Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable en... See more...

Aliases for SULT1A2 Gene

Aliases for SULT1A2 Gene

  • Sulfotransferase Family 1A Member 2 2 3 5
  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 2 2 3
  • Phenol-Sulfating Phenol Sulfotransferase 2 3 4
  • Phenol Sulfotransferase 2 3 4
  • Aryl Sulfotransferase 2 3 4
  • Sulfotransferase 1A2 3 4
  • EC 2.8.2.1 4 52
  • P-PST 2 3 4
  • ST1A2 3 4
  • STP2 3 4
  • Phenol-Preferring Phenol Sulfotransferase2 3
  • Phenolic-Metabolizing (P) Form Of PST 3
  • Thermostable Phenol Sulfotransferase 3
  • Arylamine Sulfotransferase 3
  • EC 2.8.2 52
  • TSPST2 3
  • HAST4 3
  • P-PST 3

External Ids for SULT1A2 Gene

Previous HGNC Symbols for SULT1A2 Gene

  • STP2

Previous GeneCards Identifiers for SULT1A2 Gene

  • GC16M028947
  • GC16P028687
  • GC16P028432
  • GC16P028496
  • GC16P028470
  • GC16M028510
  • GC16M028603
  • GC16M026628

Summaries for SULT1A2 Gene

Entrez Gene Summary for SULT1A2 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1A2 Gene

SULT1A2 (Sulfotransferase Family 1A Member 2) is a Protein Coding gene. Diseases associated with SULT1A2 include Pneumonic Plague and Bubonic Plague. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1A1.

UniProtKB/Swiss-Prot Summary for SULT1A2 Gene

  • Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Gene Wiki entry for SULT1A2 Gene

Additional gene information for SULT1A2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SULT1A2 Gene

Genomics for SULT1A2 Gene

GeneHancer (GH) Regulatory Elements for SULT1A2 Gene

Promoters and enhancers for SULT1A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J028608 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 542.5 -13.0 -13042 3.1 ZSCAN5C POLR2G ZIC2 TGIF2 TEAD1 ZBTB26 ZKSCAN8 CTBP1 ZSCAN9 SIN3A SULT1A2 SULT1A1 piR-49161-002 ENSG00000251417 TUFM piR-43326
GH16J028596 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 541.4 -1.6 -1645 5.3 FOXK2 CTCF POLR2G NCOR1 ZIC2 KDM6A TGIF2 SKI TEAD1 MIER1 SULT1A2 piR-49161-001 TUFM SGF29 ENSG00000278665
GH16J028622 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 504.5 -26.2 -26188 1.9 ZFX RFX1 SKI POLR2A SIN3A E2F1 SMARCB1 SMAD4 MAX RARA SULT1A2 NPIPB8 SULT1A1 TUFM piR-45772-002
GH16J028490 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 59.2 +103.2 103248 7.3 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 MYC TCF12 POLR2G USF1 APOBR CLN3 ENSG00000261832 lnc-CLN3-1 lnc-IL27-1 SULT1A2 SH2B1 ENSG00000261766 ENSG00000251417 CDC37P1
GH16J028553 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 58.5 +43.0 42982 2.2 ZNF217 EP300 CTCF NRF1 POLR2G GTF2E2 PHF8 SIX5 POLR2A CLOCK ENSG00000275441 SGF29 SULT1A2 SULT1A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SULT1A2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SULT1A2

Top Transcription factor binding sites by QIAGEN in the SULT1A2 gene promoter:
  • STAT3

Genomic Locations for SULT1A2 Gene

Genomic Locations for SULT1A2 Gene
chr16:28,591,943-28,597,083
(GRCh38/hg38)
Size:
5,141 bases
Orientation:
Minus strand
chr16:28,603,264-28,608,430
(GRCh37/hg19)
Size:
5,167 bases
Orientation:
Minus strand

