Aliases for SUCLG2 Gene
External Ids for SUCLG2 Gene
Previous GeneCards Identifiers for SUCLG2 Gene
This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
GeneCards Summary for SUCLG2 Gene
SUCLG2 (Succinate-CoA Ligase GDP-Forming Beta Subunit) is a Protein Coding gene. Diseases associated with SUCLG2 include Pyomyositis and Epiglottitis. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and GDP binding. An important paralog of this gene is SUCLA2.
UniProtKB/Swiss-Prot for SUCLG2 Gene
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.