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Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
SULT1A4 (Sulfotransferase Family 1A Member 4) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Sulfation Biotransformation Reaction. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1A3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004062 | aryl sulfotransferase activity | IEA,IMP | 9855620 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008146 | sulfotransferase activity | IEA,IDA | 20056724 |
GO:0016740 | transferase activity | IEA | -- |
GO:0043199 | sulfate binding | IDA | 10543947 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Acetaminophen Pathway (therapeutic doses), Pharmacokinetics |
2-Naphthylamine and 2-Nitronaphtalene metabolism
.31
|
|
2 | Cytochrome P450 - arranged by substrate type |
Estradiol metabolism
.01
|
|
3 | Drug metabolism - cytochrome P450 | ||
4 | Sulfation Biotransformation Reaction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006068 | ethanol catabolic process | IDA | 23207770 |
GO:0006584 | catecholamine metabolic process | IEA | -- |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006805 | xenobiotic metabolic process | IDA | 20056724 |
GO:0007212 | dopamine receptor signaling pathway | IDA | 24136195 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC454364 30 |
|
||
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | SULT1A1 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | SULT1A1 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Sult1a1 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1460887051 | - | p.Pro101His | |||
rs751527244 | - | p.Pro101Leu | |||
VAR_071114 | - | p.Arg144Cys | |||
VAR_071115 | - | p.Lys234Asn |
No disorders were found for SULT1A4 Gene.