Aliases for SULT1C3 Gene

Aliases for SULT1C3 Gene

  • Sulfotransferase Family 1C Member 3 2 3 5
  • Sulfotransferase Family, Cytosolic, 1C, Member 3 2 3
  • Sulfotransferase 1C3 3 4
  • EC 2.8.2.1 4 50
  • ST1C3 3 4
  • EC 2.8.2.2 4
  • EC 2.8.2 50
  • SULT1C3 5

External Ids for SULT1C3 Gene

Previous GeneCards Identifiers for SULT1C3 Gene

  • GC02P108323
  • GC02P108863
  • GC02P102462

Summaries for SULT1C3 Gene

GeneCards Summary for SULT1C3 Gene

SULT1C3 (Sulfotransferase Family 1C Member 3) is a Protein Coding gene. Diseases associated with SULT1C3 include Mannosidosis, Alpha B, Lysosomal. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT1C4.

UniProtKB/Swiss-Prot Summary for SULT1C3 Gene

  • [Isoform 1]: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro phenols and hydroxypyrenes. Lithocholic acid appears to be the best substrate among the endogenous compounds tested and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol shows the highest specific activity among the xenobiotic compounds.
  • [Isoform 2]: Exhibits weak sulphating activity and only toward chloro phenols (pentachlorophenol and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol).

Gene Wiki entry for SULT1C3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT1C3 Gene

Genomics for SULT1C3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SULT1C3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J108238 Enhancer 0.3 ENCODE 250.7 -0.4 -401 1.7 FOXA1 SULT1C3 SULT1C2 lnc-EDAR-5 LINC01594 SLC5A7
GH02J108265 Enhancer 1.1 Ensembl ENCODE dbSUPER 22.1 +27.4 27437 3.6 CEBPA ZFP64 HOMEZ THAP11 FOXA2 SMAD4 SAP130 ETV4 GABPB1 FOSL2 SULT1C2 SULT1C3 LINC01594 HSALNG0017717-001 HSALNG0017717-002 lnc-SULT1C2-4
GH02J108286 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 +49.0 48977 4.4 ZNF600 KLF9 CEBPA POLR2A ZIC2 MXD4 REST KLF11 FEZF1 HOMEZ SULT1C2 LINC01594-001 SULT1C3 piR-57122 LINC01594 SULT1C4
GH02J108269 Enhancer 1 ENCODE dbSUPER 11.7 +31.1 31127 3.6 IKZF1 SSRP1 ZMYM3 CEBPA HOMEZ IRF2 THAP11 ELF1 FOXA2 RXRA HSALNG0017717-001 HSALNG0017717-002 HSALNG0017717-003 SULT1C2 LINC01594 SULT1C3 WASF1P1
GH02J108193 Enhancer 0.6 Ensembl 11.3 -46.5 -46491 0.6 FOXA2 RARA FOSL2 ZBTB40 SOX5 HMG20A FOXA1 DPF2 GATAD2A TCF7 LINC01594 SULT1C3 piR-48222-184 HSALNG0017713 HSALNG0017711 SLC5A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT1C3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT1C3

Top Transcription factor binding sites by QIAGEN in the SULT1C3 gene promoter:
  • AREB6

Genomic Locations for SULT1C3 Gene

Latest Assembly
chr2:108,239,968-108,265,608
(GRCh38/hg38)
Size:
25,641 bases
Orientation:
Plus strand

Previous Assembly
chr2:108,856,424-108,881,807
(GRCh37/hg19 by Entrez Gene)
Size:
25,384 bases
Orientation:
Plus strand

chr2:108,863,651-108,881,807
(GRCh37/hg19 by Ensembl)
Size:
18,157 bases
Orientation:
Plus strand

Genomic View for SULT1C3 Gene

Genes around SULT1C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C3 Gene

Proteins for SULT1C3 Gene

  • Protein details for SULT1C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IMI6-ST1C3_HUMAN
    Recommended name:
    Sulfotransferase 1C3
    Protein Accession:
    Q6IMI6
    Secondary Accessions:
    • Q6IMI5

    Protein attributes for SULT1C3 Gene

    Size:
    304 amino acids
    Molecular mass:
    35889 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • SULT1C3 gene appears to be present only in humans and other primates.

