Aliases for SULT1A1 Gene
External Ids for SULT1A1 Gene
Previous HGNC Symbols for SULT1A1 Gene
Previous GeneCards Identifiers for SULT1A1 Gene
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SULT1A1 Gene
SULT1A1 (Sulfotransferase Family 1A Member 1) is a Protein Coding gene. Diseases associated with SULT1A1 include Ceroid Lipofuscinosis, Neuronal, 3 and Mandibulofacial Dysostosis With Alopecia. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and flavonol 3-sulfotransferase activity. An important paralog of this gene is SULT1A2.
UniProtKB/Swiss-Prot Summary for SULT1A1 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.