Aliases for SULT1C2 Gene
External Ids for SULT1C2 Gene
Previous HGNC Symbols for SULT1C2 Gene
Previous GeneCards Identifiers for SULT1C2 Gene
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SULT1C2 Gene
SULT1C2 (Sulfotransferase Family 1C Member 2) is a Protein Coding gene. Diseases associated with SULT1C2 include Colon Mucinous Adenocarcinoma and Macular Dystrophy, Corneal. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity. An important paralog of this gene is SULT1C4.
UniProtKB/Swiss-Prot for SULT1C2 Gene
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).