Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsib... See more...

Aliases for SULT1C4 Gene

Aliases for SULT1C4 Gene

  • Sulfotransferase Family 1C Member 4 2 3 5
  • Sulfotransferase Family, Cytosolic, 1C, Member 2 2 3
  • Sulfotransferase Family, Cytosolic, 1C, Member 4 2 3
  • Sulfotransferase 1C4 3 4
  • Sulfotransferase 1C2 3 4
  • SULT1C#2 3 4
  • SULT1C2 3 4
  • SULT1C 2 3
  • ST1C4 3 4
  • Sulfotransferase Family, Cytosolic, 1C, Member C2 3
  • EC 2.8.2.1 50
  • EC 2.8.2.- 4
  • EC 2.8.2 50
  • SULT1C4 5

External Ids for SULT1C4 Gene

Previous HGNC Symbols for SULT1C4 Gene

  • SULT1C2

Previous GeneCards Identifiers for SULT1C4 Gene

  • GC02P108360
  • GC02P108994
  • GC02P102593

Summaries for SULT1C4 Gene

Entrez Gene Summary for SULT1C4 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1C4 Gene

SULT1C4 (Sulfotransferase Family 1C Member 4) is a Protein Coding gene. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C2.

UniProtKB/Swiss-Prot Summary for SULT1C4 Gene

  • Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Gene Wiki entry for SULT1C4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT1C4 Gene

Genomics for SULT1C4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SULT1C4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT1C4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT1C4

Top Transcription factor binding sites by QIAGEN in the SULT1C4 gene promoter:
  • FOXI1
  • HFH-3
  • Nkx2-2

Genomic Locations for SULT1C4 Gene

Latest Assembly
chr2:108,377,911-108,388,989
(GRCh38/hg38)
Size:
11,079 bases
Orientation:
Plus strand

Previous Assembly
chr2:108,994,410-109,005,445
(GRCh37/hg19 by Entrez Gene)
Size:
11,036 bases
Orientation:
Plus strand

chr2:108,994,367-109,004,513
(GRCh37/hg19 by Ensembl)
Size:
10,147 bases
Orientation:
Plus strand

Genomic View for SULT1C4 Gene

Genes around SULT1C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C4 Gene

Proteins for SULT1C4 Gene

  • Protein details for SULT1C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75897-ST1C4_HUMAN
    Recommended name:
    Sulfotransferase 1C4
    Protein Accession:
    O75897
    Secondary Accessions:
    • Q069I8
    • Q08AS5
    • Q53S63

    Protein attributes for SULT1C4 Gene

    Size:
    302 amino acids
    Molecular mass:
    35520 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C4 Gene

    Alternative splice isoforms for SULT1C4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1C4 Gene

Selected DME Specific Peptides for SULT1C4 Gene

O75897:
  • FTVAQNE
  • SPFMRKG
  • LYLFYED

Post-translational modifications for SULT1C4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1C4 Gene

Domains & Families for SULT1C4 Gene

Gene Families for SULT1C4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SULT1C4 Gene

InterPro:
Blocks:
  • Sulfotransferase

Suggested Antigen Peptide Sequences for SULT1C4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53816, highly similar to Sulfotransferase 1C2 (EC 2.8.2.-) (Q08AS5_HUMAN)
  • Sulfotransferase family, cytosolic, 1C, member 2, isoform CRA_a (Q6PD90_HUMAN)
  • Sulfotransferase 1C2 (ST1C4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75897

UniProtKB/Swiss-Prot:

ST1C4_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C4: view

Function for SULT1C4 Gene

Molecular function for SULT1C4 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Enzyme Numbers (IUBMB) for SULT1C4 Gene

Phenotypes From GWAS Catalog for SULT1C4 Gene

Gene Ontology (GO) - Molecular Function for SULT1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IDA 23207770
GO:0008146 sulfotransferase activity NAS 9852044
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT1C4: view
genes like me logo Genes that share phenotypes with SULT1C4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1C4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1C4 Gene

Localization for SULT1C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1C4 gene
Compartment Confidence
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SULT1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1C4: view

Pathways & Interactions for SULT1C4 Gene

genes like me logo Genes that share pathways with SULT1C4: view

Pathways by source for SULT1C4 Gene

Gene Ontology (GO) - Biological Process for SULT1C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS --
GO:0051923 sulfation IDA 20056724
genes like me logo Genes that share ontologies with SULT1C4: view

