Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]
SUCNR1 (Succinate Receptor 1) is a Protein Coding gene. Diseases associated with SUCNR1 include Renovascular Hypertension and Mooren's Ulcer. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is P2RY1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0038023 | signaling receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | cAMP signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002001 | renin secretion into blood stream | IEA | -- |
GO:0002281 | macrophage activation involved in immune response | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0032611 | interleukin-1 beta production | IMP | 27481132 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Succinic acid | Approved | Nutra | Agonist, Full agonist, Target, inhibitor | 0 | ||
2-{4-[5-(3-CHLORO-4-TRIflUOROMETHOXYPHENYL)-[1,3,4]OXADIAZOL-2-YL]BUTYL}-[1,8]NAPHTHYRIDINE | Pharma | 0 | ||||
N-[{3-(3-TRIflUOROMETHYL-4-flUOROPHENYL)ISOXAZOL-5-YL}METHYL]-4-([1,8]NAPHTHYRIDIN-2-YL)BUTYRAMIDE | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-{4-[5-(3-Chloro-4-tri?¼âuoromethoxyphenyl)-[1,3,4]oxadiazol-2-yl]butyl}-[1,8]naphthyridine |
|
Antagonist |
|
|||
N-[{3-(3-tri?¼âuoromethyl-4-?¼âuorophenyl)isoxazol-5-yl}methyl]-4-([1,8]naphthyridin-2-yl)butyramide |
|
Antagonist |
|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SUCNR1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SUCNR1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SUCNR1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Sucnr1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sucnr1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | SUCNR1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SUCNR1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sucnr1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | wisp2 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713065 | Benign: not provided | 151,880,738(+) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv622n27 | CNV | loss | 19166990 |
dgv8654n54 | CNV | loss | 21841781 |
esv2759189 | CNV | loss | 17122850 |
nsv4067 | CNV | insertion | 18451855 |
nsv829758 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
renovascular hypertension |
|
|
mooren's ulcer |
|
|