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Aliases for SUCO Gene

Aliases for SUCO Gene

  • SUN Domain Containing Ossification Factor 2 3 5
  • SUN-Like Protein 1 2 3 4
  • Membrane Protein CH1 3 4
  • Osteopotentia 2 3
  • C1orf9 3 4
  • SLP1 3 4
  • OPT 3 4
  • CH1 3 4
  • SUN Domain-Containing Ossification Factor 3
  • Chromosome 1 Open Reading Frame 9 2
  • Protein Osteopotentia Homolog 4

External Ids for SUCO Gene

Previous HGNC Symbols for SUCO Gene

  • C1orf9

Summaries for SUCO Gene

GeneCards Summary for SUCO Gene

SUCO (SUN Domain Containing Ossification Factor) is a Protein Coding gene. Diseases associated with SUCO include Gamma Heavy Chain Disease and Taeniasis.

UniProtKB/Swiss-Prot for SUCO Gene

  • Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).

Additional gene information for SUCO Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCO Gene

Genomics for SUCO Gene

GeneHancer (GH) Regulatory Elements for SUCO Gene

Promoters and enhancers for SUCO Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I172531 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.6 +1.0 985 4.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SUCO GC01M172532 PIGC METTL13
GH01I172530 Enhancer 1 ENCODE dbSUPER 560.7 -2.0 -1968 0.5 HDAC1 ZNF766 ATF7 ZBTB11 ZNF592 ZNF217 MEF2D MTA1 SMARCA4 IKZF1 SUCO LOC102724528
GH01I172569 Promoter 0.5 EPDnew 560.9 +36.8 36776 0.1 SUCO GC01M172532 RNU6-693P
GH01I172448 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 21.1 -81.1 -81078 6.4 PKNOX1 CLOCK FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 C1orf105 PIGC SUCO METTL13 LOC102724528
GH01I171738 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -790.9 -790920 6.2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 VAMP4 PRRC2C METTL13 PIGC FMO4 SUCO MYOC PIR43253
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SUCO on UCSC Golden Path with GeneCards custom track

Genomic Locations for SUCO Gene

Genomic Locations for SUCO Gene
chr1:172,532,349-172,611,833
(GRCh38/hg38)
Size:
79,485 bases
Orientation:
Plus strand
chr1:172,501,489-172,580,973
(GRCh37/hg19)

Genomic View for SUCO Gene

Genes around SUCO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCO Gene

Proteins for SUCO Gene

  • Protein details for SUCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS9-SUCO_HUMAN
    Recommended name:
    SUN domain-containing ossification factor
    Protein Accession:
    Q9UBS9
    Secondary Accessions:
    • B2RNU4
    • Q9BQB9
    • Q9BXQ2
    • Q9UL04

    Protein attributes for SUCO Gene

    Size:
    1254 amino acids
    Molecular mass:
    139430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SUCO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUCO Gene

Post-translational modifications for SUCO Gene

  • Glycosylation at posLast=202202, isoforms=2236, posLast=524524, isoforms=2928, and isoforms=2955
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SUCO Gene

Domains & Families for SUCO Gene

Gene Families for SUCO Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SUCO Gene

Suggested Antigen Peptide Sequences for SUCO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SUCO: view

No data available for UniProtKB/Swiss-Prot for SUCO Gene

Function for SUCO Gene

Molecular function for SUCO Gene

UniProtKB/Swiss-Prot Function:
Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).

Phenotypes From GWAS Catalog for SUCO Gene

genes like me logo Genes that share phenotypes with SUCO: view

Animal Model Products

CRISPR Products

miRNA for SUCO Gene

miRTarBase miRNAs that target SUCO

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUCO Gene

Localization for SUCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCO Gene

Rough endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUCO gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
extracellular 2
nucleus 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005791 rough endoplasmic reticulum ISS --
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0030867 rough endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SUCO: view

