Aliases for SULT1C3 Gene
External Ids for SULT1C3 Gene
Previous GeneCards Identifiers for SULT1C3 Gene
GeneCards Summary for SULT1C3 Gene
SULT1C3 (Sulfotransferase Family 1C Member 3) is a Protein Coding gene. Diseases associated with SULT1C3 include Mannosidosis, Alpha B, Lysosomal. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and alcohol sulfotransferase activity. An important paralog of this gene is SULT1C4.
UniProtKB/Swiss-Prot Summary for SULT1C3 Gene
[Isoform 1]: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro phenols and hydroxypyrenes. Lithocholic acid appears to be the best substrate among the endogenous compounds tested and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol shows the highest specific activity among the xenobiotic compounds.
[Isoform 2]: Exhibits weak sulphating activity and only toward chloro phenols (pentachlorophenol and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol).