Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activ... See more...

Aliases for SULT1A4 Gene

Aliases for SULT1A4 Gene

  • Sulfotransferase Family 1A Member 4 2 3 5
  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 4 2 3
  • Aryl Sulfotransferase 1A3/1A4 3 4
  • Sulfotransferase 1A4 3 4
  • ST1A4 3 4
  • Catecholamine-Sulfating Phenol Sulfotransferase 3
  • Monoamine-Sulfating Phenol Sulfotransferase 3
  • Sulfotransferase, Monoamine-Preferring 3
  • Thermolabile Phenol Sulfotransferase 3
  • Placental Estrogen Sulfotransferase 3
  • Sulfotransferase 1A3/1A4 4
  • Sulfotransferase 1A3 3
  • SLX1B-SULT1A4 3
  • ST1A3/ST1A4 3
  • Sulfokinase 3
  • EC 2.8.2.1 4
  • SULT1A4 5
  • TL-PST 3
  • HAST3 3
  • M-PST 3
  • ST1A3 3
  • STM 3

External Ids for SULT1A4 Gene

Previous GeneCards Identifiers for SULT1A4 Gene

  • GC16U900494
  • GC16P029375
  • GC16P029378
  • GC16P029466
  • GC16P029479
  • GC16P029484

Summaries for SULT1A4 Gene

Entrez Gene Summary for SULT1A4 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

GeneCards Summary for SULT1A4 Gene

SULT1A4 (Sulfotransferase Family 1A Member 4) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Sulfation Biotransformation Reaction. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1A3.

UniProtKB/Swiss-Prot Summary for SULT1A4 Gene

  • Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Additional gene information for SULT1A4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT1A4 Gene

Genomics for SULT1A4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SULT1A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J029459 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 600.7 +0.3 288 0.8 SULT1A4 ENSG00000279228 SLX1B-SULT1A4 NPIPB12
GH16J029457 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.7 -2.0 -1978 0.1 SULT1A4 BOLA2 BOLA2-SMG1P6 SLX1B SLX1B-SULT1A4
GH16J029461 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.7 +1.5 1505 0.1 SULT1A4 ENSG00000279228 SLX1B-SULT1A4 NPIPB12
GH16J030089 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 +634.1 634097 9.2 ZNF221 HNRNPL CREB1 GATAD2A CTCF ZBTB33 TEAD4 PRDM10 ZNF629 REST YPEL3 TBX6 lnc-PPP4C-2 SRCAP INO80E SMG1P2 SMG1P5 BCL7C PRR14 ZNF764
GH16J029803 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +350.8 350829 14.9 ZNF221 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 REST PRRT2 ENSG00000280893 LOC112268170 MAZ piR-45320 piR-53734 piR-50884 piR-51020 PAGR1 SRCAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT1A4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT1A4

Top Transcription factor binding sites by QIAGEN in the SULT1A4 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • SRF (504 AA)

Genomic Locations for SULT1A4 Gene

Genomic Locations for SULT1A4 Gene
chr16:29,459,913-29,464,966
(GRCh38/hg38)
Size:
5,054 bases
Orientation:
Plus strand
chr16:29,467,127-29,476,301
(GRCh37/hg19)
Size:
9,175 bases
Orientation:
Plus strand

Genomic View for SULT1A4 Gene

Genes around SULT1A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A4 Gene

Proteins for SULT1A4 Gene

  • Protein details for SULT1A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMN0-ST1A4_HUMAN
    Recommended name:
    Sulfotransferase 1A4
    Protein Accession:
    P0DMN0
    Secondary Accessions:
    • B4DNV0
    • O95603
    • P50224
    • Q1ET66
    • Q6ZWJ5

    Protein attributes for SULT1A4 Gene

    Size:
    295 amino acids
    Molecular mass:
    34196 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for SULT1A4 Gene

Post-translational modifications for SULT1A4 Gene

Other Protein References for SULT1A4 Gene

No data available for DME Specific Peptides for SULT1A4 Gene

Domains & Families for SULT1A4 Gene

Gene Families for SULT1A4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT1A4 Gene

Suggested Antigen Peptide Sequences for SULT1A4 Gene

GenScript: Design optimal peptide antigens:
  • Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 (Q2TAB3_HUMAN)
  • Thermolabile phenol sulfotransferase (ST1A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0DMN0

UniProtKB/Swiss-Prot:

ST1A4_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A4: view

Function for SULT1A4 Gene

Molecular function for SULT1A4 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + a phenol = a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:12164, ChEBI:CHEBI:15378, ChEBI:CHEBI:33853, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:140317; EC=2.8.2.1;.

Enzyme Numbers (IUBMB) for SULT1A4 Gene

Phenotypes From GWAS Catalog for SULT1A4 Gene

Gene Ontology (GO) - Molecular Function for SULT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IEA,IMP 9855620
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IEA,IDA 20056724
GO:0016740 transferase activity IEA --
GO:0043199 sulfate binding IDA 10543947
genes like me logo Genes that share ontologies with SULT1A4: view
genes like me logo Genes that share phenotypes with SULT1A4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1A4

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SULT1A4 Gene

Localization for SULT1A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1A4 gene
Compartment Confidence
cytosol 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SULT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT1A4 Gene

Pathways & Interactions for SULT1A4 Gene

genes like me logo Genes that share pathways with SULT1A4: view

Pathways by source for SULT1A4 Gene

1 KEGG pathway for SULT1A4 Gene
2 GeneGo (Thomson Reuters) pathways for SULT1A4 Gene
  • 2-Naphthylamine and 2-Nitronaphtalene metabolism
  • Estradiol metabolism

Gene Ontology (GO) - Biological Process for SULT1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0006584 catecholamine metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process IDA 20056724
GO:0007212 dopamine receptor signaling pathway IDA 24136195
genes like me logo Genes that share ontologies with SULT1A4: view

No data available for SIGNOR curated interactions for SULT1A4 Gene

Drugs & Compounds for SULT1A4 Gene

(2) Drugs for SULT1A4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma 1316
Morphine Approved, Investigational Pharma Agonist, Full agonist, Partial agonist 1406
genes like me logo Genes that share compounds with SULT1A4: view

Transcripts for SULT1A4 Gene

mRNA/cDNA for SULT1A4 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1A4

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A4 Gene

No ASD Table

Relevant External Links for SULT1A4 Gene

GeneLoc Exon Structure for
SULT1A4

Expression for SULT1A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT1A4 Gene

Protein differential expression in normal tissues from HIPED for SULT1A4 Gene

This gene is overexpressed in Heart (44.0) and Skin (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULT1A4 Gene



Protein tissue co-expression partners for SULT1A4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT1A4

SOURCE GeneReport for Unigene cluster for SULT1A4 Gene:

Hs.744871

mRNA Expression by UniProt/SwissProt for SULT1A4 Gene:

P0DMN0-ST1A4_HUMAN
Tissue specificity: Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.

Evidence on tissue expression from TISSUES for SULT1A4 Gene

  • Liver(2.4)
genes like me logo Genes that share expression patterns with SULT1A4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1A4 Gene

Orthologs for SULT1A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SULT1A4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC454364 30
  • 99.32 (n)
-- 31
  • 99 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia SULT1A1 31
  • 83 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SULT1A1 31
  • 81 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Sult1a1 31
  • 73 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 71 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 46 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 58 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
Species where no ortholog for SULT1A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SULT1A4 Gene

ENSEMBL:
Gene Tree for SULT1A4 (if available)
TreeFam:
Gene Tree for SULT1A4 (if available)

Paralogs for SULT1A4 Gene

(14) SIMAP similar genes for SULT1A4 Gene using alignment to 3 proteins:

  • ST1A3_HUMAN
  • H3BNY7_HUMAN
  • Q2TAB3_HUMAN
genes like me logo Genes that share paralogs with SULT1A4: view

Variants for SULT1A4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT1A4 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1460887051 - p.Pro101His
rs751527244 - p.Pro101Leu
VAR_071114 - p.Arg144Cys
VAR_071115 - p.Lys234Asn

Additional dbSNP identifiers (rs#s) for SULT1A4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SULT1A4 Gene

Variant ID Type Subtype PubMed ID
esv22245 CNV gain 19812545
esv2714183 CNV deletion 23290073
esv2758641 CNV gain 17122850
esv2758642 CNV gain 17122850
esv29892 CNV gain 19812545
esv3388213 CNV duplication 20981092
esv3392583 CNV duplication 20981092
esv3406739 CNV duplication 20981092
esv3444439 CNV duplication 20981092
esv3451126 CNV duplication 20981092
nsv1056249 CNV gain 25217958
nsv1078392 CNV duplication 25765185
nsv1078393 CNV duplication 25765185
nsv1139652 CNV duplication 24896259
nsv1141284 CNV duplication 24896259
nsv1146152 CNV duplication 26484159
nsv1148121 CNV duplication 26484159
nsv471389 CNV gain 19718026
nsv498862 CNV loss 21111241
nsv571809 CNV loss 21841781
nsv571810 CNV loss 21841781
nsv571811 CNV loss 21841781
nsv571819 CNV gain 21841781
nsv820959 CNV duplication 20802225
nsv821543 CNV duplication 20802225
nsv9426 CNV gain 18304495
nsv9431 CNV gain+loss 18304495
nsv953799 CNV deletion 24416366
nsv960011 CNV duplication 23825009
nsv977952 CNV duplication 23825009
nsv977954 CNV duplication 23825009

Additional Variant Information for SULT1A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SULT1A4 Gene

Disorders for SULT1A4 Gene

Additional Disease Information for SULT1A4

No disorders were found for SULT1A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SULT1A4 Gene

Publications for SULT1A4 Gene

  1. Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. (PMID: 15358107) Hildebrandt MA … Weinshilboum RM (Biochemical and biophysical research communications 2004) 2 3 4
  2. Phylogenomic approaches to common problems encountered in the analysis of low copy repeats: the sulfotransferase 1A gene family example. (PMID: 15752422) Bradley ME … Benner SA (BMC evolutionary biology 2005) 2 3
  3. Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes. (PMID: 31145702) Bairam AF … Liu MC (Pharmacogenetics and genomics 2019) 3
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  5. Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3. (PMID: 29705271) Bairam AF … Liu MC (Archives of biochemistry and biophysics 2018) 3

Products for SULT1A4 Gene

Sources for SULT1A4 Gene