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Aliases for SULT1A1 Gene

Aliases for SULT1A1 Gene

  • Sulfotransferase Family 1A Member 1 2 3 5
  • Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 1 2 3
  • Phenol-Sulfating Phenol Sulfotransferase 1 3 4
  • Aryl Sulfotransferase 1 3 4
  • HAST1/HAST2 3 4
  • EC 4 56
  • P-PST 1 3 4
  • Ts-PST 3 4
  • ST1A1 3 4
  • ST1A3 3 4
  • STP1 3 4
  • STP 3 4
  • Thermostable Phenol Sulfotransferase1 3
  • Thermostable Phenol Sulfotransferase 4
  • Phenol Sulfotransferase 1 4
  • Sulfotransferase 1A1 3
  • EC 2.8.2 56
  • TSPST1 3
  • P-PST 3
  • PST 3

External Ids for SULT1A1 Gene

Previous HGNC Symbols for SULT1A1 Gene

  • STP
  • STP1

Previous GeneCards Identifiers for SULT1A1 Gene

  • GC16M028946
  • GC16P028674
  • GC16P028431
  • GC16P028469
  • GC16M028524
  • GC16M026642

Summaries for SULT1A1 Gene

Entrez Gene Summary for SULT1A1 Gene

  • Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SULT1A1 Gene

SULT1A1 (Sulfotransferase Family 1A Member 1) is a Protein Coding gene. Diseases associated with SULT1A1 include Mandibulofacial Dysostosis With Alopecia and Ceroid Lipofuscinosis, Neuronal, 3. Among its related pathways are superpathway of tryptophan utilization and Acetaminophen Pathway (therapeutic doses), Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1A2.

UniProtKB/Swiss-Prot for SULT1A1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Gene Wiki entry for SULT1A1 Gene

PharmGKB "VIP" Summary for SULT1A1 Gene

Additional gene information for SULT1A1 Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for SULT1A1 Gene

Genomics for SULT1A1 Gene

GeneHancer (GH) Regulatory Elements for SULT1A1 Gene

Promoters and enhancers for SULT1A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I028608 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 555.3 +13.5 13500 3.1 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF2 ZNF48 SLC30A9 ZNF121 SULT1A1 GC16P028612 GC16P028613 PIR42160 SULT1A2 ENSG00000251417 TUFM PIR36325
GH16I028622 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 354 1.9 ZNF687 CLOCK RFX1 MAX SIN3A MNT SMARCB1 RARA SKI E2F1 NPIPB8 SULT1A1 TUFM SULT1A2 PIR38771
GH16I028168 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 23.6 +454.6 454592 1.8 DPF2 ZKSCAN1 XPO6 SULT1A1 APOBR GC16P028181 TPRKBP2
GH16I028173 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 22.9 +449.2 449171 2.3 HDGF SULT1A1 XPO6 APOBR GC16P028181 TPRKBP2
GH16I028553 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.9 +69.5 69515 1.7 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SGF29 ENSG00000275441 SULT1A2 ATXN2L NFATC2IP SPNS1 ENSG00000260853 ENSG00000260367 NPIPB12 NPIPB10P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SULT1A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SULT1A1 gene promoter:

Genomic Locations for SULT1A1 Gene

Genomic Locations for SULT1A1 Gene
18,430 bases
Minus strand

Genomic View for SULT1A1 Gene

Genes around SULT1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULT1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULT1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULT1A1 Gene

Proteins for SULT1A1 Gene

  • Protein details for SULT1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sulfotransferase 1A1
    Protein Accession:
    Secondary Accessions:
    • Q2NL71
    • Q86U58
    • Q92818
    • Q9BVU6
    • Q9UGG7

    Protein attributes for SULT1A1 Gene

    295 amino acids
    Molecular mass:
    34165 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SULT1A1 Gene

    Alternative splice isoforms for SULT1A1 Gene


neXtProt entry for SULT1A1 Gene

Selected DME Specific Peptides for SULT1A1 Gene


Post-translational modifications for SULT1A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for SULT1A1 (Cytosolic Sulfotransferase 1A1/SULT1A1)
  • Abcam antibodies for SULT1A1
  • Santa Cruz Biotechnology (SCBT) Antibodies for SULT1A1

