Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estr... See more...

Aliases for SULT1E1 Gene

Aliases for SULT1E1 Gene

  • Sulfotransferase Family 1E Member 1 2 3 5
  • Sulfotransferase, Estrogen-Preferring 2 3 4
  • Sulfotransferase Family 1E, Estrogen-Preferring, Member 1 2 3
  • Estrogen Sulfotransferase 3 4
  • Sulfotransferase 1E1 3 4
  • EC 2.8.2.4 4 50
  • EST-1 3 4
  • ST1E1 3 4
  • EST 2 3
  • STE 3 4
  • Estrone Sulfotransferase 3
  • EC 2.8.2 50
  • SULT1E1 5

External Ids for SULT1E1 Gene

Previous HGNC Symbols for SULT1E1 Gene

  • STE

Previous GeneCards Identifiers for SULT1E1 Gene

  • GC04M071022
  • GC04M070887
  • GC04M070741
  • GC04M066504
  • GC04M070676
  • GC04M069810

Summaries for SULT1E1 Gene

Entrez Gene Summary for SULT1E1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

CIViC Summary for SULT1E1 Gene

GeneCards Summary for SULT1E1 Gene

SULT1E1 (Sulfotransferase Family 1E Member 1) is a Protein Coding gene. Diseases associated with SULT1E1 include Endometrial Cancer and Skin Angiosarcoma. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1B1.

UniProtKB/Swiss-Prot Summary for SULT1E1 Gene

  • Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).

Gene Wiki entry for SULT1E1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT1E1 Gene

Genomics for SULT1E1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SULT1E1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J069857 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 250.7 +1.1 1082 4.5 CEBPA YY1 CEBPB FOXA2 RXRA JUND HNF4A REST CEBPG SP1 SULT1E1 CSN1S1 SULT1B1 ENSG00000284695
GH04J069829 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +28.6 28560 6.4 BCLAF1 SSRP1 CEBPA CHD4 YY1 BCL11A FOXA1 KLF11 HOMEZ CTCF HSALNG0034990 SULT1B1 SULT1E1 CSN1S1 UGT2A2 piR-36921-029 HSALNG0034991 ENSG00000284695
GH04J069739 Enhancer 0.8 FANTOM5 Ensembl 11.4 +118.6 118550 5.6 HOMEZ FOXA2 RXRA ZNF585B JUND SPI1 HNF4A TFAP4 CEBPG SP1 HSALNG0034989 SULT1B1 SULT1E1 CSN1S1 piR-36393-391 UGT2A1
GH04J069726 Enhancer 0.8 Ensembl ENCODE 11 +130.6 130564 6.8 ATF3 YY1 FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 RAD21 REST SULT1B1 SULT1E1 CSN1S1 HSALNG0034988 HSALNG0034989 UGT2A1
GH04J069718 Enhancer 0.7 FANTOM5 Ensembl ENCODE 11.7 +141.4 141351 2 YY1 NFIB SP1 HSALNG0034988 SULT1E1 SULT1B1 CSN1S1 piR-32461-126 UGT2A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT1E1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT1E1

Top Transcription factor binding sites by QIAGEN in the SULT1E1 gene promoter:
  • ATF
  • E4BP4
  • FOXD1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Hlf
  • RFX1
  • S8
  • TBP

Genomic Locations for SULT1E1 Gene

Latest Assembly
chr4:69,841,212-69,860,151
(GRCh38/hg38)
Size:
18,940 bases
Orientation:
Minus strand

Previous Assembly
chr4:70,706,930-70,725,863
(GRCh37/hg19 by Entrez Gene)
Size:
18,934 bases
Orientation:
Minus strand

chr4:70,676,498-70,725,870
(GRCh37/hg19 by Ensembl)
Size:
49,373 bases
Orientation:
Minus strand

Genomic View for SULT1E1 Gene

Genes around SULT1E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1E1 Gene

Proteins for SULT1E1 Gene

  • Protein details for SULT1E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49888-ST1E1_HUMAN
    Recommended name:
    Sulfotransferase 1E1
    Protein Accession:
    P49888
    Secondary Accessions:
    • Q8N6X5

    Protein attributes for SULT1E1 Gene

    Size:
    294 amino acids
    Molecular mass:
    35126 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1E1 Gene

neXtProt entry for SULT1E1 Gene

Selected DME Specific Peptides for SULT1E1 Gene

P49888:
  • LLPASFWEK
  • MIYKEGDVEKCKED
  • ELVDRII
  • HTSFQEMKNNP
  • PKSGTTW
  • SPFMRKG
  • SPRIVKTHLP
  • GQVPYGSWY
  • FQARPDD

