This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016] See more...

Aliases for SUGT1 Gene

Aliases for SUGT1 Gene

  • SGT1 Homolog, MIS12 Kinetochore Complex Assembly Cochaperone 2 3 5
  • Protein SGT1 Homolog 3 4
  • SGT1 2 3
  • Suppressor Of G2 Allele Of SKP1, S. Cerevisiae, Homolog Of 3
  • SGT1, Suppressor Of G2 Allele Of SKP1 (S. Cerevisiae) 2
  • Suppressor Of G2 Allele Of SKP1 Homolog 4
  • SGT1, Suppressor Of G2 Allele Of SKP1 3
  • Putative 40-6-3 Protein 3
  • Protein 40-6-3 4
  • SUGT1 5
  • Sgt1 4

External Ids for SUGT1 Gene

Previous GeneCards Identifiers for SUGT1 Gene

  • GC13P047221
  • GC13P052163
  • GC13P051024
  • GC13P051025
  • GC13P052124
  • GC13P053226
  • GC13P033941

Summaries for SUGT1 Gene

Entrez Gene Summary for SUGT1 Gene

  • This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

GeneCards Summary for SUGT1 Gene

SUGT1 (SGT1 Homolog, MIS12 Kinetochore Complex Assembly Cochaperone) is a Protein Coding gene. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Innate Immune System. An important paralog of this gene is SPAG1.

UniProtKB/Swiss-Prot Summary for SUGT1 Gene

  • May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for SUGT1 Gene

Additional gene information for SUGT1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUGT1 Gene

Genomics for SUGT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SUGT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J052650 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 0.0 -2 4.2 ZNF221 BRCA1 CREB1 GATAD2A CTCF PRDM10 ZNF629 REST TFE3 RFX1 ENSG00000273723 SUGT1 ALG11 CKAP2 TPTE2P2 UTP14C HNRNPA1L2
GH13J052193 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 38 -458.2 -458203 3.4 BRCA1 SP1 HNRNPL CREB1 GATAD2A ZBTB33 PRDM10 ZNF629 TFE3 SIX5 MRPS31P5 SUGT1 CKAP2 ALG11 RPS4XP16 INTS6 INTS6-AS1 TPTE2P2 SERPINE3 ATP7B
GH13J053010 Enhancer 1 Ensembl ENCODE dbSUPER 15 +364.1 364098 17.6 REST ZNF140 ZNF316 MAFF ESRRA MAFK ZNF623 MAFG ZBTB11 SPI1 SUGT1 HNRNPA1L2 OLFM4 UTP14C piR-32214-154 lnc-PCDH8-6 PCDH8
GH13J052943 Enhancer 0.5 Ensembl 4.7 +294.5 294529 7.9 USF1 POLR2A SPI1 SMARCA4 USF2 CTCF SUGT1 HSALNG0097288 lnc-PCDH8-1 OLFM4 PCDH8
GH13J052301 Enhancer 0.2 ENCODE 4 -350.7 -350654 1.3 CKAP2 SUGT1 lnc-THSD1-4 piR-45012-140 TPTE2P2 ENSG00000217576 THSD1 NEK3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUGT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUGT1

Top Transcription factor binding sites by QIAGEN in the SUGT1 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • GATA-6
  • HEN1
  • Ik-1
  • IRF-2
  • LCR-F1
  • STAT5A

Genomic Locations for SUGT1 Gene

Genomic Locations for SUGT1 Gene
chr13:52,652,703-52,700,909
(GRCh38/hg38)
Size:
48,207 bases
Orientation:
Plus strand
chr13:53,226,831-53,275,044
(GRCh37/hg19)
Size:
48,214 bases
Orientation:
Plus strand

Genomic View for SUGT1 Gene

Genes around SUGT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGT1 Gene

Proteins for SUGT1 Gene

  • Protein details for SUGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Z0-SGT1_HUMAN
    Recommended name:
    Protein SGT1 homolog
    Protein Accession:
    Q9Y2Z0
    Secondary Accessions:
    • A2A303
    • Q5JAK5
    • Q5TAM6
    • Q6VXY6

    Protein attributes for SUGT1 Gene

    Size:
    365 amino acids
    Molecular mass:
    41024 Da
    Quaternary structure:
    • Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.

    Three dimensional structures from OCA and Proteopedia for SUGT1 Gene

    Alternative splice isoforms for SUGT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGT1 Gene

Post-translational modifications for SUGT1 Gene

  • Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
  • Ubiquitination at Lys256, Lys267, Lys274, Lys325, and Lys349
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SGT1_HUMAN (638)

No data available for DME Specific Peptides for SUGT1 Gene

Domains & Families for SUGT1 Gene

Gene Families for SUGT1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SUGT1 Gene

Suggested Antigen Peptide Sequences for SUGT1 Gene

GenScript: Design optimal peptide antigens:
  • Sgt1 (SUGT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2Z0

UniProtKB/Swiss-Prot:

