Aliases for SUCO Gene

Aliases for SUCO Gene

  • SUN Domain Containing Ossification Factor 2 3 5
  • SUN-Like Protein 1 2 3 4
  • SLP1 2 3 4
  • CH1 2 3 4
  • OPT 2 3 4
  • SUN Domain-Containing Ossification Factor 3 4
  • Membrane Protein CH1 3 4
  • Osteopotentia 2 3
  • C1orf9 3 4
  • Chromosome 1 Open Reading Frame 9 2
  • Protein Osteopotentia Homolog 4
  • SUCO 5

External Ids for SUCO Gene

Previous HGNC Symbols for SUCO Gene

  • C1orf9

Previous GeneCards Identifiers for SUCO Gene

  • GC01P172502

Summaries for SUCO Gene

GeneCards Summary for SUCO Gene

SUCO (SUN Domain Containing Ossification Factor) is a Protein Coding gene. Diseases associated with SUCO include Gamma Heavy Chain Disease and Heavy Chain Disease.

UniProtKB/Swiss-Prot Summary for SUCO Gene

  • Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).

Additional gene information for SUCO Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUCO Gene

Genomics for SUCO Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SUCO Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J172531 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 613.5 +1.1 1138 4.6 SP1 CREB1 HNRNPL ATF7 PRDM10 REST ZNF629 TFE3 ZNF512 RFX1 SUCO lnc-PIGC-4 PIGC EEF1AKNMT piR-61240-015 FASLG
GH01J172448 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.1 -81.1 -81078 6.4 CEBPG CREB1 GATAD2A CTCF REST TFE3 ZNF512 LEF1 IKZF1 NFKBIZ C1orf105 PIGC SUCO EEF1AKNMT LOC102724528
GH01J172455 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 21.4 -75.6 -75648 3.4 LEF1 IKZF1 ZNF7 JUND MTA2 PKNOX1 ZNF24 ZNF740 DPF2 HDAC1 PIGC LOC102724528 SUCO C1orf105 piR-56133-013
GH01J172495 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.6 -33.3 -33349 6 CREB1 GATAD2A TEAD4 TFE3 JUND MTA2 PKNOX1 NR2C1 SP1 HDAC1 SUCO PIGC C1orf105 piR-56133-013 lnc-SUCO-1
GH01J172470 Enhancer 1.2 Ensembl ENCODE dbSUPER 22.9 -57.2 -57151 11.2 GATAD2A TFE3 LEF1 SOX13 NFKBIZ RCOR2 FOXA1 RXRB REST IRF2 C1orf105 PIGC SUCO EEF1AKNMT RNU6-157P LOC102724528 piR-56133-013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUCO on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUCO

Genomic Locations for SUCO Gene

Genomic Locations for SUCO Gene
79,485 bases
Plus strand
79,485 bases
Plus strand

Genomic View for SUCO Gene

Genes around SUCO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCO Gene

Proteins for SUCO Gene

  • Protein details for SUCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SUN domain-containing ossification factor
    Protein Accession:
    Secondary Accessions:
    • B2RNU4
    • Q9BQB9
    • Q9BXQ2
    • Q9UL04

    Protein attributes for SUCO Gene

    1254 amino acids
    Molecular mass:
    139430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUCO Gene


neXtProt entry for SUCO Gene

Post-translational modifications for SUCO Gene

  • O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1.
  • N-glycosylated.
  • Glycosylation at Asn202, Asn236, Asn524, Asn530, Asn928, Asn955, and Asn963
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

No data available for DME Specific Peptides for SUCO Gene

Domains & Families for SUCO Gene

Gene Families for SUCO Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SUCO Gene

  • Sad1/UNC-like, C-terminal

Suggested Antigen Peptide Sequences for SUCO Gene

GenScript: Design optimal peptide antigens:
  • Protein osteopotentia homolog (OSPT_HUMAN)
genes like me logo Genes that share domains with SUCO: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SUCO Gene

Function for SUCO Gene

Molecular function for SUCO Gene

UniProtKB/Swiss-Prot Function:
Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).