Domains & Families for SULT1A1 Gene

Gene Families for SULT1A1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SULT1A1 Gene

Suggested Antigen Peptide Sequences for SULT1A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 1 family.
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with SULT1A1: view

Function for SULT1A1 Gene

Molecular function for SULT1A1 Gene

GENATLAS Biochemistry:
aryl (phenol) sulfotransferase 1,phenol preferring,cytosolic,catalyzing the sulphonation of dopamine and p-nitrophenol
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + a phenol = adenosine 3,5-bisphosphate + an aryl sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Enzyme Numbers (IUBMB) for SULT1A1 Gene

Phenotypes From GWAS Catalog for SULT1A1 Gene

Gene Ontology (GO) - Molecular Function for SULT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004062 aryl sulfotransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IDA,TAS 19548878
GO:0016740 transferase activity IEA --
GO:0047894 flavonol 3-sulfotransferase activity IDA 20056724
genes like me logo Genes that share ontologies with SULT1A1: view
genes like me logo Genes that share phenotypes with SULT1A1: view

Animal Model Products

miRNA for SULT1A1 Gene

miRTarBase miRNAs that target SULT1A1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SULT1A1 Gene

Localization for SULT1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULT1A1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SULT1A1 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SULT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SULT1A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SULT1A1 Gene

Pathways & Interactions for SULT1A1 Gene

genes like me logo Genes that share pathways with SULT1A1: view

Gene Ontology (GO) - Biological Process for SULT1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006068 ethanol catabolic process IDA 23207770
GO:0006584 catecholamine metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process IDA 12471039
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with SULT1A1: view

No data available for SIGNOR curated interactions for SULT1A1 Gene

Drugs & Compounds for SULT1A1 Gene

(35) Drugs for SULT1A1 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma Enzyme, substrate 1014
Tamoxifen Approved Pharma Antagonist, Enzyme, substrate TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 408
Phenol Approved, Experimental Pharma 52
conjugated estrogens Approved Pharma 0
nolvadex Approved October 1998 Pharma 0

(28) Additional Compounds for SULT1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phenol sulphate
  • Aryl sulfate
  • Aryl sulphate
  • phenyl hydrogen sulfate
  • phenyl hydrogen sulphate
  • phenylsulfate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with SULT1A1: view

Transcripts for SULT1A1 Gene

Unigene Clusters for SULT1A1 Gene

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SULT1A1 Gene

No ASD Table

Relevant External Links for SULT1A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SULT1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SULT1A1 Gene

mRNA differential expression in normal tissues according to GTEx for SULT1A1 Gene

This gene is overexpressed in Liver (x6.7) and Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for SULT1A1 Gene

This gene is overexpressed in Gallbladder (34.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SULT1A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SULT1A1 Gene:


SOURCE GeneReport for Unigene cluster for SULT1A1 Gene:


mRNA Expression by UniProt/SwissProt for SULT1A1 Gene:

Tissue specificity: Liver, lung, adrenal, brain, platelets and skin.

Evidence on tissue expression from TISSUES for SULT1A1 Gene

  • Liver(4.7)
  • Intestine(4.5)
  • Blood(4.4)
  • Nervous system(4.4)
  • Lung(2.7)
  • Kidney(2.5)
  • Thyroid gland(2.5)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with SULT1A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SULT1A1 Gene

Orthologs for SULT1A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULT1A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SULT1A1 33 34
  • 98.98 (n)
(Canis familiaris)
Mammalia SULT1A1 34
  • 86 (a)
(Bos Taurus)
Mammalia SULT1A1 34
  • 84 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
(Mus musculus)
Mammalia Sult1a1 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 60 (a)
-- 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sult1a1 33
  • 62.7 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64389 33
(Danio rerio)
Actinopterygii sult1st3 33
  • 55.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5428 35
  • 32 (a)
CG16733 35
  • 27 (a)
Species where no ortholog for SULT1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SULT1A1 Gene

