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Aliases for SUGP1 Gene

Aliases for SUGP1 Gene

  • SURP And G-Patch Domain Containing 1 2 3 5
  • Splicing Factor 4 2 3 4
  • RNA-Binding Protein RBP 3 4
  • SF4 3 4
  • SURP And G-Patch Domain-Containing Protein 1 3
  • F23858 3
  • RBP 3

External Ids for SUGP1 Gene

Previous HGNC Symbols for SUGP1 Gene

  • SF4

Previous GeneCards Identifiers for SUGP1 Gene

  • GC19M019389
  • GC19M018951

Summaries for SUGP1 Gene

Entrez Gene Summary for SUGP1 Gene

  • SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]

GeneCards Summary for SUGP1 Gene

SUGP1 (SURP And G-Patch Domain Containing 1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SUGP2.

UniProtKB/Swiss-Prot for SUGP1 Gene

  • Plays a role in pre-mRNA splicing.

Additional gene information for SUGP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUGP1 Gene

Genomics for SUGP1 Gene

GeneHancer (GH) Regulatory Elements for SUGP1 Gene

Promoters and enhancers for SUGP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I019319 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 552.1 -0.1 -57 2.6 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A YY1 POLR2B ZNF766 ZNF213 MAU2 SUGP1 GATAD2A ATP13A1 ENSG00000268938 ZNF506 ZNF14 MEF2B NR2C2AP ENSG00000268030
GH19I019320 Enhancer 0.4 ENCODE dbSUPER 550.8 +1.5 1467 0.2 MAU2 SUGP1 GC19M019317 PIR39883
GH19I018587 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +731.4 731404 3.6 CLOCK MLX DMAP1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 REX1BD ENSG00000268030 UPF1 ENSG00000268938 NR2C2AP ENSG00000269191 MAU2 IQCN MEF2B ELL
GH19I018657 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +661.4 661389 4.6 PKNOX1 ATF1 YBX1 ZNF48 GLIS2 ATF7 FOS REST SMARCB1 ZNF592 MAU2 IQCN ENSG00000268030 UPF1 SUGP2 CRTC1 TSSK6 ENSG00000268938 UNC13A TMEM59L
GH19I018458 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.7 +860.5 860457 2.9 CTCF NFIB SREBF2 BACH1 ARID4B ZNF195 RAD21 HIC1 ZNF121 ZNF335 SSBP4 SUGP2 NR2C2AP ENSG00000268030 MAU2 SUGP1 UPF1 ELL PGPEP1 ENSG00000280121
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SUGP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SUGP1 Gene

Genomic Locations for SUGP1 Gene
chr19:19,276,018-19,320,844
(GRCh38/hg38)
Size:
44,827 bases
Orientation:
Minus strand
chr19:19,386,827-19,431,653
(GRCh37/hg19)

Genomic View for SUGP1 Gene

Genes around SUGP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUGP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUGP1 Gene

Proteins for SUGP1 Gene

  • Protein details for SUGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWZ8-SUGP1_HUMAN
    Recommended name:
    SURP and G-patch domain-containing protein 1
    Protein Accession:
    Q8IWZ8
    Secondary Accessions:
    • O60378
    • Q6P3X9
    • Q8TCQ4
    • Q8WWT4
    • Q8WWT5
    • Q9NTG3

    Protein attributes for SUGP1 Gene

    Size:
    645 amino acids
    Molecular mass:
    72471 Da
    Quaternary structure:
    • Component of the spliceosome.
    SequenceCaution:
    • Sequence=AAC08052.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAL68960.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL68961.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUGP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUGP1 Gene

Post-translational modifications for SUGP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SUGP1 Gene

Domains & Families for SUGP1 Gene

Gene Families for SUGP1 Gene

Protein Domains for SUGP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUGP1: view

No data available for UniProtKB/Swiss-Prot for SUGP1 Gene

Function for SUGP1 Gene

Molecular function for SUGP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in pre-mRNA splicing.

