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Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
SULT1A3 (Sulfotransferase Family 1A Member 3) is a Protein Coding gene. Diseases associated with SULT1A3 include Ceroid Lipofuscinosis, Neuronal, 3 and Epilepsy, Idiopathic Generalized 2. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and aryl sulfotransferase activity. An important paralog of this gene is SULT1A4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J030208 | Promoter/Enhancer | 0.8 | EPDnew Ensembl dbSUPER | 600.7 | +0.3 | 273 | 0.6 | SULT1A3 ENSG00000278887 SLX1A-SULT1A3 NPIPB13 | ||
GH16J030200 | Promoter/Enhancer | 0.5 | EPDnew dbSUPER | 600.7 | +1.5 | 1533 | 0.1 | SULT1A3 ENSG00000278887 SLX1A-SULT1A3 NPIPB13 | ||
GH16J030204 | Promoter/Enhancer | 0.5 | EPDnew dbSUPER | 600.7 | +0.6 | 606 | 0.1 | SULT1A3 ENSG00000278887 SLX1A-SULT1A3 NPIPB13 | ||
GH16J030199 | Promoter/Enhancer | 0.5 | Ensembl dbSUPER | 600.7 | -0.3 | -327 | 0.2 | SULT1A3 BOLA2B SLX1A-SULT1A3 | ||
GH16J030198 | Enhancer | 0.2 | dbSUPER | 600.7 | -0.7 | -743 | 0.6 | SULT1A3 BOLA2B SLX1A-SULT1A3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004062 | aryl sulfotransferase activity | IMP | 9855620 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008146 | sulfotransferase activity | IEA,IDA | 20056724 |
GO:0016740 | transferase activity | IEA | -- |
GO:0043199 | sulfate binding | IDA | 10543947 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
Estradiol metabolism
.01
|
|
2 | Acetaminophen Pathway (therapeutic doses), Pharmacokinetics |
2-Naphthylamine and 2-Nitronaphtalene metabolism
.31
|
|
3 | Unfolded Protein Response (UPR) | ||
4 | Drug metabolism - cytochrome P450 | ||
5 | Propranolol Pathway, Pharmacokinetics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006068 | ethanol catabolic process | IDA | 23207770 |
GO:0006584 | catecholamine metabolic process | IEA | -- |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006805 | xenobiotic metabolic process | IDA | 20056724 |
GO:0007212 | dopamine receptor signaling pathway | IDA | 24136195 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Acetaminophen | Approved | Pharma | Enzyme, substrate | 1316 | ||
Phenol | Approved, Experimental | Pharma | 69 | |||
Apomorphine | Approved, Investigational | Pharma | Agonist, Partial agonist, Antagonist, Full agonist, Activator, Activation, Enzyme, substrate | 48 | ||
Ethinyl Estradiol | Approved | Pharma | Enzyme, substrate | Oral contraceptive | 551 | |
Phenylephrine | Approved | Pharma | Agonist, Full agonist, Enzyme, substrate | 566 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(+)-Catechin 6-C-glucoside |
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105371-27-5 |
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(+)-Catechin 8-C-glucoside |
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105371-26-4 |
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(1E)-1-(4-hydroxyphenyl)pent-1-en-3-one |
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(2E)-1-(3-hydroxyphenyl)-3-phenylprop-2-en-1-one |
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(2E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC454364 30 |
|
||
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | SULT1A1 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | SULT1A1 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Sult1a1 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5428 32 |
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CG5431 32 |
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CG16733 32 |
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SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs751527244 | -. - | p.Pro101Hisp.Pro101Leu | |||
rs1293732453 | - | p.Arg144Cys | |||
rs1328799050 | - | p.Lys234Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
ceroid lipofuscinosis, neuronal, 3 |
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epilepsy, idiopathic generalized 2 |
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dengue shock syndrome |
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antiphospholipid syndrome |
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stroke, ischemic |
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