    Three dimensional structures from OCA and Proteopedia for SULT1C3 Gene

    Alternative splice isoforms for SULT1C3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1C3 Gene

Selected DME Specific Peptides for SULT1C3 Gene

Q6IMI6:
  • FTVAQNE
  • LYLFYED
  • PKSGTTW
  • SPFMRKG
  • GDWKNYFT

Post-translational modifications for SULT1C3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1C3 Gene

Domains & Families for SULT1C3 Gene

Gene Families for SULT1C3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT1C3 Gene

InterPro:
Blocks:
  • Sulfotransferase

Suggested Antigen Peptide Sequences for SULT1C3 Gene

GenScript: Design optimal peptide antigens:
  • Sulfotransferase 1C3 (ST1C3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IMI6

UniProtKB/Swiss-Prot:

ST1C3_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C3: view

Function for SULT1C3 Gene

Molecular function for SULT1C3 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro phenols and hydroxypyrenes. Lithocholic acid appears to be the best substrate among the endogenous compounds tested and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol shows the highest specific activity among the xenobiotic compounds.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Exhibits weak sulphating activity and only toward chloro phenols (pentachlorophenol and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+); Xref=Rhea:RHEA:22552, ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:83414; EC=2.8.2.2; Evidence={ECO:0000269|PubMed:17425406, ECO:0000269|PubMed:17936463};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + a phenol = a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:12164, ChEBI:CHEBI:15378, ChEBI:CHEBI:33853, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:140317; EC=2.8.2.1; Evidence={ECO:0000269|PubMed:17425406, ECO:0000269|PubMed:28992322};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate; Xref=Rhea:RHEA:51064, ChEBI:CHEBI:15378, ChEBI:CHEBI:29744, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:133940; Evidence={ECO:0000269|PubMed:17425406, ECO:0000269|PubMed:28992322};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=11.29 uM for 3,3',5,5'-tetrachloro-4,4'-biphenyldiol {ECO:0000269|PubMed:28992322}; KM=35.17 uM for lithocholate {ECO:0000269|PubMed:28992322}; Vmax=5.45 nmol/min/mg enzyme for 3,3',5,5'-tetrachloro-4,4'-biphenyldiol {ECO:0000269|PubMed:28992322}; Vmax=0.52 nmol/min/mg enzyme for lithocholate {ECO:0000269|PubMed:28992322};

Enzyme Numbers (IUBMB) for SULT1C3 Gene

Phenotypes From GWAS Catalog for SULT1C3 Gene

Gene Ontology (GO) - Molecular Function for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004027 alcohol sulfotransferase activity IEA,IDA 17936463
GO:0004062 aryl sulfotransferase activity IEA,IDA 28992322
GO:0005515 protein binding IPI 32296183
GO:0008146 sulfotransferase activity IEA,IBA 21873635
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT1C3: view
genes like me logo Genes that share phenotypes with SULT1C3: view

Animal Models for SULT1C3 Gene

MGI Knock Outs for SULT1C3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1C3

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SULT1C3 Gene

Localization for SULT1C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1C3 gene
Compartment Confidence
cytosol 3
peroxisome 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with SULT1C3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT1C3 Gene

Pathways & Interactions for SULT1C3 Gene

genes like me logo Genes that share pathways with SULT1C3: view

Pathways by source for SULT1C3 Gene

Gene Ontology (GO) - Biological Process for SULT1C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process IEA --
GO:0006805 xenobiotic metabolic process IDA 28992322
GO:0008203 cholesterol metabolic process IDA --
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA 17425406
GO:0051923 sulfation IBA 21873635
genes like me logo Genes that share ontologies with SULT1C3: view

No data available for SIGNOR curated interactions for SULT1C3 Gene

Drugs & Compounds for SULT1C3 Gene

(6) Drugs for SULT1C3 Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methyldopa Approved Pharma Enzyme, substrate 19
Pindolol Approved, Investigational Pharma Enzyme, substrate beta3 partial agonist 16
Terbutaline Approved Pharma Enzyme, substrate 52
Candesartan Experimental Pharma Angiotensin II receptor 1 (AT1) antagonist 182
3'-phospho-5'-adenylyl sulfate Experimental Pharma 0
genes like me logo Genes that share compounds with SULT1C3: view

Transcripts for SULT1C3 Gene

mRNA/cDNA for SULT1C3 Gene

2 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1C3

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C3 Gene

No ASD Table

Relevant External Links for SULT1C3 Gene

GeneLoc Exon Structure for
SULT1C3

Expression for SULT1C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT1C3 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1C3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x37.5) and Skin - Not Sun Exposed (Suprapubic) (x6.0).