Pathways & Interactions for SUCO Gene

No Data Available

Gene Ontology (GO) - Biological Process for SUCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organism development IEA --
GO:0032967 positive regulation of collagen biosynthetic process ISS --
GO:0045669 positive regulation of osteoblast differentiation ISS --
GO:0046850 regulation of bone remodeling ISS --
genes like me logo Genes that share ontologies with SUCO: view

No data available for Pathways by source and SIGNOR curated interactions for SUCO Gene

Drugs & Compounds for SUCO Gene

No Compound Related Data Available

Transcripts for SUCO Gene

Unigene Clusters for SUCO Gene

SUN domain containing ossification factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUCO Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for SUCO Gene

GeneLoc Exon Structure for
SUCO
ECgene alternative splicing isoforms for
SUCO

Expression for SUCO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SUCO Gene

This gene is overexpressed in Bone (21.8), Plasma (17.9), Adrenal (15.1), and Neutrophil (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUCO Gene



NURSA nuclear receptor signaling pathways regulating expression of SUCO Gene:

SUCO

SOURCE GeneReport for Unigene cluster for SUCO Gene:

Hs.204559

mRNA Expression by UniProt/SwissProt for SUCO Gene:

Q9UBS9-SUCO_HUMAN
Tissue specificity: Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus, small intestine and spleen.

Evidence on tissue expression from TISSUES for SUCO Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SUCO: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUCO Gene

Orthologs for SUCO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUCO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUCO 33 34
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia SUCO 33 34
  • 91.41 (n)
dog
(Canis familiaris)
Mammalia SUCO 33 34
  • 91.17 (n)
mouse
(Mus musculus)
Mammalia Suco 33 16 34
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia Suco 33
  • 86.86 (n)
oppossum
(Monodelphis domestica)
Mammalia SUCO 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SUCO 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8H1ORF9 33
  • 73.2 (n)
SUCO 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 81 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia suco 33
  • 65.78 (n)
zebrafish
(Danio rerio)
Actinopterygii suco 33 34
  • 54.8 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG31678 34
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R12E2.2 34
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLP1 34 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13589 33
Species where no ortholog for SUCO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUCO Gene

ENSEMBL:
Gene Tree for SUCO (if available)
TreeFam:
Gene Tree for SUCO (if available)

Paralogs for SUCO Gene

No data available for Paralogs for SUCO Gene

Variants for SUCO Gene

Sequence variations from dbSNP and Humsavar for SUCO Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000027110 -- 172,535,503(+) C/G intron_variant
rs1000096698 -- 172,588,083(+) A/C intron_variant
rs1000120342 -- 172,540,258(+) G/A intron_variant
rs1000149093 -- 172,605,242(+) C/A intron_variant
rs1000153355 -- 172,568,057(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SUCO Gene

Variant ID Type Subtype PubMed ID
esv7885 CNV loss 19470904
nsv3554 CNV insertion 18451855

Variation tolerance for SUCO Gene

Residual Variation Intolerance Score: 8.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.61; 91.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUCO Gene

Human Gene Mutation Database (HGMD)
SUCO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUCO

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCO Gene

Disorders for SUCO Gene

MalaCards: The human disease database

(2) MalaCards diseases for SUCO Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
gamma heavy chain disease
  • franklin's disease
taeniasis
  • beef tapeworm infection
- elite association - COSMIC cancer census association via MalaCards
Search SUCO in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SUCO

genes like me logo Genes that share disorders with SUCO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCO Gene

Publications for SUCO Gene

  1. The C1orf9 gene encodes a putative transmembrane member of a novel protein family. (PMID: 10673381) Røsok O … Aasheim HC (Biochemical and biophysical research communications 2000) 2 3 4 58
  2. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. (PMID: 20440000) Sohaskey ML … Harland RM (The Journal of cell biology 2010) 2 3 58
  3. Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1. (PMID: 11158380) Yu N … Li WH (Molecular biology and evolution 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Exome sequencing identifies SUCO mutations in mesial temporal lobe epilepsy. (PMID: 25668491) Sha Z … Xu Q (Neuroscience letters 2015) 3 58

Products for SUCO Gene

Sources for SUCO Gene

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