Genomic View for SULT1A2 Gene

Genes around SULT1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A2 Gene

Proteins for SULT1A2 Gene

  • Protein details for SULT1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50226-ST1A2_HUMAN
    Recommended name:
    Sulfotransferase 1A2
    Protein Accession:
    P50226
    Secondary Accessions:
    • A9QY25
    • P78393
    • Q14CJ7

    Protein attributes for SULT1A2 Gene

    Size:
    295 amino acids
    Molecular mass:
    34310 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1A2 Gene

neXtProt entry for SULT1A2 Gene

Selected DME Specific Peptides for SULT1A2 Gene

P50226:
  • FTVAQNE
  • ILDMIYQ
  • YVARNAKD
  • LYLFYED
  • PKSGTTW
  • TPAPRLLKTHLPL
  • SPFMRKG
  • PKREIQK
  • YEDMKENPK
  • VSYYHFY
  • PLIKYFAE
  • FQARPDD
  • LLDQKVKV

Post-translational modifications for SULT1A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SULT1A2 Gene

Domains & Families for SULT1A2 Gene

Gene Families for SULT1A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT1A2 Gene

Blocks:
  • Sulfotransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SULT1A2 Gene

GenScript: Design optimal peptide antigens:
  • Phenol-sulfating phenol sulfotransferase 2 (ST1A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50226

UniProtKB/Swiss-Prot:

ST1A2_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A2: view

Function for SULT1A2 Gene

Molecular function for SULT1A2 Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + a phenol = a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:12164, ChEBI:CHEBI:15378, ChEBI:CHEBI:33853, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:140317; EC=2.8.2.1; Evidence=. ;.
GENATLAS Biochemistry:
aryl (phenol) sulfotransferase 2,phenol preferring,cytosolic

Enzyme Numbers (IUBMB) for SULT1A2 Gene

Phenotypes From GWAS Catalog for SULT1A2 Gene

Gene Ontology (GO) - Molecular Function for SULT1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity IDA 20417180
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity TAS 9119390
GO:0016740 transferase activity IEA --
GO:0047894 flavonol 3-sulfotransferase activity IDA 20056724
genes like me logo Genes that share ontologies with SULT1A2: view
genes like me logo Genes that share phenotypes with SULT1A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1A2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SULT1A2 Gene

Localization for SULT1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1A2 gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SULT1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SULT1A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT1A2 Gene

Pathways & Interactions for SULT1A2 Gene

genes like me logo Genes that share pathways with SULT1A2: view

Pathways by source for SULT1A2 Gene

1 KEGG pathway for SULT1A2 Gene
1 GeneGo (Thomson Reuters) pathway for SULT1A2 Gene
  • 2-Naphthylamine and 2-Nitronaphtalene metabolism

Gene Ontology (GO) - Biological Process for SULT1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0006584 catecholamine metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process IDA 20417180
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with SULT1A2: view

No data available for SIGNOR curated interactions for SULT1A2 Gene

Drugs & Compounds for SULT1A2 Gene

(3) Drugs for SULT1A2 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 66
conjugated estrogens Approved Pharma 0

(5) Additional Compounds for SULT1A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoadenylate
  • Adenosine 3',5'-bisphosphate
  • PAP
  • Phosphoadenosine phosphate
  • 3'-Phosphoadenylic acid
1053-73-2
Phenol sulphate
  • Phenol sulfate
  • Phenylsulfate
  • Phenol sulfuric acid
  • Phenol sulphate
  • Phenol sulphuric acid
Phosphoadenosine phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenylyl sulfate
  • PAPS
  • 3'-Phosphoadenosine 5'-phosphosulfuric acid
  • 3'-Phosphoadenosine 5'-phosphosulphate
482-67-7
genes like me logo Genes that share compounds with SULT1A2: view

Transcripts for SULT1A2 Gene

mRNA/cDNA for SULT1A2 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SULT1A2

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: - - - - - - - -
SP4: - - - - -
SP5:

Relevant External Links for SULT1A2 Gene

GeneLoc Exon Structure for
SULT1A2

Expression for SULT1A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SULT1A2 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1A2 Gene

This gene is overexpressed in Liver (x11.2), Small Intestine - Terminal Ileum (x8.0), and Colon - Transverse (x4.6).

