This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010] See more...

Aliases for SUCLG2 Gene

Aliases for SUCLG2 Gene

  • Succinate-CoA Ligase GDP-Forming Subunit Beta 2 3 5
  • Succinate--CoA Ligase [GDP-Forming] Subunit Beta, Mitochondrial 3 4
  • GTP-Specific Succinyl-CoA Synthetase Subunit Beta 3 4
  • EC 6.2.1.4 4 50
  • SCS-BetaG 3 4
  • GTPSCS 3 4
  • G-SCS 3 4
  • Succinyl-CoA Ligase [GDP-Forming] Subunit Beta, Mitochondrial 3
  • Succinyl-CoA Ligase, GDP-Forming, Beta Chain, Mitochondrial 3
  • GTP-Specific Succinyl-CoA Synthetase Beta Subunit 3
  • Succinate-CoA Ligase GDP-Forming Beta Subunit 3
  • Succinyl-CoA Synthetase, Beta-G Chain 3
  • Succinyl-CoA Synthetase Beta-G Chain 4
  • EC 6.2.1'); 50
  • EC 6.2.1 50
  • SUCLG2 5
  • GBETA 3

External Ids for SUCLG2 Gene

Previous GeneCards Identifiers for SUCLG2 Gene

  • GC03M066056
  • GC03M066888
  • GC03M067249
  • GC03M067507

Summaries for SUCLG2 Gene

Entrez Gene Summary for SUCLG2 Gene

  • This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

GeneCards Summary for SUCLG2 Gene

SUCLG2 (Succinate-CoA Ligase GDP-Forming Subunit Beta) is a Protein Coding gene. Diseases associated with SUCLG2 include Mitochondrial Dna Depletion Syndrome 9 and Panophthalmitis. Among its related pathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and GDP binding. An important paralog of this gene is SUCLA2.

UniProtKB/Swiss-Prot Summary for SUCLG2 Gene

  • GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SUCLG2 Gene

Genomics for SUCLG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SUCLG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J067652 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.1 126 4.3 BCLAF1 SP1 ZNF207 MYC POLR2A ZNF10 ZIC2 YY1 NONO BCL11A SUCLG2-AS1 SUCLG2 piR-33730-055 TAFA1 LOC105377148 KBTBD8
GH03J067290 Enhancer 0.9 Ensembl ENCODE 15.7 +363.7 363711 5.4 CEBPA FOXA2 CTBP1 SMAD4 IRF4 EBF1 JUND BCL6 SOX5 SPI1 lnc-SUCLG2-1 SUCLG2 ENSG00000241884 KBTBD8
GH03J067362 Enhancer 0.7 Ensembl 14.2 +291.5 291511 1.8 NCOR1 NFIC TAL1 FOSL2 JUND STAT5A SMARCA4 ETV1 FOXM1 HDAC2 SUCLG2 HSALNG0026669 HSALNG0026671 KBTBD8
GH03J067302 Enhancer 0.7 Ensembl 13.3 +351.8 351812 0.8 CEBPA FOXA2 SMAD4 RARA CREM BCL6 TBP SOX5 HMG20A HBP1 SUCLG2 ENSG00000241884 HSALNG0026668 KBTBD8
GH03J067357 Enhancer 0.8 Ensembl ENCODE 10 +296.6 296570 0.7 CTCF TEAD3 RAD21 MIER2 REST SP1 HLF SMC3 ZNF143 XRCC5 SUCLG2 HSALNG0026669 HSALNG0026671 KBTBD8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SUCLG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SUCLG2

Top Transcription factor binding sites by QIAGEN in the SUCLG2 gene promoter:
  • CREB
  • Evi-1
  • IRF-2
  • ISGF-3
  • Nkx6-1
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for SUCLG2 Gene

Latest Assembly
chr3:67,360,460-67,654,612
(GRCh38/hg38)
Size:
294,153 bases
Orientation:
Minus strand

Previous Assembly
chr3:67,410,884-67,705,036
(GRCh37/hg19 by Entrez Gene)
Size:
294,153 bases
Orientation:
Minus strand

chr3:67,410,884-67,705,038
(GRCh37/hg19 by Ensembl)
Size:
294,155 bases
Orientation:
Minus strand