Post-translational modifications for SULT1E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1E1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SULT1E1 Gene

Gene Families for SULT1E1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT1E1 Gene

InterPro:
Blocks:
  • Sulfotransferase

Suggested Antigen Peptide Sequences for SULT1E1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92529, Homo sapiens sulfotransferase, estrogen-preferring (STE), mRNA (Q53X91_HUMAN)
  • Sulfotransferase, estrogen-preferring (ST1E1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49888

UniProtKB/Swiss-Prot:

ST1E1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1E1: view

Function for SULT1E1 Gene

Molecular function for SULT1E1 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+); Xref=Rhea:RHEA:15973, ChEBI:CHEBI:15378, ChEBI:CHEBI:17263, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:60050; EC=2.8.2.4; Evidence={ECO:0000269|PubMed:11006110, ECO:0000269|PubMed:11884392, ECO:0000269|PubMed:7779757};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:52348, ChEBI:CHEBI:15378, ChEBI:CHEBI:34310, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136567; Evidence={ECO:0000269|PubMed:19589875};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:52372, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:136582; Evidence={ECO:0000269|PubMed:11006110, ECO:0000269|PubMed:7779757};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:51216, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57905, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343; Evidence={ECO:0000269|PubMed:11006110};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.3 uM for 17beta-estradiol {ECO:0000269|PubMed:11006110}; KM=0.2 uM for estrone {ECO:0000269|PubMed:11006110}; KM=0.2 uM for DHEA {ECO:0000269|PubMed:11006110}; KM=32220 uM for dopamine {ECO:0000269|PubMed:11006110}; KM=76.6 uM for p-nitrophenol {ECO:0000269|PubMed:11006110}; KM=0.9 uM for (24S)-hydroxycholesterol {ECO:0000269|PubMed:19589875}; KM=0.66 uM for PAPS {ECO:0000269|PubMed:11884392}; KM=0.46 uM for PAPS {ECO:0000269|PubMed:11006110}; Vmax=37.2 nmol/min/mg enzyme with 17beta-estradiol {ECO:0000269|PubMed:11006110}; Vmax=16.3 nmol/min/mg enzyme with estrone {ECO:0000269|PubMed:11006110}; Vmax=5.5 nmol/min/mg enzyme with DHEA {ECO:0000269|PubMed:11006110}; Vmax=13.3 nmol/min/mg enzyme with dopaminne; Vmax=135.9 nmol/min/mg enzyme with p-nitrophenol {ECO:0000269|PubMed:11006110}; Note=Kcat is 55 min(-1) with (24S)-hydroxycholesterol. {ECO:0000269|PubMed:19589875};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by estradiol.

Enzyme Numbers (IUBMB) for SULT1E1 Gene

Phenotypes From GWAS Catalog for SULT1E1 Gene

Gene Ontology (GO) - Molecular Function for SULT1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IBA 21873635
GO:0004304 estrone sulfotransferase activity TAS,IEA --
GO:0005496 steroid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IDA 19548878
genes like me logo Genes that share ontologies with SULT1E1: view
genes like me logo Genes that share phenotypes with SULT1E1: view

Animal Models for SULT1E1 Gene

MGI Knock Outs for SULT1E1:

miRNA for SULT1E1 Gene

miRTarBase miRNAs that target SULT1E1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1E1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SULT1E1 Gene

Localization for SULT1E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1E1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1E1 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 2
mitochondrion 2
peroxisome 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nuclear membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SULT1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with SULT1E1: view

Pathways & Interactions for SULT1E1 Gene

genes like me logo Genes that share pathways with SULT1E1: view

Pathways by source for SULT1E1 Gene

SIGNOR curated interactions for SULT1E1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SULT1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0006711 estrogen catabolic process IDA 23207770
GO:0008202 steroid metabolic process TAS 8185618
GO:0008210 estrogen metabolic process IDA 11884392
GO:0045600 positive regulation of fat cell differentiation IMP 24567372
genes like me logo Genes that share ontologies with SULT1E1: view

Drugs & Compounds for SULT1E1 Gene

(34) Drugs for SULT1E1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclizine Approved Pharma Target, inhibitor 4
Tamoxifen Approved Pharma Enzyme, substrate TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 469
Estrone Approved Pharma Estrogenic hormone 24
Estrone sulfate Approved Pharma 0
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 711

(12) Additional Compounds for SULT1E1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SULT1E1: view

Transcripts for SULT1E1 Gene

mRNA/cDNA for SULT1E1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1E1

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1E1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2: -
SP3: -

Relevant External Links for SULT1E1 Gene

GeneLoc Exon Structure for
SULT1E1

Expression for SULT1E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT1E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT1E1 Gene

This gene is overexpressed in Vagina (x11.5), Skin - Sun Exposed (Lower leg) (x8.4), Liver (x6.1), Adrenal Gland (x6.0), Skin - Not Sun Exposed (Suprapubic) (x5.7), and Cervix - Ectocervix (x5.5).

