Aliases for STYXL1 Gene

Aliases for STYXL1 Gene

  • Serine/Threonine/Tyrosine Interacting Like 1 2 3 5
  • Inactive Dual Specificity Protein Phosphatase MK-STYX 3 4
  • Serine/Threonine/Tyrosine-Interacting-Like Protein 1 3 4
  • Dual Specificity Phosphatase Inhibitor MK-STYX 3 4
  • Map Kinase Phosphatase-Like Protein MK-STYX 3 4
  • Dual Specificity Phosphatase 24 (Putative) 2 3
  • Dual Specificity Protein Phosphatase 24 3 4
  • DUSP24 3 4
  • MKSTYX 3 4
  • MK-STYX 3

External Ids for STYXL1 Gene

Previous HGNC Symbols for STYXL1 Gene

  • DUSP24

Previous GeneCards Identifiers for STYXL1 Gene

  • GC07M075272
  • GC07M075463
  • GC07M075625
  • GC07M070712

Summaries for STYXL1 Gene

GeneCards Summary for STYXL1 Gene

STYXL1 (Serine/Threonine/Tyrosine Interacting Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP2.

UniProtKB/Swiss-Prot Summary for STYXL1 Gene

  • Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526).

Gene Wiki entry for STYXL1 Gene

Additional gene information for STYXL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STYXL1 Gene

Genomics for STYXL1 Gene

GeneHancer (GH) Regulatory Elements for STYXL1 Gene

Promoters and enhancers for STYXL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STYXL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STYXL1 gene promoter:
  • ER-alpha
  • FOXO1
  • FOXO1a
  • GATA-1
  • GATA-2
  • GATA-3
  • ITF-2
  • Pax-4a
  • POU2F1
  • Tal-1beta

Genomic Locations for STYXL1 Gene

Genomic Locations for STYXL1 Gene
chr7:75,995,834-76,048,004
(GRCh38/hg38)
Size:
52,171 bases
Orientation:
Minus strand
chr7:75,625,655-75,677,322
(GRCh37/hg19)
Size:
51,668 bases
Orientation:
Minus strand

Genomic View for STYXL1 Gene

Genes around STYXL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STYXL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STYXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYXL1 Gene

Proteins for STYXL1 Gene

  • Protein details for STYXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6J8-STYL1_HUMAN
    Recommended name:
    Serine/threonine/tyrosine-interacting-like protein 1
    Protein Accession:
    Q9Y6J8
    Secondary Accessions:
    • Q9UBP1
    • Q9UK06
    • Q9UK07
    • Q9UKG2
    • Q9UKG3

    Protein attributes for STYXL1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35818 Da
    Quaternary structure:
    • Interacts with G3BP1 (PubMed:20180778). Interacts with PTPMT1; the interaction inhibits PTPMT1 catalytic activity (PubMed:24709986).

    Alternative splice isoforms for STYXL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STYXL1 Gene

Post-translational modifications for STYXL1 Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STYXL1 Gene

Domains & Families for STYXL1 Gene

Gene Families for STYXL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for STYXL1 Gene

GenScript: Design optimal peptide antigens:
  • Map kinase phosphatase-like protein MK-STYX (STYL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6J8

UniProtKB/Swiss-Prot:

STYL1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
genes like me logo Genes that share domains with STYXL1: view

Function for STYXL1 Gene

Molecular function for STYXL1 Gene

UniProtKB/Swiss-Prot Function:
Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526).

Phenotypes From GWAS Catalog for STYXL1 Gene

Gene Ontology (GO) - Molecular Function for STYXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001691 pseudophosphatase activity IMP 20180778
GO:0004864 protein phosphatase inhibitor activity IDA,IBA 24709986
GO:0005515 protein binding IPI 19026618
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0019903 protein phosphatase binding IBA,IPI 24709986
genes like me logo Genes that share ontologies with STYXL1: view
genes like me logo Genes that share phenotypes with STYXL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STYXL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STYXL1 Gene

Localization for STYXL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STYXL1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STYXL1 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STYXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IBA 21262771
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with STYXL1: view

Pathways & Interactions for STYXL1 Gene

PathCards logo

SuperPathways for STYXL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STYXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0010976 positive regulation of neuron projection development IMP 29250526
GO:0016311 dephosphorylation IEA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IDA 24709986
GO:0035556 intracellular signal transduction TAS 9757831
genes like me logo Genes that share ontologies with STYXL1: view

No data available for Pathways by source and SIGNOR curated interactions for STYXL1 Gene

Drugs & Compounds for STYXL1 Gene

No Compound Related Data Available

Transcripts for STYXL1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STYXL1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STYXL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - - - - -
SP8:
SP9: - - -
SP10: -

