Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsib... See more...

Aliases for SULT1C2 Gene

Aliases for SULT1C2 Gene

  • Sulfotransferase Family 1C Member 2 2 3 5
  • Sulfotransferase Family, Cytosolic, 1C, Member 1 2 3
  • Sulfotransferase Family, Cytosolic, 1C, Member 2 2 3
  • Sulfotransferase 1C2 3 4
  • Sulfotransferase 1C1 3 4
  • HumSULTC2 3 4
  • SULT1C#1 3 4
  • SULT1C1 3 4
  • ST1C1 2 3
  • ST1C2 3 4
  • EC 2.8.2.1 50
  • EC 2.8.2.2 50
  • EC 2.8.2.- 4
  • EC 2.8.2 50
  • SULT1C2 5

External Ids for SULT1C2 Gene

Previous HGNC Symbols for SULT1C2 Gene

  • SULT1C1

Previous GeneCards Identifiers for SULT1C2 Gene

  • GC02P106899
  • GC02P107474
  • GC02P108469
  • GC02P108486
  • GC02P108488
  • GC02P108452
  • GC02P108272
  • GC02P108905
  • GC02P102504

Summaries for SULT1C2 Gene

Entrez Gene Summary for SULT1C2 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1C2 Gene

SULT1C2 (Sulfotransferase Family 1C Member 2) is a Protein Coding gene. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C4.

UniProtKB/Swiss-Prot Summary for SULT1C2 Gene

  • Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Gene Wiki entry for SULT1C2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT1C2 Gene

Genomics for SULT1C2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SULT1C2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT1C2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT1C2

Top Transcription factor binding sites by QIAGEN in the SULT1C2 gene promoter:
  • AP-4
  • C/EBPalpha
  • CUTL1
  • GR
  • GR-alpha
  • Pbx1a
  • YY1
  • Zic1
  • ZIC2
  • Zic3

Genomic Locations for SULT1C2 Gene

Latest Assembly
chr2:108,288,639-108,309,915
(GRCh38/hg38)
Size:
21,277 bases
Orientation:
Plus strand

Previous Assembly
chr2:108,905,351-108,926,371
(GRCh37/hg19 by Entrez Gene)
Size:
21,021 bases
Orientation:
Plus strand

chr2:108,905,095-108,926,371
(GRCh37/hg19 by Ensembl)
Size:
21,277 bases
Orientation:
Plus strand

Genomic View for SULT1C2 Gene

Genes around SULT1C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1C2 Gene

Proteins for SULT1C2 Gene

  • Protein details for SULT1C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00338-ST1C2_HUMAN
    Recommended name:
    Sulfotransferase 1C2
    Protein Accession:
    O00338
    Secondary Accessions:
    • B2R813
    • Q53SG4

    Protein attributes for SULT1C2 Gene

    Size:
    296 amino acids
    Molecular mass:
    34880 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SULT1C2 Gene

    Alternative splice isoforms for SULT1C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SULT1C2 Gene

Selected DME Specific Peptides for SULT1C2 Gene

O00338:
  • WGSWFDHVKGWWE
  • FTVAQNE
  • RKGTVGDWKNHFTVAQ
  • GDWKNHFTVAQ
  • YVARNAKD
  • SFWENNCK
  • KDCMVSYYHF
  • ETSFEKMK
  • RHPFIEW
  • EYFETFINGKV

Post-translational modifications for SULT1C2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for SULT1C2 Gene

Gene Families for SULT1C2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SULT1C2 Gene

InterPro:
Blocks:
  • Sulfotransferase

Suggested Antigen Peptide Sequences for SULT1C2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51893, highly similar to Sulfotransferase 1C1 (EC 2.8.2.-) (B4DLP0_HUMAN)
  • humSULTC2 (ST1C2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00338

UniProtKB/Swiss-Prot:

ST1C2_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1C2: view

Function for SULT1C2 Gene

Molecular function for SULT1C2 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Enzyme Numbers (IUBMB) for SULT1C2 Gene

Phenotypes From GWAS Catalog for SULT1C2 Gene

Gene Ontology (GO) - Molecular Function for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IBA 21873635
GO:0005515 protein binding IPI 21044950
GO:0008146 sulfotransferase activity IEA,IDA 19548878
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT1C2: view
genes like me logo Genes that share phenotypes with SULT1C2: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SULT1C2

miRNA for SULT1C2 Gene

miRTarBase miRNAs that target SULT1C2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1C2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1C2 Gene

Localization for SULT1C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1C2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1C2 gene
Compartment Confidence
cytosol 5
peroxisome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1C2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT1C2 Gene

Pathways & Interactions for SULT1C2 Gene

genes like me logo Genes that share pathways with SULT1C2: view

Pathways by source for SULT1C2 Gene

Gene Ontology (GO) - Biological Process for SULT1C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009308 amine metabolic process TAS 9169148
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS --
GO:0051923 sulfation IDA 19548878
genes like me logo Genes that share ontologies with SULT1C2: view

No data available for SIGNOR curated interactions for SULT1C2 Gene

Drugs & Compounds for SULT1C2 Gene

(4) Drugs for SULT1C2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methyldopa Approved Pharma Enzyme, substrate 19
Pindolol Approved, Investigational Pharma Enzyme, substrate beta3 partial agonist 16
Terbutaline Approved Pharma Enzyme, substrate 52
Thyroid, porcine Approved Pharma Enzyme, substrate 0

(1) Additional Compounds for SULT1C2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SULT1C2: view

Transcripts for SULT1C2 Gene

mRNA/cDNA for SULT1C2 Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1C2

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1C2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - -

Relevant External Links for SULT1C2 Gene

GeneLoc Exon Structure for
SULT1C2

Expression for SULT1C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT1C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT1C2 Gene

This gene is overexpressed in Kidney - Cortex (x19.8), Stomach (x17.8), and Thyroid (x5.1).

