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STXBP3 (Syntaxin Binding Protein 3) is a Protein Coding gene. Diseases associated with STXBP3 include Hemophagocytic Lymphohistiocytosis, Familial, 4. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include syntaxin binding and syntaxin-1 binding. An important paralog of this gene is STXBP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 12773094 |
GO:0017075 | syntaxin-1 binding | IEA,IBA | 21873635 |
GO:0019905 | syntaxin binding | IEA,IPI | 12773094 |
GO:0044877 | protein-containing complex binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IBA,IDA | 18588921 |
GO:0016020 | membrane | IEA | -- |
GO:0016323 | basolateral plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
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2 | Vesicle-mediated transport | ||
3 | Translocation of GLUT4 to the plasma membrane | ||
4 | Angiopoietin Like Protein 8 Regulatory Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001678 | cellular glucose homeostasis | IEA | -- |
GO:0006886 | intracellular protein transport | IBA | 21873635 |
GO:0006887 | exocytosis | IEA | -- |
GO:0006904 | vesicle docking involved in exocytosis | IBA | 21873635 |
GO:0007269 | neurotransmitter secretion | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STXBP3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | STXBP3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | STXBP3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | STXBP3 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Stxbp3a 30 31 |
|
OneToMany | |
Stxbp3b 31 |
|
OneToMany | |||
Stxbp3 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Stxbp3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | STXBP3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | STXBP3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | STXBP3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stxbp3 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16785 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | stxbp3 30 31 |
|
OneToOne | |
wufb71h06 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Rop 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | unc-18 31 |
|
OneToMany | |
T07A9.10 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv487n54 | CNV | loss | 21841781 |
esv1070190 | CNV | deletion | 17803354 |
esv29430 | CNV | loss | 19812545 |
esv3587137 | CNV | loss | 21293372 |
nsv1013192 | CNV | gain | 25217958 |
nsv1078057 | CNV | deletion | 25765185 |
nsv1078622 | CNV | deletion | 25765185 |
nsv1140419 | CNV | tandem duplication | 24896259 |
nsv1153780 | CNV | deletion | 26484159 |
nsv2287 | CNV | deletion | 18451855 |
nsv823908 | CNV | loss | 20364138 |
nsv947442 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hemophagocytic lymphohistiocytosis, familial, 4 |
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