Gene Tree for SULT1A1 (if available)
Gene Tree for SULT1A1 (if available)

Paralogs for SULT1A1 Gene Pseudogenes for SULT1A1 Gene

genes like me logo Genes that share paralogs with SULT1A1: view

Variants for SULT1A1 Gene

Sequence variations from dbSNP and Humsavar for SULT1A1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000110349 -- 28,624,920(-) G/T upstream_transcript_variant
rs1000133438 -- 28,610,571(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000323806 -- 28,624,627(-) G/C upstream_transcript_variant
rs1000818955 -- 28,618,053(-) /A genic_upstream_transcript_variant, intron_variant
rs1000935596 -- 28,623,526(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SULT1A1 Gene

Variant ID Type Subtype PubMed ID
dgv12n14 CNV loss 18776910
dgv2830n100 CNV gain 25217958
dgv4971n54 CNV loss 21841781
dgv4972n54 CNV loss 21841781
dgv4973n54 CNV loss 21841781
dgv4974n54 CNV gain+loss 21841781
dgv4975n54 CNV gain+loss 21841781
dgv4976n54 CNV loss 21841781
dgv4977n54 CNV gain+loss 21841781
dgv4978n54 CNV gain 21841781
dgv4979n54 CNV gain+loss 21841781
dgv4980n54 CNV loss 21841781
dgv4981n54 CNV loss 21841781
dgv501e214 CNV gain 21293372
esv24682 CNV gain+loss 19812545
esv2667967 CNV deletion 23128226
esv2714170 CNV deletion 23290073
esv2758640 CNV gain+loss 17122850
esv33847 CNV gain 17666407
esv3553298 CNV deletion 23714750
esv3638338 CNV loss 21293372
esv3892821 CNV loss 25118596
esv3892822 CNV loss 25118596
esv3892823 CNV gain 25118596
esv993722 CNV gain 20482838
esv998803 CNV gain 20482838
nsv1059555 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv1066415 CNV gain 25217958
nsv1115500 CNV duplication 24896259
nsv1123028 CNV deletion 24896259
nsv1127483 CNV deletion 24896259
nsv1153455 CNV duplication 26484159
nsv1775 CNV insertion 18451855
nsv433301 CNV loss 18776910
nsv433302 CNV loss 18776910
nsv435671 CNV deletion 17901297
nsv509608 CNV insertion 20534489
nsv571749 CNV gain 21841781
nsv571755 CNV gain 21841781
nsv571756 CNV gain 21841781
nsv571766 CNV loss 21841781
nsv571767 CNV gain+loss 21841781
nsv571768 CNV loss 21841781
nsv571776 CNV loss 21841781
nsv571777 CNV gain 21841781
nsv571778 CNV loss 21841781
nsv819128 CNV loss 19587683
nsv820569 CNV duplication 20802225
nsv827606 CNV loss 20364138
nsv827607 CNV gain+loss 20364138
nsv827608 CNV gain+loss 20364138
nsv833182 CNV gain 17160897
nsv9416 CNV gain+loss 18304495
nsv977945 CNV duplication 23825009
nsv984300 CNV duplication 23825009

Variation tolerance for SULT1A1 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SULT1A1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULT1A1 Gene

Disorders for SULT1A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SULT1A1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SULT1A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SULT1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULT1A1 Gene

Publications for SULT1A1 Gene

  1. Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. (PMID: 10762004) Engelke CE … Glatt H (Pharmacogenetics 2000) 3 4 22 44 58
  2. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. (PMID: 8912648) Dooley TP … Huang Z (Biochemical and biophysical research communications 1996) 2 3 4 22 58
  3. Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. (PMID: 8288252) Dooley TP … Siciliano MJ (Genomics 1993) 2 3 4 22 58
  4. Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese. (PMID: 19126640) Chung YT … Liu TY (Carcinogenesis 2009) 3 22 44 58
  5. Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. (PMID: 18499698) Suzuki H … Li D (Carcinogenesis 2008) 3 22 44 58

Products for SULT1A1 Gene

Sources for SULT1A1 Gene

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