Genomic View for SUCLG2 Gene

Genes around SUCLG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUCLG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUCLG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUCLG2 Gene

Proteins for SUCLG2 Gene

  • Protein details for SUCLG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I99-SUCB2_HUMAN
    Recommended name:
    Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
    Protein Accession:
    Q96I99
    Secondary Accessions:
    • C9JVT2
    • O95195
    • Q6NUH7
    • Q86VX8
    • Q8WUQ1

    Protein attributes for SUCLG2 Gene

    Size:
    432 amino acids
    Molecular mass:
    46511 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
    SequenceCaution:
    • Sequence=AAH07716.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUCLG2 Gene

    Alternative splice isoforms for SUCLG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SUCLG2 Gene

Selected DME Specific Peptides for SUCLG2 Gene

Q96I99:
  • GGKPANFLD
  • PLVVRLEG
  • DAKINFD
  • AGGRGKG
  • NIFGGIVNCA
  • VGSPQGGVDIEEVAAS
  • VNIFGGI
  • VVRLEGTN
  • VNGAGLAM
  • VPLVVRL
  • SGLKGGV
  • GGVDIEEV
  • VRLEGTNV

Post-translational modifications for SUCLG2 Gene

  • Ubiquitination at Lys118
  • Modification sites at PhosphoSitePlus

Other Protein References for SUCLG2 Gene

Antibodies for research

  • Abcam antibodies for SUCLG2
  • Boster Bio Antibodies for SUCLG2

Domains & Families for SUCLG2 Gene

Gene Families for SUCLG2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SUCLG2 Gene

InterPro:
Blocks:
  • Succinyl-CoA synthetase, beta subunit
  • ATP-grasp fold, succinyl-CoA synthetase-type

Suggested Antigen Peptide Sequences for SUCLG2 Gene

GenScript: Design optimal peptide antigens:
  • SUCLG2 protein (Q3ZCW5_HUMAN)
  • Succinyl-CoA synthetase beta-G chain (SUCB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96I99

UniProtKB/Swiss-Prot:

SUCB2_HUMAN :
  • Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
Family:
  • Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
genes like me logo Genes that share domains with SUCLG2: view

Function for SUCLG2 Gene

Molecular function for SUCLG2 Gene

UniProtKB/Swiss-Prot Function:
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CoA + GTP + succinate = GDP + phosphate + succinyl-CoA; Xref=Rhea:RHEA:22120, ChEBI:CHEBI:30031, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:58189; EC=6.2.1.4; Evidence={ECO:0000255|HAMAP-Rule:MF_03221};.

Enzyme Numbers (IUBMB) for SUCLG2 Gene

Phenotypes From GWAS Catalog for SUCLG2 Gene

Gene Ontology (GO) - Molecular Function for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004775 succinate-CoA ligase (ADP-forming) activity IEA --
GO:0004776 succinate-CoA ligase (GDP-forming) activity IBA,NAS 9765291
genes like me logo Genes that share ontologies with SUCLG2: view
genes like me logo Genes that share phenotypes with SUCLG2: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SUCLG2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUCLG2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SUCLG2 Gene

Localization for SUCLG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUCLG2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUCLG2 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA,IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0005886 plasma membrane IDA --
GO:0032991 protein-containing complex IEA --
GO:0042709 succinate-CoA ligase complex IBA 21873635
genes like me logo Genes that share ontologies with SUCLG2: view

Pathways & Interactions for SUCLG2 Gene

genes like me logo Genes that share pathways with SUCLG2: view

UniProtKB/Swiss-Prot Q96I99-SUCB2_HUMAN

  • Pathway: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Gene Ontology (GO) - Biological Process for SUCLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006099 tricarboxylic acid cycle IEA,TAS --
GO:0006104 succinyl-CoA metabolic process IBA,NAS 9765291
GO:0006105 succinate metabolic process IEA --
genes like me logo Genes that share ontologies with SUCLG2: view

