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SUCNR1 Gene(Protein Coding)

Succinate Receptor 1

GCID:
GC03P151873
GIFtS:
48
Genes Participants
UDN Logo

Aliases for SUCNR1 Gene

Aliases for SUCNR1 Gene

  • Succinate Receptor 1 2 3 5
  • G-Protein Coupled Receptor 91 3 4
  • GPR91 3 4
  • G Protein-Coupled Receptor 91 2
  • P2Y Purinoceptor 1-Like 4
  • P2Y Purinoceptor 1 3

External Ids for SUCNR1 Gene

Previous HGNC Symbols for SUCNR1 Gene

  • GPR91

Previous GeneCards Identifiers for SUCNR1 Gene

  • GC03P153074
  • GC03P151591
  • GC03P148982

Summaries for SUCNR1 Gene

Entrez Gene Summary for SUCNR1 Gene

  • This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]

GeneCards Summary for SUCNR1 Gene

SUCNR1 (Succinate Receptor 1) is a Protein Coding gene. Diseases associated with SUCNR1 include Exudative Vitreoretinopathy 1. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot for SUCNR1 Gene

  • Receptor for succinate.

Gene Wiki entry for SUCNR1 Gene

Additional gene information for SUCNR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCNR1 Gene

Genomics for SUCNR1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SUCNR1 Gene

Promoters and enhancers for SUCNR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I151873 Promoter 0.6 EPDnew 550.8 0.0 -19 0.1 POLR2A SUCNR1 AADACL2-AS1 AADAC
GH03I151909 Enhancer 0.5 ENCODE 11.7 +36.3 36323 1.5 JUND JUN NFE2 FOS SUCNR1 AADAC LOC105374159 AADACL2-AS1
GH03I151925 Enhancer 0.7 Ensembl ENCODE 5.2 +53.1 53073 2.3 JUND POLR2A MAX FOS AADACL2-AS1 AADAC SUCNR1 LOC105374159
GH03I151875 Enhancer 1.4 FANTOM5 Ensembl ENCODE 0.8 +2.7 2700 1.7 HDAC1 ATF1 PKNOX1 ARNT ZNF133 ZBTB40 ZNF766 SIRT6 ETV6 ATF7 AADAC SUCNR1 LOC105374159 AADACL2-AS1
GH03I151870 Enhancer 1.3 FANTOM5 Ensembl ENCODE 0.8 -2.0 -2042 1.6 HDAC1 ATF1 ZBTB40 CHAMP1 ZNF766 ETV6 ATF7 IKZF2 CREM ZBTB11 AADAC SUCNR1 AADACL2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SUCNR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SUCNR1 gene promoter:

Genomic Locations for SUCNR1 Gene

Genomic Locations for SUCNR1 Gene
chr3:151,873,643-151,884,619
(GRCh38/hg38)
Size:
10,977 bases
Orientation:
Plus strand
chr3:151,591,431-151,602,405
(GRCh37/hg19)

Genomic View for SUCNR1 Gene

Genes around SUCNR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCNR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCNR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SUCNR1 Gene

Proteins for SUCNR1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SUCNR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXA5-SUCR1_HUMAN
    Recommended name:
    Succinate receptor 1
    Protein Accession:
    Q9BXA5
    Secondary Accessions:
    • A8K305
    • Q8TDQ8

    Protein attributes for SUCNR1 Gene

    Size:
    334 amino acids
    Molecular mass:
    38698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK29080.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SUCNR1 Gene

Protein Expression for SUCNR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SUCNR1 Gene

  • Glycosylation at isoforms=8 and posLast=168168

Other Protein References for SUCNR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SUCNR1 Gene

Domains & Families for SUCNR1 Gene

Gene Families for SUCNR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for SUCNR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SUCNR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXA5

UniProtKB/Swiss-Prot:

SUCR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SUCNR1: view

Function for SUCNR1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SUCNR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for succinate.

Gene Ontology (GO) - Molecular Function for SUCNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with SUCNR1: view
genes like me logo Genes that share phenotypes with SUCNR1: view

Animal Models for SUCNR1 Gene

MGI Knock Outs for SUCNR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SUCNR1 Gene

Localization for SUCNR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCNR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUCNR1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SUCNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with SUCNR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SUCNR1 Gene

Pathways & Interactions for SUCNR1 Gene

genes like me logo Genes that share pathways with SUCNR1: view

Pathways by source for SUCNR1 Gene

1 BioSystems pathway for SUCNR1 Gene
1 KEGG pathway for SUCNR1 Gene

Gene Ontology (GO) - Biological Process for SUCNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SUCNR1: view

No data available for SIGNOR curated interactions for SUCNR1 Gene

Drugs & Compounds for SUCNR1 Gene

Products:

