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SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
SUDS3 (SDS3 Homolog, SIN3A Corepressor Complex Component) is a Protein Coding gene. Diseases associated with SUDS3 include Cataract 28 and Isolated Growth Hormone Deficiency Type Iii. Among its related pathways are Chromatin organization and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is BRMS1L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004407 | contributes_to histone deacetylase activity | IBA,IDA | 21239494 |
GO:0005515 | protein binding | IPI | 12670868 |
GO:0019899 | enzyme binding | IPI | 21239494 |
GO:0042826 | histone deacetylase binding | ISS | 11909966 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 21239494 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0016580 | Sin3 complex | ISS | 11909966 |
GO:0016604 | nuclear body | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
2 | Chromatin organization | ||
3 | Deubiquitination |
.74
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4 | Metabolism of proteins | ||
5 | Gene Expression |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 22783022 |
GO:0006325 | chromatin organization | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0016575 | histone deacetylation | IDA | 21239494 |
GO:0016579 | protein deubiquitination | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SUDS3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SUDS3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SUDS3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Suds3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Suds3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SUDS3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SUDS3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SUDS3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | suds3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | suds3 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000738 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG14220 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
791587 | Benign: not provided | 118,414,397(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
cataract 28 |
|
|
isolated growth hormone deficiency type iii |
|
|