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Aliases for SUCLG2 Gene

Aliases for SUCLG2 Gene

  • Succinate-CoA Ligase GDP-Forming Beta Subunit 2 3 5
  • GTP-Specific Succinyl-CoA Synthetase Subunit Beta 3 4
  • EC 4 56
  • SCS-BetaG 3 4
  • GTPSCS 3 4
  • G-SCS 3 4
  • Succinate--CoA Ligase [GDP-Forming] Subunit Beta, Mitochondrial 3
  • Succinyl-CoA Ligase [GDP-Forming] Subunit Beta, Mitochondrial 3
  • Succinyl-CoA Ligase, GDP-Forming, Beta Chain, Mitochondrial 3
  • GTP-Specific Succinyl-CoA Synthetase Beta Subunit 3
  • Succinyl-CoA Synthetase, Beta-G Chain 3
  • Succinyl-CoA Synthetase Beta-G Chain 4
  • EC 6.2.1 56
  • GBETA 3

External Ids for SUCLG2 Gene

Previous GeneCards Identifiers for SUCLG2 Gene

  • GC03M066056
  • GC03M066888
  • GC03M067249
  • GC03M067507

Summaries for SUCLG2 Gene

Entrez Gene Summary for SUCLG2 Gene

  • This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

GeneCards Summary for SUCLG2 Gene

SUCLG2 (Succinate-CoA Ligase GDP-Forming Beta Subunit) is a Protein Coding gene. Diseases associated with SUCLG2 include Pyomyositis and Epiglottitis. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and GDP binding. An important paralog of this gene is SUCLA2.

UniProtKB/Swiss-Prot for SUCLG2 Gene

  • GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Additional gene information for SUCLG2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCLG2 Gene

Genomics for SUCLG2 Gene

GeneHancer (GH) Regulatory Elements for SUCLG2 Gene

Promoters and enhancers for SUCLG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I067652 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 128 4.3 HDGF MLX ZFP64 SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B ZNF207 SUCLG2-AS1 SUCLG2 GC03P067630
GH03I067646 Enhancer 1.2 Ensembl ENCODE 5.1 +5.7 5725 5.5 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ETS1 YY1 FOS RXRA SP5 SUCLG2-AS1 SUCLG2 GC03P067630
GH03I067296 Enhancer 0.5 ENCODE 10.6 +357.7 357672 0.8 SOX13 NFIL3 SSRP1 FOXA2 DMAP1 MAFK ZKSCAN1 ENSG00000241884 SUCLG2 GC03M067321
GH03I067685 Enhancer 0.8 Ensembl ENCODE 4.4 -31.1 -31140 1.4 JUNB ELF1 BATF ATF2 ZNF217 IKZF1 ATF7 RUNX3 IKZF2 SPI1 GC03P067687 SUCLG2 SUCLG2-AS1
GH03I067461 Enhancer 0.7 Ensembl ENCODE 4.3 +192.4 192372 1.7 JUND PKNOX1 GLIS1 JUN SUCLG2-AS1 SUCLG2 NDUFB4P1 GC03M067398
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SUCLG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SUCLG2 gene promoter:

Genomic Locations for SUCLG2 Gene

Genomic Locations for SUCLG2 Gene
294,155 bases
Minus strand

Genomic View for SUCLG2 Gene

Genes around SUCLG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCLG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCLG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCLG2 Gene

Proteins for SUCLG2 Gene

  • Protein details for SUCLG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • C9JVT2
    • O95195
    • Q6NUH7
    • Q86VX8
    • Q8WUQ1

    Protein attributes for SUCLG2 Gene

    432 amino acids
    Molecular mass:
    46511 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
    • Sequence=AAH07716.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for SUCLG2 Gene


neXtProt entry for SUCLG2 Gene

Selected DME Specific Peptides for SUCLG2 Gene


Post-translational modifications for SUCLG2 Gene

Domains & Families for SUCLG2 Gene

Gene Families for SUCLG2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SUCLG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
  • Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
genes like me logo Genes that share domains with SUCLG2: view