Phenotypes From GWAS Catalog for SUCO Gene

genes like me logo Genes that share phenotypes with SUCO: view

Animal Model Products

CRISPR Products

miRNA for SUCO Gene

miRTarBase miRNAs that target SUCO

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUCO

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUCO Gene

Localization for SUCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCO Gene

Rough endoplasmic reticulum membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUCO gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
extracellular 3
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005791 rough endoplasmic reticulum ISS --
GO:0016020 membrane IBA,ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SUCO: view

Pathways & Interactions for SUCO Gene

PathCards logo

SuperPathways for SUCO Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organism development IEA --
GO:0032967 positive regulation of collagen biosynthetic process ISS --
GO:0045669 positive regulation of osteoblast differentiation ISS --
GO:0046850 regulation of bone remodeling IBA,ISS --
genes like me logo Genes that share ontologies with SUCO: view

No data available for Pathways by source and SIGNOR curated interactions for SUCO Gene

Drugs & Compounds for SUCO Gene

No Compound Related Data Available

Transcripts for SUCO Gene

mRNA/cDNA for SUCO Gene

8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUCO

Alternative Splicing Database (ASD) splice patterns (SP) for SUCO Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP2: -
SP5: - -

Relevant External Links for SUCO Gene

GeneLoc Exon Structure for

Expression for SUCO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUCO Gene

This gene is overexpressed in Bone (21.8), Plasma (17.9), Adrenal (15.1), and Neutrophil (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUCO Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUCO

SOURCE GeneReport for Unigene cluster for SUCO Gene:


mRNA Expression by UniProt/SwissProt for SUCO Gene:

Tissue specificity: Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus, small intestine and spleen.

Evidence on tissue expression from TISSUES for SUCO Gene

  • Nervous system(4.6)
  • Skin(2.8)
  • Kidney(2.8)
  • Heart(2.7)
  • Bone marrow(2.7)
  • Spleen(2.7)
  • Blood(2.7)
  • Intestine(2.5)
  • Lung(2.5)
  • Muscle(2.5)
  • Liver(2.4)
  • Stomach(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with SUCO: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUCO Gene

Orthologs for SUCO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUCO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUCO 30 31
  • 99.73 (n)
(Bos Taurus)
Mammalia SUCO 30 31
  • 91.41 (n)
(Canis familiaris)
Mammalia SUCO 30 31
  • 91.17 (n)
(Mus musculus)
Mammalia Suco 30 17 31
  • 88.1 (n)
(Rattus norvegicus)
Mammalia Suco 30
  • 86.86 (n)
(Monodelphis domestica)
Mammalia SUCO 31
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SUCO 31
  • 75 (a)
(Gallus gallus)
Aves C8H1ORF9 30
  • 73.2 (n)
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 81 (a)
-- 31
  • 55 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia suco 30
  • 65.78 (n)
(Danio rerio)
Actinopterygii suco 30 31
  • 54.8 (n)
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG31678 31
  • 18 (a)
(Caenorhabditis elegans)
Secernentea R12E2.2 31
  • 23 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLP1 31 33
  • 26 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.13589 30
Species where no ortholog for SUCO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SUCO Gene

Gene Tree for SUCO (if available)
Gene Tree for SUCO (if available)
Evolutionary constrained regions (ECRs) for SUCO: view image

Paralogs for SUCO Gene

No data available for Paralogs for SUCO Gene

Variants for SUCO Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SUCO Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
707255 Benign: not provided 172,589,073(+) T/A MISSENSE_VARIANT,INTRON_VARIANT
766931 Benign: not provided 172,575,575(+) T/C SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for SUCO Gene

Structural Variations from Database of Genomic Variants (DGV) for SUCO Gene

Variant ID Type Subtype PubMed ID
esv7885 CNV loss 19470904
nsv3554 CNV insertion 18451855

Variation tolerance for SUCO Gene

Residual Variation Intolerance Score: 8.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.61; 91.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUCO Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCO Gene

Disorders for SUCO Gene

MalaCards: The human disease database

(10) MalaCards diseases for SUCO Gene - From: DISEASES

Disorder Aliases PubMed IDs
gamma heavy chain disease
  • franklin's disease
heavy chain disease
  • hcd
alpha chain disease
  • seligmann's disease
clivus chordoma
  • chordoma of clivus
mu chain disease
  • mu-chain disease
- elite association - COSMIC cancer census association via MalaCards
Search SUCO in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with SUCO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCO Gene

Publications for SUCO Gene

  1. The C1orf9 gene encodes a putative transmembrane member of a novel protein family. (PMID: 10673381) Røsok O … Aasheim HC (Biochemical and biophysical research communications 2000) 2 3 4
  2. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. (PMID: 20440000) Sohaskey ML … Harland RM (The Journal of cell biology 2010) 2 3
  3. Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1. (PMID: 11158380) Yu N … Li WH (Molecular biology and evolution 2001) 3 4
  4. Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2. (PMID: 28512129) Larsen ISB … Halim A (The Journal of biological chemistry 2017) 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for SUCO Gene

Sources for SUCO Gene