Aliases for STYXL2 Gene

Aliases for STYXL2 Gene

  • Serine/Threonine/Tyrosine Interacting Like 2 2 3
  • Dual Specificity Phosphatase 27, Atypical 2 3 5
  • Dual Specificity Phosphatase 27 (Putative) 2 3
  • Inactive Dual Specificity Phosphatase 27 3 4
  • DUSP27 3 5

External Ids for STYXL2 Gene

Previous HGNC Symbols for STYXL2 Gene

  • DUSP27

Summaries for STYXL2 Gene

GeneCards Summary for STYXL2 Gene

STYXL2 (Serine/Threonine/Tyrosine Interacting Like 2) is a Protein Coding gene. Diseases associated with STYXL2 include Variola Major. An important paralog of this gene is SSH2.

UniProtKB/Swiss-Prot Summary for STYXL2 Gene

Additional gene information for STYXL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STYXL2 Gene

Genomics for STYXL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STYXL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J167092 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.2 175 3.6 RFX1 ZNF501 BMI1 NFIC NFIB ZNF18 ZNF366 PRDM6 MEIS2 MNT STYXL2 GPA33 RPS17P6
GH01J167066 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 12.1 -27.3 -27339 0.3 CTCF JUND ZNF143 PATZ1 REST RAD21 ZNF501 TRIM22 ZNF561 MGA STYXL2 GPA33 POU2F1 ILDR2 RF00017-383 LOC105371600
GH01J167165 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 10.7 +72.4 72445 2.3 TEAD4 PRDM10 RFX1 ZNF501 POLR2A ZNF341 ZNF561 ZBTB44 ZBTB20 TCF7L2 GPA33 HSALNG0008213 LOC105371601 LINC01363 STYXL2 POU2F1
GH01J167134 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +43.2 43249 4.6 POLR2A RAD21 NFE2 NR3C1 TRIM28 FOS SMARCA4 NANOG MAX DACH1 GPA33 STYXL2 LINC01363 RPS17P6
GH01J167121 Promoter/Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 11.4 +27.7 27711 1.6 EZH2 POLR2A NFIC TBP BACH1 CTCF STYXL2 GPA33 ENSG00000227907 RPS17P6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STYXL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STYXL2

Genomic Locations for STYXL2 Gene

Genomic Locations for STYXL2 Gene
35,118 bases
Plus strand
35,121 bases
Plus strand

Genomic View for STYXL2 Gene

Genes around STYXL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STYXL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STYXL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYXL2 Gene

Proteins for STYXL2 Gene

  • Protein details for STYXL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive dual specificity phosphatase 27
    Protein Accession:
    Secondary Accessions:
    • A0AUM4
    • Q9C074

    Protein attributes for STYXL2 Gene

    1158 amino acids
    Molecular mass:
    130176 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK02011.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for STYXL2 Gene

Post-translational modifications for STYXL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STYXL2 Gene

No data available for DME Specific Peptides for STYXL2 Gene

Domains & Families for STYXL2 Gene

Gene Families for STYXL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STYXL2 Gene

Suggested Antigen Peptide Sequences for STYXL2 Gene

GenScript: Design optimal peptide antigens:
  • Inactive dual specificity phosphatase 27 (DUS27_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with STYXL2: view

Function for STYXL2 Gene

Molecular function for STYXL2 Gene

UniProtKB/Swiss-Prot Function:
May be required for myofiber maturation.

Phenotypes From GWAS Catalog for STYXL2 Gene

Gene Ontology (GO) - Molecular Function for STYXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with STYXL2: view
genes like me logo Genes that share phenotypes with STYXL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STYXL2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STYXL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STYXL2 Gene

Localization for STYXL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STYXL2 Gene

Cytoplasm, myofibril, sarcomere.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STYXL2 gene
Compartment Confidence
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STYXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0030017 sarcomere IEA --
genes like me logo Genes that share ontologies with STYXL2: view

Pathways & Interactions for STYXL2 Gene

PathCards logo

SuperPathways for STYXL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STYXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with STYXL2: view

No data available for Pathways by source and SIGNOR curated interactions for STYXL2 Gene

Drugs & Compounds for STYXL2 Gene

No Compound Related Data Available

Transcripts for STYXL2 Gene

mRNA/cDNA for STYXL2 Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STYXL2

Alternative Splicing Database (ASD) splice patterns (SP) for STYXL2 Gene

No ASD Table

Relevant External Links for STYXL2 Gene

GeneLoc Exon Structure for

Expression for STYXL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STYXL2

SOURCE GeneReport for Unigene cluster for STYXL2 Gene:


Evidence on tissue expression from TISSUES for STYXL2 Gene

  • Muscle(3)
  • Heart(2.6)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STYXL2 Gene

Orthologs for STYXL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STYXL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP27 30 31
  • 99.05 (n)
(Bos Taurus)
Mammalia DUSP27 30 31
  • 85.87 (n)
(Canis familiaris)
Mammalia DUSP27 30 31
  • 84.9 (n)
(Mus musculus)
Mammalia Dusp27 30 17 31
  • 83.1 (n)
(Rattus norvegicus)
Mammalia Dusp27 30
  • 83.05 (n)
(Monodelphis domestica)
Mammalia DUSP27 31
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP27 31
  • 68 (a)
(Gallus gallus)
Aves DUSP27 30 31
  • 63.94 (n)
(Anolis carolinensis)
Reptilia DUSP27 31
  • 57 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dusp27 30
  • 58.78 (n)
(Danio rerio)
Actinopterygii LOC792623 30
  • 59.51 (n)
DUSP27 31
  • 42 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7378 31
  • 37 (a)
Species where no ortholog for STYXL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for STYXL2 Gene

Gene Tree for STYXL2 (if available)
Gene Tree for STYXL2 (if available)
Evolutionary constrained regions (ECRs) for STYXL2: view image

Paralogs for STYXL2 Gene

Variants for STYXL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STYXL2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
715851 Benign: not provided 167,117,353(+) A/T SYNONYMOUS_VARIANT
769541 Benign: not provided 167,127,158(+) C/T MISSENSE_VARIANT
769542 Benign: not provided 167,127,609(+) C/T SYNONYMOUS_VARIANT
775621 Benign: not provided 167,119,239(+) C/T
783013 Benign: not provided 167,119,270(+) G/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for STYXL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for STYXL2 Gene

Variant ID Type Subtype PubMed ID
esv2719184 CNV deletion 23290073
esv2750815 CNV gain 17911159
esv3542134 CNV deletion 23714750
nsv1008831 CNV gain 25217958
nsv1078878 OTHER inversion 25765185
nsv1113190 CNV deletion 24896259

Variation tolerance for STYXL2 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STYXL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STYXL2 Gene

Disorders for STYXL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STYXL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
variola major
  • smallpox
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with STYXL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STYXL2 Gene

Publications for STYXL2 Gene

  1. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. (PMID: 26302245) Zhao BM … Ulrich RG (PloS one 2015) 2 3
  2. Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1. (PMID: 31067491) Sabbir MG (The Journal of steroid biochemistry and molecular biology 2019) 3
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3
  5. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (PMID: 20520587) Nielsen DA … Kreek MJ (Psychiatric genetics 2010) 3

Products for STYXL2 Gene

Sources for STYXL2 Gene