Function for SUCLG2 Gene

Molecular function for SUCLG2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
UniProtKB/Swiss-Prot Function:
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Enzyme Numbers (IUBMB) for SUCLG2 Gene

Phenotypes From GWAS Catalog for SUCLG2 Gene

Gene Ontology (GO) - Molecular Function for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004775 succinate-CoA ligase (ADP-forming) activity IEA --
GO:0004776 succinate-CoA ligase (GDP-forming) activity NAS 9765291
GO:0005515 protein binding IPI 24606901
genes like me logo Genes that share ontologies with SUCLG2: view
genes like me logo Genes that share phenotypes with SUCLG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUCLG2 Gene

Localization for SUCLG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCLG2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUCLG2 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
cytoskeleton 2
cytosol 2
extracellular 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005886 plasma membrane IDA --
GO:0043234 protein complex IEA --
GO:0045244 succinate-CoA ligase complex (GDP-forming) IEA --
genes like me logo Genes that share ontologies with SUCLG2: view

Pathways & Interactions for SUCLG2 Gene

genes like me logo Genes that share pathways with SUCLG2: view

UniProtKB/Swiss-Prot Q96I99-SUCB2_HUMAN

  • Pathway: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Gene Ontology (GO) - Biological Process for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006099 tricarboxylic acid cycle IEA,TAS --
GO:0006104 succinyl-CoA metabolic process NAS 9765291
GO:0006105 succinate metabolic process IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SUCLG2: view

No data available for SIGNOR curated interactions for SUCLG2 Gene

Drugs & Compounds for SUCLG2 Gene

(7) Drugs for SUCLG2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
Phosphoric acid Approved Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Succinyl-CoA Experimental Pharma 0

(5) Additional Compounds for SUCLG2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
inosine triphosphate
  • 2'-Inosine-5'-triphosphate
  • 5'-ITP
  • 5-ITP
  • Inosine 5
  • Inosine 5'-(tetrahydrogen triphosphate)
Itaconic acid
  • Methylenebutanedioate
  • 2-Hydroxy-3-Naphthoyl-2-Naphthylamine
  • 2-Methylenesuccinate
  • 2-Methylenesuccinic acid
  • 2-Propene-1,2-dicarboxylate
  • Itaconoyl CoA
  • Itaconoyl coenzyme A
  • S-(1-Hydrogen methylenesuccinate) CoA
  • S-(1-Hydrogen methylenesuccinate) Coenzyme A
  • S-3-Methylenesuccinate CoA
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with SUCLG2: view

Transcripts for SUCLG2 Gene

Unigene Clusters for SUCLG2 Gene

Succinate-CoA ligase, GDP-forming, beta subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUCLG2 Gene

No ASD Table

Relevant External Links for SUCLG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SUCLG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUCLG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUCLG2 Gene

This gene is overexpressed in Liver (x5.0).

Protein differential expression in normal tissues from HIPED for SUCLG2 Gene

This gene is overexpressed in Nasal epithelium (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUCLG2 Gene

Protein tissue co-expression partners for SUCLG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SUCLG2 Gene:


SOURCE GeneReport for Unigene cluster for SUCLG2 Gene:


mRNA Expression by UniProt/SwissProt for SUCLG2 Gene:

Tissue specificity: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.

Evidence on tissue expression from TISSUES for SUCLG2 Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Kidney(3)
  • Muscle(3)
  • Heart(2.8)
  • Adrenal gland(2.5)
  • Pancreas(2.5)
  • Intestine(2.4)
  • Skin(2.3)
  • Thyroid gland(2.2)
  • Eye(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with SUCLG2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SUCLG2 Gene