Phenotypes From GWAS Catalog for SUGP1 Gene

Gene Ontology (GO) - Molecular Function for SUGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22681889
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with SUGP1: view
genes like me logo Genes that share phenotypes with SUGP1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUGP1 Gene

Localization for SUGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUGP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUGP1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SUGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
genes like me logo Genes that share ontologies with SUGP1: view

Pathways & Interactions for SUGP1 Gene

genes like me logo Genes that share pathways with SUGP1: view

Pathways by source for SUGP1 Gene

Gene Ontology (GO) - Biological Process for SUGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SUGP1: view

No data available for SIGNOR curated interactions for SUGP1 Gene

Drugs & Compounds for SUGP1 Gene

No Compound Related Data Available

Transcripts for SUGP1 Gene

Unigene Clusters for SUGP1 Gene

SURP and G patch domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUGP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2:
SP3:
SP4: - - - - - - - - - - - -
SP5:
SP6:

Relevant External Links for SUGP1 Gene

GeneLoc Exon Structure for
SUGP1
ECgene alternative splicing isoforms for
SUGP1

Expression for SUGP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUGP1 Gene

Protein differential expression in normal tissues from HIPED for SUGP1 Gene

This gene is overexpressed in Heart (20.8), CD8 Tcells (8.4), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUGP1 Gene



Protein tissue co-expression partners for SUGP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUGP1 Gene:

SUGP1

SOURCE GeneReport for Unigene cluster for SUGP1 Gene:

Hs.515274

mRNA Expression by UniProt/SwissProt for SUGP1 Gene:

Q8IWZ8-SUGP1_HUMAN
Tissue specificity: Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle.

Evidence on tissue expression from TISSUES for SUGP1 Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SUGP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUGP1 Gene

Orthologs for SUGP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SUGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUGP1 33 34
  • 99.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SUGP1 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SF4 34
  • 91 (a)
OneToOne
SUGP1 33
  • 90.03 (n)
dog
(Canis familiaris)
Mammalia SUGP1 33 34
  • 89.4 (n)
mouse
(Mus musculus)
Mammalia Sugp1 33 16 34
  • 85.34 (n)
rat
(Rattus norvegicus)
Mammalia Sugp1 33
  • 84.97 (n)
oppossum
(Monodelphis domestica)
Mammalia SUGP1 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SUGP1 33 34
  • 74.95 (n)
lizard
(Anolis carolinensis)
Reptilia SUGP1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sugp1 33
  • 66.61 (n)
Str.16120 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4572 33
zebrafish
(Danio rerio)
Actinopterygii sugp1 33 34
  • 69.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31550 34
  • 17 (a)
OneToMany
Species where no ortholog for SUGP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUGP1 Gene

ENSEMBL:
Gene Tree for SUGP1 (if available)
TreeFam:
Gene Tree for SUGP1 (if available)

Paralogs for SUGP1 Gene

Paralogs for SUGP1 Gene

(1) SIMAP similar genes for SUGP1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SUGP1 Gene

genes like me logo Genes that share paralogs with SUGP1: view

Variants for SUGP1 Gene

Sequence variations from dbSNP and Humsavar for SUGP1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1057524594 uncertain-significance, not specified 19,280,253(-) G/T coding_sequence_variant, missense_variant
rs1000082428 -- 19,315,558(-) C/T intron_variant
rs1000111035 -- 19,307,292(-) C/T intron_variant
rs1000131551 -- 19,278,465(-) C/T intron_variant
rs1000149750 -- 19,296,562(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SUGP1 Gene

Variant ID Type Subtype PubMed ID
nsv1151217 CNV deletion 26484159
nsv1056419 CNV gain 25217958
esv3643848 CNV loss 21293372
esv3643847 CNV loss 21293372
esv2664832 CNV deletion 23128226

Variation tolerance for SUGP1 Gene

Residual Variation Intolerance Score: 9.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.98; 74.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUGP1 Gene

Human Gene Mutation Database (HGMD)
SUGP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUGP1 Gene

Disorders for SUGP1 Gene

Additional Disease Information for SUGP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SUGP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SUGP1 Gene

Publications for SUGP1 Gene

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PMID: 12594045) Sampson ND … Hewitt JE (Gene 2003) 2 3 4 22 58
  2. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PMID: 20864672) Waterworth DM … Sandhu MS (Arteriosclerosis, thrombosis, and vascular biology 2010) 3 44 58
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 44 58
  4. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S … Cupples LA (Nature genetics 2009) 3 44 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for SUGP1 Gene

Sources for SUGP1 Gene

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