Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008] See more...

Aliases for STYK1 Gene

Aliases for STYK1 Gene

  • Serine/Threonine/Tyrosine Kinase 1 2 3 4 5
  • Novel Oncogene With Kinase Domain 3 4
  • Tyrosine-Protein Kinase STYK1 3 4
  • Protein PK-Unique 3 4
  • NOK 3 4
  • EC 2.7.10.2 4
  • SuRTK106 3

External Ids for STYK1 Gene

Previous GeneCards Identifiers for STYK1 Gene

  • GC12M010664
  • GC12M010666
  • GC12M010771
  • GC12M010500
  • GC12M010668
  • GC12M012421
  • GC12M012640
  • GC12M010830
  • GC12M011024
  • GC12M011328
  • GC12M011546
  • GC12M011737
  • GC12M011924
  • GC12M012110
  • GC12M012287

Summaries for STYK1 Gene

Entrez Gene Summary for STYK1 Gene

  • Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]

GeneCards Summary for STYK1 Gene

STYK1 (Serine/Threonine/Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with STYK1 include Chronic Inflammatory Demyelinating Polyneuritis and Cervix Carcinoma. Among its related pathways are Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LCK.

UniProtKB/Swiss-Prot Summary for STYK1 Gene

  • Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).

Gene Wiki entry for STYK1 Gene

Additional gene information for STYK1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STYK1 Gene

Genomics for STYK1 Gene

GeneHancer (GH) Regulatory Elements for STYK1 Gene

Promoters and enhancers for STYK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STYK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STYK1 gene promoter:
  • ER-alpha
  • FAC1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pax-4a
  • STAT5A
  • STAT5B

Genomic Locations for STYK1 Gene

Genomic Locations for STYK1 Gene
chr12:10,618,923-10,674,318
(GRCh38/hg38)
Size:
55,396 bases
Orientation:
Minus strand
chr12:10,771,538-10,826,917
(GRCh37/hg19)
Size:
55,380 bases
Orientation:
Minus strand

Genomic View for STYK1 Gene

Genes around STYK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STYK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STYK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STYK1 Gene

Proteins for STYK1 Gene

  • Protein details for STYK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6J9G0-STYK1_HUMAN
    Recommended name:
    Tyrosine-protein kinase STYK1
    Protein Accession:
    Q6J9G0
    Secondary Accessions:
    • B2R9T2
    • Q52LR3
    • Q9BXY2
    • Q9NSH1

    Protein attributes for STYK1 Gene

    Size:
    422 amino acids
    Molecular mass:
    47577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for STYK1 Gene

Post-translational modifications for STYK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for STYK1
  • Santa Cruz Biotechnology (SCBT) Antibodies for STYK1

No data available for DME Specific Peptides for STYK1 Gene

Domains & Families for STYK1 Gene

Gene Families for STYK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for STYK1 Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine/tyrosine kinase 1 (STYK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6J9G0

UniProtKB/Swiss-Prot:

STYK1_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with STYK1: view

Function for STYK1 Gene

Molecular function for STYK1 Gene

UniProtKB/Swiss-Prot Function:
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=. ;.

Enzyme Numbers (IUBMB) for STYK1 Gene

Phenotypes From GWAS Catalog for STYK1 Gene

Gene Ontology (GO) - Molecular Function for STYK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA 21873635
GO:0005515 protein binding IPI 23010592
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with STYK1: view
genes like me logo Genes that share phenotypes with STYK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STYK1

CRISPR Products

Clone Products

  • Addgene plasmids for STYK1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STYK1 Gene

Localization for STYK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STYK1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STYK1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
cytosol 2
extracellular 1
nucleus 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STYK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with STYK1: view

Pathways & Interactions for STYK1 Gene

PathCards logo

SuperPathways for STYK1 Gene

SuperPathway Contained pathways
1 Focal Adhesion
genes like me logo Genes that share pathways with STYK1: view

Pathways by source for STYK1 Gene

1 BioSystems pathway for STYK1 Gene

Gene Ontology (GO) - Biological Process for STYK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0042127 regulation of cell proliferation IBA 21873635
genes like me logo Genes that share ontologies with STYK1: view

No data available for SIGNOR curated interactions for STYK1 Gene

Drugs & Compounds for STYK1 Gene

(1) Drugs for STYK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for STYK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STYK1: view

Transcripts for STYK1 Gene

mRNA/cDNA for STYK1 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for STYK1

Alternative Splicing Database (ASD) splice patterns (SP) for STYK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: - -

Relevant External Links for STYK1 Gene

GeneLoc Exon Structure for
STYK1
ECgene alternative splicing isoforms for
STYK1

Expression for STYK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STYK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STYK1 Gene

This gene is overexpressed in Colon - Transverse (x5.7).