SGT1_HUMAN :
  • The CS domain mediates interaction with HSP90.
  • Belongs to the SGT1 family.
Domain:
  • The CS domain mediates interaction with HSP90.
Family:
  • Belongs to the SGT1 family.
genes like me logo Genes that share domains with SUGT1: view

Function for SUGT1 Gene

Molecular function for SUGT1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes From GWAS Catalog for SUGT1 Gene

Gene Ontology (GO) - Molecular Function for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17420470
genes like me logo Genes that share ontologies with SUGT1: view
genes like me logo Genes that share phenotypes with SUGT1: view

Animal Models for SUGT1 Gene

MGI Knock Outs for SUGT1:
  • Sugt1 Sugt1<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for SUGT1 Gene

miRTarBase miRNAs that target SUGT1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUGT1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUGT1 Gene

Localization for SUGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGT1 Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUGT1 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex TAS 10445024
GO:0000776 kinetochore TAS 10445024
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SUGT1: view

Pathways & Interactions for SUGT1 Gene

genes like me logo Genes that share pathways with SUGT1: view

Gene Ontology (GO) - Biological Process for SUGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS 10445024
GO:0031647 regulation of protein stability IDA 23935490
GO:0043947 positive regulation by host of symbiont catalytic activity IDA 23935490
GO:0050821 protein stabilization IBA 21873635
genes like me logo Genes that share ontologies with SUGT1: view

No data available for SIGNOR curated interactions for SUGT1 Gene

Drugs & Compounds for SUGT1 Gene

No Compound Related Data Available

Transcripts for SUGT1 Gene

mRNA/cDNA for SUGT1 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUGT1

Alternative Splicing Database (ASD) splice patterns (SP) for SUGT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for SUGT1 Gene

GeneLoc Exon Structure for
SUGT1

Expression for SUGT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUGT1 Gene

Protein differential expression in normal tissues from HIPED for SUGT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUGT1 Gene



Protein tissue co-expression partners for SUGT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUGT1

SOURCE GeneReport for Unigene cluster for SUGT1 Gene:

Hs.281902

Evidence on tissue expression from TISSUES for SUGT1 Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Liver(4.3)
  • Skin(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with SUGT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUGT1 Gene

Orthologs for SUGT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUGT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SUGT1 30 31
  • 99.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 95 (a)
OneToMany
SUGT1 30
  • 94.29 (n)
-- 31
  • 94 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SUGT1 30 31
  • 93.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sugt1 30
  • 87.82 (n)
Mouse
(Mus musculus)
Mammalia Sugt1 30 17 31
  • 86.58 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SUGT1 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SUGT1 30 31
  • 76.16 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SUGT1 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sugt1 30
  • 67.51 (n)
Str.9278 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.25240 30
Zebrafish
(Danio rerio)
Actinopterygii sgut1 30 31
  • 64.92 (n)
OneToOne
wufd45a02 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3362 30
Fruit Fly
(Drosophila melanogaster)
Insecta Sgt1 30 31
  • 53.45 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006161 30
  • 52.04 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_D1054.3 30
  • 52.15 (n)
D1054.3 31
  • 36 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT1 31
  • 23 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons SGT1B 30
  • 50.5 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0624500 30
  • 51.79 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3670 31
  • 47 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8167 30
Species where no ortholog for SUGT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SUGT1 Gene

ENSEMBL:
Gene Tree for SUGT1 (if available)
TreeFam:
Gene Tree for SUGT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SUGT1: view image

Paralogs for SUGT1 Gene

(1) SIMAP similar genes for SUGT1 Gene using alignment to 2 proteins:

  • SUGT1_HUMAN
  • F5H5A9_HUMAN
genes like me logo Genes that share paralogs with SUGT1: view

Variants for SUGT1 Gene

Additional dbSNP identifiers (rs#s) for SUGT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SUGT1 Gene

Variant ID Type Subtype PubMed ID
dgv1653n100 CNV gain 25217958
nsv1044949 CNV gain 25217958
nsv819201 CNV gain 19587683
nsv820041 CNV gain 19587683
nsv974091 CNV duplication 23825009
nsv974092 CNV duplication 23825009

Variation tolerance for SUGT1 Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUGT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUGT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SUGT1 Gene

Disorders for SUGT1 Gene

No disorders were found for SUGT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUGT1 Gene

Publications for SUGT1 Gene

  1. Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. (PMID: 20404110) Davies AE … Kaplan KB (The Journal of cell biology 2010) 2 3 23
  2. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. (PMID: 14761955) Lee YT … Chazin WJ (The Journal of biological chemistry 2004) 3 4 23
  3. Identification of a novel splice variant: human SGT1B (SUGT1B). (PMID: 15018354) Niikura Y … Kitagawa K (DNA sequence : the journal of DNA sequencing and mapping 2003) 3 4 23
  4. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (PMID: 10445024) Kitagawa K … Hieter P (Molecular cell 1999) 2 3 4
  5. Nuclear translocation of Sgt1 depends on its phosphorylation state. (PMID: 21864708) Prus W … Filipek A (The international journal of biochemistry & cell biology 2011) 3 4

Products for SUGT1 Gene

Sources for SUGT1 Gene