No data available for SIGNOR curated interactions for SUCLG2 Gene

Drugs & Compounds for SUCLG2 Gene

(8) Drugs for SUCLG2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Enzyme, product of 0
Acyclovir Approved Pharma Enzyme, substrate 124
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Phosphate Experimental Pharma 0

(4) Additional Compounds for SUCLG2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IDP
  • 5'-IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
  • Inosine 5'-pyrophosphate
86-04-4
inosine triphosphate
  • 2'-Inosine-5'-triphosphate
  • Inosine 5'-triphosphate
  • Inosine tripolyphosphate
  • O(5')-(Tetrahydroxytriphosphoryl)inosine
  • 2'-Inosine-5'-triphosphoric acid
132-06-9
Itaconic acid
  • 2-Methylenesuccinic acid
  • 2-Propene-1,2-dicarboxylic acid
  • Methylenebutanedioic acid
  • Methylenesuccinic acid
  • Propylenedicarboxylic acid
97-65-4
Itaconyl-CoA
  • Itaconoyl CoA
  • Itaconoyl coenzyme A
  • S-(1-Hydrogen methylenesuccinate) CoA
  • S-(1-Hydrogen methylenesuccinate) coenzyme A
  • S-3-Methylenesuccinate CoA
6008-93-1
genes like me logo Genes that share compounds with SUCLG2: view

Transcripts for SUCLG2 Gene

mRNA/cDNA for SUCLG2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SUCLG2

Alternative Splicing Database (ASD) splice patterns (SP) for SUCLG2 Gene

No ASD Table

Relevant External Links for SUCLG2 Gene

GeneLoc Exon Structure for
SUCLG2

Expression for SUCLG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SUCLG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SUCLG2 Gene

This gene is overexpressed in Liver (x5.0).

Protein differential expression in normal tissues from HIPED for SUCLG2 Gene

This gene is overexpressed in Nasal epithelium (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SUCLG2 Gene



Protein tissue co-expression partners for SUCLG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SUCLG2

SOURCE GeneReport for Unigene cluster for SUCLG2 Gene:

Hs.644919

mRNA Expression by UniProt/SwissProt for SUCLG2 Gene:

Q96I99-SUCB2_HUMAN
Tissue specificity: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.

Evidence on tissue expression from TISSUES for SUCLG2 Gene

  • Nervous system(4.6)
  • Liver(4.6)
  • Heart(3.7)
  • Kidney(3.1)
  • Muscle(3.1)
  • Skin(3)
  • Intestine(2.8)
  • Adrenal gland(2.8)
  • Pancreas(2.7)
  • Thyroid gland(2.6)
  • Spleen(2.6)
  • Lymph node(2.6)
  • Stomach(2.4)
  • Lung(2.3)
  • Blood(2.3)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with SUCLG2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SUCLG2 Gene

Orthologs for SUCLG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUCLG2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SUCLG2 29
  • 99.61 (n)
Cow
(Bos Taurus)
Mammalia SUCLG2 29 30
  • 93.17 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SUCLG2 29 30
  • 91.67 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SUCLG2 30
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Suclg2 29
  • 88.33 (n)
Mouse
(Mus musculus)
Mammalia Suclg2 29 16 30
  • 88.23 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SUCLG2 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SUCLG2 29 30
  • 79.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SUCLG2 30
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5442 29
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.1992 29
Zebrafish
(Danio rerio)
Actinopterygii suclg2 29 30
  • 73.75 (n)
OneToOne
wufb64e03 29
Fruit Fly
(Drosophila melanogaster)
Insecta Sucb 29 30
  • 59.91 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004352 29
  • 59.22 (n)
Worm
(Caenorhabditis elegans)
Secernentea sucg-1 29 30
  • 60.03 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSC2 30
  • 42 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1791 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.911 30
  • 59 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.212 29
Species where no ortholog for SUCLG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SUCLG2 Gene

ENSEMBL:
Gene Tree for SUCLG2 (if available)
TreeFam:
Gene Tree for SUCLG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SUCLG2: view image
Alliance of Genome Resources:
Additional Orthologs for SUCLG2

