Aliases for SUDS3 Gene
External Ids for SUDS3 Gene
Previous GeneCards Identifiers for SUDS3 Gene
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SUDS3 Gene
SUDS3 (SDS3 Homolog, SIN3A Corepressor Complex Component) is a Protein Coding gene. Diseases associated with SUDS3 include Cataract 28. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is BRMS1L.
UniProtKB/Swiss-Prot Summary for SUDS3 Gene
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.