gene
Previous GeneCards Identifiers for SULT1E1 Gene
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for SULT1E1 Gene
SULT1E1 (Sulfotransferase Family 1E Member 1) is a Protein Coding gene. Diseases associated with SULT1E1 include Endometrial Cancer and Skin Angiosarcoma. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1B1.
UniProtKB/Swiss-Prot Summary for SULT1E1 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).