No data available for SIGNOR curated interactions for SULT1C4 Gene

Drugs & Compounds for SULT1C4 Gene

(6) Drugs for SULT1C4 Gene - From: DrugBank and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methyldopa Approved Pharma Enzyme, substrate 19
Pindolol Approved, Investigational Pharma Enzyme, substrate beta3 partial agonist 16
Terbutaline Approved Pharma Enzyme, substrate 52
Docetaxel Approved, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2429
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents 440
genes like me logo Genes that share compounds with SULT1C4: view

Transcripts for SULT1C4 Gene

mRNA/cDNA for SULT1C4 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1C4

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C4 Gene

No ASD Table

Relevant External Links for SULT1C4 Gene

GeneLoc Exon Structure for
SULT1C4

Expression for SULT1C4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT1C4 Gene

Protein differential expression in normal tissues from HIPED for SULT1C4 Gene

This gene is overexpressed in Heart (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT1C4 Gene



Protein tissue co-expression partners for SULT1C4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT1C4

SOURCE GeneReport for Unigene cluster for SULT1C4 Gene:

Hs.312644

mRNA Expression by UniProt/SwissProt for SULT1C4 Gene:

O75897-ST1C4_HUMAN
Tissue specificity: Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord.

Evidence on tissue expression from TISSUES for SULT1C4 Gene

  • Heart(4.3)
  • Lung(4.2)
  • Kidney(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SULT1C4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1C4 Gene

Orthologs for SULT1C4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SULT1C4 29 30
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SULT1C4 29 30
  • 87.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SULT1C4 29
  • 82.27 (n)
-- 30
  • 79 (a)
OneToMany
-- 30
  • 77 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 75 (a)
OneToMany
-- 30
  • 74 (a)
OneToMany
-- 30
  • 68 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 57 (a)
ManyToMany
-- 30
  • 56 (a)
ManyToMany
-- 30
  • 56 (a)
ManyToMany
-- 30
  • 55 (a)
ManyToMany
-- 30
  • 55 (a)
ManyToMany
-- 30
  • 53 (a)
ManyToMany
-- 30
  • 52 (a)
ManyToMany
-- 30
  • 52 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sult1c4 29
  • 59.95 (n)
Zebrafish
(Danio rerio)
Actinopterygii sult1st5 29 30
  • 58.3 (n)
ManyToMany
sult1st1 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001425 29
  • 46.82 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta St4 29
  • 45.09 (n)
St2 30
  • 29 (a)
OneToMany
Species where no ortholog for SULT1C4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SULT1C4 Gene

ENSEMBL:
Gene Tree for SULT1C4 (if available)
TreeFam:
Gene Tree for SULT1C4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT1C4: view image
Alliance of Genome Resources:
Additional Orthologs for SULT1C4

Paralogs for SULT1C4 Gene

(14) SIMAP similar genes for SULT1C4 Gene using alignment to 3 proteins:

  • ST1C4_HUMAN
  • Q08AS5_HUMAN
  • Q6PD90_HUMAN
genes like me logo Genes that share paralogs with SULT1C4: view

Variants for SULT1C4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT1C4 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1402467 -- p.Asp5Glu
rs41322445 -- p.Ile68Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SULT1C4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SULT1C4 Gene

Variant ID Type Subtype PubMed ID
dgv153e55 CNV gain 17911159
dgv4035n100 CNV gain 25217958
dgv4036n100 CNV gain 25217958
dgv724e199 CNV deletion 23128226
esv2236049 CNV deletion 18987734
esv2720498 CNV deletion 23290073
esv2759081 CNV gain 17122850
esv3559919 CNV deletion 23714750
esv3591913 CNV gain 21293372
esv3591924 CNV gain 21293372
nsv469774 CNV gain 16826518
nsv527491 CNV loss 19592680
nsv527686 CNV gain 19592680
nsv834327 CNV gain 17160897

Variation tolerance for SULT1C4 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT1C4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1C4
Leiden Open Variation Database (LOVD)
SULT1C4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C4 Gene

Disorders for SULT1C4 Gene

Additional Disease Information for SULT1C4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for SULT1C4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1C4 Gene

Publications for SULT1C4 Gene

  1. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. (PMID: 10783263) Freimuth RR … Weinshilboum RM (Genomics 2000) 2 3 4 22
  2. Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene. (PMID: 9852044) Sakakibara Y … Liu MC (The Journal of biological chemistry 1998) 2 3 4
  3. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A … Arrowsmith CH (PLoS biology 2007) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

Products for SULT1C4 Gene

Sources for SULT1C4 Gene