Protein differential expression in normal tissues from HIPED for SULT1C3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT1C3 Gene



Protein tissue co-expression partners for SULT1C3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT1C3

SOURCE GeneReport for Unigene cluster for SULT1C3 Gene:

Hs.535156

mRNA Expression by UniProt/SwissProt for SULT1C3 Gene:

Q6IMI6-ST1C3_HUMAN
Tissue specificity: [Isoform 1]: Not detectable in any of the tissues tested.
genes like me logo Genes that share expression patterns with SULT1C3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1C3 Gene

Orthologs for SULT1C3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100608286 29
  • 89.33 (n)
SULT1C3 30
  • 87 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC481309 29
  • 74.88 (n)
SULT1C3 30
  • 64 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sult1c3 29
  • 74.44 (n)
Mouse
(Mus musculus)
Mammalia Sult1c1 29 16 30
  • 74.32 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SULT1C3 29 30
  • 71.02 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SULT1C3 30
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SULT1C3 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SULT1C3 29
  • 67.26 (n)
SULT1C 30
  • 59 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 50 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493528 29
  • 66.87 (n)
Zebrafish
(Danio rerio)
Actinopterygii sult1st2 30
  • 46 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta St2 30
  • 26 (a)
OneToMany
Species where no ortholog for SULT1C3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SULT1C3 Gene

ENSEMBL:
Gene Tree for SULT1C3 (if available)
TreeFam:
Gene Tree for SULT1C3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT1C3: view image
Alliance of Genome Resources:
Additional Orthologs for SULT1C3

Paralogs for SULT1C3 Gene

(14) SIMAP similar genes for SULT1C3 Gene using alignment to 1 proteins:

  • ST1C3_HUMAN

Pseudogenes.org Pseudogenes for SULT1C3 Gene

genes like me logo Genes that share paralogs with SULT1C3: view

Variants for SULT1C3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT1C3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs112050262 Benign: not specified 108,247,302(+) G/A
NM_001008743.3(SULT1C3):c.108G>A (p.Trp36Ter)
NONSENSE
rs11903659 Benign: not provided 108,252,454(+) G/Ap.Ala88Thr
NM_001008743.3(SULT1C3):c.262G>A (p.Ala88Thr)
MISSENSE
rs61743196 Benign: not provided 108,258,814(+) G/A
NM_001008743.3(SULT1C3):c.607G>A (p.Glu203Lys)
MISSENSE
rs17035911 -- p.Tyr148Cys
rs2219078 -- p.Gly179Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SULT1C3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SULT1C3 Gene

Variant ID Type Subtype PubMed ID
dgv153e55 CNV gain 17911159
dgv4034n100 CNV gain 25217958
dgv4035n100 CNV gain 25217958
dgv4036n100 CNV gain 25217958
dgv724e199 CNV deletion 23128226
esv2720498 CNV deletion 23290073
esv2759081 CNV gain 17122850
esv3591913 CNV gain 21293372
nsv527491 CNV loss 19592680
nsv527686 CNV gain 19592680
nsv834327 CNV gain 17160897

Variation tolerance for SULT1C3 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.44; 95.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT1C3 Gene

Human Gene Mutation Database (HGMD)
SULT1C3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1C3
Leiden Open Variation Database (LOVD)
SULT1C3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C3 Gene

Disorders for SULT1C3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SULT1C3 Gene - From: COP

Disorder Aliases PubMed IDs
mannosidosis, alpha b, lysosomal
  • mansa
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SULT1C3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SULT1C3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1C3 Gene

Publications for SULT1C3 Gene

  1. Structural and chemical profiling of the human cytosolic sulfotransferases. (PMID: 17425406) Allali-Hassani A … Arrowsmith CH (PLoS biology 2007) 2 3 4
  2. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. (PMID: 14676822) Freimuth RR … Weinshilboum RM (The pharmacogenomics journal 2004) 2 3 4
  3. Human Cytosolic Sulphotransferase SULT1C3: genomic analysis and functional characterization of splice variant SULT1C3a and SULT1C3d. (PMID: 28992322) Kurogi K … Liu MC (Journal of biochemistry 2017) 3 4
  4. Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function. (PMID: 24335392) Duniec-Dmuchowski Z … Kocarek TA (Drug metabolism and disposition: the biological fate of chemicals 2014) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40

Products for SULT1C3 Gene

Sources for SULT1C3 Gene