Protein differential expression in normal tissues from HIPED for SULT1E1 Gene

This gene is overexpressed in Fetal Liver (18.2), Fetal gut (14.2), Fetal testis (12.0), Fetal ovary (8.6), Gallbladder (6.6), and Fetal heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SULT1E1 Gene



Protein tissue co-expression partners for SULT1E1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT1E1

SOURCE GeneReport for Unigene cluster for SULT1E1 Gene:

Hs.479898

mRNA Expression by UniProt/SwissProt for SULT1E1 Gene:

P49888-ST1E1_HUMAN
Tissue specificity: Liver, intestine and at lower level in the kidney.

Evidence on tissue expression from TISSUES for SULT1E1 Gene

  • Liver(4.6)
  • Lung(4.2)
  • Spleen(4.2)
  • Intestine(2.5)
  • Heart(2.4)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with SULT1E1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1E1 Gene

Orthologs for SULT1E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SULT1E1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SULT1E1 29 30
  • 99.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SULT1E1 29 30
  • 86.19 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SULT1E1 29 30
  • 80.89 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sult1e1 29 16 30
  • 80.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia ste2 29
  • 76.82 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SULT1E1 30
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SULT1E1 30
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004498 29
  • 44.61 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta St2 29
  • 43.98 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons SOT12 29
  • 48.12 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0626600 29
  • 42.44 (n)
Species where no ortholog for SULT1E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SULT1E1 Gene

ENSEMBL:
Gene Tree for SULT1E1 (if available)
TreeFam:
Gene Tree for SULT1E1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT1E1: view image
Alliance of Genome Resources:
Additional Orthologs for SULT1E1

Paralogs for SULT1E1 Gene

(14) SIMAP similar genes for SULT1E1 Gene using alignment to 3 proteins:

  • ST1E1_HUMAN
  • H0Y8G0_HUMAN
  • Q53X91_HUMAN
genes like me logo Genes that share paralogs with SULT1E1: view

Variants for SULT1E1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT1E1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11569708 Benign: not provided 69,849,474(-) G/A
NM_005420.3(SULT1E1):c.459C>T (p.Ser153=)
SYNONYMOUS
rs143726522 Benign: not provided 69,855,343(-) G/T
NM_005420.3(SULT1E1):c.229C>A (p.Arg77=)
SYNONYMOUS
rs377482558 Likely Benign: not provided 69,847,791(-) A/T
NM_005420.3(SULT1E1):c.498T>A (p.Val166=)
SYNONYMOUS
rs11569705 -- p.Asp22Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SULT1E1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SULT1E1 Gene

Variant ID Type Subtype PubMed ID
esv3600924 CNV loss 21293372

Variation tolerance for SULT1E1 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT1E1 Gene

Human Gene Mutation Database (HGMD)
SULT1E1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1E1
Leiden Open Variation Database (LOVD)
SULT1E1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1E1 Gene

Disorders for SULT1E1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SULT1E1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
skin angiosarcoma
  • angiosarcoma of skin
breast cancer
  • breast cancer, familial
estrogen excess
  • hyperestrogenism
breast disease
  • breast diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SULT1E1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SULT1E1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1E1 Gene

Publications for SULT1E1 Gene

  1. Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States. (PMID: 20142249) Yong M … Lampe JW (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 40
  2. Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. (PMID: 19776291) Ferlin A … Foresta C (Endocrine-related cancer 2010) 3 22 40
  3. Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. (PMID: 19551860) Udler MS … Pharoah PD (International journal of cancer 2009) 3 22 40
  4. CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. (PMID: 18318428) Hirata H … Dahiya R (Cancer 2008) 3 22 40
  5. SULT1E1 genetic polymorphisms modified the association between phytoestrogen consumption and bone mineral density in healthy Korean women. (PMID: 16969590) Lee SA … Kang D (Calcified tissue international 2006) 3 22 40

Products for SULT1E1 Gene

Sources for SULT1E1 Gene