Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of oth... See more...

Aliases for SULT1B1 Gene

Aliases for SULT1B1 Gene

  • Sulfotransferase Family 1B Member 1 2 3 5
  • ST1B2 2 3 4
  • Sulfotransferase Family, Cytosolic, 1B, Member 1 2 3
  • Sulfotransferase Family Cytosolic 1B Member 1 3 4
  • Thyroid Hormone Sulfotransferase 3 4
  • Sulfotransferase 1B1 3 4
  • Sulfotransferase 1B2 3 4
  • SULT1B2 3 4
  • ST1B1 3 4
  • EC 2.8.2.1 50
  • EC 2.8.2.4 50
  • EC 2.8.2.- 4
  • EC 2.8.2 50
  • SULT1B1 5

External Ids for SULT1B1 Gene

Previous GeneCards Identifiers for SULT1B1 Gene

  • GC04M070507
  • GC04M070641
  • GC04M070842
  • GC04M070909
  • GC04M070910
  • GC04M070773
  • GC04M066390
  • GC04M070586

Summaries for SULT1B1 Gene

Entrez Gene Summary for SULT1B1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1B1 Gene

SULT1B1 (Sulfotransferase Family 1B Member 1) is a Protein Coding gene. Among its related pathways are Sulfation Biotransformation Reaction and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1E1.

UniProtKB/Swiss-Prot Summary for SULT1B1 Gene

  • Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.

Gene Wiki entry for SULT1B1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT1B1 Gene

Genomics for SULT1B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SULT1B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J069757 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 275.4 +28.5 28458 4 ATF3 YY1 FOXA2 RXRA ZBTB33 JUND NFE2 SPI1 HNF4A FOXA1 SULT1B1 piR-36393-391 CSN1S1 HSALNG0034989 UGT2A1
GH04J069787 Promoter 0.4 EPDnew 250.7 0.0 -23 0.1 EP300 SULT1B1 SULT1D1P ENSG00000284695
GH04J069786 Enhancer 0.2 Ensembl 250.7 +1.2 1160 0.4 SULT1B1 piR-56759-433 UGT2A1
GH04J069829 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 24 -43.6 -43630 6.4 BCLAF1 SSRP1 CEBPA CHD4 YY1 BCL11A FOXA1 KLF11 HOMEZ CTCF HSALNG0034990 SULT1B1 SULT1E1 CSN1S1 UGT2A2 piR-36921-029 HSALNG0034991 ENSG00000284695
GH04J069713 Enhancer 1 FANTOM5 Ensembl 29.1 +74.1 74060 2.2 CEBPA ATF3 YY1 CEBPB THAP11 FOXA2 RXRA SAP130 MIER3 RARA SULT1B1 CSN1S1 HSALNG0034988 piR-32461-126 UGT2A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT1B1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT1B1

Top Transcription factor binding sites by QIAGEN in the SULT1B1 gene promoter:
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • Evi-1
  • Meis-1b
  • POU2F1
  • POU2F1a
  • USF-1
  • USF1

Genomic Locations for SULT1B1 Gene

Latest Assembly
chr4:69,721,167-69,787,961
(GRCh38/hg38)
Size:
66,795 bases
Orientation:
Minus strand

Previous Assembly
chr4:70,586,885-70,626,338
(GRCh37/hg19 by Entrez Gene)
Size:
39,454 bases
Orientation:
Minus strand

chr4:70,586,880-70,653,679
(GRCh37/hg19 by Ensembl)
Size:
66,800 bases
Orientation:
Minus strand

Genomic View for SULT1B1 Gene

Genes around SULT1B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1B1 Gene

Proteins for SULT1B1 Gene

  • Protein details for SULT1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43704-ST1B1_HUMAN
    Recommended name:
    Sulfotransferase family cytosolic 1B member 1
    Protein Accession:
    O43704
    Secondary Accessions:
    • O15497
    • Q96FI1
    • Q9UK34

    Protein attributes for SULT1B1 Gene

    Size:
    296 amino acids
    Molecular mass:
    34899 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for SULT1B1 Gene

neXtProt entry for SULT1B1 Gene

Selected DME Specific Peptides for SULT1B1 Gene

O43704:
  • FTVAQNE
  • PKSGTTW
  • SPFMRKG
  • YEDMKENPK
  • GDWKNYFT
  • SFWENNCK
  • SPRIVKTHLP

Post-translational modifications for SULT1B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1B1 Gene

Domains & Families for SULT1B1 Gene

Gene Families for SULT1B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SULT1B1 Gene

InterPro:
Blocks:
  • Sulfotransferase

Suggested Antigen Peptide Sequences for SULT1B1 Gene

GenScript: Design optimal peptide antigens:
  • Thyroid hormone sulfotransferase (ST1B1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43704

UniProtKB/Swiss-Prot:

ST1B1_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1B1: view

Function for SULT1B1 Gene

Molecular function for SULT1B1 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.