Protein differential expression in normal tissues from HIPED for SULT1C2 Gene

This gene is overexpressed in Stomach (38.5), Kidney (10.9), and Cardia (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SULT1C2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT1C2

SOURCE GeneReport for Unigene cluster for SULT1C2 Gene:

Hs.436123

mRNA Expression by UniProt/SwissProt for SULT1C2 Gene:

O00338-ST1C2_HUMAN
Tissue specificity: Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver.

Evidence on tissue expression from TISSUES for SULT1C2 Gene

  • Kidney(4.6)
  • Stomach(4.5)
  • Lung(4.2)
  • Spleen(4)
  • Thyroid gland(2.3)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with SULT1C2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1C2 Gene

Orthologs for SULT1C2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1C2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SULT1C2 29 30
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SULT1C2 29 30
  • 85.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sult1c2 29 16 30
  • 82.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SULT1C2 29 30
  • 79.59 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 56 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia SULT1C2 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sult1b1 29
  • 58.68 (n)
Str.1113 29
African clawed frog
(Xenopus laevis)
Amphibia sult1c1-prov 29
Zebrafish
(Danio rerio)
Actinopterygii sult1st6 29 30
  • 58.59 (n)
ManyToMany
sult1st1 30
  • 41 (a)
ManyToMany
sult1st3 30
  • 41 (a)
ManyToMany
sult1st7 30
  • 41 (a)
ManyToMany
sult1st8 30
  • 41 (a)
ManyToMany
sult1st4 30
  • 40 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG5428 31
  • 34 (a)
CG6704 31
  • 32 (a)
St2 30
  • 29 (a)
OneToMany
CG16733 31
  • 29 (a)
Species where no ortholog for SULT1C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SULT1C2 Gene

ENSEMBL:
Gene Tree for SULT1C2 (if available)
TreeFam:
Gene Tree for SULT1C2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT1C2: view image
Alliance of Genome Resources:
Additional Orthologs for SULT1C2

Paralogs for SULT1C2 Gene

(14) SIMAP similar genes for SULT1C2 Gene using alignment to 6 proteins:

  • ST1C2_HUMAN
  • B4DLP0_HUMAN
  • B8ZZF7_HUMAN
  • C9JSR0_HUMAN
  • H7BZ17_HUMAN
  • H7C420_HUMAN

Pseudogenes.org Pseudogenes for SULT1C2 Gene

genes like me logo Genes that share paralogs with SULT1C2: view

Variants for SULT1C2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT1C2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs143858235 Benign: not provided 108,308,425(+) GA/G
NM_001056.4(SULT1C2):c.853del (p.Met285fs)
FRAMESHIFT
rs146820413 Benign: not provided 108,305,433(+) C/T
NM_001056.4(SULT1C2):c.616C>T (p.Arg206Trp)
MISSENSE
rs17036055 Benign: not provided 108,294,279(+) G/A
NM_001056.4(SULT1C2):c.202G>A (p.Val68Met)
MISSENSE
rs17036092 Benign: not provided 108,304,705(+) G/A
NM_001056.4(SULT1C2):c.502+5G>A
INTRON
rs17838479 Benign: not provided 108,293,799(+) C/T
NM_001056.4(SULT1C2):c.132C>T (p.Ile44=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SULT1C2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SULT1C2 Gene

Variant ID Type Subtype PubMed ID
dgv153e55 CNV gain 17911159
dgv4034n100 CNV gain 25217958
dgv4035n100 CNV gain 25217958
dgv4036n100 CNV gain 25217958
dgv724e199 CNV deletion 23128226
esv2720498 CNV deletion 23290073
esv2759081 CNV gain 17122850
esv3591913 CNV gain 21293372
esv3591924 CNV gain 21293372
nsv1005832 CNV gain 25217958
nsv10112 CNV gain 18304495
nsv527491 CNV loss 19592680
nsv527686 CNV gain 19592680
nsv582640 CNV loss 21841781
nsv834327 CNV gain 17160897

Variation tolerance for SULT1C2 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT1C2 Gene

Human Gene Mutation Database (HGMD)
SULT1C2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1C2
Leiden Open Variation Database (LOVD)
SULT1C2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1C2 Gene

Disorders for SULT1C2 Gene

Additional Disease Information for SULT1C2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for SULT1C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1C2 Gene

Publications for SULT1C2 Gene

  1. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. (PMID: 10783263) Freimuth RR … Weinshilboum RM (Genomics 2000) 2 3 4 22
  2. Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization. (PMID: 9169148) Her C … Weinshilboum RM (Genomics 1997) 2 3 4 22
  3. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). (PMID: 16804942) Dombrovski L … Plotnikov AN (Proteins 2006) 3 4 22
  4. Molecular characterization of ST1C1-related human sulfotransferase. (PMID: 9635888) Yoshinari K … Yamazoe Y (Carcinogenesis 1998) 3 4 22
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 40

Products for SULT1C2 Gene

Sources for SULT1C2 Gene