Relevant External Links for STYXL1 Gene

GeneLoc Exon Structure for
STYXL1
ECgene alternative splicing isoforms for
STYXL1

Expression for STYXL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STYXL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of STYXL1 Gene:

STYXL1

SOURCE GeneReport for Unigene cluster for STYXL1 Gene:

Hs.11615

Evidence on tissue expression from TISSUES for STYXL1 Gene

  • Skin(4.3)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with STYXL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STYXL1 Gene

Orthologs for STYXL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STYXL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STYXL1 33 32
  • 98.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STYXL1 33 32
  • 82.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STYXL1 33 32
  • 79.87 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Styxl1 32
  • 75.43 (n)
mouse
(Mus musculus)
Mammalia Styxl1 17 33 32
  • 73.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STYXL1 33
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STYXL1 33
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves STYXL1 33 32
  • 59.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STYXL1 33
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia styxl1 32
  • 62.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32093 32
zebrafish
(Danio rerio)
Actinopterygii styxl1 33 32
  • 53.06 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 42 (a)
OneToOne
Species where no ortholog for STYXL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STYXL1 Gene

ENSEMBL:
Gene Tree for STYXL1 (if available)
TreeFam:
Gene Tree for STYXL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STYXL1: view image

Paralogs for STYXL1 Gene

(1) SIMAP similar genes for STYXL1 Gene using alignment to 5 proteins:

  • STYL1_HUMAN
  • C9J4H0_HUMAN
  • F8W9Q3_HUMAN
  • H0Y6C4_HUMAN
  • H7C1Y2_HUMAN
genes like me logo Genes that share paralogs with STYXL1: view

Variants for STYXL1 Gene

Sequence variations from dbSNP and Humsavar for STYXL1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs189383313 likely-benign, not provided 76,048,243(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1563451176 uncertain-significance, not specified 75,996,535(-) T/TT 3_prime_UTR_variant, coding_sequence_variant, frameshift, non_coding_transcript_variant
rs1000119984 -- 76,011,403(-) A/G intron_variant
rs1000139865 -- 76,050,022(-) G/A upstream_transcript_variant
rs1000499765 -- 76,026,852(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STYXL1 Gene

Variant ID Type Subtype PubMed ID
dgv1117n67 CNV gain 20364138
dgv11455n54 CNV loss 21841781
dgv11456n54 CNV loss 21841781
dgv11457n54 CNV loss 21841781
dgv11458n54 CNV loss 21841781
dgv11459n54 CNV loss 21841781
dgv11460n54 CNV loss 21841781
dgv11461n54 CNV loss 21841781
dgv11462n54 CNV loss 21841781
dgv11463n54 CNV loss 21841781
dgv120n16 CNV deletion 17901297
dgv1217e199 CNV deletion 23128226
esv24008 CNV gain+loss 19812545
esv2666194 CNV deletion 23128226
esv3541926 CNV deletion 23714750
esv3613742 CNV loss 21293372
esv3613746 CNV loss 21293372
esv3613748 CNV loss 21293372
esv3613749 CNV loss 21293372
esv3613750 CNV loss 21293372
esv3613751 CNV loss 21293372
esv3613752 CNV loss 21293372
esv3613753 CNV loss 21293372
esv3613754 CNV gain 21293372
nsv1112937 CNV deletion 24896259
nsv1116564 OTHER inversion 24896259
nsv428173 CNV gain 18775914
nsv528969 CNV gain 19592680
nsv607525 CNV loss 21841781
nsv607549 CNV loss 21841781
nsv819156 CNV gain 19587683
nsv821252 CNV deletion 20802225

Variation tolerance for STYXL1 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STYXL1 Gene

Human Gene Mutation Database (HGMD)
STYXL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STYXL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STYXL1 Gene

Disorders for STYXL1 Gene

Additional Disease Information for STYXL1

No disorders were found for STYXL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STYXL1 Gene

Publications for STYXL1 Gene

  1. The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation. (PMID: 20180778) Hinton SD … Tonks NK (The Biochemical journal 2010) 3 4 23 56
  2. Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. (PMID: 9757831) Wishart MJ … Dixon JE (Trends in biochemical sciences 1998) 2 3 4 56
  3. MK-STYX Alters the Morphology of Primary Neurons, and Outgrowths in MK-STYX Overexpressing PC-12 Cells Develop a Neuronal Phenotype. (PMID: 29250526) Banks DA … Hinton SD (Frontiers in molecular biosciences 2017) 3 4 56
  4. The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. (PMID: 24709986) Niemi NM … MacKeigan JP (PloS one 2014) 3 4 56
  5. The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1. (PMID: 23163895) Barr JE … Hinton SD (The FEBS journal 2013) 3 4 56

Products for STYXL1 Gene

Sources for STYXL1 Gene