Paralogs for SUCLG2 Gene

Paralogs for SUCLG2 Gene

(4) SIMAP similar genes for SUCLG2 Gene using alignment to 4 proteins:

  • SUCB2_HUMAN
  • E9PDQ8_HUMAN
  • H0Y852_HUMAN
  • Q3ZCW5_HUMAN

Pseudogenes.org Pseudogenes for SUCLG2 Gene

genes like me logo Genes that share paralogs with SUCLG2: view

Variants for SUCLG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SUCLG2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
871256 Uncertain Significance: not provided 67,520,510(-) G/A
NM_003848.4(SUCLG2):c.542C>T (p.Ala181Val)
MISSENSE
rs1052001825 Likely Benign: not provided 67,400,816(-) G/A
NM_001177599.1(SUCLG2):c.1098C>T (p.Ile366=)
SYNONYMOUS
rs115053242 Benign: not provided 67,518,274(-) T/C
NM_001177599.1(SUCLG2):c.633A>G (p.Leu211=)
SYNONYMOUS
rs13318110 Benign: not provided 67,528,200(-) C/T
NM_001177599.1(SUCLG2):c.349G>A (p.Ala117Thr)
MISSENSE
rs150352166 Benign: not specified 67,498,302(-) AAAG/A
NM_003848.3(SUCLG2):c.758-10_758-8del
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SUCLG2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SUCLG2 Gene

Variant ID Type Subtype PubMed ID
dgv126n73 CNV deletion 24416366
dgv1384e212 CNV loss 25503493
dgv2530n106 CNV deletion 24896259
esv1009299 CNV deletion 20482838
esv1366353 CNV deletion 17803354
esv2201325 CNV deletion 18987734
esv2479752 CNV deletion 19546169
esv2660821 CNV deletion 23128226
esv2665141 CNV deletion 23128226
esv2670594 CNV deletion 23128226
esv2725376 CNV deletion 23290073
esv2725377 CNV deletion 23290073
esv275108 CNV gain+loss 21479260
esv27977 CNV loss 19812545
esv2836569 CNV deletion 24192839
esv3309442 CNV mobile element insertion 20981092
esv3384382 CNV insertion 20981092
esv3411680 CNV insertion 20981092
esv3452138 CNV insertion 20981092
esv3562020 CNV deletion 23714750
esv3596456 CNV loss 21293372
esv3596457 CNV loss 21293372
esv3596458 CNV loss 21293372
esv3596459 CNV loss 21293372
esv3596460 CNV loss 21293372
esv3596461 CNV loss 21293372
esv3596462 CNV loss 21293372
esv8455 CNV gain 19470904
esv8929 CNV loss 19470904
nsv1003158 CNV loss 25217958
nsv1012416 CNV gain 25217958
nsv1073228 CNV deletion 25765185
nsv1073229 CNV deletion 25765185
nsv3860 CNV deletion 18451855
nsv435769 CNV deletion 17901297
nsv460700 CNV loss 19166990
nsv470638 CNV loss 18288195
nsv508221 CNV deletion 20534489
nsv508222 CNV deletion 20534489
nsv513049 CNV loss 21212237
nsv519439 CNV loss 19592680
nsv590560 CNV loss 21841781
nsv590561 CNV loss 21841781
nsv834719 CNV gain 17160897

Variation tolerance for SUCLG2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.60; 91.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SUCLG2 Gene

Human Gene Mutation Database (HGMD)
SUCLG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUCLG2
Leiden Open Variation Database (LOVD)
SUCLG2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCLG2 Gene

Disorders for SUCLG2 Gene

MalaCards: The human disease database

(20) MalaCards diseases for SUCLG2 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SUCLG2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SUCLG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUCLG2 Gene

Publications for SUCLG2 Gene

  1. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. (PMID: 9765291) Johnson JD … Lambeth DO (The Journal of biological chemistry 1998) 2 3 4
  2. Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. (PMID: 22144915) Fan Q … Saw SM (PLoS genetics 2011) 3 40
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 40
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 40

Products for SUCLG2 Gene

Sources for SUCLG2 Gene