Enzyme Numbers (IUBMB) for SULT1B1 Gene

Phenotypes From GWAS Catalog for SULT1B1 Gene

Gene Ontology (GO) - Molecular Function for SULT1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IDA 23207770
GO:0005515 protein binding IPI 21044950
GO:0008146 sulfotransferase activity IEA,IDA 9463486
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SULT1B1: view
genes like me logo Genes that share phenotypes with SULT1B1: view

Animal Models for SULT1B1 Gene

MGI Knock Outs for SULT1B1:

miRNA for SULT1B1 Gene

miRTarBase miRNAs that target SULT1B1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1B1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SULT1B1 Gene

Localization for SULT1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1B1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1B1 gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SULT1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1B1: view

Pathways & Interactions for SULT1B1 Gene

genes like me logo Genes that share pathways with SULT1B1: view

Pathways by source for SULT1B1 Gene

Gene Ontology (GO) - Biological Process for SULT1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0006576 cellular biogenic amine metabolic process TAS 9443824
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process IEA,IDA 20056724
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with SULT1B1: view

No data available for SIGNOR curated interactions for SULT1B1 Gene

Drugs & Compounds for SULT1B1 Gene

(10) Drugs for SULT1B1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Apomorphine Approved, Investigational Pharma Enzyme, substrate 49
Methyldopa Approved Pharma Enzyme, substrate 19
Pindolol Approved, Investigational Pharma Enzyme, substrate beta3 partial agonist 16
Terbutaline Approved Pharma Enzyme, substrate 52
Thyroid, porcine Approved Pharma Enzyme, substrate 0
genes like me logo Genes that share compounds with SULT1B1: view

Transcripts for SULT1B1 Gene

mRNA/cDNA for SULT1B1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1B1

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1B1 Gene

No ASD Table

Relevant External Links for SULT1B1 Gene

GeneLoc Exon Structure for
SULT1B1

Expression for SULT1B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT1B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULT1B1 Gene

This gene is overexpressed in Whole Blood (x19.7), Colon - Transverse (x9.4), and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for SULT1B1 Gene

This gene is overexpressed in Gallbladder (12.0), Fetal gut (11.5), Rectum (9.0), and Colon (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SULT1B1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT1B1

SOURCE GeneReport for Unigene cluster for SULT1B1 Gene:

Hs.129742

mRNA Expression by UniProt/SwissProt for SULT1B1 Gene:

O43704-ST1B1_HUMAN
Tissue specificity: Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus.

Evidence on tissue expression from TISSUES for SULT1B1 Gene

  • Liver(4.6)
  • Bone marrow(4)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with SULT1B1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1B1 Gene

Orthologs for SULT1B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1B1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SULT1B1 29 30
  • 99.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SULT1B1 29 30
  • 87.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SULT1B1 29 30
  • 86.82 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sult1b1 29 16 30
  • 80.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sult1b1 29
  • 79.28 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SULT1B1 30
  • 67 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 64 (a)
OneToMany
-- 30
  • 35 (a)
OneToMany
Chicken
(Gallus gallus)
Aves SULT1B1 29 30
  • 62.28 (n)
OneToMany
-- 30
  • 59 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia SULT1B1 30
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC779590 29
  • 63.74 (n)
Str.12317 29
Zebrafish
(Danio rerio)
Actinopterygii sult1st2 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010987 29
  • 45.51 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta St1 29
  • 44.89 (n)
CG5428 31
  • 33 (a)
CG6704 31
  • 31 (a)
CG16733 31
  • 29 (a)
Worm
(Caenorhabditis elegans)
Secernentea ssu-1 29
  • 51.42 (n)
Y113G7A.11 31
  • 32 (a)
Species where no ortholog for SULT1B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SULT1B1 Gene

ENSEMBL:
Gene Tree for SULT1B1 (if available)
TreeFam:
Gene Tree for SULT1B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT1B1: view image
Alliance of Genome Resources:
Additional Orthologs for SULT1B1

Paralogs for SULT1B1 Gene

(13) SIMAP similar genes for SULT1B1 Gene using alignment to 3 proteins:

  • ST1B1_HUMAN
  • D6RD70_HUMAN
  • D6RIA8_HUMAN

Pseudogenes.org Pseudogenes for SULT1B1 Gene

genes like me logo Genes that share paralogs with SULT1B1: view

Variants for SULT1B1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT1B1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11569736 Benign: not provided 69,734,207(-) A/C
NM_014465.4(SULT1B1):c.433T>G (p.Leu145Val)
MISSENSE
rs140281103 Benign: not provided 69,754,755(-) A/G
NM_014465.4(SULT1B1):c.192T>C (p.Asp64=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SULT1B1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SULT1B1 Gene

Variant ID Type Subtype PubMed ID
nsv594641 CNV loss 21841781

Variation tolerance for SULT1B1 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT1B1 Gene

Human Gene Mutation Database (HGMD)
SULT1B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1B1
Leiden Open Variation Database (LOVD)
SULT1B1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1B1 Gene

Disorders for SULT1B1 Gene

Additional Disease Information for SULT1B1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for SULT1B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1B1 Gene

Publications for SULT1B1 Gene

  1. Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. (PMID: 9443824) Fujita K … Yamazoe Y (Journal of biochemistry 1997) 2 3 4 22
  2. Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene. (PMID: 11688987) Meinl W … Glatt H (Biochemical and biophysical research communications 2001) 2 3 22
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 40
  4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross CJ … CPNDS Consortium (Nature genetics 2009) 3 40
  5. Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). (PMID: 16804942) Dombrovski L … Plotnikov AN (Proteins 2006) 3 4

Products for SULT1B1 Gene

Sources for SULT1B1 Gene