Protein differential expression in normal tissues from HIPED for SULT1A2 Gene

This gene is overexpressed in Heart (34.8), Liver (18.1), and Skin (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SULT1A2 Gene



Protein tissue co-expression partners for SULT1A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SULT1A2

SOURCE GeneReport for Unigene cluster for SULT1A2 Gene:

Hs.546304

Evidence on tissue expression from TISSUES for SULT1A2 Gene

  • Liver(4.6)
  • Nervous system(4.2)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with SULT1A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1A2 Gene

Orthologs for SULT1A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULT1A2 31 30
  • 98.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SULT1A1 31
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SULT1A1 31
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sult1a1 31
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 59 (a)
ManyToMany
-- 31
  • 59 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5428 32
  • 33 (a)
CG16733 32
  • 28 (a)
Species where no ortholog for SULT1A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SULT1A2 Gene

ENSEMBL:
Gene Tree for SULT1A2 (if available)
TreeFam:
Gene Tree for SULT1A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SULT1A2: view image

Paralogs for SULT1A2 Gene

(14) SIMAP similar genes for SULT1A2 Gene using alignment to 4 proteins:

  • ST1A2_HUMAN
  • E9PKR8_HUMAN
  • E9PKW4_HUMAN
  • E9PM76_HUMAN
genes like me logo Genes that share paralogs with SULT1A2: view

Variants for SULT1A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SULT1A2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1059491 - p.Asn235Thr
rs10797300 - p.Pro19Leu
rs1136703 - p.Ile7Thr
rs27742 - p.Lys282Glu
rs45472392 - p.Asn239Ser

Additional dbSNP identifiers (rs#s) for SULT1A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SULT1A2 Gene

Variant ID Type Subtype PubMed ID
dgv12n14 CNV loss 18776910
dgv4971n54 CNV loss 21841781
esv2667967 CNV deletion 23128226
esv2714170 CNV deletion 23290073
esv2758640 CNV gain+loss 17122850
esv3638337 CNV gain 21293372
esv3892823 CNV gain 25118596
nsv1059555 CNV gain 25217958
nsv1066415 CNV gain 25217958
nsv1775 CNV insertion 18451855
nsv436734 CNV insertion 17901297
nsv509608 CNV insertion 20534489
nsv833182 CNV gain 17160897
nsv9416 CNV gain+loss 18304495
nsv984300 CNV duplication 23825009

Variation tolerance for SULT1A2 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.14; 90.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT1A2 Gene

Human Gene Mutation Database (HGMD)
SULT1A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SULT1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1A2 Gene

Disorders for SULT1A2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SULT1A2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pneumonic plague
  • primary pneumonic plague
bubonic plague
  • black death
plague
  • yersiniosis
septicemic plague
  • plague, septicemic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SULT1A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SULT1A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1A2 Gene

Publications for SULT1A2 Gene

  1. Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. (PMID: 8661000) Her C … Weinshilboum RM (Genomics 1996) 2 3 4 23 54
  2. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. (PMID: 8912648) Dooley TP … Huang Z (Biochemical and biophysical research communications 1996) 2 3 4 23 54
  3. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. (PMID: 12419832) Sachse C … Colorectal Cancer Study Group (Carcinogenesis 2002) 3 23 41 54
  4. Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene. (PMID: 9119390) Gaedigk A … Grant DM (Genomics 1997) 3 4 23 54
  5. cDNA cloning and expression of a new form of human aryl sulfotransferase. (PMID: 8697101) Zhu X … McManus ME (The international journal of biochemistry & cell biology 1996) 3 4 23 54

Products for SULT1A2 Gene

Sources for SULT1A2 Gene