Protein differential expression in normal tissues from HIPED for STYK1 Gene

This gene is overexpressed in Plasma (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STYK1 Gene



Protein tissue co-expression partners for STYK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of STYK1 Gene:

STYK1

SOURCE GeneReport for Unigene cluster for STYK1 Gene:

Hs.24979

mRNA Expression by UniProt/SwissProt for STYK1 Gene:

Q6J9G0-STYK1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.

Evidence on tissue expression from TISSUES for STYK1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with STYK1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STYK1 Gene

Orthologs for STYK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STYK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STYK1 33 32
  • 96.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STYK1 33 32
  • 86.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STYK1 33 32
  • 82.93 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Styk1 17 33 32
  • 81.75 (n)
rat
(Rattus norvegicus)
Mammalia Styk1 32
  • 81.43 (n)
oppossum
(Monodelphis domestica)
Mammalia STYK1 33
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 18 (a)
ManyToMany
-- 33
  • 4 (a)
ManyToMany
chicken
(Gallus gallus)
Aves STYK1 33 32
  • 61.89 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia styk1 32
  • 56.82 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886109 32
  • 53.21 (n)
STYK1 (2 of 3) 33
  • 34 (a)
OneToMany
styk1 33
  • 33 (a)
OneToMany
STYK1 (3 of 3) 33
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3277 33
  • 13 (a)
OneToMany
tor 33
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R151.4 33
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 39 (a)
OneToMany
-- 33
  • 33 (a)
OneToMany
-- 33
  • 32 (a)
OneToMany
Species where no ortholog for STYK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STYK1 Gene

ENSEMBL:
Gene Tree for STYK1 (if available)
TreeFam:
Gene Tree for STYK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STYK1: view image

Paralogs for STYK1 Gene

(5) SIMAP similar genes for STYK1 Gene using alignment to 7 proteins:

  • STYK1_HUMAN
  • F5GZF6_HUMAN
  • F5H2I9_HUMAN
  • F5H366_HUMAN
  • F5H4G3_HUMAN
  • H0YGL5_HUMAN
  • L8ECH9_HUMAN
genes like me logo Genes that share paralogs with STYK1: view

Variants for STYK1 Gene

Sequence variations from dbSNP and Humsavar for STYK1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_041844 A glioblastoma multiforme sample p.Val395Ile
rs1000013879 -- 10,658,050(-) T/C intron_variant
rs1000049330 -- 10,664,595(-) G/A intron_variant
rs1000059472 -- 10,665,181(-) T/A intron_variant
rs1000114283 -- 10,638,728(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STYK1 Gene

Variant ID Type Subtype PubMed ID
dgv767n106 CNV deletion 24896259
esv1480871 CNV deletion 17803354
esv2671184 CNV deletion 23128226
esv2745539 CNV deletion 23290073
esv2745540 CNV deletion 23290073
esv2745542 CNV deletion 23290073
esv3537 CNV loss 18987735
esv3548753 CNV deletion 23714750
nsv1050613 CNV gain 25217958
nsv1069416 CNV deletion 25765185
nsv1152262 CNV deletion 26484159
nsv527604 CNV loss 19592680
nsv607 CNV deletion 18451855
nsv832329 CNV gain 17160897
nsv958675 CNV deletion 24416366

Variation tolerance for STYK1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STYK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STYK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STYK1 Gene

Disorders for STYK1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for STYK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic inflammatory demyelinating polyneuritis
  • polyradiculoneuropathy, chronic inflammatory demyelinating
cervix carcinoma
  • cancer of cervix
ophthalmia neonatorum
  • gonococcal conjunctivitis
- elite association - COSMIC cancer census association via MalaCards
Search STYK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STYK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STYK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STYK1 Gene

Publications for STYK1 Gene

  1. Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. (PMID: 17298854) Amachika T … Watanabe N (Lung cancer (Amsterdam, Netherlands) 2007) 3 4 23 56
  2. A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. (PMID: 15150103) Liu L … Fu XY (Cancer research 2004) 3 4 23 56
  3. Isolation and characterization of a human putative receptor protein kinase cDNA STYK1. (PMID: 12841579) Ye X … Mao Y (Molecular biology reports 2003) 2 3 4 56
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  5. Overexpression of serine threonine tyrosine kinase 1/novel oncogene with kinase domain mRNA in patients with acute leukemia. (PMID: 19409952) Kondoh T … Watanabe N (Experimental hematology 2009) 3 23 56

Products for STYK1 Gene

Sources for STYK1 Gene