  1. Drug

(3) Drugs for SUCNR1 Gene - From: DrugBank, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target, inhibitor 0
2-{4-[5-(3-CHLORO-4-TRIflUOROMETHOXYPHENYL)-[1,3,4]OXADIAZOL-2-YL]BUTYL}-[1,8]NAPHTHYRIDINE Pharma 0
N-[{3-(3-TRIflUOROMETHYL-4-flUOROPHENYL)ISOXAZOL-5-YL}METHYL]-4-([1,8]NAPHTHYRIDIN-2-YL)BUTYRAMIDE Pharma 0

(2) Additional Compounds for SUCNR1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-{4-[5-(3-Chloro-4-tri?OEauoromethoxyphenyl)-[1,3,4]oxadiazol-2-yl]butyl}-[1,8]naphthyridine
Antagonist
N-[{3-(3-tri?OEauoromethyl-4-?OEauorophenyl)isoxazol-5-yl}methyl]-4-([1,8]naphthyridin-2-yl)butyramide
Antagonist
genes like me logo Genes that share compounds with SUCNR1: view

Transcripts for SUCNR1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SUCNR1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SUCNR1 Gene

Succinate receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUCNR1 Gene

No ASD Table

Relevant External Links for SUCNR1 Gene

GeneLoc Exon Structure for
SUCNR1
ECgene alternative splicing isoforms for
SUCNR1

Expression for SUCNR1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUCNR1 Gene

mRNA expression in normal human tissues for SUCNR1 Gene
mRNA expression by GTEx for SUCNR1 GenemRNA expression by BioGPS for SUCNR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUCNR1 Gene

This gene is overexpressed in Thyroid (x13.3) and Kidney - Cortex (x8.0).

Protein differential expression in normal tissues from HIPED for SUCNR1 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUCNR1 Gene



Protein tissue co-expression partners for SUCNR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SUCNR1 Gene:

SUCNR1

SOURCE GeneReport for Unigene cluster for SUCNR1 Gene:

Hs.279575

mRNA Expression by UniProt/SwissProt for SUCNR1 Gene:

Q9BXA5-SUCR1_HUMAN
Tissue specificity: Expressed specifically in kidney.

Evidence on tissue expression from TISSUES for SUCNR1 Gene

  • Kidney(4.5)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with SUCNR1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SUCNR1 Gene

Orthologs for SUCNR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SUCNR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SUCNR1 33 34
  • 99.1 (n)
dog
(Canis familiaris)
 Mammalia SUCNR1 33 34
  • 87.58 (n)
cow
(Bos Taurus)
 Mammalia SUCNR1 33 34
  • 83.65 (n)
mouse
(Mus musculus)
 Mammalia Sucnr1 33 16 34
  • 76.51 (n)
rat
(Rattus norvegicus)
 Mammalia Sucnr1 33
  • 76.4 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 68 (a)
 OneToMany
-- 34
  • 68 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves SUCNR1 33 34
  • 62.12 (n)
lizard
(Anolis carolinensis)
 Reptilia SUCNR1 34
  • 55 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia sucnr1 33
  • 61 (n)
zebrafish
(Danio rerio)
 Actinopterygii wisp2 34
  • 29 (a)
 ManyToMany
Species where no ortholog for SUCNR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUCNR1 Gene

ENSEMBL:
Gene Tree for SUCNR1 (if available)
TreeFam:
Gene Tree for SUCNR1 (if available)

Paralogs for SUCNR1 Gene

Paralogs for SUCNR1 Gene

(10) SIMAP similar genes for SUCNR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SUCNR1: view

Variants for SUCNR1 Gene

Sequence variations from dbSNP and Humsavar for SUCNR1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000034320 -- 151,879,511(+) C/T intron_variant
rs1000490987 -- 151,879,787(+) T/A/C intron_variant
rs1001095406 -- 151,878,506(+) AAAAAA/AAAAA/AAAAAAA intron_variant
rs1001127932 -- 151,875,595(+) A/G intron_variant
rs1001160294 -- 151,879,222(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SUCNR1 Gene

Variant ID Type Subtype PubMed ID
dgv622n27 CNV loss 19166990
dgv8654n54 CNV loss 21841781
esv2759189 CNV loss 17122850
nsv4067 CNV insertion 18451855
nsv829758 CNV gain 17160897

Variation tolerance for SUCNR1 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUCNR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUCNR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCNR1 Gene

Disorders for SUCNR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SUCNR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 1
  • evr1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SUCNR1

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SUCNR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCNR1 Gene

Publications for SUCNR1 Gene

  1. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. (PMID: 15141213) He W … Ling L (Nature 2004) 2 3 4 58
  2. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T … Hellebrand S (Journal of molecular biology 2001) 2 3 4 58
  3. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay IC … Ouwehand WH (Blood 2007) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice. (PMID: 27527650) Rubić-Schneider T … Carballido JM (Allergy 2017) 3 58

Products for SUCNR1 Gene

Sources for SUCNR1 Gene

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