Aliases for SULT1A2 Gene
External Ids for SULT1A2 Gene
Previous HGNC Symbols for SULT1A2 Gene
Previous GeneCards Identifiers for SULT1A2 Gene
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for SULT1A2 Gene
SULT1A2 (Sulfotransferase Family 1A Member 2) is a Protein Coding gene. Diseases associated with SULT1A2 include Pneumonic Plague and Bubonic Plague. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1A4.
UniProtKB/Swiss-Prot Summary for SULT1A2 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.