Orthologs for SUCLG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUCLG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SUCLG2 33
  • 99.61 (n)
(Bos Taurus)
Mammalia SUCLG2 33 34
  • 93.17 (n)
(Canis familiaris)
Mammalia SUCLG2 33 34
  • 91.67 (n)
(Ornithorhynchus anatinus)
Mammalia SUCLG2 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Suclg2 33
  • 88.33 (n)
(Mus musculus)
Mammalia Suclg2 33 16 34
  • 88.23 (n)
(Monodelphis domestica)
Mammalia SUCLG2 34
  • 67 (a)
(Gallus gallus)
Aves SUCLG2 33 34
  • 79.44 (n)
(Anolis carolinensis)
Reptilia SUCLG2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1992 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5442 33
(Danio rerio)
Actinopterygii suclg2 33 34
  • 73.75 (n)
wufb64e03 33
fruit fly
(Drosophila melanogaster)
Insecta Sucb 33 34
  • 59.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004352 33
  • 59.22 (n)
(Caenorhabditis elegans)
Secernentea sucg-1 33 34
  • 60.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSC2 34
  • 42 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1791 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.911 34
  • 59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.212 33
Species where no ortholog for SUCLG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUCLG2 Gene

Gene Tree for SUCLG2 (if available)
Gene Tree for SUCLG2 (if available)

Paralogs for SUCLG2 Gene

Paralogs for SUCLG2 Gene

(4) SIMAP similar genes for SUCLG2 Gene using alignment to 4 proteins: Pseudogenes for SUCLG2 Gene

genes like me logo Genes that share paralogs with SUCLG2: view

Variants for SUCLG2 Gene

Sequence variations from dbSNP and Humsavar for SUCLG2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs150352166 benign, not specified 67,498,303(-) AAGAAGAA/AAGAA intron_variant
rs2290174 benign, not specified 67,609,616(-) G/A intron_variant
rs74675534 benign, not specified 67,529,111(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs7623258 benign, not specified 67,400,773(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs902320 benign, not specified 67,360,679(-) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SUCLG2 Gene

Variant ID Type Subtype PubMed ID
nsv834719 CNV gain 17160897
nsv590561 CNV loss 21841781
nsv590560 CNV loss 21841781
nsv519439 CNV loss 19592680
nsv513049 CNV loss 21212237
nsv508222 CNV deletion 20534489
nsv508221 CNV deletion 20534489
nsv470638 CNV loss 18288195
nsv460700 CNV loss 19166990
nsv435769 CNV deletion 17901297
nsv3860 CNV deletion 18451855
nsv1073229 CNV deletion 25765185
nsv1073228 CNV deletion 25765185
nsv1012416 CNV gain 25217958
nsv1003158 CNV loss 25217958
esv8929 CNV loss 19470904
esv8455 CNV gain 19470904
esv3596462 CNV loss 21293372
esv3596461 CNV loss 21293372
esv3596460 CNV loss 21293372
esv3596459 CNV loss 21293372
esv3596458 CNV loss 21293372
esv3596457 CNV loss 21293372
esv3596456 CNV loss 21293372
esv3562020 CNV deletion 23714750
esv3452138 CNV insertion 20981092
esv3411680 CNV insertion 20981092
esv3384382 CNV insertion 20981092
esv3309442 CNV mobile element insertion 20981092
esv2836569 CNV deletion 24192839
esv27977 CNV loss 19812545
esv275108 CNV gain+loss 21479260
esv2725377 CNV deletion 23290073
esv2725376 CNV deletion 23290073
esv2670594 CNV deletion 23128226
esv2665141 CNV deletion 23128226
esv2660821 CNV deletion 23128226
esv2479752 CNV deletion 19546169
esv2201325 CNV deletion 18987734
esv1366353 CNV deletion 17803354
esv1009299 CNV deletion 20482838
dgv2530n106 CNV deletion 24896259
dgv1384e212 CNV loss 25503493
dgv126n73 CNV deletion 24416366

Variation tolerance for SUCLG2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.60; 91.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUCLG2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCLG2 Gene

Disorders for SUCLG2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SUCLG2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • tropical pyomyositis
  • acute epiglottitis
subacute bacterial endocarditis
  • endocarditis lenta
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SUCLG2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SUCLG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCLG2 Gene

Publications for SUCLG2 Gene

  1. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. (PMID: 9765291) Johnson JD … Lambeth DO (The Journal of biological chemistry 1998) 2 3 4 58
  2. Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. (PMID: 22144915) Fan Q … Saw SM (PLoS genetics 2011) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for SUCLG2 Gene

Sources for SUCLG2 Gene

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